Intervertebral Disc ProtrusionNCT06521294
Mulligan SNAG Technique in Individuals With Lumbar Intervertebral Disc Protrusion
A study testing Mulligan SNAG mobilization tecnique and Conventional Physiotherapy in people with Intervertebral Disc Protrusion, run by Biruni University at 1 site in Turkey (Türkiye).
Trial summary
This study aimed to examine the effects of the Mulligan SNAG mobilization technique, applied in addition to conventional physiotherapy on the structure of the intervertebral disc and physical functioning in patients diagnosed with low back pain due to lumbar intervertebral disc protrusion. Read more about this study
- Who is it for?
- Ages 20 to 60 years
- Conditions the study is for
- Intervertebral Disc Protrusion
- What is being tested?
- Mulligan SNAG mobilization tecnique and Conventional Physiotherapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 16 Feb 2025to 15 Jan 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Being between the ages of 20-60
- Those diagnosed with lumbar intervertebral disc heniation (protrusion on L1-L2, L2-L3, L3-L4, L4-L5, L5-S1) at a single level
- Those who voluntarily agreed to participate in the study
Who cannot join
- Individuals diagnosed with Lumbar Bulging, Extruded, Sequestered discs
- Individuals who have undergone lumbar region spinal surgery
- Individuals with spinal deformity (scoliosis, spondylolisthesis, Ankylosing Spondylitis)
- Individuals with lumbar stenosis
- Pregnant women
- Individuals receiving treatment for malignancy (primary or metastatic tumoral conditions in the lumbar region)
- Individuals diagnosed with advanced osteoporosis
- Individuals diagnosed with discitis
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Faculty of Health Sciences in Biruni University
Istanbul, ZEYTINBURNU, 34010
About this study
Official title: Effect of the Mulligan SNAG Technique on Structure of Intervertebral Disc and Physical Functioning in Individuals With Lumbar Intervertebral Disc Protrusion: A Randomized Controlled Study
This study aimed to examine the effects of the Mulligan SNAG mobilization technique, applied in addition to conventional physiotherapy on the structure of the intervertebral disc and physical functioning in patients diagnosed with low back pain due to lumbar intervertebral disc protrusion. 38 volunteer patients will participate in the study. The participants will be randomized as an interventional and control gropus.
Read the detailed description
Participants will be treated 3 days a week for 4 weeks. The session duration will be 40-45 minutes. Visual analog scale-VAS, oswestry disability index, magnetic imaging-MRI assessment, functıonal independence scale-FIM, Tampa kinesiophobia scale, one leg stand test, sit-stand test, 10-meter walking test, cadence , Nottingham health profile will be used to assses the participants in the two groups. All participants will be evaluated in the 5th week of the study. The program includes physical therapy session (Hot packed, trans cuteneal electric stimulation, therapeutic ultrasound, and therapautic exercises) and the Mulligan SNAG mobilization technique.
- Conditions
- Intervertebral Disc Protrusion
- Being tested
- Mulligan SNAG mobilization tecnique, Conventional Physiotherapy
- Keywords
- Lumbar disc herniation, Mulligan Snag technique, Low back pain, MRI, Physical Functioning, Quality of life
- Medical subject headings
- Intervertebral Disc Displacement, Low Back Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mulligan SNAG mobilization tecniqueOther
Mulligan SNAG mobilization tecnique
Conventional PhysiotherapyOther
Conventional Physiotherapy
| Study group | Role | What they receive |
|---|---|---|
| Group 1 | Experimental | SNAG Receives: Other: Mulligan SNAG mobilization tecnique; Other: Conventional Physiotherapy |
| Group 2 | Active comparator | Physiotherapy Receives: Other: Conventional Physiotherapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Magnetic Resonance Imaging
to measure protrusion (bigger amount means worse outcome)
Measured: baseline and iafter the intervention (in the 5th week)
Visual Analog Scale-VAS
to measure pain intensity (min. score is 0 and max. score is 10- higher score means worse outcome)
Measured: baseline and immediately after the intervention (in the 5th week)
Secondary outcomes (7)
Oswestry Disability Index-ODI
to describe disabilty level resulting from pain (min. score is 0 and max. score is 50- higher score means worse outcome)
Measured: baseline and immediately after the intervention (in the 5th week)
Functional Independence Measure- FIM
to measure independency in daily living activities (min. score is 18 and max score is 156- higger score means better independency in daily living activities)
Measured: baseline and immediately after the intervention (in the 5th week)
Tampa Kinesiophobia Scale- TKS
to measure anxiety-avoidance state (min. score is 17 and max. score is 68- higher score means worse outcome)
Measured: baseline and immediately after the intervention (in the 5th week)
One Leg stand Test- OLST
to measure static balance ability (min. score 0 and max. score is 60- Higher score means better balance)
Measured: before and after the intervention (in the 5th week)
Sit-Stand Test-SST
to measure lower extremity performance (min. score is 0 and max. score is 30- higher score means better outcome)
Measured: before and after the intervention (in the 5th week)
10-m Walking test and cadance measurement
to measure walking speed (in second- higher score means worse outcome) and cadance (number of steps during the test- higher score means better outcome)
Measured: before and after the intervention (in the 5th week)
Nottingham Health profile-NHP
to describe level of quality of life (min. score is 38 and max. score is 3800 - higher score means poor health)
Measured: before and after the intervention (in the 5th week)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jul 2024
- Study start16 Feb 2025
- Primary completion30 Dec 2025 (estimated)
- Study completion15 Jan 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Intervertebral Disc ProtrusionStudies of the same condition, open and under way.
- More trials run by Biruni UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized controlled trial
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 38 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Biruni University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ugur Cavlak, Biruni University
- Investigators
- UGUR CAVLAK, Prof., Principal investigator, Biruni University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06521294
- Sponsor's protocol ID
- BiruniUniversity34
- Status last verified
- Apr 2025
- First submitted
- 16 Jul 2024
- Last updated
- 6 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Hussien HM, Abdel-Raoof NA, Kattabei OM, Ahmed HH. Effect of Mulligan Concept Lumbar SNAG on Chronic Nonspecific Low Back Pain. J Chiropr Med. 2017 Jun;16(2):94-102. doi: 10.1016/j.jcm.2017.01.003. Epub 2017 Mar 30.
PubMed 28559749
Study at a glance
From the registry record, last updated by the sponsor on 6 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of the Mulligan SNAG Technique on Structure of Intervertebral Disc and Physical Functioning in Individuals With Lumbar Intervertebral Disc Protrusion: A Randomized Controlled Study
- ClinicalTrials.gov ID
- NCT06521294
- Acronym / sponsor ID
- BiruniUniversity34
- Conditions
- Intervertebral Disc Protrusion
- Keywords
- Lumbar disc herniation, Mulligan Snag technique, Low back pain, MRI, Physical Functioning, Quality of life
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 38 participants (estimated)
- Lead sponsor
- Biruni UniversityUniversity, hospital or other
- Study start
- 16 Feb 2025 (actual)
- Primary completion
- 30 Dec 2025 (estimated)
- Study completion
- 15 Jan 2026 (estimated)
- First posted
- 25 Jul 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aimed to examine the effects of the Mulligan SNAG mobilization technique, applied in addition to conventional physiotherapy on the structure of the intervertebral disc and physical functioning in patients diagnosed with low back pain due to lumbar intervertebral disc protrusion. 38 volunteer patients will participate in the study. The participants will be randomized as an interventional and control gropus.
Detailed description
Participants will be treated 3 days a week for 4 weeks. The session duration will be 40-45 minutes. Visual analog scale-VAS, oswestry disability index, magnetic imaging-MRI assessment, functıonal independence scale-FIM, Tampa kinesiophobia scale, one leg stand test, sit-stand test, 10-meter walking test, cadence , Nottingham health profile will be used to assses the participants in the two groups. All participants will be evaluated in the 5th week of the study. The program includes physical therapy session (Hot packed, trans cuteneal electric stimulation, therapeutic ultrasound, and therapautic exercises) and the Mulligan SNAG mobilization technique.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Randomized controlled trial
| Arm | Type | Receives |
|---|---|---|
| Group 1 | Experimental | Other: Mulligan SNAG mobilization tecnique, Other: Conventional PhysiotherapySNAG |
| Group 2 | Active comparator | Other: Conventional PhysiotherapyPhysiotherapy |
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Being between the ages of 20-60
- Those diagnosed with lumbar intervertebral disc heniation (protrusion on L1-L2, L2-L3, L3-L4, L4-L5, L5-S1) at a single level
- Those who voluntarily agreed to participate in the study
Key exclusion criteria (8 listed)
- Individuals diagnosed with Lumbar Bulging, Extruded, Sequestered discs
- Individuals who have undergone lumbar region spinal surgery
- Individuals with spinal deformity (scoliosis, spondylolisthesis, Ankylosing Spondylitis)
- Individuals with lumbar stenosis
- Pregnant women
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mulligan SNAG mobilization tecniqueMulligan SNAG mobilization tecnique | Other | Group 1 |
| Conventional PhysiotherapyConventional Physiotherapy | Other | Group 1, Group 2 |
Primary outcome
Magnetic Resonance Imaging
Time frame: baseline and iafter the intervention (in the 5th week)
to measure protrusion (bigger amount means worse outcome)
Visual Analog Scale-VAS
Time frame: baseline and immediately after the intervention (in the 5th week)
to measure pain intensity (min. score is 0 and max. score is 10- higher score means worse outcome)
7 secondary outcomes
Oswestry Disability Index-ODI
Time frame: baseline and immediately after the intervention (in the 5th week)
Functional Independence Measure- FIM
Time frame: baseline and immediately after the intervention (in the 5th week)
Tampa Kinesiophobia Scale- TKS
Time frame: baseline and immediately after the intervention (in the 5th week)
One Leg stand Test- OLST
Time frame: before and after the intervention (in the 5th week)
Sit-Stand Test-SST
Time frame: before and after the intervention (in the 5th week)
10-m Walking test and cadance measurement
Time frame: before and after the intervention (in the 5th week)
Nottingham Health profile-NHP
Time frame: before and after the intervention (in the 5th week)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Apr 2025.
- Results publication: PubMed 28559749Hussien HM, Abdel-Raoof NA, Kattabei OM, Ahmed HH. Effect of Mulligan Concept Lumbar SNAG on Chronic Nonspecific Low Back Pain. J Chiropr Med. 2017 Jun;16(2):94-102. doi: 10.1016/j.jcm.2017.01.003. Epub 2017 Mar 30.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
UGUR CAVLAK, Prof. principal investigator
Biruni University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mulligan SNAG mobilization tecnique and Conventional Physiotherapy in people with Intervertebral Disc Protrusion, run by Biruni University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 6 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Magnetic Resonance Imaging (time frame: baseline and iafter the intervention (in the 5th week)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06521294, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Apr 2025.