Health Knowledge, Attitudes, PracticePhase 4NCT06619249
Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners
A Phase 4 study testing CoQ10 supplementation in people with Health Knowledge, Attitudes, Practice, run by Gdansk University of Physical Education and Sport at 1 site in Poland.
Trial summary
The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners. Read more about this study
- Who is it for?
- Ages 30 to 50 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Health Knowledge, Attitudes, Practice
- What is being tested?
- CoQ10 supplementation
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 24 participants
- Where
- 1 sitePoland
- Study dates
- 23 Aug 2024to 30 Jul 2026
- Phase
- Phase 4
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 50 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- training experienced for minimum 2 years
- running training at least 2 times per week
- Personal Best on 10k (<50 minutes)
Who cannot join
- taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)
- injured in last 6 months to avoid n number reduction
Trial locations and contacts
1 site in 1 country.
Poland1 site, 1 recruiting
- Recruiting
Gdansk University of Physical Education and Sport
Gdansk, 80-333
Zbigniew Jost, PhD, +48663892068, zbigniew.jost@awf.gda.pl
About this study
The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners.
Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners?
Participants will:
Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.
- Conditions
- Health Knowledge, Attitudes, Practice
- Being tested
- CoQ10 supplementation, Placebo supplementation
- Keywords
- Coenzyme Q10, Supplementation, Myokine, Exerkine, Cognition, Long-distance runners
- Medical subject headings
- Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CoQ10 supplementationDietary supplement
Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period.
Placebo supplementationDietary supplement
Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period.
| Study group | Role | What they receive |
|---|---|---|
| CoQ10-treated participants | Experimental | The participants will be treated with CoQ10 supplements Receives: Dietary Supplement: CoQ10 supplementation |
| Placebo-treated participants | Placebo comparator | The participants will be treated with placebo Receives: Dietary Supplement: Placebo supplementation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test.
The investigators assume that supplementation with CoQ10 will change cognition (measured via cognitive function tests - Stroop Test, Trial Making Test A and Trial Making Test B) in long-distance runners. The results will be obtained as time (seconds) needed to complete tasks while testing.
Measured: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation.
The investigators will assess the concentration of blood myokine and exerkine concentration (pg or ug/dl) of blood plasma using the colorimetric method.
Measured: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
Secondary outcomes (1)
Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill
The investigators assume that supplementation with CoQ10 will change the aerobic capacity (oxygen uptake in ml-1 x min-1 x kg-1) in long-distance runners. The determination of aerobic capacity will be done through progressive test to volitional exhaustion on a motorized treadmill and gas analyzer
Measured: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Oct 2024
- Study start23 Aug 2024
- Primary completion21 Jul 2025
- Study completion30 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Health Knowledge, Attitudes, PracticeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- A randomized, double-blind, placebo-controlled, cross-over study
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 24 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Gdansk University of Physical Education and Sport
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06619249
- Sponsor's protocol ID
- AWFiS/2024_3_ZJ
- Status last verified
- Aug 2024
- First submitted
- 6 Aug 2024
- Last updated
- 26 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners
- ClinicalTrials.gov ID
- NCT06619249
- Acronym / sponsor ID
- AWFiS/2024_3_ZJ
- Conditions
- Health Knowledge, Attitudes, Practice
- Keywords
- Coenzyme Q10, Supplementation, Myokine, Exerkine, Cognition, Long-distance runners
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 24 participants (estimated)
- Lead sponsor
- Gdansk University of Physical Education and SportUniversity, hospital or other
- Study start
- 23 Aug 2024 (actual)
- Primary completion
- 21 Jul 2025 (actual)
- Study completion
- 30 Jul 2026 (estimated)
- First posted
- 1 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners.
Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners?
Participants will:
Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
- Model description
- A randomized, double-blind, placebo-controlled, cross-over study
| Arm | Type | Receives |
|---|---|---|
| CoQ10-treated participants | Experimental | Dietary Supplement: CoQ10 supplementationThe participants will be treated with CoQ10 supplements |
| Placebo-treated participants | Placebo comparator | Dietary Supplement: Placebo supplementationThe participants will be treated with placebo |
Who may qualify
- Ages
- 30 to 50 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- training experienced for minimum 2 years
- running training at least 2 times per week
- Personal Best on 10k (<50 minutes)
Key exclusion criteria (2 listed)
- taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)
- injured in last 6 months to avoid n number reduction
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CoQ10 supplementationLong-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period. | Dietary supplement | CoQ10-treated participants |
| Placebo supplementationLong-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period. | Dietary supplement | Placebo-treated participants |
Primary outcome
Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test.
Time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
The investigators assume that supplementation with CoQ10 will change cognition (measured via cognitive function tests - Stroop Test, Trial Making Test A and Trial Making Test B) in long-distance runners. The results will be obtained as time (seconds) needed to complete tasks while testing.
Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation.
Time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
The investigators will assess the concentration of blood myokine and exerkine concentration (pg or ug/dl) of blood plasma using the colorimetric method.
1 secondary outcome
Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill
Time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Aug 2025.
Related trials for Health Knowledge, Attitudes, Practice
Not yet recruiting
The Effectiveness of Comic-based Learning Materials on Nursing Students' Knowledge, Attitudes, and Confidence in Dementia Care
Dementia Care Education, Students, Nursing
Recruiting
Climate-Responsive Nutrition, WASH, and Heat Counselling for Maternal and Child Health in Sindh, Pakistan
Maternal Nutrition, Child Nutrition
Active, not recruitingPhase 3
PREVENT HPV -Related Cancers Trial
HPV Vaccination, Uptake Vaccination
Active, not recruiting
A Multilevel Intervention to Improve Adherence to Childhood Cancer Survivorship
Childhood Cancer, Survivorship
Not yet recruiting
Pilot Study to Co-create and Implement a Multicomponent Intervention to Reduce Mental Health Stigma in Primary Care
Mental Health, Stigma of Mental Illness
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing CoQ10 supplementation in people with Health Knowledge, Attitudes, Practice, run by Gdansk University of Physical Education and Sport at 1 site in Poland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 26 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test. (time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Aug 2025.