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Psoriatic ArthritisPERISNCT06764693

An Ex-US Study to Assess Treatment Persistence With Risankizumab in Adult Participants With Psoriatic Arthritis

An observational study of Psoriatic Arthritis, run by AbbVie at 132 sites in 15 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

Psoriatic arthritis (PsA) is a type of arthritis (swelling and stiffness in the joints) that is frequently seen in trial participants who also have the skin condition psoriasis. It is caused by an overactive immune system where the body attacks healthy tissue by mistake. Read more about this study

Who is it for?
Ages 18 to 75 years
Conditions the study is for
Psoriatic Arthritis
How many people
1,200 participants
Where
132 sitesin 15 countries
Study dates
31 Jan 2025to Feb 2029
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 75 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: Participants that currently are treated with Risankizumab or other advanced treatment options for the management of active psoriatic arthritis in clinical practice.

Who may be able to join

  • Participant with a clinical diagnosis of psoriatic arthritis (PsA) with symptom onset at least 6 months prior to the Screening visit and fulfillment of ClASsification for Psoriatic ARthritis (CASPAR) at Baseline visit to confirm that the participant has active disease.
  • Participant must have demonstrated an inadequate response to at least 1 Disease-modifying antirheumatic drug (DMARD) (with max 50% Biologic DMARD-Inadequate Response); alternatively, participant must have demonstrated an intolerance to or contraindication for csDMARDs as determined by the investigator.

Who cannot join

  • Participants demonstrated an inadequate response to three or more bDMARDs/targeted synthetic DMARDs (tsDMARDs).

Trial locations and contacts

132 sites in 15 countries. Contact the study team or a site near you to ask about taking part.

Shari Chapman contact

844-663-3742

shari.chapman@abbvie.com

132 sites in 15 countries

France27 sites, 27 recruiting

  • Hôpital Privé De Provence /ID# 275797

    Aix-en-Provence, Provence-Alpes-Côte d'Azur Region, 13080

    Recruiting

  • Centre Hospitalier D'Arras /ID# 275192

    Arras, Hauts-de-France, 62022

    Recruiting

  • Centre Hospitalier Regional Universitaire de Besancon - Hopital Jean Minjoz /ID# 277881

    Besançon, Doubs, 25000

    Recruiting

  • Centre Hospitalier Boulogne-Sur-Mer /ID# 277269

    Boulogne-sur-Mer, Pas-de-Calais, 62321

    Recruiting

  • CH de Cahors /ID# 275092

    Cahors, 46005

    Recruiting

  • Infirmerie Protestante De Lyon /ID# 274922

    Caluire-et-Cuire, Auvergne-Rhône-Alpes, 69300

    Recruiting

  • Centre Hospitalier De Cannes - Hôpital De Cannes /ID# 275193

    Cannes, Provence-Alpes-Côte d'Azur Region, 06414

    Recruiting

  • Centre Hospitalier Régional Universitaire De Tours - Hôpital Trousseau /ID# 275397

    Chambray-lès-Tours, Indre-et-Loire, 37170

    Recruiting

  • Centre Hospitalier Universitaire Gabriel-Montpied /ID# 275399

    Clermont-Ferrand, Auvergne-Rhône-Alpes, 63000

    Recruiting

  • Centre Hospitalier Sud Francilien /ID# 275038

    Corbeil-Essonnes, Île-de-France Region, 91106

    Recruiting

  • Henri Mondor Hospital /ID# 275360

    Créteil, Val-de-Marne, 94000

    Recruiting

  • Chu Grenoble - Hôpital Sud /ID# 275200

    Échirolles, Auvergne-Rhône-Alpes, 38130

    Recruiting

  • CHU de Lille - Hôpital Salengro /ID# 274980

    Lille, Hauts-de-France, 59037

    Recruiting

  • Clinique François Chénieux /ID# 276516

    Limoges, Limousin, 87039

    Recruiting

  • CHU Limoges - Dupuytren 2 /ID# 274918

    Limoges, New Aquitaine, 87000

    Recruiting

  • Pôle Santé du Pont de Chaume /ID# 275608

    Montauban, Occitanie, 82000

    Recruiting

  • Chu Montpellier /ID# 274925

    Montpellier, Herault, 34295

    Recruiting

  • Centre Hospitalier Universitaire de Nantes, Hotel Dieu -HME /ID# 275396

    Nantes, Pays de la Loire Region, 44000

    Recruiting

  • Centre Hospitalier Universitaire de Nice - Hopital Pasteur /ID# 274923

    Nice, Alpes-Maritimes, 06001

    Recruiting

  • Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 275377

    Orléans, 45067

    Recruiting

  • AP-HP - Groupe Hospitalier 10e - Hopital Lariboisiere /ID# 275182

    Paris, 75010

    Recruiting

  • Groupe Hospitalier Paris Saint-Joseph /ID# 274981

    Paris, 75014

    Recruiting

  • Hopital Pitie Salpetriere /ID# 275368

    Paris, Île-de-France Region, 75013

    Recruiting

  • Cabinet libéral du Dr PAUPIERE /ID# 275401

    Péronne, Somme, 80200

    Recruiting

  • Chru De Rennes - Hôpital Sud /ID# 277115

    Rennes, Ille-et-Vilaine, 35203

    Recruiting

  • Centre Hospitalier Universitaire de Rouen (CHU)- Hopital Charles Nicolle /ID# 275366

    Rouen, Seine-Maritime, 76031

    Recruiting

  • Centre Hospitalier de Valenciennes /ID# 276354

    Valenciennes, 59300

    Recruiting

Other trials in France

Germany23 sites, 22 recruiting

  • Private Practice - Dr. Thomas Kupka /ID# 276236

    Altenburg, Thuringia, 04600

    Completed

  • Dr. Med. Thomas Marycz /ID# 280489

    Amberg, Bavaria, 92224

    Recruiting

  • Rheumapraxis Steglitz /ID# 279413

    Berlin, 12161

    Recruiting

  • Private Practice - Dr. Silke Zinke /ID# 279350

    Berlin, 13055

    Recruiting

  • MVZ Herzogin Elisabeth Hospital /ID# 275583

    Braunschweig, 38114

    Recruiting

  • Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 276484

    Frankfurt am Main, Hesse, 60329

    Recruiting

  • Praxis Fiene /ID# 279363

    Greifswald, 17493

    Recruiting

  • Rheumapraxis Dr. Liebhaber /ID# 276235

    Halle, Saxony-Anhalt, 06128

    Recruiting

  • Praxis. F. Bigdeli-Wilshusen /ID# 275522

    Hanover, Lower Saxony, 30173

    Recruiting

  • Private Practice - Dr. Dirk Wernicke /ID# 279748

    Hohen Neuendorf, Brandenburg, 16540

    Recruiting

  • Praxis Dr. med. Florian Beyer /ID# 276233

    Kaiserslautern, Rhineland-Palatinate, 67657

    Recruiting

  • Rheumatologie Kassel /ID# 276311

    Kassel, Lower Saxony, 34125

    Recruiting

  • Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 275711

    Lübeck, Schleswig-Holstein, 23538

    Recruiting

  • Rheumatologische Facharztpraxis /ID# 276359

    Magdeburg, Saxony-Anhalt, 39104

    Recruiting

  • Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 276208

    Planegg, Bavaria, 82152

    Recruiting

  • Knappschaftsklinikum Saar /ID# 279850

    Püttlingen, Saarland, 66346

    Recruiting

  • Rheumapraxis Dr. Prothmann /ID# 275712

    Püttlingen, Saarland, 66346

    Recruiting

  • Rheumazentrum Ratingen /ID# 278190

    Ratingen, North Rhine-Westphalia, 40882

    Recruiting

  • Private Practice - Dr. Jochen Walter /ID# 280067

    Rendsburg, Schleswig-Holstein, 24768

    Recruiting

  • Rheumatologisch Immunologisch /ID# 275832

    Templin, Brandenburg, 17268

    Recruiting

  • Krankenhaus der Barmherzigen Brüder Trier /ID# 278759

    Trier, Rhineland-Palatinate, 54292

    Recruiting

  • Rheumateam Lahn-Dill-Siegerland /ID# 276019

    Wetzlar, Hesse, 35578

    Recruiting

  • Cellitinnen-Krankenhaus St. Josef /ID# 275710

    Wuppertal, 42105

    Recruiting

Other trials in Germany

Greece16 sites, 16 recruiting

  • University General Hospital of Alexandroupolis /ID# 272411

    Alexandroupoli, Evros, 68100

    Recruiting

  • Athens Naval Hospital /ID# 272313

    Athens, Attica, 11521

    Recruiting

  • General Hospital of Athens Ippokratio /ID# 262528

    Athens, Attica, 11527

    Recruiting

  • General Hospital of Athens Laiko /ID# 272325

    Athens, Attica, 11527

    Recruiting

  • General Hospital of Athens Laiko /ID# 272410

    Athens, Attica, 11527

    Recruiting

  • University General Hospital Attikon /ID# 272358

    Athens, Attica, 12462

    Recruiting

  • KAT Atttica General Hospital /ID# 271741

    Athens, 14561

    Recruiting

  • University General Hospital of Heraklion /ID# 271743

    Heraklion, Crete, 71500

    Recruiting

  • General Hospital of Ioannina G. Hatzikosta /ID# 272327

    Ioannina, 45445

    Recruiting

  • The University Hospital of Larissa /ID# 272315

    Larissa, Larisa, 41110

    Recruiting

  • Olympion General Clinic /ID# 271685

    Pátrai, Achaia, 25443

    Recruiting

  • Bioclinic Thessaloniki /ID# 272316

    Thessaloniki, 54622

    Recruiting

  • General Hospital of Thessaloniki Hippokrateio /ID# 272314

    Thessaloniki, 54642

    Recruiting

  • Euromedica General Clinic of Thessaloniki /ID# 272412

    Thessaloniki, 54645

    Recruiting

  • Euromedica General Clinic of Thessaloniki /ID# 275805

    Thessaloniki, 54645

    Recruiting

  • Asklipieio General Hospital of Voula /ID# 272326

    Voula, Attica, 16673

    Recruiting

Other trials in Greece

Italy13 sites, 13 recruiting

  • Azienda Ospedaliero Universitaria delle Marche /ID# 264636

    Ancona, 60020

    Recruiting

  • ASST degli Spedali Civili di Brescia /ID# 264699

    Brescia, 25123

    Recruiting

  • Universita degli Studi del Molise /ID# 265162

    Campobasso, 86100

    Recruiting

  • AOU Policlinico G. Rodolico - San Marco /ID# 264459

    Catania, 95123

    Site Coordinator, +39-957-435-045

    Recruiting

  • ASL 2 Abruzzo Lanciano-Vasto-Chieti /ID# 265640

    Chieti, 67100

    Recruiting

  • ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO /ID# 265161

    Milan, Milano, 20122

    Recruiting

  • IRCCS Ospedale San Raffaele /ID# 266212

    Milan, Milano, 20132

    Recruiting

  • Azienda Ospedaliera Universitaria Luigi Vanvitelli /ID# 266888

    Naples, Napoli, 80138

    Recruiting

  • Azienda Ospedaliero Universitaria Pisana /ID# 264938

    Pisa, 56126

    Recruiting

  • Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 265145

    Rome, Roma, 00161

    Recruiting

  • IRCCS Istituto Clinico Humanitas /ID# 264463

    Rozzano, Lombardy, 20089

    Recruiting

  • Azienda Ospedaliera Universitaria Senese /ID# 265207

    Siena, 53100

    Recruiting

  • ASU FC - P.O. Universitario Santa Maria della Misericordia /ID# 264698

    Udine, 33100

    Recruiting

Other trials in Italy

Spain11 sites, 11 recruiting

  • Hospital Universitario Virgen de las Nieves /ID# 275741

    Granada, 18014

    Recruiting

  • Hospital Universitario Clinico San Cecilio /ID# 272665

    Granada, 18016

    Recruiting

  • Hospital Juan Ramón Jiménez /ID# 272667

    Huelva, 21005

    Recruiting

  • Hospital Rafael Mendez /ID# 272663

    Lorca, Murcia, 30817

    Recruiting

  • Hospital Universitario de La Princesa /ID# 264073

    Madrid, 28006

    Recruiting

  • Hospital Universitario 12 de Octubre /ID# 272660

    Madrid, 28041

    Recruiting

  • Hospital Universitario La Paz /ID# 264316

    Madrid, 28046

    Recruiting

  • Hospital Universitario Virgen de la Victoria /ID# 264317

    Málaga, Malaga, 29010

    Recruiting

  • Hospital General Universitario Reina Sofía /ID# 272664

    Murcia, 30003

    Recruiting

  • Hospital Universitario de Valme /ID# 264314

    Seville, Sevilla, 41014

    Recruiting

  • Hospital Xeral Cies (CHUVI) /ID# 272659

    Vigo, Pontevedra, 36204

    Recruiting

Other trials in Spain

Belgium7 sites, 7 recruiting

  • OLV Ziekenhuis Aalst /ID# 274456

    Aalst, Oost-Vlaanderen, 9300

    Recruiting

  • Universite Libre de Bruxelles - Hopital Erasme /ID# 272763

    Anderlecht, Brussels Capital, 1070

    Recruiting

  • Rhumaconsult Sprl /ID# 272797

    Charleroi, Hainaut, 6000

    Recruiting

  • Reumacentrum Genk - Medisch Centrum Genk /ID# 272796

    Genk, Limburg, 3600

    Recruiting

  • ReumaClinic /ID# 272782

    Genk, Limburg, 3600

    Recruiting

  • UZ Leuven /ID# 272781

    Leuven, Vlaams-Brabant, 3000

    Recruiting

  • CHU de Liege /ID# 272784

    Liège, 4000

    Recruiting

Other trials in Belgium

Bulgaria7 sites, 7 recruiting

  • Military Hospital - Pleven /ID# 276054

    Pleven, 5803

    Recruiting

  • Medical Center Epiona /ID# 276037

    Plovdiv, 4001

    Recruiting

  • University Multiprofile Hospital For Active Treatment Pulmed /ID# 276157

    Plovdiv, 4002

    Recruiting

  • Dr. Tsvetanka Petranova ELIMED - 2 /ID# 276158

    Sofia, 1408

    Recruiting

  • Medical Center Academy /ID# 276041

    Sofia, 1612

    Recruiting

  • Diagnostic Consultative Centre (Dcc) - Foкus 5 /ID# 275952

    Sofiya, Sofia, 1463

    Recruiting

  • AIPSMPR -d-r Gerganov /ID# 275953

    Varna, 9002

    Recruiting

Other trials in Bulgaria

Ireland6 sites, 6 recruiting

  • Cork University Hospital /ID# 268263

    Cork, T12 E8YV

    Recruiting

  • St James Hospital /ID# 260024

    Dublin, Dublin, D08 NHY1

    Recruiting

  • Beaumont Hospital /ID# 271961

    Dublin, D09 XR63

    Recruiting

  • Tallaght University Hospital /ID# 277000

    Dublin, D24 NR0A

    Site Coordinator, 01 414 3350

    Recruiting

  • St Vincents University Hospital /ID# 261237

    Elm Park, Dublin, D04 T6F4

    Recruiting

  • University Hospital Kerry /ID# 266733

    Tralee, Kerry, V92 NX94

    Recruiting

Other trials in Ireland

Israel6 sites, 6 recruiting

  • The Lady Davis Carmel Medical Center /ID# 273312

    Haifa, 34362

    Recruiting

  • Hadassah Medical Center-Hebrew University /ID# 273314

    Jerusalem, 91120

    Recruiting

  • Meir Medical Center /ID# 273315

    Kfar Saba, Central District, 4428164

    Recruiting

  • Galilee Medical Center /ID# 275431

    Nahariya, 2210001

    Recruiting

  • The Chaim Sheba Medical Center /ID# 273313

    Ramat Gan, Tel Aviv, 5265601

    Recruiting

  • Tel Aviv Sourasky Medical Center /ID# 273311

    Tel Aviv, Tel Aviv, 6423906

    Recruiting

Other trials in Israel

Austria4 sites, 4 recruiting

  • Medizinische Universitaet Graz /ID# 273765

    Graz, Styria, 8010

    Recruiting

  • Krankenhaus Der Barmherzigen Brueder Graz /ID# 273764

    Graz, Styria, 8020

    Recruiting

  • Landesklinikum Stockerau /ID# 275618

    Stockerau, Lower Austria, 2000

    Recruiting

  • Rheuma-Zentrum Wien-Oberlaa GmbH /ID# 275617

    Vienna, State of Vienna, 1100

    Recruiting

Other trials in Austria

Argentina3 sites, 3 recruiting

  • Cer Instituto Médico /ID# 274445

    Quilmes, Buenos Aires, 1878

    Recruiting

  • Instituto Médico Río Cuarto /ID# 274421

    Río Cuarto, Córdoba Province, 5800

    Recruiting

  • Instituto Medico de Alta Complejidad San Isidro S.A. /ID# 274417

    San Isidro, Buenos Aires, 1642

    Recruiting

Other trials in Argentina

Taiwan3 sites, 3 recruiting

  • Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare /ID# 274352

    New Taipei City, 235

    Recruiting

  • Taichung Veterans General Hospital /ID# 274896

    Taichung, 407

    Recruiting

  • National Taiwan University Hospital /ID# 280714

    Taipei, 100

    Recruiting

Other trials in Taiwan

Czechia2 sites, 2 recruiting

  • MAPO revma /ID# 272409

    Ostrava, Ostrava-mesto, 710 00

    Recruiting

  • Fakultni Nemocnice Plzen /ID# 276061

    Pilsen, Praha 17, 301 00

    Recruiting

Other trials in Czechia

Poland2 sites, 2 recruiting

  • Indywidualna Specjalistyczna Praktyka Lekarska dr hab.n.med.Katarzyna Pawlak-Buś /ID# 276483

    Poznan, Greater Poland Voivodeship, 61-324

    Site Coordinator, +48 601 446 031

    Recruiting

  • SOMED Renata Sokolik /ID# 276480

    Wroclaw, Lower Silesian Voivodeship, 52-317

    Recruiting

Other trials in Poland

Saudi Arabia2 sites, 2 recruiting

  • Imam Abdulrahman Bin Faisal University /ID# 277716

    Dammam, Eastern Province, 34212

    Recruiting

  • King Saud University /ID# 279463

    Riyadh, Riyadh Region, 12372

    Recruiting

Other trials in Saudi Arabia

About this study

Official title: Prospective Multi-country, Real-world, Multi-arm Study of Treatment PErsistence With RISankizumab in Psoriatic Arthritis (PERIS)

Psoriatic arthritis (PsA) is a type of arthritis (swelling and stiffness in the joints) that is frequently seen in trial participants who also have the skin condition psoriasis. It is caused by an overactive immune system where the body attacks healthy tissue by mistake. This study aims to describe the long term usage and effectiveness with risankizumab (RZB) relative to other advanced therapeutic options for the management of PsA in daily clinical practice.

Risankizumab is an approved drug for the treatment of psoriatic arthritis. The study will not be conducted in the United States, however it will be conducted in approximately 15 countries and include at least 900 and up to 1200 participants with a 2 to1 ratio of participant allocation between participants receiving risankizumab and participants receiving other advanced therapeutic agents.

Read more

The therapy is prescribed in the usual manner in accordance with the terms of the local marketing authorization and professional and reimbursement guidelines with regards to dose, population, and indication. All study visits will occur during routine clinical practice and participants will be followed for 24 months.

There is expected to be no additional burden for participants in this study.

Keywords
Risankizumab, Skyrizi
Medical subject headings
Arthritis, Psoriatic

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT06764693
Study groupRoleWhat they receive
Biologic Disease-Modifying Antirheumatic Drugs (bDMARD)Participants will receive bDMARDs as prescribed by their physician according to local label.
RisankizumabParticipants will receive risankizumab as prescribed by their physician according to local label.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Number of participants that show persistence in treatment until 24 months

    Persistence over 24 months, defined as a participant who starts PsA treatment and is still on the same therapy until 24 months.

    Measured: 24 Months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 Jan 2025
  2. Study start31 Jan 2025
  3. Primary completionJan 2029 (estimated)
  4. Study completionFeb 2029 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
1,200 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06764693
Sponsor's protocol ID
P24-390
Acronym
PERIS
Status last verified
Feb 2026
First submitted
2 Jan 2025
Last updated
17 Feb 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Questions about this trial

What is this clinical trial studying?

An observational study of Psoriatic Arthritis, run by AbbVie at 132 sites in 15 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 17 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 132 sites in France, Germany, Greece, Italy, Spain and 10 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Shari Chapman (844-663-3742, shari.chapman@abbvie.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Number of participants that show persistence in treatment until 24 months (time frame: 24 Months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06764693.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Feb 2026.

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