HIVNCT06848686
Prevention Ambassadors: Intervention to Promote HIV Service Engagement in the Networks of SSP Clients
A study testing Prevention Ambassadors in people with HIV, run by San Diego State University at 1 site in United States.
Trial summary
HIV testing and service uptake are infrequent among people who use drugs (PWUD) in the United States. In partnership with a community-based syringe service program (SSP), this project will develop the SSP-based "Prevention Ambassadors" (PA) intervention to promote HIV testing and service uptake among PWUD via the… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- HIV
- What is being tested?
- Prevention Ambassadors
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 170 participants
- Where
- 1 siteUnited States
- Study dates
- 3 Feb 2025to 14 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
None listed.
Who cannot join
- Persons who participated in formative study activities related to the development of the PA intervention will not be eligible to participate.
Trial locations and contacts
1 site in 1 country.
United States1 site
San Diego State University
San Diego, California, 92182
About this study
Official title: Prevention Ambassadors: an HIV Self-testing Intervention to Promote HIV Service Engagement in the Networks of SSP Clients
HIV testing and service uptake are infrequent among people who use drugs (PWUD) in the United States. In partnership with a community-based syringe service program (SSP), this project will develop the SSP-based "Prevention Ambassadors" (PA) intervention to promote HIV testing and service uptake among PWUD via the secondary distribution (i.e., peer delivery) of HIV self-testing (HIVST) kits with local HIV service information and referrals to HIV service navigation in the social networks of SSP clients (i.e., PWUD). The PA intervention will then be piloted to assess its preliminary effects, acceptability, and feasibility among PWUD in the Ending the HIV Epidemic priority jurisdiction of Riverside County, California.
- Conditions
- HIV
- Being tested
- Prevention Ambassadors, SSP Standard of Care
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Prevention AmbassadorsBehavioural
Delivery of prevention supplies and information on local services plus training to build the capacity of PWUD to distribute HIV self-testing (HIVST) kits with information and referrals to other PWUD in their social networks to promote HIV testing and HIV service engagement among PWUD.
SSP Standard of CareBehavioural
Delivery of prevention supplies and information on local services.
| Study group | Role | What they receive |
|---|---|---|
| Prevention Ambassadors | Experimental | Not described Receives: Behavioral: Prevention Ambassadors |
| SSP Standard of Care | Other | Not described Receives: Behavioral: SSP Standard of Care |
What is being measured
The primary outcome is the main question the study is designed to answer.
HIV testing (past 3 months)
Self-reported via survey and abstracted from medical record
Measured: 3-month follow-up
Linkage to PrEP/HIV care (past 3 months)
Self-reported via survey and abstracted from medical record
Measured: 3-month follow-up
PrEP/ART uptake (past 3 months)
Self-reported via survey and abstracted from medical record
Measured: 3-month follow-up
Secondary outcomes (4)
PA Acceptability (Peer-Recruit Participants)
Self-reported via survey
Measured: Baseline
PA Acceptability (Index Participants)
Self-reported via survey
Measured: 3-month follow-up
PA Feasibility (Peer-Recruit Participants)
Self-reported via survey
Measured: Baseline
PA Feasibility (Index Participants)
Self-reported via survey
Measured: 3-month follow-up
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Feb 2025
- Study start3 Feb 2025
- Primary completion14 Aug 2026
- Study completion14 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HIVStudies of the same condition, open and under way.
- More trials run by San Diego State UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 170 participants (actual)
Sponsor and investigators
- Lead sponsor
- San Diego State University
- Sponsor type
- University, hospital or other
- Collaborators
- University of California, San Diego, University of California, Riverside, Dap Health, National Institute on Drug Abuse (NIDA)
- Responsible party
- Sponsor
- Investigators
- Heather A Pines, Principal investigator, San Diego State UniversityAngela R Bazzi, Principal investigator, University of California, San Diego
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06848686
- Sponsor's protocol ID
- HS-2023-0051
- Other IDs
- R34DA058389
- Status last verified
- Oct 2026
- First submitted
- 18 Feb 2025
- Last updated
- 6 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified data will be made available upon review of written requests from researchers.
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prevention Ambassadors: an HIV Self-testing Intervention to Promote HIV Service Engagement in the Networks of SSP Clients
- ClinicalTrials.gov ID
- NCT06848686
- Acronym / sponsor ID
- HS-2023-0051
- Conditions
- HIV
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 170 participants (actual)
- Lead sponsor
- San Diego State UniversityUniversity, hospital or other
- Collaborators
- University of California, San Diego, University of California, Riverside, Dap Health, National Institute on Drug Abuse (NIDA)
- Study start
- 3 Feb 2025 (actual)
- Primary completion
- 14 Aug 2026 (actual)
- Study completion
- 14 Aug 2026 (actual)
- First posted
- 27 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
HIV testing and service uptake are infrequent among people who use drugs (PWUD) in the United States. In partnership with a community-based syringe service program (SSP), this project will develop the SSP-based "Prevention Ambassadors" (PA) intervention to promote HIV testing and service uptake among PWUD via the secondary distribution (i.e., peer delivery) of HIV self-testing (HIVST) kits with local HIV service information and referrals to HIV service navigation in the social networks of SSP clients (i.e., PWUD). The PA intervention will then be piloted to assess its preliminary effects, acceptability, and feasibility among PWUD in the Ending the HIV Epidemic priority jurisdiction of Riverside County, California.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Prevention Ambassadors | Experimental | Behavioral: Prevention Ambassadors |
| SSP Standard of Care | Other | Behavioral: SSP Standard of Care |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (0 listed)
Key exclusion criteria (1 listed)
- Persons who participated in formative study activities related to the development of the PA intervention will not be eligible to participate.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Prevention AmbassadorsDelivery of prevention supplies and information on local services plus training to build the capacity of PWUD to distribute HIV self-testing (HIVST) kits with information and referrals to other PWUD in their social networks to promote HIV testing and HIV service engagement among PWUD. | Behavioural | Prevention Ambassadors |
| SSP Standard of CareDelivery of prevention supplies and information on local services. | Behavioural | SSP Standard of Care |
Primary outcome
HIV testing (past 3 months)
Time frame: 3-month follow-up
Self-reported via survey and abstracted from medical record
Linkage to PrEP/HIV care (past 3 months)
Time frame: 3-month follow-up
Self-reported via survey and abstracted from medical record
PrEP/ART uptake (past 3 months)
Time frame: 3-month follow-up
Self-reported via survey and abstracted from medical record
4 secondary outcomes
PA Acceptability (Peer-Recruit Participants)
Time frame: Baseline
PA Acceptability (Index Participants)
Time frame: 3-month follow-up
PA Feasibility (Peer-Recruit Participants)
Time frame: Baseline
PA Feasibility (Index Participants)
Time frame: 3-month follow-up
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
- Individual participant dataSharing planned: Yes. De-identified data will be made available upon review of written requests from researchers.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Heather A Pines principal investigator
San Diego State University
Angela R Bazzi principal investigator
University of California, San Diego
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Prevention Ambassadors in people with HIV, run by San Diego State University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
HIV testing (past 3 months) (time frame: 3-month follow-up). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.