Medical EducationCERESNCT06759012
An Agentic Co-educator System for Personalized Medical Education
A study testing EyeTeacher in people with Medical Education, run by Tsinghua University at 7 sites in 6 countries.
Trial summary
With the rise of generative artificial intelligence and large language models, medical education is undergoing a significant transformation. Numerous studies have highlighted the limitations of traditional educational knowledge acquisition and the potential impact of artificial intelligence on medical education… Read more about this study
- Who is it for?
- Ages 21 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Medical Education
- What is being tested?
- EyeTeacher
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 269 participants
- Where
- 7 sitesin 6 countries
- Study dates
- 2 Mar 2025to 30 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Clinical medical students who have not taken ophthalmology courses
- Age 21-40
- Gender not restricted
- Sign the informed consent form
Who cannot join
- Refusal of the research protocol.
- Participants unwilling or unable to understand and complete the questionnaire.
Trial locations and contacts
7 sites in 6 countries.
7 sites in 6 countries
China2 sites
Peking Union Medical College Hospital
Beijing, Beijing Municipality, 430022
BenQ Medical Center, Nanjing Medical University Affiliated Hospital
Nanjing, Jiangsu, 210019
About this study
With the rise of generative artificial intelligence and large language models, medical education is undergoing a significant transformation. Numerous studies have highlighted the limitations of traditional educational knowledge acquisition and the potential impact of artificial intelligence on medical education, resident training, and continuing education for clinical practitioners. However, there is a lack of real-world experiments on the effectiveness of AI-integrated education.
Artificial intelligence can provide extensive educational resources and tools that are not limited by geographical location or language, thereby lowering the barrier to accessing high-quality medical education and promoting educational equity. Nevertheless, the performance of AI models trained by different medical institutions or healthcare systems may vary.
To offer a more universal, accessible, high-quality, and interconnected educational journey. We have developed a virtual ophthalmology teacher, which developed based on foundational model and large language models. This model, named EyeTeacher provide comprehensive theoretical knowledge and clinical skills enhancement for untrained medical students. To verify the effectiveness of our EyeTeacher across different national ophthalmology education systems and languages, we plan to implement a randomized controlled trial. This trial will assess the clinical capabilities of all participants and explore the advantages and disadvantages of the system compared to traditional teaching methods.
- Conditions
- Medical Education
- Being tested
- EyeTeacher
- Keywords
- Medical education, Multimodality AI, Generative AI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EyeTeacherOther
Participants randomized to the intervention group will receive access to the EyeTeacher system, along with their username, password, and a user manual, one week before the start of the course. They will follow instructions on the website and complete a quiz before and after each course. After completing the EyeTeacher curriculum, they will take the first examination (Examination 1) and complete a set of questionnaires. A classroom will be provided for study purposes, but no restrictions will be imposed on the study location. Following the EyeTeacher section, participants will attend the ophthalmology course in the regular training program, with support from the EyeTeacher system. They will be evaluated according to the ophthalmology posting's evaluation criteria (Examination 2).
| Study group | Role | What they receive |
|---|---|---|
| Interventional group | Experimental | Attend EyeTeacher lecture before taking the regular ophthalmology lecture in medical school. Receives: Other: EyeTeacher |
| Control group | No intervention | Attend regular ophthalmology lectures in medical school. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Grade of ophthalmology examination
Title: Ophthalmology Theoretical Examination. The examination includes 40 multiple-choice questions and two essay questions related to ophthalmology knowledge, to be completed within one hour without the use of reference materials. The exam will be graded by experts based on a standardized answer key. The score ranges from 0 to 100, with a higher score indicating a deeper understanding of the ophthalmology knowledge.
Students in both the interventional group and the control group will complete the exam within the specified time on the EyeTeacher system. The data will be collected in the system's backend.
Measured: 1 day after complete lectures
Secondary outcomes (2)
Time of studying ophthalmology
The study time spent using each teaching module in the interventional group is tracked by the EyeTeacher system website, while the study time for the control group and the out-of-system study time for the interventional group are collected through a questionnaire.
Questionnaire title: Time of Study in Ophthalmology The questionnaire consists of fill-in-the-blank questions, with time measured in minutes. The content includes: class time, exercise time, discussion time, and reading reference material time. The questionnaires for both the interventional and control groups are completed on the EyeTeacher system, and the data is collected through the backend.
Measured: 1 day after complete lectures
Feedback of teaching from students
Questionnaire title: Feedback of Study in Ophthalmology:
The Likert scale is used for scoring. The topics include students' evaluations of course design, teacher guidance, empathy, as well as students' self-assessment and evaluation of their interest in ophthalmology.
The questionnaires for both the interventional and control groups are completed on the EyeTeacher system, and the data is collected through the backend.
Measured: 1 day after complete lectures
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jan 2025
- Study start2 Mar 2025
- Primary completion15 Jun 2026
- Study completion30 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Medical EducationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 269 participants (actual)
Sponsor and investigators
- Lead sponsor
- Tsinghua University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tien Yin Wong, Tsinghua University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06759012
- Sponsor's protocol ID
- THU01-20240100
- Acronym
- CERES
- Status last verified
- Aug 2026
- First submitted
- 5 Dec 2024
- Last updated
- 19 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
He B, Kwan AC, Cho JH, Yuan N, Pollick C, Shiota T, Ebinger J, Bello NA, Wei J, Josan K, Duffy G, Jujjavarapu M, Siegel R, Cheng S, Zou JY, Ouyang D. Blinded, randomized trial of sonographer versus AI cardiac function assessment. Nature. 2023 Apr;616(7957):520-524. doi: 10.1038/s41586-023-05947-3. Epub 2023 Apr 5.
PubMed 37020027Benitez TM, Xu Y, Boudreau JD, Kow AWC, Bello F, Van Phuoc L, Wang X, Sun X, Leung GK, Lan Y, Wang Y, Cheng D, Tham YC, Wong TY, Chung KC. Harnessing the potential of large language models in medical education: promise and pitfalls. J Am Med Inform Assoc. 2024 Feb 16;31(3):776-783. doi: 10.1093/jamia/ocad252.
PubMed 38269644
Study at a glance
From the registry record, last updated by the sponsor on 19 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- An Agentic Co-educator System for Personalized Medical Education
- ClinicalTrials.gov ID
- NCT06759012
- Acronym / sponsor ID
- CERES / THU01-20240100
- Conditions
- Medical Education
- Keywords
- Medical education, Multimodality AI, Generative AI
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 269 participants (actual)
- Lead sponsor
- Tsinghua UniversityUniversity, hospital or other
- Study start
- 2 Mar 2025 (actual)
- Primary completion
- 15 Jun 2026 (actual)
- Study completion
- 30 Jul 2026 (actual)
- First posted
- 6 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
With the rise of generative artificial intelligence and large language models, medical education is undergoing a significant transformation. Numerous studies have highlighted the limitations of traditional educational knowledge acquisition and the potential impact of artificial intelligence on medical education, resident training, and continuing education for clinical practitioners. However, there is a lack of real-world experiments on the effectiveness of AI-integrated education.
Artificial intelligence can provide extensive educational resources and tools that are not limited by geographical location or language, thereby lowering the barrier to accessing high-quality medical education and promoting educational equity. Nevertheless, the performance of AI models trained by different medical institutions or healthcare systems may vary.
To offer a more universal, accessible, high-quality, and interconnected educational journey. We have developed a virtual ophthalmology teacher, which developed based on foundational model and large language models. This model, named EyeTeacher provide comprehensive theoretical knowledge and clinical skills enhancement for untrained medical students. To verify the effectiveness of our EyeTeacher across different national ophthalmology education systems and languages, we plan to implement a randomized controlled trial. This trial will assess the clinical capabilities of all participants and explore the advantages and disadvantages of the system compared to traditional teaching methods.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Interventional group | Experimental | Other: EyeTeacherAttend EyeTeacher lecture before taking the regular ophthalmology lecture in medical school. |
| Control group | No intervention | –Attend regular ophthalmology lectures in medical school. |
Who may qualify
- Ages
- 21 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Clinical medical students who have not taken ophthalmology courses
- Age 21-40
- Gender not restricted
- Sign the informed consent form
Key exclusion criteria (2 listed)
- Refusal of the research protocol.
- Participants unwilling or unable to understand and complete the questionnaire.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EyeTeacherParticipants randomized to the intervention group will receive access to the EyeTeacher system, along with their username, password, and a user manual, one week before the start of the course. They will follow instructions on the website and complete a quiz before and after each course. After completing the EyeTeacher curriculum, they will take the first examination (Examination 1) and complete a set of questionnaires. A classroom will be provided for study purposes, but no restrictions will be imposed on the study location. Following the EyeTeacher section, participants will attend the ophthalmology course in the regular training program, with support from the EyeTeacher system. They will be evaluated according to the ophthalmology posting's evaluation criteria (Examination 2). | Other | Interventional group |
Primary outcome
Grade of ophthalmology examination
Time frame: 1 day after complete lectures
Title: Ophthalmology Theoretical Examination. The examination includes 40 multiple-choice questions and two essay questions related to ophthalmology knowledge, to be completed within one hour without the use of reference materials. The exam will be graded by experts based on a standardized answer key. The score ranges from 0 to 100, with a higher score indicating a deeper understanding of the ophthalmology knowledge. Students in both the interventional group and the control group will complete the exam within the specified time on the EyeTeacher system. The data will be collected in the system's backend.
2 secondary outcomes
Time of studying ophthalmology
Time frame: 1 day after complete lectures
Feedback of teaching from students
Time frame: 1 day after complete lectures
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Aug 2026.
- Background: PubMed 37020027He B, Kwan AC, Cho JH, Yuan N, Pollick C, Shiota T, Ebinger J, Bello NA, Wei J, Josan K, Duffy G, Jujjavarapu M, Siegel R, Cheng S, Zou JY, Ouyang D. Blinded, randomized trial of sonographer versus AI cardiac function assessment. Nature. 2023 Apr;616(7957):520-524. doi: 10.1038/s41586-023-05947-3. Epub 2023 Apr 5.
- Background: PubMed 38269644Benitez TM, Xu Y, Boudreau JD, Kow AWC, Bello F, Van Phuoc L, Wang X, Sun X, Leung GK, Lan Y, Wang Y, Cheng D, Tham YC, Wong TY, Chung KC. Harnessing the potential of large language models in medical education: promise and pitfalls. J Am Med Inform Assoc. 2024 Feb 16;31(3):776-783. doi: 10.1093/jamia/ocad252.
- Individual participant dataSharing planned: No
Related trials for Medical Education
Not yet recruitingObservational study
Federated Learning in Renal Tumor Model
Renal Tumors
Not yet recruiting
Generative AI-Assisted Personalized Feedback for Laparoscopic Skill Learning in Medical Undergraduates
Medical Education
Not yet recruiting
Comparing the Efficacy of a Conversational Agent (QuitBot) Versus Standard Health Education on Smoking Cessation Among Medical Students; A Randomized Controlled Trial.
Conversational Agent, Smoking Cessation
RecruitingObservational study
Artificial Intelligence for Automated Clinical Data Exploration From Electronic Medical Records (CardioMining-AI)
Artificial Intelligence, Machine Learning
Not yet recruiting
AI Smart Glasses Feedback for Intubation Training in Medical Students
Intubation, Intratracheal, Medical Education
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
7 sites in 6 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing EyeTeacher in people with Medical Education, run by Tsinghua University at 7 sites in 6 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 7 sites in China, Australia, Ghana, India, Malaysia and 1 more country. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Grade of ophthalmology examination (time frame: 1 day after complete lectures). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06759012, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Aug 2026.