Smoke InhalationNCT06836414
Lung Cancer Screening CT for Firefighters
A study testing Low-dose Computerized tomography (CT) of Chest, Questionnaires and Medical History in people with Smoke Inhalation and Exposure, Inhalation, run by University of California, San Francisco.
Trial summary
Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational exposures such as firefighting. Read more about this study
- Who is it for?
- Ages 35 years and olderHealthy volunteers can take part
- Conditions the study is for
- Smoke Inhalation, Exposure, Inhalation, Exposure to Pollution
- What is being tested?
- Low-dose Computerized tomography (CT) of Chest, Questionnaires and Medical History
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 0 participants
- Where
- No sites listed yet
- Study dates
- 31 Mar 2026to 31 Dec 2035
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age 35 years or greater. If the participant is above the age of 80, participants must be otherwise healthy and well-fit to undergo treatment if lung cancer were to be discovered.
- Never smoker or quit more than 15 years ago.
- Able to understand study procedures and to comply with them for the entire length of the study.
- Ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it.
- Length in profession for 10 or more years. This includes both volunteer firefighting and professional firefighting, self-attested as verifiable by professional records.
- Additional cases for Aim 2:
- Age 18+, may include deceased firefighters.
- A previous or current history of confirmed thoracic malignancy (except localized skin cancer, cancer in situ, or other localized cancers)
Who cannot join
- Aim 1:
- Contraindication to any study-related procedure or assessment.
- Personal history of malignancy within 5 years (except localized skin cancer, cancer in situ, or localized cancers that are definitively treated and are unlikely to recur) or lung cancer at any time.
- Participants will be assessed for active pregnancy per standard procedure for clinical lung cancer screening CT at University of California, San Francisco which includes asking the participants directly along with documentation of whether the negative pregnancy was self-reported or confirmed with a urine pregnancy test.
- Prior CT chest within 1 year.
- Symptoms highly suggestive of lung cancer, including unexplained weight loss of over 30 pounds (lbs) within the past 12 months or unexplained hemoptysis.
- Aim 2:
- No exclusion criteria
About this study
Official title: Early Cancer Detection in Firefighters With Low-Dose Chest CT: A Community-Based Approach
Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational exposures such as firefighting. This study aims to provide chest computed tomography (CT) scans to firefighters to determine the prevalence of lung cancer, other cancers detectable on CT chest, and lung diseases associated with increased cancer risk.
Read the detailed description
This is a single-group prospective interventional study and a community-based participatory project led by University of California, San Francisco and in close collaboration with the firefighter community in California.
PRIMARY OBJECTIVE:
- Determine the prevalence of lung cancer, other cancers and cancer risk factors detectable on chest Computerized Tomography (CT) (Aim 1).
II. Identify imaging and non-imaging predictors of lung cancer and other cancers detectable on chest CT.
SECONDARY OBJECTIVE:
- Determine the prevalence of incidental findings on chest CT (Aim 1).
II. Determine the risk factors for cancer development in firefighters (Aim 2).
EXPLORATORY OBJECTIVES:
- Long term follow-up to determine the incidence of lung cancer and other cancers among firefighters.
II. Develop a firefighter cancer imaging registry.
OUTLINE:
Participants will be administered a single, low dose chest CT to included participants and collect comprehensive demographic, clinical, and occupational data. Participants will be followed up at 1-2 months, for at least 1 year and up to 10 years to collect any follow-up imaging and biopsy results, if applicable.
- Conditions
- Smoke Inhalation, Exposure, Inhalation, Exposure to Pollution, Exposure Occupational, Lung Diseases, Lung Cancer
- Being tested
- Low-dose Computerized tomography (CT) of Chest, Questionnaires, Medical History
- Keywords
- Population research, Cancer Screening
- Medical subject headings
- Smoke Inhalation Injury, Respiratory Aspiration, Lung Diseases, Lung Neoplasms, Lung Diseases, Interstitial
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Low-dose Computerized tomography (CT) of ChestProcedure or surgery
Also called Chest CT, Chest CT Scan, Low-dose Chest CT
Undergo CT for lung cancer screening
QuestionnairesOther
Participants will complete questionnaires on or before the day of the scan.
Medical HistoryOther
Also called Medical Record Review, Medical Chart Review
Medical history will be obtained in person and via medical record review
| Study group | Role | What they receive |
|---|---|---|
| Firefighters (Lung Screening CT) | Other | Participants will receive a single, low-dose, chest CT without contrast as indicated for lung cancer screening. Participants will be followed up for at least 1 year following the scan and have ongoing medical record reviews. Receives: Procedure: Low-dose Computerized tomography (CT) of Chest; Other: Questionnaires; Other: Medical History |
| Firefighters with Previously Diagnosed Malignancy | Other | Participants with a history of cancer will have a medical record review as part of a case-control cohort. Receives: Other: Medical History |
What is being measured
The primary outcome is the main question the study is designed to answer.
Proportion of participants with detected lung cancers (Aim 1)
The proportion of participants with detected lung cancers will be determined by the frequency of image findings that indicate lung cancer, and an ultimate clinical diagnosis associated with the imaging finding.
Measured: Up to 10 years
Proportion of participants with detected other cancers (Aim 1)
The proportion of participants with detected cancers, other than lung, will be determined by the frequency of image findings that indicate other cancer, and an ultimate clinical diagnosis associated with the imaging finding.
Measured: Up to 10 years
Proportion of participants with occupational lung disease (Aim 1)
Occupational or work-related lung diseases are lung conditions that have been caused or made worse by long-term exposure to certain irritants in the workplace. The proportion of participants with occupational lung disease will be determined by the frequency of image findings that indicate occupationally associated lung disease, and an ultimate clinical diagnosis associated with the imaging finding.
Measured: Up to 10 years
Proportion of participants with diagnosed interstitial lung disease (Aim 1)
Interstitial Lung Disease (ILD) is a group of diseases that irritate, inflame, or scar the lungs and supporting air sacs. The proportion of participants with diagnosed interstitial lung disease will be determined by the frequency of image findings that indicate ILD, and an ultimate clinical diagnosis associated with the imaging finding.
Measured: Up to 10 years
Number of participants within of each Lung-RADS risk group
The Lung CT Screening Reporting and Data System (Lung-RADS) is a measure developed by the American College of Radiologists to standardize the reporting and management of screen-detected pulmonary nodules. Nodules are categorized as 0=Incomplete, 1=Negative, 2=Benign Appearance or Behavior, 3=Probably Benign, or 4A /4B /4X = Suspicious with an additional modifier of S=Other or C=Prior Lung Cancer to be added to the 4 category codes as needed. The frequency of participants within each Lung-RADS risk group as determined by imaging procedures will be reported.
Measured: Up to 10 years
Secondary outcomes (2)
Percentage of participants with incidental clinical findings
The percentage of participants with incidental findings be determined by the frequency of image findings that indicate presence of possible coronary calcium, aortic aneurysm, thyroid nodules, liver pathology and osseous pathology and an ultimate clinical diagnosis associated with the imaging finding.
Measured: Up to 10 years
Number of risk factors identified as associated with cancer development
The number of not-yet identified risk factors that are determined to be significantly associated with the development of thoracic cancers will be determined using logistic regression methods.
Measured: Up to 10 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Feb 2025
- Study start31 Mar 2026 (estimated)
- Primary completion31 Dec 2035 (estimated)
- Study completion31 Dec 2035 (estimated)
Why it stopped: Funding
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Smoke InhalationStudies of the same condition, open and under way.
- More trials run by University of California, San FranciscoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of California, San Francisco
- Sponsor type
- University, hospital or other
- Collaborators
- Hayward Firefighters Local 1909 of the International Association of Firefighters
- Responsible party
- Sponsor
- Investigators
- Jae Ho Sohn, MD, MS, Principal investigator, University of California, San Francisco
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06836414
- Sponsor's protocol ID
- 24053
- Other IDs
- NCI-2025-00336
- Status last verified
- Mar 2026
- First submitted
- 14 Feb 2025
- Last updated
- 13 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Early Cancer Detection in Firefighters With Low-Dose Chest CT: A Community-Based Approach
- ClinicalTrials.gov ID
- NCT06836414
- Acronym / sponsor ID
- 24053
- Conditions
- Smoke Inhalation, Exposure, Inhalation, Exposure to Pollution, Exposure Occupational, Lung Diseases, Lung Cancer
- Keywords
- Population research, Cancer Screening
- Study type
- Interventional
- Recruitment status
- WithdrawnReason stopped: Funding
- Enrolment
- 0 participants (actual)
- Lead sponsor
- University of California, San FranciscoUniversity, hospital or other
- Collaborators
- Hayward Firefighters Local 1909 of the International Association of Firefighters
- Study start
- 31 Mar 2026 (estimated)
- Primary completion
- 31 Dec 2035 (estimated)
- Study completion
- 31 Dec 2035 (estimated)
- First posted
- 20 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational exposures such as firefighting. This study aims to provide chest computed tomography (CT) scans to firefighters to determine the prevalence of lung cancer, other cancers detectable on CT chest, and lung diseases associated with increased cancer risk.
Detailed description
This is a single-group prospective interventional study and a community-based participatory project led by University of California, San Francisco and in close collaboration with the firefighter community in California.
PRIMARY OBJECTIVE:
- Determine the prevalence of lung cancer, other cancers and cancer risk factors detectable on chest Computerized Tomography (CT) (Aim 1).
II. Identify imaging and non-imaging predictors of lung cancer and other cancers detectable on chest CT.
SECONDARY OBJECTIVE:
- Determine the prevalence of incidental findings on chest CT (Aim 1).
II. Determine the risk factors for cancer development in firefighters (Aim 2).
EXPLORATORY OBJECTIVES:
- Long term follow-up to determine the incidence of lung cancer and other cancers among firefighters.
II. Develop a firefighter cancer imaging registry.
OUTLINE:
Participants will be administered a single, low dose chest CT to included participants and collect comprehensive demographic, clinical, and occupational data. Participants will be followed up at 1-2 months, for at least 1 year and up to 10 years to collect any follow-up imaging and biopsy results, if applicable.
Study design
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Firefighters (Lung Screening CT) | Other | Procedure: Low-dose Computerized tomography (CT) of Chest, Other: Questionnaires, Other: Medical HistoryParticipants will receive a single, low-dose, chest CT without contrast as indicated for lung cancer screening. Participants will be followed up for at least 1 year following the scan and have ongoing medical record reviews. |
| Firefighters with Previously Diagnosed Malignancy | Other | Other: Medical HistoryParticipants with a history of cancer will have a medical record review as part of a case-control cohort. |
Who may qualify
- Ages
- 35 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Age 35 years or greater. If the participant is above the age of 80, participants must be otherwise healthy and well-fit to undergo treatment if lung cancer were to be discovered.
- Never smoker or quit more than 15 years ago.
- Able to understand study procedures and to comply with them for the entire length of the study.
- Ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it.
- Length in profession for 10 or more years. This includes both volunteer firefighting and professional firefighting, self-attested as verifiable by professional records.
Key exclusion criteria (8 listed)
- Aim 1:
- Aim 2:
- No exclusion criteria
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Low-dose Computerized tomography (CT) of ChestAlso: Chest CT, Chest CT Scan, Low-dose Chest CTUndergo CT for lung cancer screening | Procedure or surgery | Firefighters (Lung Screening CT) |
| QuestionnairesParticipants will complete questionnaires on or before the day of the scan. | Other | Firefighters (Lung Screening CT) |
| Medical HistoryAlso: Medical Record Review, Medical Chart ReviewMedical history will be obtained in person and via medical record review | Other | Firefighters (Lung Screening CT), Firefighters with Previously Diagnosed Malignancy |
Primary outcome
Proportion of participants with detected lung cancers (Aim 1)
Time frame: Up to 10 years
The proportion of participants with detected lung cancers will be determined by the frequency of image findings that indicate lung cancer, and an ultimate clinical diagnosis associated with the imaging finding.
Proportion of participants with detected other cancers (Aim 1)
Time frame: Up to 10 years
The proportion of participants with detected cancers, other than lung, will be determined by the frequency of image findings that indicate other cancer, and an ultimate clinical diagnosis associated with the imaging finding.
Proportion of participants with occupational lung disease (Aim 1)
Time frame: Up to 10 years
Occupational or work-related lung diseases are lung conditions that have been caused or made worse by long-term exposure to certain irritants in the workplace. The proportion of participants with occupational lung disease will be determined by the frequency of image findings that indicate occupationally associated lung disease, and an ultimate clinical diagnosis associated with the imaging finding.
Proportion of participants with diagnosed interstitial lung disease (Aim 1)
Time frame: Up to 10 years
Interstitial Lung Disease (ILD) is a group of diseases that irritate, inflame, or scar the lungs and supporting air sacs. The proportion of participants with diagnosed interstitial lung disease will be determined by the frequency of image findings that indicate ILD, and an ultimate clinical diagnosis associated with the imaging finding.
Number of participants within of each Lung-RADS risk group
Time frame: Up to 10 years
The Lung CT Screening Reporting and Data System (Lung-RADS) is a measure developed by the American College of Radiologists to standardize the reporting and management of screen-detected pulmonary nodules. Nodules are categorized as 0=Incomplete, 1=Negative, 2=Benign Appearance or Behavior, 3=Probably Benign, or 4A /4B /4X = Suspicious with an additional modifier of S=Other or C=Prior Lung Cancer to be added to the 4 category codes as needed. The frequency of participants within each Lung-RADS risk group as determined by imaging procedures will be reported.
2 secondary outcomes
Percentage of participants with incidental clinical findings
Time frame: Up to 10 years
Number of risk factors identified as associated with cancer development
Time frame: Up to 10 years
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jae Ho Sohn, MD, MS principal investigator
University of California, San Francisco
Questions about this trial
What is this clinical trial studying?
A study testing Low-dose Computerized tomography (CT) of Chest, Questionnaires and Medical History in people with Smoke Inhalation and Exposure, Inhalation, run by University of California, San Francisco.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Proportion of participants with detected lung cancers (Aim 1) (time frame: Up to 10 years). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.