Muscle PerformanceNCT06562322
Acute Effect of Photobiomodulation Therapy on Muscle Performance in Female Futsal Players
A study testing 300 J, 600 J and 1260 J in people with Muscle Performance and Photobiomodulation Therapy, run by Universidade Norte do Paraná at 1 site in Brazil.
Trial summary
Photobiomodulation therapy (PBMT) has recently been indicated as a potential therapeutic strategy in diverse health and sports contexts. However, its efficacy on muscle performance in female futsal players remains unknown. Read more about this study
- Who is it for?
- Ages 18 to 35 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Performance, Photobiomodulation Therapy
- What is being tested?
- 300 J, 600 J and 1260 J
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 15 participants
- Where
- 1 siteBrazil
- Study dates
- 15 Feb 2024to 18 Mar 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between 18 and 35 years
- Playing futsal regularly for more than 1 year.
Who cannot join
- Use of any ergogenic or anabolic supplement within 6 months prior to the start of the study,
- Take any medication that may affect the ability to perform the physical tests,
- Have any physical limitation (e.g. joint or muscle injury) that may affect the ability to perform the physical test,
- Be engaged in a restricted diet program (e.g. weight loss diet),
- Have any skin sensitivity or diseases (e.g. erysipelas, eczema, dermatitis, psoriasis and urticaria) in the irradiated area that may be aggravated by PBMT.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Acute Dose-response Effect of Photobiomodulation Therapy on Muscle Performance in Female Futsal Players: a Randomized, Double-blind, Placebo-controlled, Crossover Study
Photobiomodulation therapy (PBMT) has recently been indicated as a potential therapeutic strategy in diverse health and sports contexts. However, its efficacy on muscle performance in female futsal players remains unknown. The purpose of this study was to investigate the dose-response effect of PBMT on muscle performance in female futsal players.
Read the detailed description
Background: Photobiomodulation therapy (PBMT) has recently been indicated as a potential therapeutic strategy in diverse health and sports contexts. However, its efficacy on muscle performance in female futsal players remains unknown. The purpose of this study is to investigate the dose-response effect of PBMT on muscle performance in female futsal players. Methods: In a crossover design, fifteen female futsal athletes (age: 18-30 years) will be randomized to receive 1 of 4 PBMT conditions (placebo, 300, 900, and 1260 joules [J]) on four occasions, separated by a 2-wk washout period. PBMT treatments will be applied on the quadriceps muscle of both legs using a device containing 200 light-emitting diodes (LEDs), immediately before the following tests (dependent variables): countermovement jump (CMJ) (i.e., flight time as indicator of muscle power), maximum voluntary isometric contraction (MVIC) for the leg extension exercise (i.e., muscle strength), and 3 sets of repetitions-to-failure (i.e., local muscular endurance) for the 45º leg press exercise, with recording of rating of perceived exertion (RPE) after each set. The fatigue index will be determined by the number of repetitions between sets 1 and 3. Statistical analyses will be performe using IBM SPSS Statistics for Windows (version 24.0; IBM Corp., Armonk, NY). Data will be tested for normality and homogeneity using the Shapiro-Wilk's and Levene's tests, respectively. One-way ANOVA tests will be performed to evaluate the differences in the fatigue index, flight time, and peak and mean torque between the treatment conditions (placebo, 300, 900, and 1260 J). Changes over time and between treatment conditions in maximum number of repetitions and RPE will be analyzed with two-way repeated measures ANOVA. Violation of sphericity was corrected using the Greenhouse-Geisser method. When significant differences will be confirmed with the ANOVA, multiple comparison testing will be performed using the Bonferroni post hoc correction to identify these differences. Values will be expressed as mean (standard deviation and 95% confidence interval). The significance level was set at p < 0.05.
- Conditions
- Muscle Performance, Photobiomodulation Therapy
- Being tested
- Placebo, 300 J, 600 J, 1260 J
- Keywords
- Physical test, Photobiomodulation therapy, Futsal, Light-emitting diodes, Muscle power, Muscle strength
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PlaceboDevice
Participants will be received placebo PBMT on the quadriceps muscle of both legs, immediately before physical tests, using a device containing 200 LEDs (100 red and 100 infrared)
300 JDevice
Participants will be received PBMT at 300 J on the quadriceps muscle of both legs, immediately before physical tests, using a device containing 200 LEDs (100 red and 100 infrared)
600 JDevice
Participants will be received PBMT at 600 J on the quadriceps muscle of both legs, immediately before physical tests, using a device containing 200 LEDs (100 red and 100 infrared)
1260 JDevice
Participants will be received PBMT at 1260 J on the quadriceps muscle of both legs, immediately before physical tests, using a device containing 200 LEDs (100 red and 100 infrared)
| Study group | Role | What they receive |
|---|---|---|
| placebo PBMT | Placebo comparator | Participants will be received placebo PBMT immediately before physical tests. Receives: Device: Placebo |
| 300 J PBMT | Active comparator | Participants will be received PBMT at 300 J immediately before physical tests. Receives: Device: 300 J |
| 600 J PBMT | Active comparator | Participants will be received PBMT at 600 J immediately before physical tests. Receives: Device: 600 J |
| 1260 J PBMT | Active comparator | Participants will be received PBMT at 1260 J immediately before physical tests. Receives: Device: 1260 J |
What is being measured
The primary outcome is the main question the study is designed to answer.
Repetitions-to-failure
The repetitions-to-failure test in the 45º leg press exercise consists of 3 sets at 70% of 1RM, with a 60-s rest interval between each set. Participants will perform as many repetitions as possible until momentary failure (i.e., when the participant is unable to complete the concentric portion of their current repetition across the full range of motion despite using maximal effort), and the maximum number of repetitions in each set will be recorded.
Measured: 10 minutes
Fatigue index (FI)
The fatigue index (FI) will be determined by the equation: [(REPS3 - REPS1)/REPS1]*100, where: REPS3 = number of repetitions in set 3, multiplied by the load lifted, and REPS1 = number of repetitions in set 1, multiplied by the load lifted. The higher the FI value (%), the higher the level of muscle fatigue.
Measured: 10 minutes
Rating of perceive exterion (RPE)
Rating of perceived exertion (RPE) will be recorded immediately after completion of each set using the OMNI-RES scale. The participants will be instructed to report the perceived exertion value by indicating a number on the OMNI-RES scale (0 for ''no effort'' and 10 for ''maximal effort'') that best represented their momentary exertion.
Measured: 10 minutes
Countermovement vertical jump (CMJ)
The CMJ test will be performed on a force platform (BIOMEC400-412, EMG System to Brazil Ltda, São Paulo, Brazil) to assess the flight time. Participants will perform three CMJs, interspersed with 1 min of rest, and the highest flight time will be used as an indicator of muscle power. The test will began with the participant standing, knees extended, and hands fixed on the iliac crest region (hips). The participant then will flexed their legs at an angle of approximately 90º and then quickly extended their legs to maximize the height of the jump. Hands will be kepted on hips throughout the jump.
Measured: 10 minutes
Maximum voluntary isometric contraction (MVIC)
The MVIC test for the leg extension exercise (bilateral) will be performed using an isometric dynamometer (CEFISE Biotechnology, São Carlos, Brazil). Briefly, participants will perform three MVICs at 120º of knee flexion (180º = full extension) lasting 5 s, interspersed with 5 s of rest. Participants will be instructed and verbally encouraged to exert maximum force during all attempts. The highest value obtained for peak and mean torque of the three MVICs will be used for the analysis.
Measured: 10 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Aug 2024
- Study start15 Feb 2024
- Primary completion15 Mar 2024
- Study completion18 Mar 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Muscle PerformanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 15 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universidade Norte do Paraná
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Andreo Fernando Aguiar, Universidade Norte do Paraná
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06562322
- Sponsor's protocol ID
- Photobiomodulation and futsal
- Status last verified
- Aug 2024
- First submitted
- 16 Aug 2024
- Last updated
- 9 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Steele J, Fisher J, Giessing J, Gentil P. Clarity in reporting terminology and definitions of set endpoints in resistance training. Muscle Nerve. 2017 Sep;56(3):368-374. doi: 10.1002/mus.25557. Epub 2017 Apr 1.
PubMed 28044366Robertson RJ, Goss FL, Rutkowski J, Lenz B, Dixon C, Timmer J, Frazee K, Dube J, Andreacci J. Concurrent validation of the OMNI perceived exertion scale for resistance exercise. Med Sci Sports Exerc. 2003 Feb;35(2):333-41. doi: 10.1249/01.MSS.0000048831.15016.2A.
PubMed 12569225Luque MZ, Aguiar AF, da Silva-Araujo AK, Zaninelli TH, Heintz OK, Saraiva-Santos T, Bertozzi MM, Souza NA, Junior EO, Verri WA Jr, Borghi SM. Evaluation of a preemptive intervention regimen with hesperidin methyl chalcone in delayed-onset muscle soreness in young adults: a randomized, double-blinded, and placebo-controlled trial study. Eur J Appl Physiol. 2023 Sep;123(9):1949-1964. doi: 10.1007/s00421-023-05207-2. Epub 2023 Apr 29.
PubMed 37119360Borim JM, Borghi SM, do Nascimento AP, da Silva AV, Ribeiro AS, Casonatto J, Ferraresi C, Aguiar AF. Acute dose-response effect of photobiomodulation therapy on muscle performance in female futsal players: A randomized, double-blind, placebo-controlled, crossover study. J Bodyw Mov Ther. 2025 Mar;41:35-43. doi: 10.1016/j.jbmt.2024.11.006. Epub 2024 Nov 7.
PubMed 39663094
Study at a glance
From the registry record, last updated by the sponsor on 9 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Dose-response Effect of Photobiomodulation Therapy on Muscle Performance in Female Futsal Players: a Randomized, Double-blind, Placebo-controlled, Crossover Study
- ClinicalTrials.gov ID
- NCT06562322
- Acronym / sponsor ID
- Photobiomodulation and futsal
- Conditions
- Muscle Performance, Photobiomodulation Therapy
- Keywords
- Physical test, Photobiomodulation therapy, Futsal, Light-emitting diodes, Muscle power, Muscle strength
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 15 participants (actual)
- Lead sponsor
- Universidade Norte do ParanáUniversity, hospital or other
- Study start
- 15 Feb 2024 (actual)
- Primary completion
- 15 Mar 2024 (actual)
- Study completion
- 18 Mar 2024 (actual)
- First posted
- 20 Aug 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Photobiomodulation therapy (PBMT) has recently been indicated as a potential therapeutic strategy in diverse health and sports contexts. However, its efficacy on muscle performance in female futsal players remains unknown. The purpose of this study was to investigate the dose-response effect of PBMT on muscle performance in female futsal players.
Detailed description
Background: Photobiomodulation therapy (PBMT) has recently been indicated as a potential therapeutic strategy in diverse health and sports contexts. However, its efficacy on muscle performance in female futsal players remains unknown. The purpose of this study is to investigate the dose-response effect of PBMT on muscle performance in female futsal players. Methods: In a crossover design, fifteen female futsal athletes (age: 18-30 years) will be randomized to receive 1 of 4 PBMT conditions (placebo, 300, 900, and 1260 joules [J]) on four occasions, separated by a 2-wk washout period. PBMT treatments will be applied on the quadriceps muscle of both legs using a device containing 200 light-emitting diodes (LEDs), immediately before the following tests (dependent variables): countermovement jump (CMJ) (i.e., flight time as indicator of muscle power), maximum voluntary isometric contraction (MVIC) for the leg extension exercise (i.e., muscle strength), and 3 sets of repetitions-to-failure (i.e., local muscular endurance) for the 45º leg press exercise, with recording of rating of perceived exertion (RPE) after each set. The fatigue index will be determined by the number of repetitions between sets 1 and 3. Statistical analyses will be performe using IBM SPSS Statistics for Windows (version 24.0; IBM Corp., Armonk, NY). Data will be tested for normality and homogeneity using the Shapiro-Wilk's and Levene's tests, respectively. One-way ANOVA tests will be performed to evaluate the differences in the fatigue index, flight time, and peak and mean torque between the treatment conditions (placebo, 300, 900, and 1260 J). Changes over time and between treatment conditions in maximum number of repetitions and RPE will be analyzed with two-way repeated measures ANOVA. Violation of sphericity was corrected using the Greenhouse-Geisser method. When significant differences will be confirmed with the ANOVA, multiple comparison testing will be performed using the Bonferroni post hoc correction to identify these differences. Values will be expressed as mean (standard deviation and 95% confidence interval). The significance level was set at p < 0.05.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 4
- Model description
- Crossover
| Arm | Type | Receives |
|---|---|---|
| placebo PBMT | Placebo comparator | Device: PlaceboParticipants will be received placebo PBMT immediately before physical tests. |
| 300 J PBMT | Active comparator | Device: 300 JParticipants will be received PBMT at 300 J immediately before physical tests. |
| 600 J PBMT | Active comparator | Device: 600 JParticipants will be received PBMT at 600 J immediately before physical tests. |
| 1260 J PBMT | Active comparator | Device: 1260 JParticipants will be received PBMT at 1260 J immediately before physical tests. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Age between 18 and 35 years
- Playing futsal regularly for more than 1 year.
Key exclusion criteria (5 listed)
- Use of any ergogenic or anabolic supplement within 6 months prior to the start of the study,
- Take any medication that may affect the ability to perform the physical tests,
- Have any physical limitation (e.g. joint or muscle injury) that may affect the ability to perform the physical test,
- Be engaged in a restricted diet program (e.g. weight loss diet),
- Have any skin sensitivity or diseases (e.g. erysipelas, eczema, dermatitis, psoriasis and urticaria) in the irradiated area that may be aggravated by PBMT.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PlaceboParticipants will be received placebo PBMT on the quadriceps muscle of both legs, immediately before physical tests, using a device containing 200 LEDs (100 red and 100 infrared) | Device | placebo PBMT |
| 300 JParticipants will be received PBMT at 300 J on the quadriceps muscle of both legs, immediately before physical tests, using a device containing 200 LEDs (100 red and 100 infrared) | Device | 300 J PBMT |
| 600 JParticipants will be received PBMT at 600 J on the quadriceps muscle of both legs, immediately before physical tests, using a device containing 200 LEDs (100 red and 100 infrared) | Device | 600 J PBMT |
| 1260 JParticipants will be received PBMT at 1260 J on the quadriceps muscle of both legs, immediately before physical tests, using a device containing 200 LEDs (100 red and 100 infrared) | Device | 1260 J PBMT |
Primary outcome
Repetitions-to-failure
Time frame: 10 minutes
The repetitions-to-failure test in the 45º leg press exercise consists of 3 sets at 70% of 1RM, with a 60-s rest interval between each set. Participants will perform as many repetitions as possible until momentary failure (i.e., when the participant is unable to complete the concentric portion of their current repetition across the full range of motion despite using maximal effort), and the maximum number of repetitions in each set will be recorded.
Fatigue index (FI)
Time frame: 10 minutes
The fatigue index (FI) will be determined by the equation: [(REPS3 - REPS1)/REPS1]*100, where: REPS3 = number of repetitions in set 3, multiplied by the load lifted, and REPS1 = number of repetitions in set 1, multiplied by the load lifted. The higher the FI value (%), the higher the level of muscle fatigue.
Rating of perceive exterion (RPE)
Time frame: 10 minutes
Rating of perceived exertion (RPE) will be recorded immediately after completion of each set using the OMNI-RES scale. The participants will be instructed to report the perceived exertion value by indicating a number on the OMNI-RES scale (0 for ''no effort'' and 10 for ''maximal effort'') that best represented their momentary exertion.
Countermovement vertical jump (CMJ)
Time frame: 10 minutes
The CMJ test will be performed on a force platform (BIOMEC400-412, EMG System to Brazil Ltda, São Paulo, Brazil) to assess the flight time. Participants will perform three CMJs, interspersed with 1 min of rest, and the highest flight time will be used as an indicator of muscle power. The test will began with the participant standing, knees extended, and hands fixed on the iliac crest region (hips). The participant then will flexed their legs at an angle of approximately 90º and then quickly extended their legs to maximize the height of the jump. Hands will be kepted on hips throughout the jump.
Maximum voluntary isometric contraction (MVIC)
Time frame: 10 minutes
The MVIC test for the leg extension exercise (bilateral) will be performed using an isometric dynamometer (CEFISE Biotechnology, São Carlos, Brazil). Briefly, participants will perform three MVICs at 120º of knee flexion (180º = full extension) lasting 5 s, interspersed with 5 s of rest. Participants will be instructed and verbally encouraged to exert maximum force during all attempts. The highest value obtained for peak and mean torque of the three MVICs will be used for the analysis.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jan 2026.
- Background: PubMed 28044366Steele J, Fisher J, Giessing J, Gentil P. Clarity in reporting terminology and definitions of set endpoints in resistance training. Muscle Nerve. 2017 Sep;56(3):368-374. doi: 10.1002/mus.25557. Epub 2017 Apr 1.
- Background: PubMed 12569225Robertson RJ, Goss FL, Rutkowski J, Lenz B, Dixon C, Timmer J, Frazee K, Dube J, Andreacci J. Concurrent validation of the OMNI perceived exertion scale for resistance exercise. Med Sci Sports Exerc. 2003 Feb;35(2):333-41. doi: 10.1249/01.MSS.0000048831.15016.2A.
- Background: PubMed 37119360Luque MZ, Aguiar AF, da Silva-Araujo AK, Zaninelli TH, Heintz OK, Saraiva-Santos T, Bertozzi MM, Souza NA, Junior EO, Verri WA Jr, Borghi SM. Evaluation of a preemptive intervention regimen with hesperidin methyl chalcone in delayed-onset muscle soreness in young adults: a randomized, double-blinded, and placebo-controlled trial study. Eur J Appl Physiol. 2023 Sep;123(9):1949-1964. doi: 10.1007/s00421-023-05207-2. Epub 2023 Apr 29.
- Derived from this study: PubMed 39663094Borim JM, Borghi SM, do Nascimento AP, da Silva AV, Ribeiro AS, Casonatto J, Ferraresi C, Aguiar AF. Acute dose-response effect of photobiomodulation therapy on muscle performance in female futsal players: A randomized, double-blind, placebo-controlled, crossover study. J Bodyw Mov Ther. 2025 Mar;41:35-43. doi: 10.1016/j.jbmt.2024.11.006. Epub 2024 Nov 7.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing 300 J, 600 J and 1260 J in people with Muscle Performance and Photobiomodulation Therapy, run by Universidade Norte do Paraná at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Repetitions-to-failure (time frame: 10 minutes). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06562322, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jan 2026.