PropofolNCT06666959
Sevoflurane Versus Propofol in Endovascular Coiling of Cerebral Aneurysm
An observational study of Propofol and Sevoflurane, run by Tongji Hospital at 1 site in China.
Trial summary
The goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. The main question it aims to answer is: Does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage? Participants already… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Propofol, Sevoflurane
- What is being tested?
- Anesthesia Agent
- Type of treatment
- Injection or infusion
- How many people
- 80 participants
- Where
- 1 siteChina
- Study dates
- 1 May 2023to 8 May 2024
- How long will I take part?
- 3 Months
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: In Tongji hospital
Who may be able to join
- Consecutive patients aged 18 years and older presenting to the Tongji hospital for endovascular coiling of cerebral aneurysm were eligible for enrollment.
Who cannot join
- have an endocrine system disease
- pregnancy
- have other brain disorders
- take drugs that alter endocrine hormones
- receive perioperative blood derivatives
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison of the Neuroprotective Effect of Sevoflurane Versus Propofol in Patients Undergoing Endovascular Coiling of Cerebral Aneurysm
The goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. The main question it aims to answer is:
Does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage?
Participants already undergoing endovascular coiling of cerebral aneurysm will have their serum levels of inflammatory factors measured.
- Conditions
- Propofol, Sevoflurane
- Being tested
- Anesthesia Agent
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Anesthesia AgentDrug
Also called sevoflurane, propofol
intravenous anesthetic and inhalation anesthetic
| Study group | Role | What they receive |
|---|---|---|
| patients undergoing endovascular coiling of cerebral aneurysm in Tongji hospital | The present clinical study was carried out with the aim of determine whether the inflammatory effect differs when using propofol or sevoflurane anesthesia. Receives: Drug: Anesthesia Agent |
What is being measured
The primary outcome is the main question the study is designed to answer.
Concentration of interleukin-10
Test the concentration of interleukin-10 of the participants
Measured: From enrollment to 3 months postoperation
Secondary outcomes (9)
Concentration of interleukin-1
Test the Concentration of interleukin-1 in participants
Measured: From enrollment to 3 months postoperation
Concentration of interleukin-2
Test the concentration of interleukin-2 in participants
Measured: From enrollment to 3 months postoperation
Concentration of interleukin-6
Test the concentration of interleukin-6 in participants
Measured: From enrollment to 3 months postoperation
Concentration of interleukin-8
Test the concentration of interleukin-8 in participants
Measured: From enrollment to 3 months postoperation
Concentration of tumor necrosis factor
Test the concentration of tumor necrosis factor in participants
Measured: From enrollment to 3 months postoperation
Concentration of S100B
Test the concentration of S100B in participants
Measured: From enrollment to 3 months postoperation
length of stay
The time from admission to discharge
Measured: through study completion, an average of 6 months
costs
Hospitalization expenses
Measured: through study completion, an average of 6 months
Glasgow Coma Score
The scores are ranging from 3 to 15. And higher scores mean a betterr outcome .
Measured: From enrollment to 3 months postoperation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Oct 2024
- Study start1 May 2023
- Primary completion8 Feb 2024
- Study completion8 May 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for PropofolStudies of the same condition, open and under way.
- More trials run by Tongji HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 80 participants (actual)
- Target duration
- 3 Months
Sponsor and investigators
- Lead sponsor
- Tongji Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, mingxin zhu, Tongji Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06666959
- Sponsor's protocol ID
- TJ-IRB20230413
- Other IDs
- SW-001
- Status last verified
- Oct 2024
- First submitted
- 26 Oct 2024
- Last updated
- 31 Oct 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
Publications
Zhou M, Nie B, Wu Z, Chen C, Chen H, Zhu M, Li M. Effect of sevoflurane versus propofol on immune inflammation in patients undergoing endovascular coiling of cerebral aneurysm. BMC Anesthesiol. 2026 May 13;26(1):399. doi: 10.1186/s12871-026-03902-z.
PubMed 42129719
Study at a glance
From the registry record, last updated by the sponsor on 31 Oct 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Neuroprotective Effect of Sevoflurane Versus Propofol in Patients Undergoing Endovascular Coiling of Cerebral Aneurysm
- ClinicalTrials.gov ID
- NCT06666959
- Acronym / sponsor ID
- TJ-IRB20230413
- Conditions
- Propofol, Sevoflurane
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Tongji HospitalUniversity, hospital or other
- Study start
- 1 May 2023 (actual)
- Primary completion
- 8 Feb 2024 (actual)
- Study completion
- 8 May 2024 (actual)
- First posted
- 31 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. The main question it aims to answer is:
Does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage?
Participants already undergoing endovascular coiling of cerebral aneurysm will have their serum levels of inflammatory factors measured.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 3 Months
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| patients undergoing endovascular coiling of cerebral aneurysm in Tongji hospital | – | Drug: Anesthesia AgentThe present clinical study was carried out with the aim of determine whether the inflammatory effect differs when using propofol or sevoflurane anesthesia. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- In Tongji hospital
Key inclusion criteria (1 listed)
- Consecutive patients aged 18 years and older presenting to the Tongji hospital for endovascular coiling of cerebral aneurysm were eligible for enrollment.
Key exclusion criteria (5 listed)
- have an endocrine system disease
- pregnancy
- have other brain disorders
- take drugs that alter endocrine hormones
- receive perioperative blood derivatives
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Anesthesia AgentAlso: sevoflurane, propofolintravenous anesthetic and inhalation anesthetic | Drug | patients undergoing endovascular coiling of cerebral aneurysm in Tongji hospital |
Primary outcome
Concentration of interleukin-10
Time frame: From enrollment to 3 months postoperation
Test the concentration of interleukin-10 of the participants
9 secondary outcomes
Concentration of interleukin-1
Time frame: From enrollment to 3 months postoperation
Concentration of interleukin-2
Time frame: From enrollment to 3 months postoperation
Concentration of interleukin-6
Time frame: From enrollment to 3 months postoperation
Concentration of interleukin-8
Time frame: From enrollment to 3 months postoperation
Concentration of tumor necrosis factor
Time frame: From enrollment to 3 months postoperation
Concentration of S100B
Time frame: From enrollment to 3 months postoperation
length of stay
Time frame: through study completion, an average of 6 months
costs
Time frame: through study completion, an average of 6 months
Glasgow Coma Score
Time frame: From enrollment to 3 months postoperation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Oct 2024.
- Derived from this study: PubMed 42129719Zhou M, Nie B, Wu Z, Chen C, Chen H, Zhu M, Li M. Effect of sevoflurane versus propofol on immune inflammation in patients undergoing endovascular coiling of cerebral aneurysm. BMC Anesthesiol. 2026 May 13;26(1):399. doi: 10.1186/s12871-026-03902-z.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Propofol and Sevoflurane, run by Tongji Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Oct 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Concentration of interleukin-10 (time frame: From enrollment to 3 months postoperation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06666959, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Oct 2024.