Clinical trials: Upper Limb Edema
Cirrhosis
A Study to Investigate Pharmacodynamics and Pharmacokinetics of OPC-41061 in Patients With Hepatic Edema
OPC-41061 at 3.75 mg/day or 7.5 mg/day will be orally administered once daily for 7 days to cirrhosis patients with ascites despite having received treatment with conventional diuretics and pharmacodynamics, pharmacokinetics…
- Trial name
- NCT01114828
- Testing
- OPC-41061
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Stereotactic Body Radiation Therapy
Stereotactic Radiosurgery Combination With Anlotinib for Limited Brain Metastases With Perilesional Edema in NSCLC
The purpose of this study is to determine whether stereotactic radiosurgery combination with Anlotinib is safe, effective in the treatment of limited brain metastases with Perilesional edema in non-small cell lung cancer.
- Trial name
- Rvision-001 (NCT04147728)
- Testing
- Anlotinib, Stereotactic Radiosurgery
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital
Quality of Life, Lymphedema
Transcutaneous Auricular Vagus Nerve Stimulation in Upper Extremity Lymphedema
Lymphedema is an inflammatory disease characterized by abnormal accumulation of excess water, plasma proteins, and extravascular blood and parenchymal cells in the affected upper and lower arms, chest and/or trunk due to…
- Conditions
- Quality of Life, Lymphedema, Hand Grasp, Grip
- Trial name
- NCT06069908
- Testing
- Complex Decongestive Treatment, Transcutaneous Auricular Vagus Nerve Stimulation, Exercise
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Seda Saka
Diabetic Macular Edema
Safety and Efficacy of Ranibizumab for Diabetic Macular Edema
The primary objective of the study is to assess the ocular and systemic adverse events of ranibizumab (Lucentis)for DME (diabetic macular edema) following previous treatment with intravitreal bevacizumab (Avastin).
- Trial name
- REACT (NCT01982435)
- Testing
- Ranibizumab
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Justis Ehlers
Lymphedema of Upper Arm
Circaid® Compression Sleeve Versus Short-stretching Bandage in Upper Limb Lymphatic Edema
One of the difficulties encountered in the treatment of lymphedema, both in the active reduction phase and in the maintenance phase, is the appliance of the short-length compression bandages which requires good technicality and…
- Trial name
- NCT03492476
- Testing
- Circaid, Short-stretching Bandage (Reference treatment)
- Where
- 4 sites in France
- Volunteers
- 142 people
- Sponsor
- CEN Biotech
Descemet Stripping Automated Endothelial Keratoplasty (DSAEK), Descemet Membrane Endothelial Keratoplasty (DMEK)
DSAEK/DMEK and Cystoid Macular Edema - the Role for Topical NSAIDs (Nepafenac) (DMEC)
The DMEC trial is a randomized clinical two-arm trial comparing inflammation and cystoid macular edema for the medication regimens postoperative topical NSAIDs and steroids to only postoperative topical steroids in patients…
- Trial name
- DMEC (NCT05072262)
- Testing
- Nepafenac Ophthalmic, Dexamethasone Ophthalmic
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Oslo University Hospital
Corneal Edema
EndoArt® Implantation in Subjects With Chronic Corneal Edema - US Study
The EndoArt® device is intended to treat patients with chronic corneal edema due to endothelial dysfunction, in whom prior multiple keratoplasty (EK/PK) have failed, and who are not reasonable candidates for any form of corneal…
- Trial name
- NCT07344168
- Testing
- The EndoArt® (Corneal Artificial Endothelial layer)
- Volunteers
- 123 people
- Sponsor
- Eye-yon Medical
Diabetic Macular Edema
Laser (Selective Retina Therapy) and Drug Combined Intervention in Clinically Significant Diabetic Macular Edema
The objective of this clinical trial is to compare and evaluate the safety and efficacy of Ranibizumab (Lucentis®; Novartis AG, Basel, Switzerland) monotherapy and Ranibizumab combined with R:GEN (Selective Retina Therapy) in…
- Trial name
- NCT03759860
- Testing
- R:GEN laser treatment (Selective Retina Therapy) and Lucentis (ranibizumab) combination therapy
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- CynosureLutronic
Diabetic Retinopathy, Macular Edema
A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)
Researchers are looking for new ways to treat diabetic macular edema (DME). In this trial, researchers want to learn if a trial medicine called MK-8748 can treat DME.
- Trial name
- NCT07705555
- Testing
- MK-8748, Aflibercept
- Where
- 35 sites in United States, Argentina and 2 more
- Volunteers
- 960 people
- Sponsor
- Merck Sharp & Dohme LLC
Post-traumatic Carpal Tunnel Syndrome, Complex Regional Pain Syndrome
Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial
Distal radius fractures (DRF) are the most common type of fracture in the human body, and a large proportion of DRFs result in complications.
- Conditions
- Post-traumatic Carpal Tunnel Syndrome, Complex Regional Pain Syndrome, Edema
- Trial name
- NCT01118715
- Testing
- Compression glove
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- J&M Shuler
Corneal Edema
Study of Cryopreserved AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction
The purpose of this study is to assess the safety and efficacy of cryopreserved AURN001 in patients with corneal edema secondary to endothelial dysfunction.
- Trial name
- NCT06630169
- Testing
- Cryopreserved AURN001
- Where
- El Salvador
- Volunteers
- 25 people
- Sponsor
- Aurion Biotech
Distal Radius Fractures
Mechanical Modalities vs. Standard Care for Edema and Pain Management After DRF Fixation
This single-blinded, randomized controlled trial (RCT) will evaluate the added benefit of mechanical modalities (continuous passive motion (CPM) and intermittent pneumatic compression (IPC)) when integrated into standard therapy…
- Trial name
- NCT06913920
- Testing
- Continuous Passive Motion (CPM), Intermittent Pneumatic Compression (IPC), Standard Therapy Program
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al Hayah University In Cairo
Ankle Fractures, Swelling
Effect of Cool Spray and Cold Packs in Reducing Preoperative Edema and Pain in Ankle Fractures in Ubonratchathani
The use of evaporative coolants in the management of acute musculoskeletal injury has received increasing attention recently. However, its efficacy compared with conventional cryotherapy in treating injured human subjects remains…
- Conditions
- Ankle Fractures, Swelling, Cryotherapy Effect
- Trial name
- 3-armRCT (NCT06293209)
- Testing
- 3M cold pack, Perskindol cold spray
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thai Traditional Medical Knowledge Fund
Corneal Edema, Corneal Endothelial Dysfunction
A Phase 1/2 Study of AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction (ABA-1)
The goal of this clinical trial is to compare different doses of AURN001 in patients with corneal edema secondary to corneal endothelial dysfunction.
- Trial name
- CLARA (NCT06041256)
- Testing
- AURN001, Corneal Endothelial Cells, Y27632
- Where
- 20 sites in United States, Canada
- Volunteers
- 97 people
- Sponsor
- Aurion Biotech
Lymphedema
Lymphedema Study for Arm or Leg Lymphedema
This study compares the effectiveness of a study drug versus placebo in the treatment of lymphedema.
- Trial name
- NCT02257970
- Testing
- Ketoprofen
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Stanford University
Macular Edema
A Study in Patients With Neovascular Age Related Macular Degeneration or Macular Edema Secondary To Retinal Vein Occlusion to Evaluate Usability of the Ranibizumab (Lucentis®) Prefilled Syringe (PFS)
This is a multicenter study designed to evaluate usability of ranibizumab PFS in patients with neovascular age related macular degeneration or macular edema secondary to retinal vein occlusion.
- Trial name
- NCT02698566
- Testing
- Ranibizumab
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- Genentech, Inc.
Volume Overload, Dialysis
Haemodialysis Outcomes & Patient Empowerment Study 03
This is a prospective, single-arm observational study that aims to assess the validity and reproducibility of an algorithm for assessing fluid status in a cohort of dialysis patients.
- Trial name
- HOPE-03 (NCT05735288)
- Where
- 2 sites in Ireland
- Volunteers
- 24 people
- Sponsor
- Royal College of Surgeons, Ireland
Lymphedema, Lymphedema Arm
Screening For BCRL In Targeted Therapy For Breast Cancer
This a prospective, longitudinal study designed to track edema and Breast Cancer Related Lymphedema (BCRL) onset in breast cancer patients taking targeted therapy treatments for early and metastatic breast cancer.
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Upper Arm, Lymphedema of Upper Limb
- Trial name
- NCT05142800
- Testing
- Perometer, SOZO device
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Age-Related Macular Degeneration, Branch Retinal Vein Occlusion with Macular Edema
Ocular Safety and Usability Study for FYB203 PFS
The objective of the study is to assess the ocular safety of the FYB203 pre-filled syringe in terms of preparation and administration by Retina Specialists in the clinical setting.
- Conditions
- Age-Related Macular Degeneration, Branch Retinal Vein Occlusion with Macular Edema, Central Retinal Vein Occlusion with Macular Edema, Diabetic Macular Edema
- Trial name
- NCT06708637
- Testing
- FYB203 2 mg (0.05 mL of 40 mg/mL)
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Formycon AG
Branch Retinal Vein Occlusion
Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Branch Retinal Vein Occlusion
The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO).
- Trial name
- RAPTOR (NCT03802630)
- Testing
- Brolucizumab 6 mg, Aflibercept 2 mg
- Where
- 102 sites in United States, Austria and 17 more
- Volunteers
- 450 people
- Sponsor
- Novartis Pharmaceuticals