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Pancreatic CancerPhase 2NCT06766019

Adebrelimab Combined With Irinotecan Liposomal (II), Oxaliplatin, and 5-FU/LV Conversion Therapy for Locally Advanced Pancreatic Cancer

A Phase 2 study testing Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LV in people with Pancreatic Cancer, run by The First Affiliated Hospital with Nanjing Medical University at 1 site in China.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
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Trial summary

This trial is a prospective, single-arm, single-center, phase II clinical study, mainly targeting subjects with locally advanced pancreatic cancer, to explore the efficacy and safety of adebrelimab combined with irinotecan liposome (II), oxaliplatin, and 5-FU/LV conversion in the treatment of locally advanced… Read more about this study

Who is it for?
Ages 18 to 70 years
Conditions the study is for
Pancreatic Cancer
What is being tested?
Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LV
Type of treatment
Injection or infusion
Could I receive a placebo?
No, everyone receives an active treatment
How many people
47 participants
Where
1 siteChina
Study dates
16 Oct 2024to 30 Sep 2027
Phase
Phase 2
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 70 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • -
  • Patients must meet all of the following inclusion criteria to be enrolled in this trial:
  • Sign written informed consent before implementing any trial-related procedures;
  • Age ≥ 18 years old and ≤ 70 years old, regardless of gender;
  • Locally advanced pancreatic cancer confirmed by histopathological/cytopathological examination;
  • Patients with locally advanced stage and no previous anti-tumor treatment (radiotherapy, chemotherapy, targeted or immunotherapy, etc.);
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  • Definition of locally advanced pancreatic cancer:
  • The tumor has no distant metastasis;
  • Pancreatic head/uncinate process: the tumor contacts the superior mesenteric artery > 180 ˚;
  • Body and tail of pancreas: the tumor contacts the superior mesenteric artery or trunk celiac artery > 180 ˚; The tumor contacted the celiac trunk artery and infiltrated the abdominal aorta;
  • The tumor invaded the jejunal branch of the superior mesenteric artery. The portal vein-superior mesenteric vein cannot be safely reconstructed due to tumor invasion, venous occlusion or involvement of a large area of the jejunal branch of the superior mesenteric vein;
  • According to the efficacy evaluation criteria of solid tumors (RECIST version 1.1) with at least one radiographically measurable lesion;
  • ECOG score 0-1;
  • If the biliary obstruction needs to be lifted, the expected survival time is > 3 months;
  • Sufficient organ function, subjects must meet the following laboratory indicators:
  • Absolute neutrophil value (ANC) ≥ 1.5 × 109/L in the absence of granulocyte colony-stimulating factor in the past 14 days;
  • platelets ≥ 100 × 109/L in the absence of blood transfusion in the past 14 days;
  • hemoglobin > 9 g/dL in the absence of blood transfusion or use of erythropoietin in the past 14 days;
  • total bilirubin ≤ 1.5 × upper limit of normal (ULN);
  • aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are ≤ 2.5 × ULN;
  • blood creatinine ≤ 1.5 × ULN and creatinine clearance (calculated using the Cockcroft-Gault formula) ≥ 60 mL/min;
  • Good coagulation function, defined as International Normalized Ratio (INR) or Prothrombin Time (PT) ≤ 1.5 times the ULN;
  • euthyroidism, defined as thyroid stimulating hormone (TSH) within the normal range. If the baseline TSH is outside the normal range, subjects with total T3 (or FT3) and FT4 within the normal range can also be enrolled;
  • For female subjects of childbearing age, a negative urine or serum pregnancy test should be performed within 3 days prior to the first dose of study drug (Cycle 1, Day 1). If the urine pregnancy test result cannot be confirmed as negative, a blood pregnancy test is ordered. Women of non-childbearing age are defined as at least 1 year after menopause, or have undergone surgical sterilization or hysterectomy;
  • If there is a risk of conception, all subjects (whether male or female) are required to use contraception with an annual failure rate of less than 1% throughout the entire treatment period until 120 days after the last dose of study drug (or 180 days after the last dose of chemotherapy drug).

Who cannot join

  • -
  • Subjects who meet any of the following criteria will not be allowed to enter the study:
  • Patients with portal hypertension or cavernous degeneration of portal vein; Patients with gastrointestinal bleeding caused by tumors that have involved the gastrointestinal tract; Patients with tumor involvement of digestive tract causing intra-abdominal fistula or abscess; The tumor surrounds the celiac trunk or superior mesenteric artery (SMA) and causes significant involvement of the vascular wall (worm-like changes); Presence of distant metastatic lesions;
  • There is a third space effusion that cannot be controlled by drainage or other methods (such as medium-massive pleural effusion, medium-massive pericardial effusion, ascites); A small amount of pleural effusion or ascites that has no clinical symptoms and does not require clinical intervention should be strictly controlled before enrollment;
  • Those with poor compliance and inability to cooperate and describe treatment responses;
  • Other malignant diseases other than pancreatic cancer diagnosed within 5 years before the first dose (excluding radical basal cell carcinoma of the skin, squamous cell carcinoma of the skin, and/or radical resection of carcinoma in situ);
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  • Currently participating in interventional clinical study treatment, or received other study drugs or treatment with study devices within 4 weeks prior to the first dose;
  • Have previously received the following therapies: anti-PD-1, anti-PD-L1, or anti-PD-L2 drugs or drugs directed at another stimulation or synergistic inhibition of T cell receptors (e.g., CTLA-4, OX-40, CD137);
  • Have received systemic systemic treatment with ready-for-use traditional Chinese medicine or immunomodulatory drugs with anti-tumor indications (including thymosin, interferon, interleukin, except for local use to control ascites) within 2 weeks before the first dose;
  • Active autoimmune disease requiring systemic therapy (e.g., use of disease-modifying drugs, glucocorticoids, or immunosuppressants) within 2 years prior to the first dose. Replacement therapy (e.g. thyroxine, insulin, or physiological glucocorticoids for adrenal or pituitary insufficiency, etc.) is not considered systemic therapy;
  • Were receiving systemic glucocorticoid therapy (excluding nasal spray, inhalation, or other routes of topical glucocorticoids) or any other form of immunosuppressive therapy within 7 days prior to the first dose of the study; Note: Physiological doses of glucocorticoids (≤ 10 mg/d of prednisone or equivalent) are allowed;
  • Known allogeneic organ transplantation (except corneal transplantation) or allogeneic hematopoietic stem cell transplantation;
  • Those who are known to be allergic to the active ingredients or excipients of the study drug adebelimab, leucovorin, 5-fluorouracil, irinotecan and oxaliplatin;
  • have not sufficiently recovered from any intervention-induced toxicities and/or complications prior to initiation of treatment (toxicities that have not been resolved by prior antineoplastic therapy, defined as not resolved to the level specified in the National Cancer Institute Common Terminology Criteria for Adverse Events ((NCI CTCAE v5.0) Grade 0 or 1, or inclusion/exclusion criteria, Except for hair loss/pigmentation. For subjects with irreversible toxicity that is not expected to worsen after study drug administration (e.g. hearing loss), enrollment will be determined at the discretion of the investigator);
  • People who are addicted to bad drugs such as drug abuse, long-term alcoholics, and people with infectious diseases such as AIDS (i.e. HIV 1/2 antibody positive);
  • Uncontrolled active hepatitis B (defined as HBsAg positive and detected HBV-DNA copy number greater than the upper limit of normal value in the laboratory of the study center);
  • Note: Subjects with hepatitis B who meet the following criteria can also be enrolled:
  • HBV viral load < 1000 copies/mL (200 IU/mL) prior to the first dose, subjects should receive anti-HBV therapy to avoid viral reactivation throughout the study drug treatment period;
  • For subjects with anti-HBc (+), HBsAg (-), anti-HBs (-), and HBV viral load (-), prophylactic anti-HBV therapy is not required, but close monitoring for viral reactivation is required; (15) Active HCV-infected subjects (HCV antibody positive and HCV-RNA levels above the lower detection limit); (16) Live vaccination within 30 days prior to the first dose (Cycle 1, Day 1); Note: Injectable inactivated viral vaccine against seasonal influenza is allowed up to 30 days prior to the first dose; However, it is not allowed to receive live attenuated influenza vaccine administered intranasally.
  • pregnant or breastfeeding women; (18) Presence of any serious or uncontrollable systemic disease, such as:
  • The resting electrocardiogram has major abnormalities in rhythm, conduction or morphology with severe symptoms that are difficult to control, such as complete left bundle branch block, heart block above degree II, ventricular arrhythmia or atrial fibrillation;
  • Unstable angina pectoris, congestive heart failure, and chronic heart failure with New York Heart Association (NYHA) grade ≥ 2;
  • Any arterial thrombosis, embolism or ischemia, such as myocardial infarction, unstable angina pectoris, cerebrovascular accident or transient ischemic attack, has occurred within 6 months before enrollment for treatment;
  • Unsatisfactory blood pressure control (systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg);
  • History of non-infectious pneumonia requiring glucocorticoid therapy within 1 year prior to the first dose, or current clinically active interstitial lung disease;
  • active pulmonary tuberculosis;
  • the presence of an active or uncontrolled infection requiring systemic treatment;
  • Clinically active diverticulitis, abdominal abscess, and gastrointestinal obstruction;
  • liver diseases such as cirrhosis, decompensated liver disease, acute or chronic active hepatitis;
  • Urine routine suggests urine protein ≥ + +, and 24-hour urine protein quantification > 1.0 g is confirmed;
  • Those who have mental disorders and are unable to cooperate with treatment;
  • Medical history or disease evidence that may interfere with the results of the trial, prevent the subject from participating in the whole study, abnormal treatment or laboratory test values, or other situations that the investigator believes are not suitable for enrollment. The investigator believes that there are other potential risks that the investigator is not suitable for participating in this study.

Trial locations and contacts

1 site in 1 country.

China1 site

  • The First Affiliated Hospital with Nanjing Medical University

    Nanjing, Jiangsu, 025

Other trials in China

About this study

Official title: Adebrelimab Combined With Irinotecan Liposomal (II), Oxaliplatin, and 5-FU/LV Conversion Therapy for Locally Advanced Pancreatic Cancer: a Prospective, Single-arm, Exploratory Clinical Study

This trial is a prospective, single-arm, single-center, phase II clinical study, mainly targeting subjects with locally advanced pancreatic cancer, to explore the efficacy and safety of adebrelimab combined with irinotecan liposome (II), oxaliplatin, and 5-FU/LV conversion in the treatment of locally advanced pancreatic cancer.

Read the detailed description

Subjects enter the screening period after being fully informed and signing an informed consent form. The screening period for the study is 28 days.

After completing the screening inspection and evaluation, patients will receive adebrelimab once and irinotecan liposomal (II), oxaliplatin, 5-FU/LV twice per cycle (4 weeks), and imaging of tumor lesions will be performed every 2 cycles (8 weeks ± 7 days) to evaluate whether patients can undergo surgery until surgical resection, disease progression, or intolerable toxicity, start of new anticancer drug therapy, withdrawal from the study, death, or loss to follow-up.

After 6 cycles of treatment, patients who are assessed to have no progression but are still unable to undergo radical surgical resection will receive maintenance treatment regimen (using capecitabine or teggio plus adebrelimab), and imaging efficacy will be evaluated every 12 weeks (± 7 days) during maintenance treatment. Surgical resectability will still be evaluated during maintenance treatment until disease progression or intolerable toxicity, start of new anticancer drug treatment, withdrawal from the study, death, or loss to follow-up.

Being tested
Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LV
Keywords
Locally advanced pancreatic cancer
Medical subject headings
Pancreatic Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LVDrug

    1. adebrelimab 1200mg, i.v. D1, q28d
    2. irinotecan liposomal (II) 60mg/m^2, i.v. D1, Q2W
    3. oxaliplatin 85mg/m^2, i.v. D1, Q2W
    4. 5-FU/LV 2400mg/400mg/m^2, i.v. D1, Q2W 4-week cycles, 6 cycles
Study groups in NCT06766019
Study groupRoleWhat they receive
Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LVExperimentalAdebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LV
Receives: Drug: Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LV

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Surgical conversion rate

    Refers to the proportion of subjects with successful conversion to all subjects receiving conversion therapy. Achievement of R0/R1 resection after conversion therapy was defined as successful conversion.

    Measured: Up to 6 months

Secondary outcomes (7)

  1. Overall Survival (OS)

    Time from start of patient treatment to death from any cause

    Measured: 5 years

  2. 1-year OS rate

    Proportion of subjects who have survived 1 year from the date of first treatment after enrollment to all treated subjects

    Measured: 1 year

  3. Objective response rate (ORR)

    Proportion of subjects including complete response (CR) or partial response (PR)

    Measured: Up to 3 years

  4. Event-free survival (EFS)

    The EFS endpoint is a composite time-to-event endpoint, and the "treatment failure" event is defined as the earliest occurrence of the following events: a. Failure to achieve local disease-free status after completion of conversion therapy and/or surgery (i.e., failed resection or disease progression resulting in inoperability); b. Local or distant recurrence; c. Death;

    Measured: Up to 3 years

  5. Disease Control Rate (DCR)

    Proportion of subjects whose best response observed throughout the study was CR, PR, or stable disease (SD)

    Measured: Up to 3 years

  6. Duration of response (DoR)

    From the first tumor response (CR or PR) to disease progression (PD) or death (whichever occurs earlier)

    Measured: Up to 3 years

  7. Time to disease progression (TTP)

    The time from the date of enrollment to the first observation of PD

    Measured: Up to 3 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted9 Jan 2025
  2. Study start16 Oct 2024
  3. Primary completion30 Sep 2027 (estimated)
  4. Study completion30 Sep 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
47 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06766019
Sponsor's protocol ID
PC-IIT-003
Status last verified
Jan 2025
First submitted
5 Jan 2025
Last updated
9 Jan 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LV in people with Pancreatic Cancer, run by The First Affiliated Hospital with Nanjing Medical University at 1 site in China.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 25 inclusion and 32 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 9 Jan 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Surgical conversion rate (time frame: Up to 6 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06766019.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jan 2025.

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