Cardiac ArrestNCT06836908
CCSV - Post Market Clinical Follow-up Study
An observational study of Cardiac Arrest, run by Medical University of Vienna at 1 site in Austria.
Trial summary
The main goal of this observational study is the evaluation of Chest Compression Synchronized Ventilation (CCSV) regarding oxygenation in terms of PaO2 assessed by routine blood gas analysis, hemodynamic effects, 30-day outcome and safety in comparison to Intermittent Positive Pressure Ventilation (IPPV) as data in… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest
- How many people
- 50 participants
- Where
- 1 siteAustria
- Study dates
- 1 Jun 2024to 31 Mar 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult out-of-hospital cardiac arrest patients in Vienna
Who may be able to join
- OHCA
- Correct endotracheal intubation (seen by capnography)
- The patient is being treated by the Vienna Emergency Medical Services within the scope of emergency ventilation.
- MEDUMAT Standard from Weinmann Emergency is used.
- Mechanical ventilation is performed according to the specified indications.
Who cannot join
- Patients eligible for eCPR (as defined by the standard operating procedure of the Emergency Medical Service Vienna)
- Patients recovering (reaching sustained ROSC) before starting mechanical ventilation or in the first three minutes of it
- Any other mechanical ventilation during the ongoing CPR before study inclusion
- Traumatic cardiac arrest
- Suspected or known pregnancy
- Clinically suspected (tension-)pneumothorax
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Chest Compression Synchronized Ventilation (CCSV) - An Exploratory Post Market Clinical Follow-up Study
The main goal of this observational study is the evaluation of Chest Compression Synchronized Ventilation (CCSV) regarding oxygenation in terms of PaO2 assessed by routine blood gas analysis, hemodynamic effects, 30-day outcome and safety in comparison to Intermittent Positive Pressure Ventilation (IPPV) as data in humans is sparse especially in direct comparison to other ventilation modes.
Cardiac arrest patients in Vienna, Austria will be preclinically randomized (IPPV and CCSV) and ventilated accordingly during CPR. Differences in oxygenation, decarboxylation, systemic perfusion and cerebral oxygenation, the patient's 30-day outcome as well as ventilator-associated adverse events (e.g., pneumothorax) will be recorded and analyzed.
- Conditions
- Cardiac Arrest
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| IPPV | Cardiac arrest patients ventilated with IPPV | |
| CCSV | Cardiac arrest patients ventilated with CCSV |
What is being measured
The primary outcome is the main question the study is designed to answer.
Oxygenation
Difference in PaO2 between IPPV and CCSV group
Measured: 24 months
Secondary outcomes (4)
Decarboxylation
Difference in PaCO2 between IPPV and CCSV group
Measured: 24 months
systemic perfusion
differences between IPPV and CCSV in cerebral oxygenation measured by near-infrared spectroscopy (NIRS)
Measured: 24 months
patient outcome
sustained return of spontaneous circulation (ROSC)
Measured: 27 months
ventilator-associated adverse events
Pneumothorax (until hospital admission)
Measured: 27 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Feb 2025
- Study start1 Jun 2024
- Primary completion28 Feb 2026
- Study completion31 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac ArrestStudies of the same condition, open and under way.
- More trials run by Medical University of ViennaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Medical University of Vienna
- Sponsor type
- University, hospital or other
- Collaborators
- WEINMANN Emergency, Medical Technology GmbH & Co. KG, Berufsrettung Wien
- Responsible party
- Principal investigator, Sebastian Schnaubelt, MD, Medical University of Vienna
- Investigators
- Sebastian Schnaubelt, MD, PhD, Principal investigator, Department of Emergency Medicine, Medical University of Vienna
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06836908
- Sponsor's protocol ID
- CCSV 1
- Status last verified
- Jul 2026
- First submitted
- 28 May 2024
- Last updated
- 20 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Chest Compression Synchronized Ventilation (CCSV) - An Exploratory Post Market Clinical Follow-up Study
- ClinicalTrials.gov ID
- NCT06836908
- Acronym / sponsor ID
- CCSV 1
- Conditions
- Cardiac Arrest
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Medical University of ViennaUniversity, hospital or other
- Collaborators
- WEINMANN Emergency, Medical Technology GmbH & Co. KG, Berufsrettung Wien
- Study start
- 1 Jun 2024 (actual)
- Primary completion
- 28 Feb 2026 (actual)
- Study completion
- 31 Mar 2026 (actual)
- First posted
- 20 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The main goal of this observational study is the evaluation of Chest Compression Synchronized Ventilation (CCSV) regarding oxygenation in terms of PaO2 assessed by routine blood gas analysis, hemodynamic effects, 30-day outcome and safety in comparison to Intermittent Positive Pressure Ventilation (IPPV) as data in humans is sparse especially in direct comparison to other ventilation modes.
Cardiac arrest patients in Vienna, Austria will be preclinically randomized (IPPV and CCSV) and ventilated accordingly during CPR. Differences in oxygenation, decarboxylation, systemic perfusion and cerebral oxygenation, the patient's 30-day outcome as well as ventilator-associated adverse events (e.g., pneumothorax) will be recorded and analyzed.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| IPPV | – | –Cardiac arrest patients ventilated with IPPV |
| CCSV | – | –Cardiac arrest patients ventilated with CCSV |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult out-of-hospital cardiac arrest patients in Vienna
Key inclusion criteria (5 listed)
- OHCA
- Correct endotracheal intubation (seen by capnography)
- The patient is being treated by the Vienna Emergency Medical Services within the scope of emergency ventilation.
- MEDUMAT Standard from Weinmann Emergency is used.
- Mechanical ventilation is performed according to the specified indications.
Key exclusion criteria (6 listed)
- Patients eligible for eCPR (as defined by the standard operating procedure of the Emergency Medical Service Vienna)
- Patients recovering (reaching sustained ROSC) before starting mechanical ventilation or in the first three minutes of it
- Any other mechanical ventilation during the ongoing CPR before study inclusion
- Traumatic cardiac arrest
- Suspected or known pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Oxygenation
Time frame: 24 months
Difference in PaO2 between IPPV and CCSV group
4 secondary outcomes
Decarboxylation
Time frame: 24 months
systemic perfusion
Time frame: 24 months
patient outcome
Time frame: 27 months
ventilator-associated adverse events
Time frame: 27 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jul 2026.
- CCSV WhitepaperLink provided by the sponsor.
- Individual participant dataSharing planned: No
Related trials for Cardiac Arrest
RecruitingObservational study
Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax
Chronic Lymphocytic Leukemia (CLL), Waldenstr(SqrRoot)(Delta)m s Macroglobulinemia
Active, not recruiting
The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest
Cardiac Arrest, Out-Of-Hospital
RecruitingObservational study
Accuracy of Doppler Ultrasound Versus Manual Palpation of Pulse in Cardiac Arrest
Cardiac Arrest
Active, not recruiting
RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems
Cardiac Arrest
Not yet recruitingObservational study
Therapeutic Outcomes of In-Hospital Resuscitation of Patients Admitted to the Internal Medicine Wards
Survival to Discharge With Good Neurologic Outcome Among in Hospital Cardiac Arrest Patients
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sebastian Schnaubelt, MD, PhD principal investigator
Department of Emergency Medicine, Medical University of Vienna
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiac Arrest, run by Medical University of Vienna at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Oxygenation (time frame: 24 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jul 2026.