Healthy Older AdultsNCT06588920
Brain Activity, Cognitive Function, and Walking Ability in Parkinson's Disease
An observational study of Healthy Older Adults and Parkinson Disease, run by National Yang Ming Chiao Tung University at 2 sites in Taiwan.
Trial summary
The dual-task automated walking performance in people with Parkinson\'s disease (PD) is affected by their gait disturbances and impaired executive functions. Currently, the relationship between brain activity related to inhibitory control, executive functions, and dual-task walking performance in people with PD is… Read more about this study
- Who is it for?
- Ages 40 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Older Adults, Parkinson Disease
- What is being tested?
- Cognitive function, gait, and electroencephalogram
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 70 participants
- Where
- 2 sitesTaiwan
- Study dates
- 9 Oct 2024to 31 Aug 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Hospital and community
Who may be able to join
- Diagnoses of idiopathic Parkinson disease
- Stable dopaminergic medicine ≥ 2 weeks
- Able to walk 10 meters without aid
- Mini-Mental Status Examination ≥ 24 points
- No uncorrected visual or auditory disorders
- Education at least junior high school
- No other disease may affect balance
Who cannot join
- Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
- History of brain surgery (e.g. deep brain stimulation)
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan2 sites, 2 recruiting
- Recruiting
National Yang Ming Chiao Tung University
Taipei
Yea-Ru Yang, yryang@nycu.edu.tw
- Recruiting
National Yang Ming Chiao Tung University
Taipei
Yea-Ru Yang, Professor, 886-2-2826-7279, yryang@nycu.edu.tw
About this study
Official title: Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson's Disease
The dual-task automated walking performance in people with Parkinson\'s disease (PD) is affected by their gait disturbances and impaired executive functions. Currently, the relationship between brain activity related to inhibitory control, executive functions, and dual-task walking performance in people with PD is not well understood. Therefore, this study aims to investigate the significance of different executive function domains on gait stability in healthy older adults and people with PD; whether brain activation related to inhibitory control is associated with gait stability in healthy older adults and people with PD.
- Conditions
- Healthy Older Adults, Parkinson Disease
- Being tested
- Cognitive function, gait, and electroencephalogram
- Keywords
- Executive function, Gait, Electroencephalography
- Medical subject headings
- Parkinson Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cognitive function, gait, and electroencephalogramBehavioural
Measurement of cognitive function, gait performance, and electroencephalogram
| Study group | Role | What they receive |
|---|---|---|
| Parkinson disease | People with Parkinson disease Receives: Behavioral: Cognitive function, gait, and electroencephalogram | |
| Healthy older adults | Healthy older adults Receives: Behavioral: Cognitive function, gait, and electroencephalogram |
What is being measured
The primary outcome is the main question the study is designed to answer.
Gait variability
Using GAITRite system to measure the coefficient of variation (CV). The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean * 100%
Measured: 1 day
Gait speed
Using GAITRite system to measure gait speed.
Measured: 1 day
Step length
Using GAITRite system to measure step length
Measured: 1 day
Step width
Using GAITRite system to measure step width.
Measured: 1 day
Single support time
Using GAITRite system to measure single support time
Measured: 1 day
Double support time
Using GAITRite system to measure double support time
Measured: 1 day
Frontal Assessment Battery
The score ranged from 0 to 18. Higher scores show better executive function.
Measured: 1 day
Trail making test
Trail making test contain part A and part B. Faster completing the test indicates better executive function.
Measured: 1 day
Stroop color and word test
Record numbers of corrected color words which the subject responds within 45 sec.
Measured: 1 day
Digit span test
Digit span test contain forward and backward part. Scores of forward digit span ranges from 0 to 16. Score of backward digit span ranges from 0 to 14. Higher scores indicate better executive function.
Measured: 1 day
Event-related potential - N2
Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Measured: 1 day
Event-related potential - P300
Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Measured: 1 day
Go/Nogo test
Behavioral test during measuring electroencephalography.
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2024
- Study start9 Oct 2024
- Primary completion31 Aug 2027 (estimated)
- Study completion31 Aug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy Older AdultsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Yang Ming Chiao Tung University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yea-Ru Yang, National Yang Ming Chiao Tung University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06588920
- Sponsor's protocol ID
- NYCU113006AF1
- Status last verified
- Mar 2026
- First submitted
- 5 Sep 2024
- Last updated
- 24 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson's Disease
- ClinicalTrials.gov ID
- NCT06588920
- Acronym / sponsor ID
- NYCU113006AF1
- Conditions
- Healthy Older Adults, Parkinson Disease
- Keywords
- Executive function, Gait, Electroencephalography
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- National Yang Ming Chiao Tung UniversityUniversity, hospital or other
- Study start
- 9 Oct 2024 (actual)
- Primary completion
- 31 Aug 2027 (estimated)
- Study completion
- 31 Aug 2027 (estimated)
- First posted
- 19 Sep 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The dual-task automated walking performance in people with Parkinson\'s disease (PD) is affected by their gait disturbances and impaired executive functions. Currently, the relationship between brain activity related to inhibitory control, executive functions, and dual-task walking performance in people with PD is not well understood. Therefore, this study aims to investigate the significance of different executive function domains on gait stability in healthy older adults and people with PD; whether brain activation related to inhibitory control is associated with gait stability in healthy older adults and people with PD.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Parkinson disease | – | Behavioral: Cognitive function, gait, and electroencephalogramPeople with Parkinson disease |
| Healthy older adults | – | Behavioral: Cognitive function, gait, and electroencephalogramHealthy older adults |
Who may qualify
- Ages
- 40 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Hospital and community
Key inclusion criteria (7 listed)
- Diagnoses of idiopathic Parkinson disease
- Stable dopaminergic medicine ≥ 2 weeks
- Able to walk 10 meters without aid
- Mini-Mental Status Examination ≥ 24 points
- No uncorrected visual or auditory disorders
Key exclusion criteria (2 listed)
- Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
- History of brain surgery (e.g. deep brain stimulation)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cognitive function, gait, and electroencephalogramMeasurement of cognitive function, gait performance, and electroencephalogram | Behavioural | Healthy older adults, Parkinson disease |
Primary outcome
Gait variability
Time frame: 1 day
Using GAITRite system to measure the coefficient of variation (CV). The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean * 100%
Gait speed
Time frame: 1 day
Using GAITRite system to measure gait speed.
Step length
Time frame: 1 day
Using GAITRite system to measure step length
Step width
Time frame: 1 day
Using GAITRite system to measure step width.
Single support time
Time frame: 1 day
Using GAITRite system to measure single support time
Double support time
Time frame: 1 day
Using GAITRite system to measure double support time
Frontal Assessment Battery
Time frame: 1 day
The score ranged from 0 to 18. Higher scores show better executive function.
Trail making test
Time frame: 1 day
Trail making test contain part A and part B. Faster completing the test indicates better executive function.
Stroop color and word test
Time frame: 1 day
Record numbers of corrected color words which the subject responds within 45 sec.
Digit span test
Time frame: 1 day
Digit span test contain forward and backward part. Scores of forward digit span ranges from 0 to 16. Score of backward digit span ranges from 0 to 14. Higher scores indicate better executive function.
Event-related potential - N2
Time frame: 1 day
Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Event-related potential - P300
Time frame: 1 day
Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Go/Nogo test
Time frame: 1 day
Behavioral test during measuring electroencephalography.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Mar 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Healthy Older Adults and Parkinson Disease, run by National Yang Ming Chiao Tung University at 2 sites in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yea-Ru Yang, PhD (+886228267279, yryang@nycu.edu.tw), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Gait variability (time frame: 1 day). The study lists 13 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Mar 2026.