Clinical trials: Exposure, Inhalation
Inflammation, Sleep Deprivation
Circadian Rhythm Disruption Effects on Smoke Inhalation
Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians.
- Conditions
- Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation
- Trial name
- NCT04955431
- Testing
- Sleep Restriction, Normal Sleep
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Montana
Birch Pollen Allergy, Healthy Control Subjects
Effect of the Nasal Provocation on the Breathing Style
The purpose of this study is to find out how the provocation of the nose changes breathing style (specifically, frequency and tidal volume changes)
- Trial name
- NCT02146300
- Testing
- 1. session birch pollen nasal exposure 2. session xylometazoline nasal exposure
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Healthy, Blood Pressure
The Effectiveness of the Wim Hof Method
The Wim Hof Method is a multi-disciplinary approach to physical and mental well-being combining cold exposure, breathing exercises, and meditation.
- Conditions
- Healthy, Blood Pressure, Cold Exposure, Stress
- Trial name
- NCT05894031
- Testing
- Wim Hof Method
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Bern
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 2 of 7)
NOTE: This is the second of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02882529
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Inhalational Anthrax
A Field Study Evaluating Clinical Benefit and Safety of AIGIV (ANTHRASIL®) in Inhalational Anthrax Patients
This study will evaluate safety and clinical benefit of AIGIV used for treatment of patients with inhalational anthrax. This study will be implemented only in the event of a major anthrax exposure event.
- Trial name
- NCT03569553
- Testing
- AIGIV
- Volunteers
- 100 people
- Sponsor
- Emergent BioSolutions
Lung Disease
Ozone Exposure and Dose Delivered to Human Lungs
Ozone is an air pollutant formed in at ground level by the chemical reaction between oxygen and automobile emissions in the presence of sunlight.
- Trial name
- NCT00013780
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Tobacco Smoking, Eustachian Tube Dysfunction
Buteyko Breathing and Approach of Smoking Hygiene: Effects on Dysfucntion of Eustachian Tube and Lung Functions
adolescents are usually exposed to tobacco smoke passively. this can reduce their lung functions and negatively impact functions of Eustachian tube.
- Trial name
- NCT07236580
- Testing
- Buteyko breathing plus smoking hyeigne approach, smoking hygiene appraoch
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Acrophobia
Single Session Virtual Reality Therapy in Acrophobia - and the Role of Respiration
In recent years, in the treatment of phobias, exposure therapy in virtual reality is becoming more and more popular as an alternative for in-vivo exposure.
- Trial name
- NCT03893214
- Testing
- virtual reality exposure for acrophobia, movie
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Type 1 Diabetes Mellitus
Comparison of Technosphere Insulin Inhalation Powder & Subcutaneous Rapid-Acting Analog in Subjects With Type 1 Diabetes
This is an Open-label, randomized study in Type 1 diabetics looking at exposure and response (PK/PD) of TI using GEN2C Inhaler versus rapid acting analog.
- Trial name
- NCT01544881
- Testing
- Technosphere Insulin Inhalation Powder, Rapid Acting Analog
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Mannkind Corporation
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 3 of 7)
NOTE: This is the third of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02882542
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Bern
Second Hand Smoke Exposure
The Protective Role of the Nose During Acute Exposure to Passive Smoking.
The aim of this study was to compare the acute effects of second hand smoke exposure between nasal and oral breathing and to assess the potential protective role of the nose during acute exposure, in exposure conditions similar…
- Trial name
- NCT01988467
- Testing
- exposure to second hand smoking
- Where
- Greece
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hellenic Anticancer Society
Asthma Childhood, Asthma
Advancing Diagnosis and Treatment of Pediatric Asthma
Asthma is one of the most common chronic diseases in children, and treatment success often depends on proper inhaler use and consistent medication adherence.
- Conditions
- Asthma Childhood, Asthma, Inhalation Spacers
- Trial name
- Care4Asthma (NCT07500246)
- Testing
- Whizz spacer system, AeroChamber Plus® Flow-Vu®
- Where
- Luxembourg
- Volunteers
- 208 people
- Sponsor
- Luxembourg Institute of Health
Breast Cancer, Radiotherapy
BRAVE-HEART: Breast Cancer Radiotherapy Using Active Breathing Coordinator to aVoid Exposure of HEART
The BRAVE-HEART trial is an ambispective, observational, non-randomized study conducted at Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Policlinico San Matteo (Pavia, Italy).
- Trial name
- BRAVE-HEART (NCT07299812)
- Testing
- Breast Radiotherapy with or without Deep Inspiration Breath Hold (DIBH)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Psoriasis, Stress
Non-pharmacological Mitigation of Psoriasis
In the past few years, research has provided evidence for a possibility of dampening immune system by one's will after undergoing a specific training program.
- Conditions
- Psoriasis, Stress, Inflammation, Depression
- Trial name
- NCT04745429
- Testing
- breathing exercises, cold exposure and meditation
- Where
- Poland
- Volunteers
- 38 people
- Sponsor
- Medical University of Lodz
Pollution; Exposure, Acute Coronary Syndrome
Impact of Air Pollution and Climate Changes on the Epidemiology of Cardiovascular Disease
Despite the fact that the topic of air pollution has been in focus of researchers for many years, there are no big studies that take up the matter of its influence on acute coronary, cerebral syndromes and CVD mortality in…
- Conditions
- Pollution; Exposure, Acute Coronary Syndrome, Chronic Coronary Insufficiency, Particulate Matter Inhalation Injury
- Trial name
- PL-PARTICLES (NCT04541498)
- Testing
- Impact of air pollution and climate changes
- Where
- Poland
- Volunteers
- 150,000 people
- Sponsor
- Medical University of Bialystok
Influenza, Human
Safety of Inhaled Zanamivir in Pregnancy
Zanamivir is a neuraminidase inhibitor that has demonstrated effectiveness against the pandemic H1N1 virus. Zanamivir was first authorized in Sweden in June 1999 and is approved in the European Union (EU) through mutual…
- Trial name
- NCT01462487
- Testing
- Treatment with zanamivir
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Exposure to Pollution, Inhalation of Ozone
Epigenetic Effects of Diesel Exhaust and Ozone Exposure
Purpose: The purpose of this protocol is to compare the genetic and epigenetic effects between diesel exhaust and ozone exposure in healthy individuals and in mild/moderate asthmatics.
- Trial name
- Lamarck (NCT01492517)
- Testing
- Ozone exposure, Diesel exhaust, Ozone18
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Pulmonary Disease, Chronic Obstructive
Study of Safety and Drug Levels of CCI15106 Inhalation Powder in Healthy Adults and Adults With Moderate Chronic Obstructive Pulmonary Disease. Study of CCI15106 Levels in People Standing Near the Person Inhaling the Drug
This single and repeat increasing dose study will collect information on safety, tolerability and drug levels in the body of the CCI15106 inhalation powder.
- Trial name
- NCT03235726
- Testing
- CCI15106
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiovascular Diseases
Novel Strategies for Reducing Heart Disease Risk Disparities
This Western Pennsylvania-based study will (1) improve cardiovascular risk stratification to identify high-risk populations, (2) identify differences in cardiovascular risk, (3) evaluate mechanisms for population differences in…
- Trial name
- HeartSCORE (NCT00143923)
- Testing
- Nutrition, Exercise, Stress Management Counseling, usual care
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy
Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Using the Gen2C Inhaler
This is an open-Label, Randomized Study in Healthy Normal Volunteers looking at exposure and effects (PK/PD) of multiple doses of Technosphere® Insulin (TI) using the Gen2C inhaler.
- Trial name
- NCT01490762
- Testing
- Technosphere Insulin Inhalation Powder using the Gen2C inhaler, Regular Human Insulin
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mannkind Corporation