Multiple SclerosisNCT06462339
The Effect of Online Pilates on Cognitive Function and Dual-Task Performance
A study testing Experimental: Intervention Group in people with Multiple Sclerosis, run by Gazi University at 1 site in Turkey (Türkiye).
Trial summary
Multiple sclerosis (MS) is a chronic, inflammatory, degenerative disease of the central nervous system, causing demyelination and axonal damage. MS typically begins with attacks resulting from demyelination of axons, eventually evolving into a neurodegenerative disease associated with neurotrophic support deficiency… Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Multiple Sclerosis
- What is being tested?
- Experimental: Intervention Group
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 28 Jun 2024to 12 Nov 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 18-65 years of age
- Voluntarily participate in research to accept
- Having a diagnosis of "Multiple Sclerosis" by a specialist physician
- Relapse free in the last 3 mounts
- An Expanded Disability Status Scale (EDSS) score: 0-5
Who cannot join
- Any cardiovascular, orthopedic, visual, hearing, and perception problems that may affect the results of the research
- Having a cardiovascular, pulmonary or hormonal disorder that would prevent exercise
- Having an accompanying neurological disorder other than MS
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Investigation of the Effects of Online Pilates Training on Cognitive Functions and Dual-Task Performance in Multiple Sclerosis Patients
Multiple sclerosis (MS) is a chronic, inflammatory, degenerative disease of the central nervous system, causing demyelination and axonal damage. MS typically begins with attacks resulting from demyelination of axons, eventually evolving into a neurodegenerative disease associated with neurotrophic support deficiency and neuronal loss. Depending on the location and degeneration, various neurological disorders and symptoms such as walking and balance problems, fatigue, sensory loss, and cognitive impairments are observed in MS patients. Cognitive impairments in MS are associated with lesion count, localization, axonal loss, and brain atrophy, affecting approximately 50-60% of patients. Patients exhibit impairments in verbal fluency, visual-spatial memory, processing speed, executive functions, and episodic memory. Cognitive impairments also lead to a decrease in dual-task performance, referred to as the ability to perform two tasks simultaneously, in MS patients. Cognitive problems and impaired dual-task performance negatively impact various aspects of daily life, including social participation and employment status, thus reducing their quality of life.
Clinical-based exercise interventions are frequently utilized and effective in improving cognitive functions and dual-task performance in MS. Pilates is a commonly used exercise modality in clinical practice. Pilates is a core stability-based exercise method involving endurance, flexibility, movement, posture, and respiratory control. Previous studies have indicated that clinical Pilates improves cognitive functions. On the other hand, telerehabilitation approaches, the use of which has increased rapidly due to technological developments in recent times, enable the delivery of rehabilitation services to patients in distant places by using communication technologies. For this purpose, it is highly valuable to implement Pilates, which consists of core stability exercise content, through telerehabilitation. While there are studies on clinical-based Pilates interventions, no study has investigated the efficacy of one-on-one online Pilates exercises on cognitive functions and dual-task performance in an online platform. Therefore, this study aims to investigate the effects of online Pilates on cognitive functions and dual-task performance in patients with MS.
Read the detailed description
This study is a randomized controlled study. The patients will be randomly divided into two groups exercise and control. Pilates exercises consisting of 3 days a week for 6 weeks will be given to the exercise group.
The control group will be a wait-list group without any additional specific treatment.
All assessments will be done before and after the 6-week intervention program or waiting period. The demographic characteristics of the participants initially will be taken and the Expanded Disability Status Scale score of those of MS will be recorded. As the outcome measures, cognitive functions and dual-task performance will be evaluated.
- Conditions
- Multiple Sclerosis
- Being tested
- Experimental: Intervention Group
- Keywords
- Multiple Sclerosis, Cognitive Function, Dual-task, Pilates, Telerehabilitation
- Medical subject headings
- Multiple Sclerosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Experimental: Intervention GroupBehavioural
The group that will receive pilates training via telerehabilitation
| Study group | Role | What they receive |
|---|---|---|
| Pilates training via telerehabilitation | Experimental | The intervention group will be received online pilates training three times a week for 6 weeks. Receives: Behavioral: Experimental: Intervention Group |
| Waitlist | No intervention | The control group will be a wait-list group without any additional specific treatment. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mini-Mental test-Baseline
Mini Mental Test (MMT) consists of eleven items grouped under five main headings: orientation, recording memory, attention and calculation, recall and language, and is evaluated out of a total score of 30. Accordingly, getting 24 points and above is considered normal.
Measured: Assessment will be conducted before the intervention
Mini-Mental test-Post intervention
Mini Mental Test (MMT) consists of eleven items grouped under five main headings: orientation, recording memory, attention and calculation, recall and language, and is evaluated out of a total score of 30. Accordingly, getting 24 points and above is considered normal.
Measured: Assessment will be conducted immediately after the intervention
Montreal Cognitive Assessment-Baseline
The Montreal Cognitive Assessment (MoCA) was developed as a rapid screening test for mild cognitive impairment. MoCA evaluates different cognitive functions. These; attention and concentration, executive functions, memory, language, visual structuring skills, abstract thinking, calculation and orientation. The highest total score that can be obtained from the test is 30. Higher scores mean a better outcome.
Measured: Assessment will be conducted before the intervention
Montreal Cognitive Assessment-Post intervention
The Montreal Cognitive Assessment (MoCA) was developed as a rapid screening test for mild cognitive impairment. MoCA evaluates different cognitive functions. These; attention and concentration, executive functions, memory, language, visual structuring skills, abstract thinking, calculation and orientation. The highest total score that can be obtained from the test is 30. Higher scores mean a better outcome.
Measured: Assessment will be conducted immediately after the intervention
Trail Making Test-Baseline
Trail Making Test (TMT) is used to evaluate individuals' executive functions, task-sequence switching ability, attention, visual scanning speed, visual-motor perception, planning, organization, abstract thinking and reaction limitation. The test consists of 2 parts: A and B. In part A, the individual is asked to combine numbers from 1 to 25 and the completion time is recorded. In part B, the individual completes the sequence corresponding to a number and a letter respectively, and the completion time is recorded.
Measured: Assessment will be conducted before the intervention
Trail Making Test-Post intervention
Trail Making Test (TMT) is used to evaluate individuals' executive functions, task-sequence switching ability, attention, visual scanning speed, visual-motor perception, planning, organization, abstract thinking and reaction limitation. The test consists of 2 parts: A and B. In part A, the individual is asked to combine numbers from 1 to 25 and the completion time is recorded. In part B, the individual completes the sequence corresponding to a number and a letter respectively, and the completion time is recorded.
Measured: Assessment will be conducted immediately after the intervention
Stroop Test-Baseline
Stroop Test, one of the neuropsychological tests, is used to evaluate selective attention, information processing speed and cognitive flexibility. The test consists of three parts. The first section contains words written in black (e.g. 'blue'), the second section contains colors, and the last section contains words written in different colors (e.g. the word blue written in red ink). The participant is expected to fulfill the tasks in these three sections respectively. While keeping time for each part, the participant must read the words correctly at first, say the colors in the next part, and say the color in which the word is written in the last part. In the test, reading time, number of errors made and number of spontaneous corrections are recorded.
Measured: Assessment will be conducted before the intervention
Stroop Test-Post intervention
Stroop Test, one of the neuropsychological tests, is used to evaluate selective attention, information processing speed and cognitive flexibility. The test consists of three parts. The first section contains words written in black (e.g. 'blue'), the second section contains colors, and the last section contains words written in different colors (e.g. the word blue written in red ink). The participant is expected to fulfill the tasks in these three sections respectively. While keeping time for each part, the participant must read the words correctly at first, say the colors in the next part, and say the color in which the word is written in the last part. In the test, reading time, number of errors made and number of spontaneous corrections are recorded.
Measured: Assessment will be conducted immediately after the intervention
Functional mobility-baseline
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.
Measured: Assessment will be conducted before the intervention
Dual task performance in functional mobility, Cognitive additional task (arithmetic)-baseline
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.
Cognitive additional task (arithmetic): Individuals will be asked to perform tasks by counting backward from 3 to 3 from 100.
Measured: Assessment will be conducted before the intervention
Dual task performance in functional mobility, Cognitive additional task (verbal)-baseline
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.
Cognitive additional task (verbal): Individuals will be asked to fulfill their duties by producing name.
Measured: Assessment will be conducted before the intervention
functional mobility-post intervention
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.
Measured: Assessment will be conducted immediately after the intervention
Dual task performance in functional mobility, Cognitive additional task (arithmetic)-post intervention
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.
Cognitive additional task (arithmetic): Individuals will be asked to perform tasks by counting backward from 3 to 3 from 100.
Measured: Assessment will be conducted immediately after the intervention
Dual task performance in functional mobility, Cognitive additional task (verbal)-post intervention
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.
Cognitive additional task (verbal): Individuals will be asked to fulfill their duties by producing name.
Measured: Assessment will be conducted immediately after the intervention
balance-baseline
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.
Measured: Assessment will be conducted before the intervention
balance, Cognitive additional task (arithmetic)-baseline
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.
Cognitive additional task (arithmetic)
Measured: Assessment will be conducted before the intervention
Dual task performance in balance, Cognitive additional task (verbal)-baseline
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.
Cognitive additional task (verbal)
Measured: Assessment will be conducted before the intervention
Dual task performance in balance,Cognitive additional task (arithmetic)-post intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.
Cognitive additional task (arithmetic)
Measured: Assessment will be conducted immediately after the intervention
balance-post intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.
Measured: Assessment will be conducted immediately after the intervention
Dual task performance in balance,Cognitive additional task (arithmetic) -post intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.
Cognitive additional task (arithmetic)
Measured: Assessment will be conducted immediately after the intervention
Dual task performance in balance,Cognitive additional task (verbal) -post intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.
Cognitive additional task (verbal)
Measured: Assessment will be conducted immediately after the intervention
gait-baseline
Wearable system (G-Walk) will be used to assess gait parameters.
Measured: Assessment will be conducted before the intervention
Dual task performance in gait, Cognitive additional task (arithmetic)-baseline
Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (arithmetic)
Measured: Assessment will be conducted before the intervention
Dual task performance in gait, Cognitive additional task (verbal)-baseline
Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (verbal)
Measured: Assessment will be conducted before the intervention
gait-post intervention
Wearable system (G-Walk) will be used to assess gait parameters.
Measured: Assessment will be conducted immediately after the intervention
Dual task performance in gait, Cognitive additional task (arithmetic)-post intervention
Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (arithmetic)
Measured: Assessment will be conducted immediately after the intervention
Dual task performance in gait, Cognitive additional task (verbal)-post intervention
Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (verbal)
Measured: Assessment will be conducted immediately after the intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jun 2024
- Study start28 Jun 2024
- Primary completion12 Sep 2024
- Study completion12 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Multiple SclerosisStudies of the same condition, open and under way.
- More trials run by Gazi UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Two groups as exercise group and control group
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Gazi University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kader Eldemir, Ordu University
- Investigators
- Kader Eldemir, PT, MSc., Study chair, Ordu University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06462339
- Sponsor's protocol ID
- MS-Cognition-Onlinepilates
- Status last verified
- Mar 2025
- First submitted
- 24 May 2024
- Last updated
- 18 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is not a plan to make individual participant data but when the statistical analysis of all data are made, all results will be shared
Publications
Abasiyanik Z, Ertekin O, Kahraman T, Yigit P, Ozakbas S. The effects of Clinical Pilates training on walking, balance, fall risk, respiratory, and cognitive functions in persons with multiple sclerosis: A randomized controlled trial. Explore (NY). 2020 Jan-Feb;16(1):12-20. doi: 10.1016/j.explore.2019.07.010. Epub 2019 Jul 17.
PubMed 31377306Ozkul C, Guclu-Gunduz A, Eldemir K, Apaydin Y, Yazici G, Irkec C. Combined exercise training improves cognitive functions in multiple sclerosis patients with cognitive impairment: A single-blinded randomized controlled trial. Mult Scler Relat Disord. 2020 Oct;45:102419. doi: 10.1016/j.msard.2020.102419. Epub 2020 Jul 23.
PubMed 32736216Eldemir K, Eldemir S, Ozkul C, Irkec C, Guclu-Gunduz A. The effects of online pilates training on cognitive functions and dual task performance in people with multiple sclerosis: A randomized controlled study. Mult Scler Relat Disord. 2025 May;97:106393. doi: 10.1016/j.msard.2025.106393. Epub 2025 Mar 17.
PubMed 40120159
Study at a glance
From the registry record, last updated by the sponsor on 18 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Effects of Online Pilates Training on Cognitive Functions and Dual-Task Performance in Multiple Sclerosis Patients
- ClinicalTrials.gov ID
- NCT06462339
- Acronym / sponsor ID
- MS-Cognition-Onlinepilates
- Conditions
- Multiple Sclerosis
- Keywords
- Multiple Sclerosis, Cognitive Function, Dual-task, Pilates, Telerehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Gazi UniversityUniversity, hospital or other
- Study start
- 28 Jun 2024 (actual)
- Primary completion
- 12 Sep 2024 (actual)
- Study completion
- 12 Nov 2024 (actual)
- First posted
- 17 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Multiple sclerosis (MS) is a chronic, inflammatory, degenerative disease of the central nervous system, causing demyelination and axonal damage. MS typically begins with attacks resulting from demyelination of axons, eventually evolving into a neurodegenerative disease associated with neurotrophic support deficiency and neuronal loss. Depending on the location and degeneration, various neurological disorders and symptoms such as walking and balance problems, fatigue, sensory loss, and cognitive impairments are observed in MS patients. Cognitive impairments in MS are associated with lesion count, localization, axonal loss, and brain atrophy, affecting approximately 50-60% of patients. Patients exhibit impairments in verbal fluency, visual-spatial memory, processing speed, executive functions, and episodic memory. Cognitive impairments also lead to a decrease in dual-task performance, referred to as the ability to perform two tasks simultaneously, in MS patients. Cognitive problems and impaired dual-task performance negatively impact various aspects of daily life, including social participation and employment status, thus reducing their quality of life.
Clinical-based exercise interventions are frequently utilized and effective in improving cognitive functions and dual-task performance in MS. Pilates is a commonly used exercise modality in clinical practice. Pilates is a core stability-based exercise method involving endurance, flexibility, movement, posture, and respiratory control. Previous studies have indicated that clinical Pilates improves cognitive functions. On the other hand, telerehabilitation approaches, the use of which has increased rapidly due to technological developments in recent times, enable the delivery of rehabilitation services to patients in distant places by using communication technologies. For this purpose, it is highly valuable to implement Pilates, which consists of core stability exercise content, through telerehabilitation. While there are studies on clinical-based Pilates interventions, no study has investigated the efficacy of one-on-one online Pilates exercises on cognitive functions and dual-task performance in an online platform. Therefore, this study aims to investigate the effects of online Pilates on cognitive functions and dual-task performance in patients with MS.
Detailed description
This study is a randomized controlled study. The patients will be randomly divided into two groups exercise and control. Pilates exercises consisting of 3 days a week for 6 weeks will be given to the exercise group.
The control group will be a wait-list group without any additional specific treatment.
All assessments will be done before and after the 6-week intervention program or waiting period. The demographic characteristics of the participants initially will be taken and the Expanded Disability Status Scale score of those of MS will be recorded. As the outcome measures, cognitive functions and dual-task performance will be evaluated.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
- Model description
- Two groups as exercise group and control group
| Arm | Type | Receives |
|---|---|---|
| Pilates training via telerehabilitation | Experimental | Behavioral: Experimental: Intervention GroupThe intervention group will be received online pilates training three times a week for 6 weeks. |
| Waitlist | No intervention | –The control group will be a wait-list group without any additional specific treatment. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- 18-65 years of age
- Voluntarily participate in research to accept
- Having a diagnosis of "Multiple Sclerosis" by a specialist physician
- Relapse free in the last 3 mounts
- An Expanded Disability Status Scale (EDSS) score: 0-5
Key exclusion criteria (3 listed)
- Any cardiovascular, orthopedic, visual, hearing, and perception problems that may affect the results of the research
- Having a cardiovascular, pulmonary or hormonal disorder that would prevent exercise
- Having an accompanying neurological disorder other than MS
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Experimental: Intervention GroupThe group that will receive pilates training via telerehabilitation | Behavioural | Pilates training via telerehabilitation |
Primary outcome
Mini-Mental test-Baseline
Time frame: Assessment will be conducted before the intervention
Mini Mental Test (MMT) consists of eleven items grouped under five main headings: orientation, recording memory, attention and calculation, recall and language, and is evaluated out of a total score of 30. Accordingly, getting 24 points and above is considered normal.
Mini-Mental test-Post intervention
Time frame: Assessment will be conducted immediately after the intervention
Mini Mental Test (MMT) consists of eleven items grouped under five main headings: orientation, recording memory, attention and calculation, recall and language, and is evaluated out of a total score of 30. Accordingly, getting 24 points and above is considered normal.
Montreal Cognitive Assessment-Baseline
Time frame: Assessment will be conducted before the intervention
The Montreal Cognitive Assessment (MoCA) was developed as a rapid screening test for mild cognitive impairment. MoCA evaluates different cognitive functions. These; attention and concentration, executive functions, memory, language, visual structuring skills, abstract thinking, calculation and orientation. The highest total score that can be obtained from the test is 30. Higher scores mean a better outcome.
Montreal Cognitive Assessment-Post intervention
Time frame: Assessment will be conducted immediately after the intervention
The Montreal Cognitive Assessment (MoCA) was developed as a rapid screening test for mild cognitive impairment. MoCA evaluates different cognitive functions. These; attention and concentration, executive functions, memory, language, visual structuring skills, abstract thinking, calculation and orientation. The highest total score that can be obtained from the test is 30. Higher scores mean a better outcome.
Trail Making Test-Baseline
Time frame: Assessment will be conducted before the intervention
Trail Making Test (TMT) is used to evaluate individuals' executive functions, task-sequence switching ability, attention, visual scanning speed, visual-motor perception, planning, organization, abstract thinking and reaction limitation. The test consists of 2 parts: A and B. In part A, the individual is asked to combine numbers from 1 to 25 and the completion time is recorded. In part B, the individual completes the sequence corresponding to a number and a letter respectively, and the completion time is recorded.
Trail Making Test-Post intervention
Time frame: Assessment will be conducted immediately after the intervention
Trail Making Test (TMT) is used to evaluate individuals' executive functions, task-sequence switching ability, attention, visual scanning speed, visual-motor perception, planning, organization, abstract thinking and reaction limitation. The test consists of 2 parts: A and B. In part A, the individual is asked to combine numbers from 1 to 25 and the completion time is recorded. In part B, the individual completes the sequence corresponding to a number and a letter respectively, and the completion time is recorded.
Stroop Test-Baseline
Time frame: Assessment will be conducted before the intervention
Stroop Test, one of the neuropsychological tests, is used to evaluate selective attention, information processing speed and cognitive flexibility. The test consists of three parts. The first section contains words written in black (e.g. 'blue'), the second section contains colors, and the last section contains words written in different colors (e.g. the word blue written in red ink). The participant is expected to fulfill the tasks in these three sections respectively. While keeping time for each part, the participant must read the words correctly at first, say the colors in the next part, and say the color in which the word is written in the last part. In the test, reading time, number of errors made and number of spontaneous corrections are recorded.
Stroop Test-Post intervention
Time frame: Assessment will be conducted immediately after the intervention
Stroop Test, one of the neuropsychological tests, is used to evaluate selective attention, information processing speed and cognitive flexibility. The test consists of three parts. The first section contains words written in black (e.g. 'blue'), the second section contains colors, and the last section contains words written in different colors (e.g. the word blue written in red ink). The participant is expected to fulfill the tasks in these three sections respectively. While keeping time for each part, the participant must read the words correctly at first, say the colors in the next part, and say the color in which the word is written in the last part. In the test, reading time, number of errors made and number of spontaneous corrections are recorded.
Functional mobility-baseline
Time frame: Assessment will be conducted before the intervention
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.
Dual task performance in functional mobility, Cognitive additional task (arithmetic)-baseline
Time frame: Assessment will be conducted before the intervention
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again. Cognitive additional task (arithmetic): Individuals will be asked to perform tasks by counting backward from 3 to 3 from 100.
Dual task performance in functional mobility, Cognitive additional task (verbal)-baseline
Time frame: Assessment will be conducted before the intervention
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again. Cognitive additional task (verbal): Individuals will be asked to fulfill their duties by producing name.
functional mobility-post intervention
Time frame: Assessment will be conducted immediately after the intervention
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.
Dual task performance in functional mobility, Cognitive additional task (arithmetic)-post intervention
Time frame: Assessment will be conducted immediately after the intervention
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again. Cognitive additional task (arithmetic): Individuals will be asked to perform tasks by counting backward from 3 to 3 from 100.
Dual task performance in functional mobility, Cognitive additional task (verbal)-post intervention
Time frame: Assessment will be conducted immediately after the intervention
Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again. Cognitive additional task (verbal): Individuals will be asked to fulfill their duties by producing name.
balance-baseline
Time frame: Assessment will be conducted before the intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.
balance, Cognitive additional task (arithmetic)-baseline
Time frame: Assessment will be conducted before the intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (arithmetic)
Dual task performance in balance, Cognitive additional task (verbal)-baseline
Time frame: Assessment will be conducted before the intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (verbal)
Dual task performance in balance,Cognitive additional task (arithmetic)-post intervention
Time frame: Assessment will be conducted immediately after the intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (arithmetic)
balance-post intervention
Time frame: Assessment will be conducted immediately after the intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.
Dual task performance in balance,Cognitive additional task (arithmetic) -post intervention
Time frame: Assessment will be conducted immediately after the intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (arithmetic)
Dual task performance in balance,Cognitive additional task (verbal) -post intervention
Time frame: Assessment will be conducted immediately after the intervention
The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (verbal)
gait-baseline
Time frame: Assessment will be conducted before the intervention
Wearable system (G-Walk) will be used to assess gait parameters.
Dual task performance in gait, Cognitive additional task (arithmetic)-baseline
Time frame: Assessment will be conducted before the intervention
Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (arithmetic)
Dual task performance in gait, Cognitive additional task (verbal)-baseline
Time frame: Assessment will be conducted before the intervention
Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (verbal)
gait-post intervention
Time frame: Assessment will be conducted immediately after the intervention
Wearable system (G-Walk) will be used to assess gait parameters.
Dual task performance in gait, Cognitive additional task (arithmetic)-post intervention
Time frame: Assessment will be conducted immediately after the intervention
Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (arithmetic)
Dual task performance in gait, Cognitive additional task (verbal)-post intervention
Time frame: Assessment will be conducted immediately after the intervention
Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (verbal)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Mar 2025.
- Background: PubMed 31377306Abasiyanik Z, Ertekin O, Kahraman T, Yigit P, Ozakbas S. The effects of Clinical Pilates training on walking, balance, fall risk, respiratory, and cognitive functions in persons with multiple sclerosis: A randomized controlled trial. Explore (NY). 2020 Jan-Feb;16(1):12-20. doi: 10.1016/j.explore.2019.07.010. Epub 2019 Jul 17.
- Background: PubMed 32736216Ozkul C, Guclu-Gunduz A, Eldemir K, Apaydin Y, Yazici G, Irkec C. Combined exercise training improves cognitive functions in multiple sclerosis patients with cognitive impairment: A single-blinded randomized controlled trial. Mult Scler Relat Disord. 2020 Oct;45:102419. doi: 10.1016/j.msard.2020.102419. Epub 2020 Jul 23.
- Derived from this study: PubMed 40120159Eldemir K, Eldemir S, Ozkul C, Irkec C, Guclu-Gunduz A. The effects of online pilates training on cognitive functions and dual task performance in people with multiple sclerosis: A randomized controlled study. Mult Scler Relat Disord. 2025 May;97:106393. doi: 10.1016/j.msard.2025.106393. Epub 2025 Mar 17.
- Individual participant dataSharing planned: No. There is not a plan to make individual participant data but when the statistical analysis of all data are made, all results will be shared
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Pain Phenotypes in Individuals With Multiple Sclerosis
Multiple Sclerosis, Chronic Pain
Not yet recruiting
Evaluating the Effect of the Zeen Mobility Device on Clinical Practicality, Safety, and Impact (Via Assessments of Walking, Standing Tolerance, Balance, Endurance, Effort, and Participation in Daily Tasks) in an Outpatient Rehabilitation Setting for Individuals With Mobility Impairments.
Stroke, Parkinson's Disease (PD)
RecruitingPhase 3
Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis
Multiple Sclerosis
RecruitingPhase 2
Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis
Multiple Sclerosis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Kader Eldemir, PT, MSc. study chair
Ordu University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Experimental: Intervention Group in people with Multiple Sclerosis, run by Gazi University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mini-Mental test-Baseline (time frame: Assessment will be conducted before the intervention). The study lists 27 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06462339, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Mar 2025.