Environmental ExposureBCCEHCNCT06447974
The Barts Charity Children's Environmental Health Clinic
A study testing Exposure mitigations in people with Environmental Exposure and Health Behavior, run by Queen Mary University of London at 2 sites in United Kingdom.
Trial summary
The study will be based from a newly formed NHS service, the children's environmental health service. Participants will be children with a known chronic respiratory condition. Participants will undergo personal environmental exposure monitoring as well as home environmental assessments, before personalised exposure… Read more about this study
- Who is it for?
- Ages 4 to 17 yearsHealthy volunteers can take part
- Conditions the study is for
- Environmental Exposure, Health Behavior, Asthma in Children
- What is being tested?
- Exposure mitigations
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 2 sitesUnited Kingdom
- Study dates
- 24 Jul 2025to Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 4 to 17 years
- All sexes
- Healthy volunteers accepted
- Child
Who may be able to join
- Parent/Guardian able to provide written informed consent
- Referral made by paediatric asthma team
- Child aged 4-17 years at the time of consent to study
- A diagnosis of a chronic respiratory condition (diagnosis by a medical professional)
- Contactable for regular follow up by the research team
- Reasonable level of English language
- Ability to engage with technology and devices used in the study
Who cannot join
- Inability to use the tools and devices in the research study
- Inability to visit the hospital for the initial hospital visit
- Inability to allow home environmental assessment
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Abigail Whitehouse contact
United Kingdom2 sites, 2 recruiting
- Enrolling by invitation
Queen Mary University of London
London, E1 2AT
- Recruiting
The Royal London Hospital
London, E1
Dr Jonathan Grigg
About this study
The study will be based from a newly formed NHS service, the children's environmental health service. Participants will be children with a known chronic respiratory condition. Participants will undergo personal environmental exposure monitoring as well as home environmental assessments, before personalised exposure reports will be provided including a summary of their exposure and advising mitigation strategies based on exposure patterns and behaviours. The monitoring will be repeated after introduction of mitigation strategies. This will allow a comparison of the effectiveness of each method of mitigation.
Read the detailed description
Data will be collected from multiple sources during the study, including retrospective medical records and results, as well as data recorded as part of the study. These will include the following sources; Medical records from Royal London (including investigation results), Questionnaire responses, clinical interviews at clinic visits, new clinical investigations and home assessments.
These data will be both quantitative and qualitative. The data will be recorded on bespoke electronic databases, which will be securely stored on servers within the Bart's Health/ QMUL, More information on the collection and storage of each type of data can be found below.
Medical records from Royal London: Relevant clinical information and demographics will be extracted from the NHS electronic medical records as baseline information for the assessment in the environmental health clinic. This will be performed by members of the investigative team. Extracted information will include demographics, medical diagnoses, respiratory history, hospital visit history and clinical investigation results. Investigation results may include lung function, FeNO, blood test results, chest x-ray reports and any other relevant results from the child's medical history.
Questionnaires: Participants or their families will complete and return an Environmental Health Questionnaire which was designed for the purposes of the study. Answers to questions from the environmental health questionnaire will be in the form of multiple choice and short answer written questions. The questionnaire will be repeated throughout the participant's involvement in the clinic at designated points. The data from the questionnaires will be recorded in a digital database, will be created for the purpose of the clinic. This database will be stored securely within Barts Health / QMUL servers.
Medical Reviews: At visits in the clinic, interviews of the participants and their families will take place. This will include detailed medical and social history taking by medical sub investigators and a formal physical examination. To improve standardisation of data collected during interviews, a structured proforma will be developed, to be used while the interviews are being conducted. The data collected during these interviews will be recorded in the medical notes, as well as used to create personalised exposure reports.
Clinical investigations will be performed as part of the clinic. This will include blood eosinophils, FeNO, salivary cotinine and custom mould sensitivity. These investigations will be performed by medical members of staff during clinic visits. The results of these tests will be recorded in the medical notes, as well as in the digital database and secure in the servers based at Barts Health
Home assessments: During the period of home monitoring, participants will undergo assessments of their homes, their personal exposure to pollutants and undergo further health monitoring through the monitoring period. The home assessment will review mould and include a custom mould test comparing the child's blood IgG with a scraping from the mould in their home. The assessment of personal exposure will be performed using the Atmotube air quality monitor attached to a backpack (this is not a medical device). This monitor will be kept with the child at home, on their commutes and also at school. The portable air quality monitor measures air concentrations of particulate matter and volatile organic compounds (VOCs), humidity, temperature as well as GPS data and compares this against time. The encrypted anonymous data is then uploaded to a secure API before being stored within secure databases within the Barts health NHS servers. This database is stored securely within protected servers. No personal identifiable data or demographics is shared with Atmo or any other team otuside the clinic team.
After initial data collection and the home monitoring period, the data is collated and analysed by a medical member of the team to create a personal exposure report for each participant. This report will be provided to the participant, saved in the medical records, and used to recommend any appropriate exposure mitigation strategies. Follow up reviews will repeat the monitoring process and update the database, to compare the results before and after mitigation strategies have been introduced.
- Being tested
- Exposure mitigations
- Keywords
- asthma, Air pollution, environmental, Environmental health clinic
- Medical subject headings
- Health Behavior, Environmental Illness, Asthma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exposure mitigationsBehavioural
Behavioural interventions with an aim to reduce exposure by targeting occurrences of high exposure
| Study group | Role | What they receive |
|---|---|---|
| Pre and post intervention | Other | A single arm for measurement both pre and post introduction of intervention Receives: Behavioral: Exposure mitigations |
What is being measured
The primary outcome is the main question the study is designed to answer.
How effective is a specialist NHS environmental health clinic in reducing exposure to environmental contaminants in children with chronic respiratory disease, and what is the change in health outcomes.
Measurement of the concentrations of common air contaminants (PM1, PM2.5, PM5, PM10, VOCs), the GPs location of areas of high concentration and the behaviours of the individual at times of high and low exposure. For each participant, the social and behavioural factors affecting their exposure will be measured using the environmental health questionnaire (type of accommodation, proximity of school and home to main roads, type of cooking fuel and sprays used in the home, presence or absence of damp or mould, and mode and duration of school commute.
Measured: 3 years
Secondary outcomes (8)
What is the environmental exposure of children attending the environmental health clinic?
What is the concentration and duration of exposure of common air contaminants over a three day period - PM2.5, PM5, PM10, NO2 and CO2, in children attending the environmental health clinic?
Measured: 3 years
Are clinical tests such as salivary cotinine, exhaled carbon monoxide or blood eosinophils useful in screening for children who have a high environmental exposure to pollutants?
Do children who have high or positive results for salivary cotinine, exhaled carbon monoxide or blood eosinophils, have a higher air pollution exposure (concentration and duration of exposure of common air contaminants over a three day period - PM2.5, PM5, PM10, NO2 and CO2)?
Measured: 3 years
At which locations and times of day are children exposed to the most air pollution?
When and where are the highest concentrations of air pollution , when measured over a 72 hour period representative of the participants' normal day to day life.
Measured: 3 years
Does exposure to indoor and outdoor air pollution follow a repeated pattern each day?
When concentrations of common air contaminants is measured over a three day period, do the peaks in concentration occur at similar times and locations each day?
Measured: 3 years
Which factors affect the levels of environmental exposure to pollutants?
Comparison between air pollution exposure (concentration and frequency of exposure to common air contaminants over a three day period - PM2.5, PM5, PM10, NO2 and CO2) against social and behavioral factors assessed in the environmental health questionnaire ( type of accommodation, proximity of school and home to main roads, type of cooking fuel and sprays used in the home, and mode and duration of school commute)
Measured: 3 years
How does exposure to pollutants affect the health of children and young people with chronic respiratory disease?
Comparison of health outcomes (attendances for medical assessment, escalation of treatment and disease control) with the level of air pollution exposure (concentration and frequency of exposure to common air contaminants over a three day period - PM2.5, PM5, PM10, NO2 and CO2)
Measured: 3 years
Which mitigation strategies are effective in reducing the effects of pollution exposure and in which patients are they efficacious?
A comparison of air pollution exposure (concentrations of PM2.5, PM5, PM10, NO2 and CO2) before and after the implementation of mitigation strategies.
Measured: 3 years
Is an NHS environmental health clinic effective in delivering improvements in respiratory health of children with chronic respiratory disease?
A comparison of respiratory health outcomes (including symptoms control, number of attendances for medical assessment and treatment, and use of additional medication) before being seen in the clinic and after being seen in the clinic
Measured: 3 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jun 2024
- Study start24 Jul 2025
- Primary completionJun 2027 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (28)Papers the sponsor has linked to this study.
- Other trials for Environmental ExposureStudies of the same condition, open and under way.
- More trials run by Queen Mary University of LondonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Participants undergo personal exposure monitoring before and after the introduction of mitigation strategies.
- Masking
- None (open label)
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Queen Mary University of London
- Sponsor type
- University, hospital or other
- Collaborators
- Barts & The London NHS Trust
- Responsible party
- Sponsor
- Investigators
- Charles S Moorcroft, MBChB, Principal investigator, Queen Mary University of London
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06447974
- Sponsor's protocol ID
- 325076
- Acronym
- BCCEHC
- Status last verified
- Aug 2026
- First submitted
- 24 Apr 2023
- Last updated
- 13 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Brook RD, Rajagopalan S, Pope CA 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC Jr, Whitsel L, Kaufman JD; American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Council on Nutrition, Physical Activity and Metabolism. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010 Jun 1;121(21):2331-78. doi: 10.1161/CIR.0b013e3181dbece1. Epub 2010 May 10.
PubMed 20458016Kampa M, Castanas E. Human health effects of air pollution. Environ Pollut. 2008 Jan;151(2):362-7. doi: 10.1016/j.envpol.2007.06.012. Epub 2007 Jul 23.
PubMed 17646040GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1345-1422. doi: 10.1016/S0140-6736(17)32366-8.
PubMed 28919119Sram RJ, Binkova B, Dejmek J, Bobak M. Ambient air pollution and pregnancy outcomes: a review of the literature. Environ Health Perspect. 2005 Apr;113(4):375-82. doi: 10.1289/ehp.6362.
PubMed 15811825Brugha R, Grigg J. Urban air pollution and respiratory infections. Paediatr Respir Rev. 2014 Jun;15(2):194-9. doi: 10.1016/j.prrv.2014.03.001. Epub 2014 Mar 12.
PubMed 24704510Gehring U, Wijga AH, Koppelman GH, Vonk JM, Smit HA, Brunekreef B. Air pollution and the development of asthma from birth until young adulthood. Eur Respir J. 2020 Jul 2;56(1):2000147. doi: 10.1183/13993003.00147-2020. Print 2020 Jul.
PubMed 32299858Lacasana M, Esplugues A, Ballester F. Exposure to ambient air pollution and prenatal and early childhood health effects. Eur J Epidemiol. 2005;20(2):183-99. doi: 10.1007/s10654-004-3005-9.
PubMed 15792286Li X, Huang S, Jiao A, Yang X, Yun J, Wang Y, Xue X, Chu Y, Liu F, Liu Y, Ren M, Chen X, Li N, Lu Y, Mao Z, Tian L, Xiang H. Association between ambient fine particulate matter and preterm birth or term low birth weight: An updated systematic review and meta-analysis. Environ Pollut. 2017 Aug;227:596-605. doi: 10.1016/j.envpol.2017.03.055. Epub 2017 Apr 28.
PubMed 28457735Bobak M, Leon DA. The effect of air pollution on infant mortality appears specific for respiratory causes in the postneonatal period. Epidemiology. 1999 Nov;10(6):666-70.
PubMed 10535778Cai Y, Hansell AL, Granell R, Blangiardo M, Zottoli M, Fecht D, Gulliver J, Henderson AJ, Elliott P. Prenatal, Early-Life, and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort. Am J Respir Crit Care Med. 2020 Jul 1;202(1):112-123. doi: 10.1164/rccm.201902-0286OC.
PubMed 32142356Smith RB, Fecht D, Gulliver J, Beevers SD, Dajnak D, Blangiardo M, Ghosh RE, Hansell AL, Kelly FJ, Anderson HR, Toledano MB. Impact of London's road traffic air and noise pollution on birth weight: retrospective population based cohort study. BMJ. 2017 Dec 5;359:j5299. doi: 10.1136/bmj.j5299.
PubMed 29208602Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson Children's Respiratory Study: 1980 to present. J Allergy Clin Immunol. 2003 Apr;111(4):661-75; quiz 676. doi: 10.1067/mai.2003.162.
PubMed 12704342Achakulwisut P, Brauer M, Hystad P, Anenberg SC. Global, national, and urban burdens of paediatric asthma incidence attributable to ambient NO2 pollution: estimates from global datasets. Lancet Planet Health. 2019 Apr;3(4):e166-e178. doi: 10.1016/S2542-5196(19)30046-4. Epub 2019 Apr 11.
PubMed 30981709Beasley R, Semprini A, Mitchell EA. Risk factors for asthma: is prevention possible? Lancet. 2015 Sep 12;386(9998):1075-85. doi: 10.1016/S0140-6736(15)00156-7.
PubMed 26382999Mukherjee M, Stoddart A, Gupta RP, Nwaru BI, Farr A, Heaven M, Fitzsimmons D, Bandyopadhyay A, Aftab C, Simpson CR, Lyons RA, Fischbacher C, Dibben C, Shields MD, Phillips CJ, Strachan DP, Davies GA, McKinstry B, Sheikh A. The epidemiology, healthcare and societal burden and costs of asthma in the UK and its member nations: analyses of standalone and linked national databases. BMC Med. 2016 Aug 29;14(1):113. doi: 10.1186/s12916-016-0657-8.
PubMed 27568881
Study at a glance
From the registry record, last updated by the sponsor on 13 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Barts Charity Children's Environmental Health Clinic
- ClinicalTrials.gov ID
- NCT06447974
- Acronym / sponsor ID
- BCCEHC / 325076
- Keywords
- asthma, Air pollution, environmental, Environmental health clinic
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Queen Mary University of LondonUniversity, hospital or other
- Collaborators
- Barts & The London NHS Trust
- Study start
- 24 Jul 2025 (actual)
- Primary completion
- Jun 2027 (estimated)
- Study completion
- Jun 2027 (estimated)
- First posted
- 7 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study will be based from a newly formed NHS service, the children's environmental health service. Participants will be children with a known chronic respiratory condition. Participants will undergo personal environmental exposure monitoring as well as home environmental assessments, before personalised exposure reports will be provided including a summary of their exposure and advising mitigation strategies based on exposure patterns and behaviours. The monitoring will be repeated after introduction of mitigation strategies. This will allow a comparison of the effectiveness of each method of mitigation.
Detailed description
Data will be collected from multiple sources during the study, including retrospective medical records and results, as well as data recorded as part of the study. These will include the following sources; Medical records from Royal London (including investigation results), Questionnaire responses, clinical interviews at clinic visits, new clinical investigations and home assessments.
These data will be both quantitative and qualitative. The data will be recorded on bespoke electronic databases, which will be securely stored on servers within the Bart's Health/ QMUL, More information on the collection and storage of each type of data can be found below.
Medical records from Royal London: Relevant clinical information and demographics will be extracted from the NHS electronic medical records as baseline information for the assessment in the environmental health clinic. This will be performed by members of the investigative team. Extracted information will include demographics, medical diagnoses, respiratory history, hospital visit history and clinical investigation results. Investigation results may include lung function, FeNO, blood test results, chest x-ray reports and any other relevant results from the child's medical history.
Questionnaires: Participants or their families will complete and return an Environmental Health Questionnaire which was designed for the purposes of the study. Answers to questions from the environmental health questionnaire will be in the form of multiple choice and short answer written questions. The questionnaire will be repeated throughout the participant's involvement in the clinic at designated points. The data from the questionnaires will be recorded in a digital database, will be created for the purpose of the clinic. This database will be stored securely within Barts Health / QMUL servers.
Medical Reviews: At visits in the clinic, interviews of the participants and their families will take place. This will include detailed medical and social history taking by medical sub investigators and a formal physical examination. To improve standardisation of data collected during interviews, a structured proforma will be developed, to be used while the interviews are being conducted. The data collected during these interviews will be recorded in the medical notes, as well as used to create personalised exposure reports.
Clinical investigations will be performed as part of the clinic. This will include blood eosinophils, FeNO, salivary cotinine and custom mould sensitivity. These investigations will be performed by medical members of staff during clinic visits. The results of these tests will be recorded in the medical notes, as well as in the digital database and secure in the servers based at Barts Health
Home assessments: During the period of home monitoring, participants will undergo assessments of their homes, their personal exposure to pollutants and undergo further health monitoring through the monitoring period. The home assessment will review mould and include a custom mould test comparing the child's blood IgG with a scraping from the mould in their home. The assessment of personal exposure will be performed using the Atmotube air quality monitor attached to a backpack (this is not a medical device). This monitor will be kept with the child at home, on their commutes and also at school. The portable air quality monitor measures air concentrations of particulate matter and volatile organic compounds (VOCs), humidity, temperature as well as GPS data and compares this against time. The encrypted anonymous data is then uploaded to a secure API before being stored within secure databases within the Barts health NHS servers. This database is stored securely within protected servers. No personal identifiable data or demographics is shared with Atmo or any other team otuside the clinic team.
After initial data collection and the home monitoring period, the data is collated and analysed by a medical member of the team to create a personal exposure report for each participant. This report will be provided to the participant, saved in the medical records, and used to recommend any appropriate exposure mitigation strategies. Follow up reviews will repeat the monitoring process and update the database, to compare the results before and after mitigation strategies have been introduced.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Participants undergo personal exposure monitoring before and after the introduction of mitigation strategies.
| Arm | Type | Receives |
|---|---|---|
| Pre and post intervention | Other | Behavioral: Exposure mitigationsA single arm for measurement both pre and post introduction of intervention |
Who may qualify
- Ages
- 4 to 17 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (7 listed)
- Parent/Guardian able to provide written informed consent
- Referral made by paediatric asthma team
- Child aged 4-17 years at the time of consent to study
- A diagnosis of a chronic respiratory condition (diagnosis by a medical professional)
- Contactable for regular follow up by the research team
Key exclusion criteria (3 listed)
- Inability to use the tools and devices in the research study
- Inability to visit the hospital for the initial hospital visit
- Inability to allow home environmental assessment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exposure mitigationsBehavioural interventions with an aim to reduce exposure by targeting occurrences of high exposure | Behavioural | Pre and post intervention |
Primary outcome
How effective is a specialist NHS environmental health clinic in reducing exposure to environmental contaminants in children with chronic respiratory disease, and what is the change in health outcomes.
Time frame: 3 years
Measurement of the concentrations of common air contaminants (PM1, PM2.5, PM5, PM10, VOCs), the GPs location of areas of high concentration and the behaviours of the individual at times of high and low exposure. For each participant, the social and behavioural factors affecting their exposure will be measured using the environmental health questionnaire (type of accommodation, proximity of school and home to main roads, type of cooking fuel and sprays used in the home, presence or absence of damp or mould, and mode and duration of school commute.
8 secondary outcomes
What is the environmental exposure of children attending the environmental health clinic?
Time frame: 3 years
Are clinical tests such as salivary cotinine, exhaled carbon monoxide or blood eosinophils useful in screening for children who have a high environmental exposure to pollutants?
Time frame: 3 years
At which locations and times of day are children exposed to the most air pollution?
Time frame: 3 years
Does exposure to indoor and outdoor air pollution follow a repeated pattern each day?
Time frame: 3 years
Which factors affect the levels of environmental exposure to pollutants?
Time frame: 3 years
How does exposure to pollutants affect the health of children and young people with chronic respiratory disease?
Time frame: 3 years
Which mitigation strategies are effective in reducing the effects of pollution exposure and in which patients are they efficacious?
Time frame: 3 years
Is an NHS environmental health clinic effective in delivering improvements in respiratory health of children with chronic respiratory disease?
Time frame: 3 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Aug 2026.
- Background: PubMed 20458016Brook RD, Rajagopalan S, Pope CA 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC Jr, Whitsel L, Kaufman JD; American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Council on Nutrition, Physical Activity and Metabolism. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010 Jun 1;121(21):2331-78. doi: 10.1161/CIR.0b013e3181dbece1. Epub 2010 May 10.
- Background: PubMed 17646040Kampa M, Castanas E. Human health effects of air pollution. Environ Pollut. 2008 Jan;151(2):362-7. doi: 10.1016/j.envpol.2007.06.012. Epub 2007 Jul 23.
- Background: PubMed 28919119GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1345-1422. doi: 10.1016/S0140-6736(17)32366-8.
- Background: PubMed 15811825Sram RJ, Binkova B, Dejmek J, Bobak M. Ambient air pollution and pregnancy outcomes: a review of the literature. Environ Health Perspect. 2005 Apr;113(4):375-82. doi: 10.1289/ehp.6362.
- Background: PubMed 24704510Brugha R, Grigg J. Urban air pollution and respiratory infections. Paediatr Respir Rev. 2014 Jun;15(2):194-9. doi: 10.1016/j.prrv.2014.03.001. Epub 2014 Mar 12.
- Background: PubMed 32299858Gehring U, Wijga AH, Koppelman GH, Vonk JM, Smit HA, Brunekreef B. Air pollution and the development of asthma from birth until young adulthood. Eur Respir J. 2020 Jul 2;56(1):2000147. doi: 10.1183/13993003.00147-2020. Print 2020 Jul.
- Background: PubMed 15792286Lacasana M, Esplugues A, Ballester F. Exposure to ambient air pollution and prenatal and early childhood health effects. Eur J Epidemiol. 2005;20(2):183-99. doi: 10.1007/s10654-004-3005-9.
- Background: PubMed 28457735Li X, Huang S, Jiao A, Yang X, Yun J, Wang Y, Xue X, Chu Y, Liu F, Liu Y, Ren M, Chen X, Li N, Lu Y, Mao Z, Tian L, Xiang H. Association between ambient fine particulate matter and preterm birth or term low birth weight: An updated systematic review and meta-analysis. Environ Pollut. 2017 Aug;227:596-605. doi: 10.1016/j.envpol.2017.03.055. Epub 2017 Apr 28.
- Background: PubMed 10535778Bobak M, Leon DA. The effect of air pollution on infant mortality appears specific for respiratory causes in the postneonatal period. Epidemiology. 1999 Nov;10(6):666-70.
- Background: PubMed 32142356Cai Y, Hansell AL, Granell R, Blangiardo M, Zottoli M, Fecht D, Gulliver J, Henderson AJ, Elliott P. Prenatal, Early-Life, and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort. Am J Respir Crit Care Med. 2020 Jul 1;202(1):112-123. doi: 10.1164/rccm.201902-0286OC.
- Background: PubMed 29208602Smith RB, Fecht D, Gulliver J, Beevers SD, Dajnak D, Blangiardo M, Ghosh RE, Hansell AL, Kelly FJ, Anderson HR, Toledano MB. Impact of London's road traffic air and noise pollution on birth weight: retrospective population based cohort study. BMJ. 2017 Dec 5;359:j5299. doi: 10.1136/bmj.j5299.
- Background: PubMed 12704342Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson Children's Respiratory Study: 1980 to present. J Allergy Clin Immunol. 2003 Apr;111(4):661-75; quiz 676. doi: 10.1067/mai.2003.162.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Abigail Whitehouse contact
Charles S Moorcroft, MBChB principal investigator
Queen Mary University of London
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exposure mitigations in people with Environmental Exposure and Health Behavior, run by Queen Mary University of London at 2 sites in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Charles S Moorcroft (07808061892, c.moorcroft@qmul.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
How effective is a specialist NHS environmental health clinic in reducing exposure to environmental contaminants in children with chronic respiratory disease, and what is the change in health outcomes. (time frame: 3 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06447974, which also lists 28 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2026.