Upper Limb EdemaNCT06602180
Scapular PNF and Activity Oriented Antiedema Proprioceptive Therapy on Shoulder Dysfunction Post Mastectomy Lymphedema
A study testing Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)., Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT) and Scapular proprioceptive neuromuscular facilitation PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT) in people with Upper Limb Edema, run by Cairo University at 1 site in Egypt.
Trial summary
Eighty -four female patients suffering from shoulder dysfunction after breast cancer-related arm lymphedema, will Cairo University hospitals be randomly distributed into three groups equal in number. Read more about this study
- Who is it for?
- Ages 40 to 65 years, women only
- Conditions the study is for
- Upper Limb Edema
- What is being tested?
- Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)., Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT) and Scapular proprioceptive neuromuscular facilitation PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 84 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2026to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 65 years
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- The subject selection will be according to the following criteria:
- Age range between 40-65 years.
- Only female patients will participate in the study.
- All female patients diagnosed as unilateral breast cancer.
- All Female patients operated on for BC with BCRL in stages I and II.
- All female patients suffering from shoulder dysfunction after breast cancer-related arm lymphedema.
- All patients enrolled to the study will have their informed consent.
Who cannot join
- The potential participants will be excluded if they meet one of the following criteria:
- Patients with health problems, diseases or dysfunctions that prevented them from participating in the intervention.
- Patients with bilateral lymphedema.
- Patients with previous primary lymphedema.
- Patients with metastasis.
- Patients whom staging was not possible due to atypical findings or poor image.
- Patients with active arm infection.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Scapular Proprioceptive Neuromuscular Facilitation and Activity Oriented Antiedema Proprioceptive Therapy on Shoulder Dysfunction Post Mastectomy Lymphedema
Eighty -four female patients suffering from shoulder dysfunction after breast cancer-related arm lymphedema, will Cairo University hospitals be randomly distributed into three groups equal in number.
Read the detailed description
In this study the patients will be randomly assigned into three groups ( Twenty-eight patient for each group):
Group (A):
Twenty-eight patients will receive: Scapular PNF technique, Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT).
Group (B):
Twenty-eight patients will receive Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)
Group (C):
Twenty-eight patients will receive Scapular PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of Complex decongestive therapy (CDT)
- Conditions
- Upper Limb Edema
- Being tested
- Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)., Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT), Scapular proprioceptive neuromuscular facilitation PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT).Other
Complex or combined decongestive physical therapy (CDT):
skin care and patient education, manual lymphatic drainage MLD, joints exercises, and compression garments.
Scapular PNF:
Proprioceptive Neuromuscular Facilitation (PNF) is treatment approach that focus on motor learning, helps the patient to relax, improves coordination, and normalizes the motion. The repeated contractions technique increases active range of motion and strength and guides the patient's motion towards the desired motion,
TAPA involves an intervention protocol composed of:
10-min neuro dynamics oriented to the activity 10-min proprioceptive neuromuscular facilitation activities. 10-min proprioceptive anti-edema bandaging, including patient and/or caretaker instructions for placement, as well as assistance on techniques to use for performing everyday activities,
Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)Other
Activity-Oriented Proprioceptive Antiedema Therapy TAPA:
TAPA involves an intervention protocol composed of:
- 10-min neuro dynamics oriented to the activity
- 10-min proprioceptive neuromuscular facilitation activities.
- 10-min proprioceptive anti-edema bandaging, including patient and/or caretaker instructions for placement, as well as assistance on techniques to use for performing everyday activities,
Complex or combined decongestive physical therapy (CDT):
skin care and patient education, manual lymphatic drainage MLD, joints exercises, and compression garments
Scapular proprioceptive neuromuscular facilitation PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)Other
Proprioceptive Neuromuscular Facilitation (PNF) is treatment approach that focus on motor learning, helps the patient to relax, improves coordination, and normalizes the motion. The repeated contractions technique increases active range of motion and strength and guides the patient's motion towards the desired motion,
Complex or combined decongestive physical therapy (CDT):
skin care and patient education, manual lymphatic drainage MLD, joints exercises, and compression garments
| Study group | Role | What they receive |
|---|---|---|
| Exprimental group A | Experimental | Twenty-eight patients will receive: Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (CDT). Receives: Other: Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT). |
| Experimental: group B | Experimental | Twenty-eight patients will receive Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT) Receives: Other: Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT) |
| Experimental: group C: | Experimental | Twenty-eight patients will receive Scapular PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of Complex decongestive therapy (CDT) Receives: Other: Scapular proprioceptive neuromuscular facilitation PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cone formula for lymphedema assessment
the truncated cone formula. V = h C12 + C1C2 + C22 =12 (where V = extremity volume, h = height, C1 = circumference of the top of the cone, C2 = circumference of the base of the cone) as both extremities will be measured from the wrist to the top of the arm (axillary fold) at 4-cm intervals
Measured: 6 weeks
Digital inclinometer for scapular range and shoulder range assessment
The digital inclinometer demonstrates moderate to excellent reliability in evaluating both shoulder and scapular range in case of shoulder disorder
Measured: 6 weeks
Upper limb function/activity performance: Measured with e Quick Disabilities of the Arm, Shoulder and Hand (Quick-DASH):
The arm, shoulder, and hand problems quick questionnaire (Quick-Dash) used to evaluate the symptom severity and functional capacity of the patients
Measured: 6 weeks
Hand grip assessment : Measured with hand grip dynamometer
A hand grip dynamometer is a, typically electronic,, device used to measure maximum isometric grip strength, acting as a key tool for health assessments
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2024
- Study start1 Jan 2026
- Primary completion30 Jun 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Upper Limb EdemaStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 84 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rasha Abdalfattah Ahmed Selim, Cairo University
- Investigators
- rasha ahmed, master, Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06602180
- Sponsor's protocol ID
- 152427
- Status last verified
- Sep 2026
- First submitted
- 12 Sep 2024
- Last updated
- 2 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Scapular Proprioceptive Neuromuscular Facilitation and Activity Oriented Antiedema Proprioceptive Therapy on Shoulder Dysfunction Post Mastectomy Lymphedema
- ClinicalTrials.gov ID
- NCT06602180
- Acronym / sponsor ID
- 152427
- Conditions
- Upper Limb Edema
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 84 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 19 Sep 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Eighty -four female patients suffering from shoulder dysfunction after breast cancer-related arm lymphedema, will Cairo University hospitals be randomly distributed into three groups equal in number.
Detailed description
In this study the patients will be randomly assigned into three groups ( Twenty-eight patient for each group):
Group (A):
Twenty-eight patients will receive: Scapular PNF technique, Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT).
Group (B):
Twenty-eight patients will receive Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)
Group (C):
Twenty-eight patients will receive Scapular PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of Complex decongestive therapy (CDT)
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Exprimental group A | Experimental | Other: Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT).Twenty-eight patients will receive: Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (CDT). |
| Experimental: group B | Experimental | Other: Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)Twenty-eight patients will receive Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT) |
| Experimental: group C: | Experimental | Other: Scapular proprioceptive neuromuscular facilitation PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)Twenty-eight patients will receive Scapular PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of Complex decongestive therapy (CDT) |
Who may qualify
- Ages
- 40 to 65 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Age range between 40-65 years.
- Only female patients will participate in the study.
- All female patients diagnosed as unilateral breast cancer.
- All Female patients operated on for BC with BCRL in stages I and II.
- All female patients suffering from shoulder dysfunction after breast cancer-related arm lymphedema.
Key exclusion criteria (7 listed)
- Patients with health problems, diseases or dysfunctions that prevented them from participating in the intervention.
- Patients with bilateral lymphedema.
- Patients with previous primary lymphedema.
- Patients with metastasis.
- Patients whom staging was not possible due to atypical findings or poor image.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT).Complex or combined decongestive physical therapy (CDT): skin care and patient education, manual lymphatic drainage MLD, joints exercises, and compression garments. Scapular PNF: Proprioceptive Neuromuscular Facilitation (PNF) is treatment approach that focus on motor learning, helps the patient to relax, improves coordination, and normalizes the motion. The repeated contractions technique increases active range of motion and strength and guides the patient's motion towards the desired motion, TAPA involves an intervention protocol composed of: 10-min neuro dynamics oriented to the activity 10-min proprioceptive neuromuscular facilitation activities. 10-min proprioceptive anti-edema bandaging, including patient and/or caretaker instructions for placement, as well as assistance on techniques to use for performing everyday activities, | Other | Exprimental group A |
| Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)Activity-Oriented Proprioceptive Antiedema Therapy TAPA: TAPA involves an intervention protocol composed of: * 10-min neuro dynamics oriented to the activity * 10-min proprioceptive neuromuscular facilitation activities. * 10-min proprioceptive anti-edema bandaging, including patient and/or caretaker instructions for placement, as well as assistance on techniques to use for performing everyday activities, Complex or combined decongestive physical therapy (CDT): skin care and patient education, manual lymphatic drainage MLD, joints exercises, and compression garments | Other | Experimental: group B |
| Scapular proprioceptive neuromuscular facilitation PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)Proprioceptive Neuromuscular Facilitation (PNF) is treatment approach that focus on motor learning, helps the patient to relax, improves coordination, and normalizes the motion. The repeated contractions technique increases active range of motion and strength and guides the patient's motion towards the desired motion, Complex or combined decongestive physical therapy (CDT): skin care and patient education, manual lymphatic drainage MLD, joints exercises, and compression garments | Other | Experimental: group C: |
Primary outcome
Cone formula for lymphedema assessment
Time frame: 6 weeks
the truncated cone formula. V = h C12 + C1C2 + C22 =12 (where V = extremity volume, h = height, C1 = circumference of the top of the cone, C2 = circumference of the base of the cone) as both extremities will be measured from the wrist to the top of the arm (axillary fold) at 4-cm intervals
Digital inclinometer for scapular range and shoulder range assessment
Time frame: 6 weeks
The digital inclinometer demonstrates moderate to excellent reliability in evaluating both shoulder and scapular range in case of shoulder disorder
Upper limb function/activity performance: Measured with e Quick Disabilities of the Arm, Shoulder and Hand (Quick-DASH):
Time frame: 6 weeks
The arm, shoulder, and hand problems quick questionnaire (Quick-Dash) used to evaluate the symptom severity and functional capacity of the patients
Hand grip assessment : Measured with hand grip dynamometer
Time frame: 6 weeks
A hand grip dynamometer is a, typically electronic,, device used to measure maximum isometric grip strength, acting as a key tool for health assessments
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
rasha ahmed, master principal investigator
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)., Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT) and Scapular proprioceptive neuromuscular facilitation PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT) in people with Upper Limb Edema, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cone formula for lymphedema assessment (time frame: 6 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026.