OsseointegrationNCT06665451
Erythropoietin Gel Effect on Dental Implant Stability
A study testing Non coated dental implants and Erythropoietin gel coated implants in people with Osseointegration, run by Al-Azhar University at 1 site in Egypt.
Trial summary
Achieving and maintaining long-term osseointegration for dental implants is a key objective in the field of dentistry. The success of osseointegration is influenced by the surface treatment applied to dental implants. Numerous coating techniques have been developed to improve and speed up osseointegration. Read more about this study
- Who is it for?
- Ages 20 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Osseointegration
- What is being tested?
- Non coated dental implants and Erythropoietin gel coated implants
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteEgypt
- Study dates
- 15 Mar 2025to Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- All patients Should have nonrestorable teeth in the anterior maxilla indicated for extraction and seeking implant placement.
- Good general periodontal health and maintenance.
Who cannot join
- Heavy smokers who smoke more than ten cigarettes per day
- Acute infected socket
- Ant socket with wall defect.
- Pregnency
- Local or systemic conditions that will interfere with bone healing (uncontrolled diabetes mellitus or human immune deficiency virus infections, resonance therapy), bone disorders (hyperparathyroidism, osteoporosis, or Paget's disease.
- Patients who had subjected to intravenous and/or oral bisphosphonate therapy.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Mohamed Mahjob Head of oral and maxillofacial surgery department contact
Egypt1 site, 1 recruiting
- Recruiting
Faculty of dental medicine Al-Azhar university
Asyut, Asyut Governorate, 088
Mohamed Mahjob Head of oral and maxillofacial surgery department, 00201001544056
Mohamed Alaa Lecturer of OMFS, 00201091919870
About this study
Official title: Evaluation of Erythropoietin Gel Effect on Stability of Immediate Implant ( Clinical and Radiographical Study )
- Achieving and maintaining long-term osseointegration for dental implants is a key objective in the field of dentistry. The success of osseointegration is influenced by the surface treatment applied to dental implants. Numerous coating techniques have been developed to improve and speed up osseointegration.
- The aim of the current study is to assess immediate dental implant stability coated with erythropoietin gel, both clinically and radiographically.
- Materials and Methods: We conducted a randomized controlled clinical trial.The sample will include patients demanding immediate implant treatment in the anterior maxilla . Patients will be randomly allocated into the two groups of the study. The group A will be treated with erythropoietin gel coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla . Group B will be treated with non coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla .
- The primary outcome variable will be implant stability and the secondary outcome will be crestal marginal bone level and bone density around implants. It will be measured at time of implant placement and reevaluated after 6-months .
- Conditions
- Osseointegration
- Being tested
- Non coated dental implants, Erythropoietin gel coated implants
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non coated dental implantsOther
Patients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant .
Erythropoietin gel coated implantsOther
Patients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel.
| Study group | Role | What they receive |
|---|---|---|
| Test Group | Experimental | Patients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel . |
| Control group | Active comparator | Patients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant . Receives: Other: Non coated dental implants |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in implant stability
Implant stability will be assessed by using ( AnyCheck - Implant Stability Tester ) Utilizes physical tapping technique and dumping capacity analysis to measure implant stability with precision
Measured: Baseline and after 6 month
Secondary outcomes (1)
Change in marginal bone level and bone density around implants
To evaluate the amount of marginal bone loss and bone density around osseointegrated implants, all patient will be subjected to Cone beam computed tomography (CBCT) immediate postoperative and after 6 months.
Measured: Baseline and after 6 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Oct 2024
- Study start15 Mar 2025
- Primary completionJun 2026 (estimated)
- Study completionJul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OsseointegrationStudies of the same condition, open and under way.
- More trials run by Al-Azhar UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 24 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Mohsen Farghaly, Al-Azhar University
- Investigators
- Mohamed Alaa Lecturer of OMFS, Study director, faculty of Dental medicine Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06665451
- Sponsor's protocol ID
- Implant surface modification
- Status last verified
- May 2026
- First submitted
- 25 Oct 2024
- Last updated
- 18 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 18 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Erythropoietin Gel Effect on Stability of Immediate Implant ( Clinical and Radiographical Study )
- ClinicalTrials.gov ID
- NCT06665451
- Acronym / sponsor ID
- Implant surface modification
- Conditions
- Osseointegration
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 24 participants (estimated)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- 15 Mar 2025 (actual)
- Primary completion
- Jun 2026 (estimated)
- Study completion
- Jul 2026 (estimated)
- First posted
- 30 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- Achieving and maintaining long-term osseointegration for dental implants is a key objective in the field of dentistry. The success of osseointegration is influenced by the surface treatment applied to dental implants. Numerous coating techniques have been developed to improve and speed up osseointegration.
- The aim of the current study is to assess immediate dental implant stability coated with erythropoietin gel, both clinically and radiographically.
- Materials and Methods: We conducted a randomized controlled clinical trial.The sample will include patients demanding immediate implant treatment in the anterior maxilla . Patients will be randomly allocated into the two groups of the study. The group A will be treated with erythropoietin gel coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla . Group B will be treated with non coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla .
- The primary outcome variable will be implant stability and the secondary outcome will be crestal marginal bone level and bone density around implants. It will be measured at time of implant placement and reevaluated after 6-months .
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Test Group | Experimental | –Patients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel . |
| Control group | Active comparator | Other: Non coated dental implantsPatients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant . |
Who may qualify
- Ages
- 20 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- All patients Should have nonrestorable teeth in the anterior maxilla indicated for extraction and seeking implant placement.
- Good general periodontal health and maintenance.
Key exclusion criteria (6 listed)
- Heavy smokers who smoke more than ten cigarettes per day
- Acute infected socket
- Ant socket with wall defect.
- Pregnency
- Local or systemic conditions that will interfere with bone healing (uncontrolled diabetes mellitus or human immune deficiency virus infections, resonance therapy), bone disorders (hyperparathyroidism, osteoporosis, or Paget's disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non coated dental implantsPatients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant . | Other | Control group |
| Erythropoietin gel coated implantsPatients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel. | Other | – |
Primary outcome
Change in implant stability
Time frame: Baseline and after 6 month
Implant stability will be assessed by using ( AnyCheck - Implant Stability Tester ) Utilizes physical tapping technique and dumping capacity analysis to measure implant stability with precision
1 secondary outcome
Change in marginal bone level and bone density around implants
Time frame: Baseline and after 6 month
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 May 2026.
- Individual participant dataSharing planned: Undecided
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Dental Implant
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mohamed Mahjob Head of oral and maxillofacial surgery department contact
Mohamed Alaa Lecturer of OMFS study director
faculty of Dental medicine Al-Azhar University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Non coated dental implants and Erythropoietin gel coated implants in people with Osseointegration, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 18 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Mohsen Principle investigator (00201020994802, a7medmohsen453@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in implant stability (time frame: Baseline and after 6 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 May 2026.