Knee OsteoarthritisNCT06757946
Effect of Mulligan Medial/Lateral Glide w/wo Compression/Decompression Technique on Pain ROM and Function KO
A study testing Mulligan Medial/Lateral glide with compression/ decompression technique and Mulligan Medial/Lateral glide in people with Knee Osteoarthritis, run by Superior University at 1 site in Pakistan.
Trial summary
The Effect of Mulligan Medial/Lateral Glide Techniques with and without Compression-Decompression on Pain, Range of Motion and Function in Patients with Knee Osteoarthritis. This study aims to investigate these effects to develop more effective, non-invasive treatment protocols for improving pain, range of motion and… Read more about this study
- Who is it for?
- Ages 30 to 60 years
- Conditions the study is for
- Knee Osteoarthritis
- What is being tested?
- Mulligan Medial/Lateral glide with compression/ decompression technique and Mulligan Medial/Lateral glide
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Feb 2024to 1 Mar 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Unilateral Knee OA, Males and females between 30 and 60 years of age,
- Patients with restricted ROM,
- Patients are having more than grade III strength of knee muscles,
- l Willingness to take part in the intervention and evaluations
Who cannot join
- Patients having unstable knee joint after Total Knee Arthroplasty or medical conditions affecting rehabilitation,
- l Joint infection of hip and knee,
- l Soft tissue injuries around knee joints,
- including tendinitis and bursitis,
- l Any fracture including patellar fracture, femur or tibia
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Mulligan Medial/Lateral Glide With and Without Compression/ Decompression Technique on Pain, Range of Motion and Function on Patients With Knee Osteoarthritis
The Effect of Mulligan Medial/Lateral Glide Techniques with and without Compression-Decompression on Pain, Range of Motion and Function in Patients with Knee Osteoarthritis. This study aims to investigate these effects to develop more effective, non-invasive treatment protocols for improving pain, range of motion and overall function in knee OA
Read the detailed description
patients, for the better understanding of response by both treatments (i.e Mulligan medial/lateral glide with and without compression/decompression technique). Patient which meet inclusion criteria, gave their consent.
- Conditions
- Knee Osteoarthritis
- Being tested
- Mulligan Medial/Lateral glide with compression/ decompression technique, Mulligan Medial/Lateral glide
- Medical subject headings
- Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mulligan Medial/Lateral glide with compression/ decompression techniqueCombination product
Warm up (10 minutes with hot pack) and cool down exercises for a period of 5 to 10 minutes was given before starting and after the completion of exercises in supervised exercise program in all the groups. The following ergonomical advice were given to all the subjects, Avoid extreme knee bent positions, avoid squatting, crossed-leg sitting, frequent stair climbing or lifting heavy objects, avoid fatiguing postures except for infrequent short durations tasks, change posture frequently and use support where possible and avoid giving excess strain to the knees.
Mulligan mobilisation consisted of Medial glide mobilisation with movement, Lateral glide mobilisation with movement, with active knee flexion (61) depending on the subjects condition. The gliding force was sustained while the patient performed 3 sets of 10 repetitions.
Total 12 treatment sessions was given to each subject with the frequency of 3 sessions per week for 4 consecutive weeks.
Mulligan Medial/Lateral glideCombination product
Warm up (10 minutes with hot pack) and cool down exercises for a period of 5 to 10 minutes was given before starting and after the completion of exercises in supervised exercise program in all the groups. The following ergonomical advice were given to all the subjects, Avoid extreme knee bent positions, avoid squatting, crossed-leg sitting, frequent stair climbing or lifting heavy objects, avoid fatiguing postures except for infrequent short durations tasks, change posture frequently and use support where possible and avoid giving excess strain to the knees.
Total 12 treatment sessions was given to each subject with the frequency of 3 sessions per week for 4 consecutive weeks. After completing the therapeutic session, post- intervention data of the outcome parameters were taken.
| Study group | Role | What they receive |
|---|---|---|
| Interventional group I | Experimental | Not described Receives: Combination Product: Mulligan Medial/Lateral glide with compression/ decompression technique |
| Interventional group II | Active comparator | Not described Receives: Combination Product: Mulligan Medial/Lateral glide |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Rating Scale (NPRS)
This tool was utilized to assess the intensity of pain. A score of 0 denotes ""having no pain at all,"" while a score of 10 indicates ""the worst pain I've ever experienced."" The participants were asked to choose a number on the scale that accurately represented how much knee discomfort they were experiencing.According to a study conducted on individuals with knee OA, the interclass correlation was 0.95. Higher scores denote more intense pain; scores range from 0 to 10.
Measured: 12 Months
Western Ontario and McMaster Osteoarthritis Index (WOMAC)
It is commonly used to assess lower extremity functional status, discomfort, and associated stiffness. The questionnaire consists of twenty-four questions: seventeen pertain to physical status, five concern pain status, and two address stiffness. Each question contains five alternatives starting from 0 which signifies no symptom or trouble at all to 4 which represents considerable difficulty in doing activities with severe symptoms. There are subscale scores for stiffness, discomfort, and functional status. The sum of the 24 items that were listed, with scores ranging from 0 to 96, was the definition of the total scores.
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Jan 2025
- Study start15 Feb 2024
- Primary completion1 Aug 2024
- Study completion1 Mar 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- More trials run by Superior UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 54 participants (actual)
Sponsor and investigators
- Lead sponsor
- Superior University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Muhammad Naveed Babur, Superior University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06757946
- Sponsor's protocol ID
- MSRSW/Batch-Fall22/761
- Status last verified
- Dec 2024
- First submitted
- 26 Dec 2024
- Last updated
- 3 Jan 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Jan 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Mulligan Medial/Lateral Glide With and Without Compression/ Decompression Technique on Pain, Range of Motion and Function on Patients With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT06757946
- Acronym / sponsor ID
- MSRSW/Batch-Fall22/761
- Conditions
- Knee Osteoarthritis
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 54 participants (actual)
- Lead sponsor
- Superior UniversityUniversity, hospital or other
- Study start
- 15 Feb 2024 (actual)
- Primary completion
- 1 Aug 2024 (actual)
- Study completion
- 1 Mar 2025 (estimated)
- First posted
- 3 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The Effect of Mulligan Medial/Lateral Glide Techniques with and without Compression-Decompression on Pain, Range of Motion and Function in Patients with Knee Osteoarthritis. This study aims to investigate these effects to develop more effective, non-invasive treatment protocols for improving pain, range of motion and overall function in knee OA
Detailed description
patients, for the better understanding of response by both treatments (i.e Mulligan medial/lateral glide with and without compression/decompression technique). Patient which meet inclusion criteria, gave their consent.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Interventional group I | Experimental | Combination Product: Mulligan Medial/Lateral glide with compression/ decompression technique |
| Interventional group II | Active comparator | Combination Product: Mulligan Medial/Lateral glide |
Who may qualify
- Ages
- 30 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Unilateral Knee OA, Males and females between 30 and 60 years of age,
- Patients with restricted ROM,
- Patients are having more than grade III strength of knee muscles,
- l Willingness to take part in the intervention and evaluations
Key exclusion criteria (5 listed)
- Patients having unstable knee joint after Total Knee Arthroplasty or medical conditions affecting rehabilitation,
- l Joint infection of hip and knee,
- l Soft tissue injuries around knee joints,
- including tendinitis and bursitis,
- l Any fracture including patellar fracture, femur or tibia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mulligan Medial/Lateral glide with compression/ decompression techniqueWarm up (10 minutes with hot pack) and cool down exercises for a period of 5 to 10 minutes was given before starting and after the completion of exercises in supervised exercise program in all the groups. The following ergonomical advice were given to all the subjects, Avoid extreme knee bent positions, avoid squatting, crossed-leg sitting, frequent stair climbing or lifting heavy objects, avoid fatiguing postures except for infrequent short durations tasks, change posture frequently and use support where possible and avoid giving excess strain to the knees. Mulligan mobilisation consisted of Medial glide mobilisation with movement, Lateral glide mobilisation with movement, with active knee flexion (61) depending on the subjects condition. The gliding force was sustained while the patient performed 3 sets of 10 repetitions. Total 12 treatment sessions was given to each subject with the frequency of 3 sessions per week for 4 consecutive weeks. | Combination product | Interventional group I |
| Mulligan Medial/Lateral glideWarm up (10 minutes with hot pack) and cool down exercises for a period of 5 to 10 minutes was given before starting and after the completion of exercises in supervised exercise program in all the groups. The following ergonomical advice were given to all the subjects, Avoid extreme knee bent positions, avoid squatting, crossed-leg sitting, frequent stair climbing or lifting heavy objects, avoid fatiguing postures except for infrequent short durations tasks, change posture frequently and use support where possible and avoid giving excess strain to the knees. Total 12 treatment sessions was given to each subject with the frequency of 3 sessions per week for 4 consecutive weeks. After completing the therapeutic session, post- intervention data of the outcome parameters were taken. | Combination product | Interventional group II |
Primary outcome
Pain Rating Scale (NPRS)
Time frame: 12 Months
This tool was utilized to assess the intensity of pain. A score of 0 denotes ""having no pain at all,"" while a score of 10 indicates ""the worst pain I've ever experienced."" The participants were asked to choose a number on the scale that accurately represented how much knee discomfort they were experiencing.According to a study conducted on individuals with knee OA, the interclass correlation was 0.95. Higher scores denote more intense pain; scores range from 0 to 10.
Western Ontario and McMaster Osteoarthritis Index (WOMAC)
Time frame: 12 months
It is commonly used to assess lower extremity functional status, discomfort, and associated stiffness. The questionnaire consists of twenty-four questions: seventeen pertain to physical status, five concern pain status, and two address stiffness. Each question contains five alternatives starting from 0 which signifies no symptom or trouble at all to 4 which represents considerable difficulty in doing activities with severe symptoms. There are subscale scores for stiffness, discomfort, and functional status. The sum of the 24 items that were listed, with scores ranging from 0 to 96, was the definition of the total scores.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jan 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mulligan Medial/Lateral glide with compression/ decompression technique and Mulligan Medial/Lateral glide in people with Knee Osteoarthritis, run by Superior University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 3 Jan 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Rating Scale (NPRS) (time frame: 12 Months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jan 2025.