Caffeine and Resistance TrainingNCT06610136
Caffeine and Resistance Training in Young Adults
A study testing Caffeine plus Resistance training in people with Caffeine and Resistance Training, run by University of Alcala at 1 site in Spain.
Trial summary
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effect of this supplement on neuromuscular adaptations to strength training. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Caffeine and Resistance Training
- What is being tested?
- Caffeine plus Resistance training
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 48 participants
- Where
- 1 siteSpain
- Study dates
- 15 Jan 2023to 30 May 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between ≥ 18 and ≤ 35 years.
- Body mass index (BMI) \< 25 kg/m².
- Physically active subjects (\>150 min/week of moderate exercise).
- Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
- Participants capable of performing the tests.
Who cannot join
- History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
- Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
- Body mass index (BMI) \> 25 kg/m².
- Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
- Performing strenuous exercise within 48 hours prior to the tests.
- Failing to replicate the same food intake on the two experimental days.
- Consuming caffeine after 6 PM on the day prior to training or testing.
Trial locations and contacts
1 site in 1 country.
Spain1 site
Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá
Alcalá de Henares, Madrid, 28805
About this study
Official title: Effects of Acute and Prolonged Caffeine Intake on Neuromuscular Adaptations to Resistance Training in Young Adults
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effect of this supplement on neuromuscular adaptations to strength training.
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effects of this supplement on neuromuscular adaptations to strength training.
Objectives: The present study aims to analyze the effects of acute and chronic caffeine intake on neuromuscular adaptations to strength training, according to sex (men vs. women) and type of exercise (bench press vs. squat), as well as on fatigue resistance during repeated sprints, fatigue perception, mood state, reaction time, diet, and potential side effects.
- Conditions
- Caffeine and Resistance Training
- Being tested
- Caffeine plus Resistance training, Placebo + Resistance training
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Caffeine plus Resistance trainingDietary supplement
Acute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program.
Placebo + Resistance trainingOther
Acute placebo intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program.
| Study group | Role | What they receive |
|---|---|---|
| Caffeine - Males | Experimental | Not described Receives: Dietary Supplement: Caffeine plus Resistance training |
| Placebo - Males | Placebo comparator | Not described Receives: Other: Placebo + Resistance training |
| Caffeine - Females | Experimental | Not described Receives: Dietary Supplement: Caffeine plus Resistance training |
| Placebo - Females | Placebo comparator | Not described Receives: Other: Placebo + Resistance training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean velocity at different %1RM
Measuring bar mean velocity desplacement during bench press and back squat exercises.
Measured: Through study completion, an average of 12 weeks
Peak velocity at different %1RM
Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.
Measured: Through study completion, an average of 12 weeks
Mean power output at different %1RM
Measuring during bench press and back squat exercises.
Measured: Through study completion, an average of 12 weeks
Peak power output and time to reach peak power output at different %1RM
Measuring during bench press and back squat exercises.
Measured: Through study completion, an average of 12 weeks
Number of repetitions performed at 65%1RM until task failure
In bench press and back squat exercises
Measured: Through study completion, an average of 12 weeks
Bar velocity deplacement performed in 1 set at 65%1RM until task failure
In bench press and back squat exercises
Measured: Through study completion, an average of 12 weeks
Power output generated in 1 set at 65%1RM until task failure
In bench press and back squat exercise
Measured: Through study completion, an average of 12 weeks
Secondary outcomes (8)
Resting Metabolic Rate (RMR)
Kcal at rest using a metabolic chart.
Measured: Through study completion, an average of 12 weeks
Maximal Fat Oxidation Rate (MFO)
g/min using a metabolic chart.
Measured: Through study completion, an average of 12 weeks
Fat mass
Using electrical bioimpedance (kg and % of body mass)
Measured: Through study completion, an average of 12 weeks
Fat-free mass
Using electrical bioimpedance (kg and % of body mass)
Measured: Through study completion, an average of 12 weeks
Physical activity (METs-min/wk)
Using IPAQ
Measured: Through study completion, an average of 12 weeks
Dietary (g/kg of macronutrients)
Using a 24-total recall
Measured: Through study completion, an average of 12 weeks
Mood state
Mood. Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question;How do you feel at this moment?; to assess six scales: tension, depression, anger, vigor, fatigue and confusion.
Measured: Through study completion, an average of 12 weeks
Adverse effects
Adverse effects. perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort.
Measured: Through study completion, an average of 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Sep 2024
- Study start15 Jan 2023
- Primary completion30 May 2024
- Study completion30 May 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Caffeine and Resistance TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized controlled trial
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 48 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Alcala
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alberto Pérez-López, University of Alcala
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06610136
- Sponsor's protocol ID
- CEIP2021/6/138
- Status last verified
- Sep 2024
- First submitted
- 9 Sep 2024
- Last updated
- 24 Sep 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 24 Sep 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Acute and Prolonged Caffeine Intake on Neuromuscular Adaptations to Resistance Training in Young Adults
- ClinicalTrials.gov ID
- NCT06610136
- Acronym / sponsor ID
- CEIP2021/6/138
- Conditions
- Caffeine and Resistance Training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 48 participants (actual)
- Lead sponsor
- University of AlcalaUniversity, hospital or other
- Study start
- 15 Jan 2023 (actual)
- Primary completion
- 30 May 2024 (actual)
- Study completion
- 30 May 2024 (actual)
- First posted
- 24 Sep 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effect of this supplement on neuromuscular adaptations to strength training.
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effects of this supplement on neuromuscular adaptations to strength training.
Objectives: The present study aims to analyze the effects of acute and chronic caffeine intake on neuromuscular adaptations to strength training, according to sex (men vs. women) and type of exercise (bench press vs. squat), as well as on fatigue resistance during repeated sprints, fatigue perception, mood state, reaction time, diet, and potential side effects.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 4
- Model description
- Randomized controlled trial
| Arm | Type | Receives |
|---|---|---|
| Caffeine - Males | Experimental | Dietary Supplement: Caffeine plus Resistance training |
| Placebo - Males | Placebo comparator | Other: Placebo + Resistance training |
| Caffeine - Females | Experimental | Dietary Supplement: Caffeine plus Resistance training |
| Placebo - Females | Placebo comparator | Other: Placebo + Resistance training |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age between ≥ 18 and ≤ 35 years.
- Body mass index (BMI) \< 25 kg/m².
- Physically active subjects (\>150 min/week of moderate exercise).
- Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
- Participants capable of performing the tests.
Key exclusion criteria (7 listed)
- History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
- Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
- Body mass index (BMI) \> 25 kg/m².
- Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
- Performing strenuous exercise within 48 hours prior to the tests.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Caffeine plus Resistance trainingAcute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program. | Dietary supplement | Caffeine - Females, Caffeine - Males |
| Placebo + Resistance trainingAcute placebo intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program. | Other | Placebo - Females, Placebo - Males |
Primary outcome
Mean velocity at different %1RM
Time frame: Through study completion, an average of 12 weeks
Measuring bar mean velocity desplacement during bench press and back squat exercises.
Peak velocity at different %1RM
Time frame: Through study completion, an average of 12 weeks
Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.
Mean power output at different %1RM
Time frame: Through study completion, an average of 12 weeks
Measuring during bench press and back squat exercises.
Peak power output and time to reach peak power output at different %1RM
Time frame: Through study completion, an average of 12 weeks
Measuring during bench press and back squat exercises.
Number of repetitions performed at 65%1RM until task failure
Time frame: Through study completion, an average of 12 weeks
In bench press and back squat exercises
Bar velocity deplacement performed in 1 set at 65%1RM until task failure
Time frame: Through study completion, an average of 12 weeks
In bench press and back squat exercises
Power output generated in 1 set at 65%1RM until task failure
Time frame: Through study completion, an average of 12 weeks
In bench press and back squat exercise
8 secondary outcomes
Resting Metabolic Rate (RMR)
Time frame: Through study completion, an average of 12 weeks
Maximal Fat Oxidation Rate (MFO)
Time frame: Through study completion, an average of 12 weeks
Fat mass
Time frame: Through study completion, an average of 12 weeks
Fat-free mass
Time frame: Through study completion, an average of 12 weeks
Physical activity (METs-min/wk)
Time frame: Through study completion, an average of 12 weeks
Dietary (g/kg of macronutrients)
Time frame: Through study completion, an average of 12 weeks
Mood state
Time frame: Through study completion, an average of 12 weeks
Adverse effects
Time frame: Through study completion, an average of 12 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Sep 2024.
- Individual participant dataSharing planned: Yes
Related trials for Caffeine and Resistance Training
Active, not recruiting
Caffeine and Resistance Training in Older Adults
Caffeine and Resistance Training
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Caffeine plus Resistance training in people with Caffeine and Resistance Training, run by University of Alcala at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Sep 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean velocity at different %1RM (time frame: Through study completion, an average of 12 weeks). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Sep 2024.