Acute Lymphoblastic LeukemiaNCT06794762
Effects of Core Stabilization Exercises in Children With Acute Lymphoblastic Leukemia
A study testing Conventional exercises and Core stabilization exercises in addition to conventional exercises in people with Acute Lymphoblastic Leukemia, run by Karamanoğlu Mehmetbey University at 1 site in Turkey (Türkiye).
Trial summary
The goal of this clinical trial is to investigate the effects of core stabilization exercises applied in addition to the conventional exercise program on physical function, functional muscle strength, functional exercise capacity, postural control and fatigue in children with acute lymphoblastic leukemia receiving… Read more about this study
- Who is it for?
- Ages 5 to 18 years
- Conditions the study is for
- Acute Lymphoblastic Leukemia
- What is being tested?
- Conventional exercises and Core stabilization exercises in addition to conventional exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 27 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 14 Jan 2025to 15 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 5 to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Children aged 5-18
- Diagnosed with ALL
- In the maintenance phase of chemotherapy
- Children without acute thrombosis, active ischemia, hemodynamic instability
- Children without uncontrolled pain
- Children who can follow verbal instructions.
Who cannot join
- Children who have received or are receiving cranial radiotherapy
- Children with any cardiovascular disease, acute or chronic respiratory disease
- Children with acute or chronic bone, joint, muscle problems
- Children diagnosed with neuromotor deficits or genetic disorders
- Children with vision problems other than refractive errors
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Examination of the Effects of Core Stabilization Exercises on Physical Function, Functional Muscle Strength, Functional Exercise Capacity, Postural Control and Fatigue in Children With Acute Lymphoblastic Leukemia Receiving Maintenance Treatment
The goal of this clinical trial is to investigate the effects of core stabilization exercises applied in addition to the conventional exercise program on physical function, functional muscle strength, functional exercise capacity, postural control and fatigue in children with acute lymphoblastic leukemia receiving maintenance treatment.
Participants will be divided into two groups; the first group will be given a conventional exercise program, while the second group will be given core stabilization exercises in addition to the conventional exercise program.
Read the detailed description
Acute Lymphoblastic Leukemia (ALL) is a malignancy resulting from the abnormal proliferation of lymphoid cells that can invade the bone marrow, blood, and extramedullary regions, and it is the most common malignancy in childhood. Specific chemotherapy-related problems are frequently observed in children with ALL. These include a reduction in cardiopulmonary fitness, balance, posture, proximal muscle strength, and flexibility, as well as postural control issues and functional mobility impairments, in addition to fatigue.
The aim of this study is to investigate the effects of core stabilization exercises, applied in addition to a conventional exercise program, on physical function, functional muscle strength, functional exercise capacity, postural control, and fatigue in children with Acute Lymphoblastic Leukemia undergoing maintenance therapy.
Participants will be divided into two groups: the first group will follow a conventional exercise program, while the second group will receive core stabilization exercises in addition to the conventional program. All participants will be randomly assigned to the groups using the software available at http://www.randomizer.org. The exercise sessions will be conducted three times a week for a total of 8 weeks, with 24 sessions in total. Demographic information will be recorded for participants who agree to take part in the study and meet the inclusion criteria. The scales and tests designed to assess the participants' physical function, functional muscle strength, functional exercise capacity, postural control, and fatigue will be administered both before and after the study.
- Conditions
- Acute Lymphoblastic Leukemia
- Being tested
- Conventional exercises, Core stabilization exercises in addition to conventional exercises
- Keywords
- Acute Lymphoblastic Leukemia, Maintenance Chemotherapy, Rehabilitation, Exercise, Core Stabilization Exercises, Cancer, Physical Function, Functional Muscle Strength, Functional Exercise Capacity, Postural Control, Fatigue
- Medical subject headings
- Precursor Cell Lymphoblastic Leukemia-Lymphoma, Motor Activity, Neoplasms, Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional exercisesOther
Aerobic exercise and stretching exercises will be applied in the conventional exercise program.
A 20-30 minute walking will be done as aerobic exercise. Stretching exercises will be done for major muscle groups in 3 sets and 10 repetitions.
Core stabilization exercises in addition to conventional exercisesOther
In addition to the conventional exercise program, core stabilization exercises will be applied. During the exercises, participants will be trained on neutralizing the spine and working the transverse abdominis and multifidus muscles, correct postural control, and performing the exercises with diaphragmatic breathing.
| Study group | Role | What they receive |
|---|---|---|
| Control group | Experimental | Exercises will be applied to the participants participating in the study 3 days a week, 8 weeks, and 24 sessions in total. Receives: Other: Conventional exercises |
| Intervention group | Experimental | Exercises will be applied to the individuals participating in the study 3 days a week, 8 weeks, and 24 sessions in total. Exercises will be applied after the conventional therapy sessions. Receives: Other: Core stabilization exercises in addition to conventional exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Timed Up and Go Test (TUG)
This test aims to evaluate the physical function.
Measured: Before 8 weeks of treatment
Timed Up and Go Test (TUG)
This test aims to evaluate the physical function.
Measured: After 8 weeks of treatment
Sit-up Test
This test aims to evaluate the functional muscle strength
Measured: Before 8 weeks of treatment
Sit-up Test
This aims to evaluate the functional muscle strength.
Measured: After 8 weeks of treatment
6-Minute Walk Test
This test aims to evaluate the functional exercise capacity.
Measured: Before 8 weeks of treatment
6-Minute Walk Test
This test aims to evaluate the functional exercise capacity.
Measured: After 8 weeks of treatment
Balance Error Scoring System
This test aims to evaluate the postural control.
Measured: Before 8 weeks of treatment
Balance Error Scoring System
This test aims to evaluate the postural control.
Measured: After 8 weeks of treatment
Pediatric Quality of Life Multidimensional Fatigue Scale
This scale aims to evaluate the fatigue in pediatric patients.
Measured: Before 8 weeks of treatment
Pediatric Quality of Life Multidimensional Fatigue Scale
This scale aims to evaluate the fatigue in pediatric patients.
Measured: After 8 weeks of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jan 2025
- Study start14 Jan 2025
- Primary completion15 Mar 2026
- Study completion15 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Lymphoblastic LeukemiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 27 participants (actual)
Sponsor and investigators
- Lead sponsor
- Karamanoğlu Mehmetbey University
- Sponsor type
- University, hospital or other
- Collaborators
- Saglik Bilimleri Universitesi
- Responsible party
- Principal investigator, Melike Müsevitoğlu, Karamanoğlu Mehmetbey University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06794762
- Sponsor's protocol ID
- 2024/023-12
- Status last verified
- Oct 2026
- First submitted
- 13 Jan 2025
- Last updated
- 7 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Examination of the Effects of Core Stabilization Exercises on Physical Function, Functional Muscle Strength, Functional Exercise Capacity, Postural Control and Fatigue in Children With Acute Lymphoblastic Leukemia Receiving Maintenance Treatment
- ClinicalTrials.gov ID
- NCT06794762
- Acronym / sponsor ID
- 2024/023-12
- Conditions
- Acute Lymphoblastic Leukemia
- Keywords
- Acute Lymphoblastic Leukemia, Maintenance Chemotherapy, Rehabilitation, Exercise, Core Stabilization Exercises, Cancer, Physical Function, Functional Muscle Strength
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 27 participants (actual)
- Lead sponsor
- Karamanoğlu Mehmetbey UniversityUniversity, hospital or other
- Collaborators
- Saglik Bilimleri Universitesi
- Study start
- 14 Jan 2025 (actual)
- Primary completion
- 15 Mar 2026 (actual)
- Study completion
- 15 Mar 2026 (actual)
- First posted
- 27 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to investigate the effects of core stabilization exercises applied in addition to the conventional exercise program on physical function, functional muscle strength, functional exercise capacity, postural control and fatigue in children with acute lymphoblastic leukemia receiving maintenance treatment.
Participants will be divided into two groups; the first group will be given a conventional exercise program, while the second group will be given core stabilization exercises in addition to the conventional exercise program.
Detailed description
Acute Lymphoblastic Leukemia (ALL) is a malignancy resulting from the abnormal proliferation of lymphoid cells that can invade the bone marrow, blood, and extramedullary regions, and it is the most common malignancy in childhood. Specific chemotherapy-related problems are frequently observed in children with ALL. These include a reduction in cardiopulmonary fitness, balance, posture, proximal muscle strength, and flexibility, as well as postural control issues and functional mobility impairments, in addition to fatigue.
The aim of this study is to investigate the effects of core stabilization exercises, applied in addition to a conventional exercise program, on physical function, functional muscle strength, functional exercise capacity, postural control, and fatigue in children with Acute Lymphoblastic Leukemia undergoing maintenance therapy.
Participants will be divided into two groups: the first group will follow a conventional exercise program, while the second group will receive core stabilization exercises in addition to the conventional program. All participants will be randomly assigned to the groups using the software available at http://www.randomizer.org. The exercise sessions will be conducted three times a week for a total of 8 weeks, with 24 sessions in total. Demographic information will be recorded for participants who agree to take part in the study and meet the inclusion criteria. The scales and tests designed to assess the participants' physical function, functional muscle strength, functional exercise capacity, postural control, and fatigue will be administered both before and after the study.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control group | Experimental | Other: Conventional exercisesExercises will be applied to the participants participating in the study 3 days a week, 8 weeks, and 24 sessions in total. |
| Intervention group | Experimental | Other: Core stabilization exercises in addition to conventional exercisesExercises will be applied to the individuals participating in the study 3 days a week, 8 weeks, and 24 sessions in total. Exercises will be applied after the conventional therapy sessions. |
Who may qualify
- Ages
- 5 to 18 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (6 listed)
- Children aged 5-18
- Diagnosed with ALL
- In the maintenance phase of chemotherapy
- Children without acute thrombosis, active ischemia, hemodynamic instability
- Children without uncontrolled pain
Key exclusion criteria (5 listed)
- Children who have received or are receiving cranial radiotherapy
- Children with any cardiovascular disease, acute or chronic respiratory disease
- Children with acute or chronic bone, joint, muscle problems
- Children diagnosed with neuromotor deficits or genetic disorders
- Children with vision problems other than refractive errors
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional exercisesAerobic exercise and stretching exercises will be applied in the conventional exercise program. A 20-30 minute walking will be done as aerobic exercise. Stretching exercises will be done for major muscle groups in 3 sets and 10 repetitions. | Other | Control group |
| Core stabilization exercises in addition to conventional exercisesIn addition to the conventional exercise program, core stabilization exercises will be applied. During the exercises, participants will be trained on neutralizing the spine and working the transverse abdominis and multifidus muscles, correct postural control, and performing the exercises with diaphragmatic breathing. | Other | Intervention group |
Primary outcome
Timed Up and Go Test (TUG)
Time frame: Before 8 weeks of treatment
This test aims to evaluate the physical function.
Timed Up and Go Test (TUG)
Time frame: After 8 weeks of treatment
This test aims to evaluate the physical function.
Sit-up Test
Time frame: Before 8 weeks of treatment
This test aims to evaluate the functional muscle strength
Sit-up Test
Time frame: After 8 weeks of treatment
This aims to evaluate the functional muscle strength.
6-Minute Walk Test
Time frame: Before 8 weeks of treatment
This test aims to evaluate the functional exercise capacity.
6-Minute Walk Test
Time frame: After 8 weeks of treatment
This test aims to evaluate the functional exercise capacity.
Balance Error Scoring System
Time frame: Before 8 weeks of treatment
This test aims to evaluate the postural control.
Balance Error Scoring System
Time frame: After 8 weeks of treatment
This test aims to evaluate the postural control.
Pediatric Quality of Life Multidimensional Fatigue Scale
Time frame: Before 8 weeks of treatment
This scale aims to evaluate the fatigue in pediatric patients.
Pediatric Quality of Life Multidimensional Fatigue Scale
Time frame: After 8 weeks of treatment
This scale aims to evaluate the fatigue in pediatric patients.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional exercises and Core stabilization exercises in addition to conventional exercises in people with Acute Lymphoblastic Leukemia, run by Karamanoğlu Mehmetbey University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Timed Up and Go Test (TUG) (time frame: Before 8 weeks of treatment). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Oct 2026.