Eating DisordersEDCRNNCT06537895
Eating Disorders Clinical Research Network
An observational study of Eating Disorders, run by King's College London.
Trial summary
UK Eating Disorder services are facing unprecedented demand, with effective service delivery hampered by inadequate resources, fragmented services and variable care pathways. Individuals with eating disorders, families and clinicians all agree on the critical need to improve care pathways and treatment, leading to… Read more about this study
- Who is it for?
- Ages 8 to 100 years
- Conditions the study is for
- Eating Disorders
- What is being tested?
- EDCRN questionnaires
- How many people
- 12,000 participants
- Where
- No sites listed yet
- Study dates
- 1 Oct 2024to 29 Oct 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 8 to 100 years
- All sexes
- Child, Adult, Older adult
Study population: The study population are individuals who are receiving treatment for an eating disorder(s) at a UK-based eating disorder service which is part of the EDCRN and (if desired by the patient and caregiver) their parents/guardians.
Who may be able to join
- Patients who have been diagnosed with an eating disorder under at least 1 of the criteria specified in the DSM-5 and/or ICD-9, 10 or 11.
- Patients who are receiving treatment as inpatients, day-patients or outpatients at a CAMHS or Adult service who is participating in the EDCRN.
- Patients who are receiving treatment in the UK.
- OR:
- Parents/guardians of patients who have been diagnosed with an eating disorder under at least 1 of the criteria specified in the DSM-5 and/or ICD-9, 10 or 11.
- Parents/guardians of patients who are receiving treatment as inpatients, day-patients or outpatients at a CAMHS or Adult service who is participating in the EDCRN.
- Parents/guardians of patients who are receiving treatment in the UK.
Who cannot join
- Individuals who do not meet the criteria specified above will be considered ineligible to participate in the EDCRN.
Trial locations and contacts
No sites are listed yet.
About this study
UK Eating Disorder services are facing unprecedented demand, with effective service delivery hampered by inadequate resources, fragmented services and variable care pathways. Individuals with eating disorders, families and clinicians all agree on the critical need to improve care pathways and treatment, leading to better outcomes.
Eating disorders are serious, complex conditions influenced by a blend of biological, psychological, and environmental factors. The approach of this project is grounded in the "biopsychosocial" model. Recently, anorexia research confirms a genetic component, with biological, metabolic, and psychological mechanisms at play. Further biological research across eating disorders could allow a better understanding of the mechanisms underlying eating disorder development and better, more personalised treatments.
Read more
This project will test the feasibility of establishing a UK-wide NHS research network spanning child and adult eating disorder services to enable a step change in the ability to conduct eating disorder research. It will help address fragmentation and facilitate novel biological, psychological, and social research collaborations. The data the investigators gather will be open to all researchers for data analyses, and the collaborations established will form a collaborative network to enable future clinical trials, experimental medicine and psychology.
The study will be conducted at child and adult eating disorder services who opt to join the Network. Participants will be patients receiving treatment for an eating disorder at one of the participating services, and their parents/guardians if applicable.
Participants will complete questionnaires and have blood and other physical tests as specified in the EDCRN dataset. The study will last until 29th October 2026 (the end of the current funding period) and/or when a participant is discharged from treatment, whichever is sooner. For participants discharged before the study ends, there will be an opportunity for patients to complete optional follow-up questionnaires on a periodic basis.
- Conditions
- Eating Disorders
- Being tested
- EDCRN questionnaires
- Medical subject headings
- Feeding and Eating Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EDCRN questionnairesOther
Participants will complete questionnaires and have blood and other physical tests as specified in the EDCRN dataset.
What is being measured
The primary outcome is the main question the study is designed to answer.
EDCRN dataset
The existence of a well-described dataset (maintained by at >50% eating disorder services across the UK) of eating disorder presentation, treatment, outcomes, demographics, social risk factors, and blood test results which can be accessed (with appropriate permissions) by researchers and others for the purposes of addressing novel research questions and facilitating service improvement efforts.
The EDCRN dataset comprises the following parameters:
- ED Behaviours/cognitions
- Depression
- Anxiety
- Autism
- OCD
- Perfectionism
- Emotional regulation
- Psychosocial impairment
- Adverse experiences
- Self-injurious behaviour
- Food insecurity
- Physical/somatic symptoms
- ADHD
- Alcohol use
- PTSD symptoms
- Self-administered comorbidity
- Weight stigma
- Treatment experience
- Comorbidities
- Caregiver impact
- Weight history
- Muscle power
- Endocrine function
- Liver function
- Cardiac function
- Electrolytes
- Bone health
- Demographics
Measured: 29th October 2026
Secondary outcomes (3)
Data on treatment effects
Data which provides insights into treatment moderators and mediators for different demographic groups.
Measured: 29th October 2026
Genetic Biomarkers
Indicators of genetic biomarkers of treatment response.
Measured: 29th October 2026
Socio-economic influences
Data which indicates socio-economic factors (e.g. the local food environment) influencing ED development, maintenance and outcomes.
Measured: 29th October 2026
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Aug 2024
- Study start1 Oct 2024 (estimated)
- Primary completion29 Oct 2026 (estimated)
- Study completion29 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Eating DisordersStudies of the same condition, open and under way.
- More trials run by King's College LondonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 12,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- King's College London
- Sponsor type
- University, hospital or other
- Collaborators
- South London and Maudsley NHS Foundation Trust, Imperial College London, University College, London, Oxford Health NHS Foundation Trust, NHS Greater Glasgow and Clyde, Birmingham Women's and Children's NHS Foundation Trust
- Responsible party
- Sponsor
- Investigators
- Gerome Breen, PhD, Principal investigator, King's College London (KCL)Karina Allen, PhD, Principal investigator, South London and Maudsley NHS Foundation Trust (SLaM)
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06537895
- Sponsor's protocol ID
- RE22072
- Other IDs
- MR/X030539/1, 341570
- Acronym
- EDCRN
- Status last verified
- Jul 2024
- First submitted
- 23 Jul 2024
- Last updated
- 5 Aug 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Aug 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Eating Disorders Clinical Research Network
- ClinicalTrials.gov ID
- NCT06537895
- Acronym / sponsor ID
- EDCRN / RE22072
- Conditions
- Eating Disorders
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 12,000 participants (estimated)
- Lead sponsor
- King's College LondonUniversity, hospital or other
- Collaborators
- South London and Maudsley NHS Foundation Trust, Imperial College London, University College, London, Oxford Health NHS Foundation Trust, NHS Greater Glasgow and Clyde, Birmingham Women's and Children's NHS Foundation Trust
- Study start
- 1 Oct 2024 (estimated)
- Primary completion
- 29 Oct 2026 (estimated)
- Study completion
- 29 Oct 2026 (estimated)
- First posted
- 5 Aug 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
UK Eating Disorder services are facing unprecedented demand, with effective service delivery hampered by inadequate resources, fragmented services and variable care pathways. Individuals with eating disorders, families and clinicians all agree on the critical need to improve care pathways and treatment, leading to better outcomes.
Eating disorders are serious, complex conditions influenced by a blend of biological, psychological, and environmental factors. The approach of this project is grounded in the "biopsychosocial" model. Recently, anorexia research confirms a genetic component, with biological, metabolic, and psychological mechanisms at play. Further biological research across eating disorders could allow a better understanding of the mechanisms underlying eating disorder development and better, more personalised treatments.
This project will test the feasibility of establishing a UK-wide NHS research network spanning child and adult eating disorder services to enable a step change in the ability to conduct eating disorder research. It will help address fragmentation and facilitate novel biological, psychological, and social research collaborations. The data the investigators gather will be open to all researchers for data analyses, and the collaborations established will form a collaborative network to enable future clinical trials, experimental medicine and psychology.
The study will be conducted at child and adult eating disorder services who opt to join the Network. Participants will be patients receiving treatment for an eating disorder at one of the participating services, and their parents/guardians if applicable.
Participants will complete questionnaires and have blood and other physical tests as specified in the EDCRN dataset. The study will last until 29th October 2026 (the end of the current funding period) and/or when a participant is discharged from treatment, whichever is sooner. For participants discharged before the study ends, there will be an opportunity for patients to complete optional follow-up questionnaires on a periodic basis.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 8 to 100 years
- Sex
- All
- Age groups
- Child, Adult, Older adult
- Study population
- The study population are individuals who are receiving treatment for an eating disorder(s) at a UK-based eating disorder service which is part of the EDCRN and (if desired by the patient and caregiver) their parents/guardians.
Key inclusion criteria (7 listed)
- Patients who have been diagnosed with an eating disorder under at least 1 of the criteria specified in the DSM-5 and/or ICD-9, 10 or 11.
- Patients who are receiving treatment as inpatients, day-patients or outpatients at a CAMHS or Adult service who is participating in the EDCRN.
- Patients who are receiving treatment in the UK.
- Parents/guardians of patients who have been diagnosed with an eating disorder under at least 1 of the criteria specified in the DSM-5 and/or ICD-9, 10 or 11.
- Parents/guardians of patients who are receiving treatment as inpatients, day-patients or outpatients at a CAMHS or Adult service who is participating in the EDCRN.
Key exclusion criteria (1 listed)
- Individuals who do not meet the criteria specified above will be considered ineligible to participate in the EDCRN.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EDCRN questionnairesParticipants will complete questionnaires and have blood and other physical tests as specified in the EDCRN dataset. | Other | – |
Primary outcome
EDCRN dataset
Time frame: 29th October 2026
The existence of a well-described dataset (maintained by at >50% eating disorder services across the UK) of eating disorder presentation, treatment, outcomes, demographics, social risk factors, and blood test results which can be accessed (with appropriate permissions) by researchers and others for the purposes of addressing novel research questions and facilitating service improvement efforts. The EDCRN dataset comprises the following parameters: * ED Behaviours/cognitions * Depression * Anxiety * Autism * OCD * Perfectionism * Emotional regulation * Psychosocial impairment * Adverse experiences * Self-injurious behaviour * Food insecurity * Physical/somatic symptoms * ADHD * Alcohol use * PTSD symptoms * Self-administered comorbidity * Weight stigma * Treatment experience * Comorbidities * Caregiver impact * Weight history * Muscle power * Endocrine function * Liver function * Cardiac function * Electrolytes * Bone health * Demographics
3 secondary outcomes
Data on treatment effects
Time frame: 29th October 2026
Genetic Biomarkers
Time frame: 29th October 2026
Socio-economic influences
Time frame: 29th October 2026
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Aug 2024.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gerome Breen, PhD principal investigator
King's College London (KCL)
Karina Allen, PhD principal investigator
South London and Maudsley NHS Foundation Trust (SLaM)
Questions about this trial
What is this clinical trial studying?
An observational study of Eating Disorders, run by King's College London.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 5 Aug 2024. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Anna Carnegie (020 7836 5454, anna.carnegie@kcl.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
EDCRN dataset (time frame: 29th October 2026). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Aug 2024.