Coronary Artery DiseaseNCT06850233
The Validation of a CAD Screening Algorithm Based on Facial Photos in Community Population
An observational study of Coronary Artery Disease, run by China National Center for Cardiovascular Diseases at 1 site in China.
Trial summary
The purpose of this study is to evaluate the effectiveness of a coronary heart disease screening algorithm based on facial photos in community population. Read more about this study
- Who is it for?
- Ages 30 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Coronary Artery Disease
- How many people
- 100 participants
- Where
- 1 siteChina
- Study dates
- 4 Mar 2025to 24 Jun 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: community sample
Who may be able to join
- Community population with a pre-test probability greater than 5% for coronary artery disease
Who cannot join
- Prior percutaneous coronary intervention (PCI)
- Prior coronary artery bypass graft (CABG)
- The history of heart failure
- With artificially facial alteration (i.e. cosmetic surgery, facial trauma or make-up)
- Other situations which make patients fail to be photographed
Trial locations and contacts
1 site in 1 country.
China1 site
People's Road Community Health Service Center
Zhoukou, Henan, 466099
About this study
Official title: The Validation of a Coronary Artery Disease Screening Algorithm Based on Facial Photos in Community Population
The purpose of this study is to evaluate the effectiveness of a coronary heart disease screening algorithm based on facial photos in community population.
- Conditions
- Coronary Artery Disease
- Being tested
- No intervention
- Keywords
- Artificial Intelligence
- Medical subject headings
- Coronary Artery Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No interventionOther
No intervention
| Study group | Role | What they receive |
|---|---|---|
| Algorithm external validation group | Not described Receives: Other: No intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Sensitivity of the algorithm
The sensitivity of the CAD screening algorithm assessed in the group
Measured: at the end of enrollment (6 months)
Specificity of the algorithm
The specificity of the CAD screening algorithm assessed in the group
Measured: at the end of enrollment (6 months)
Secondary outcomes (4)
Discriminative capabilities
Area under receiver operating curve (AUC) of the algorithm assessed in the group
Measured: at the end of enrollment (6 months)
Positive predictive value (PPV)
PPV of the CAD screening algorithm assessed in the group
Measured: at the end of enrollment (6 months)
Negative predictive value (NPV)
NPV of the CAD screening algorithm assessed in the group
Measured: at the end of enrollment (6 months)
Diagnostic accuracy rate
Diagnostic accuracy rate of the algorithm assessed in the group
Measured: at the end of enrollment (6 months)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Feb 2025
- Study start4 Mar 2025
- Primary completion24 Jun 2025
- Study completion24 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Coronary Artery DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- China National Center for Cardiovascular Diseases
- Sponsor type
- Other government
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06850233
- Sponsor's protocol ID
- 2024-ZX050
- Status last verified
- Dec 2025
- First submitted
- 21 Feb 2025
- Last updated
- 5 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Validation of a Coronary Artery Disease Screening Algorithm Based on Facial Photos in Community Population
- ClinicalTrials.gov ID
- NCT06850233
- Acronym / sponsor ID
- 2024-ZX050
- Conditions
- Coronary Artery Disease
- Keywords
- Artificial Intelligence
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- China National Center for Cardiovascular DiseasesOther government
- Study start
- 4 Mar 2025 (actual)
- Primary completion
- 24 Jun 2025 (actual)
- Study completion
- 24 Jun 2025 (actual)
- First posted
- 27 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to evaluate the effectiveness of a coronary heart disease screening algorithm based on facial photos in community population.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Algorithm external validation group | – | Other: No intervention |
Who may qualify
- Ages
- 30 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- community sample
Key inclusion criteria (1 listed)
- Community population with a pre-test probability greater than 5% for coronary artery disease
Key exclusion criteria (5 listed)
- Prior percutaneous coronary intervention (PCI)
- Prior coronary artery bypass graft (CABG)
- The history of heart failure
- With artificially facial alteration (i.e. cosmetic surgery, facial trauma or make-up)
- Other situations which make patients fail to be photographed
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No interventionNo intervention | Other | Algorithm external validation group |
Primary outcome
Sensitivity of the algorithm
Time frame: at the end of enrollment (6 months)
The sensitivity of the CAD screening algorithm assessed in the group
Specificity of the algorithm
Time frame: at the end of enrollment (6 months)
The specificity of the CAD screening algorithm assessed in the group
4 secondary outcomes
Discriminative capabilities
Time frame: at the end of enrollment (6 months)
Positive predictive value (PPV)
Time frame: at the end of enrollment (6 months)
Negative predictive value (NPV)
Time frame: at the end of enrollment (6 months)
Diagnostic accuracy rate
Time frame: at the end of enrollment (6 months)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Dec 2025.
Related trials for Coronary Artery Disease
Recruiting
Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
Stable Angina, Multivessel Coronary Artery Disease
Not yet recruitingPhase 3
Efficacy of Lipoic Acid on Chronic Ischemic Heart Failure Patients
Heart Failure Due to Coronary Artery Disease
RecruitingObservational study
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Rare Disorders, Undiagnosed Disorders
Not yet recruitingObservational study
Prognostic Value of Functional-Nutritional Status in Older Adults With Acute Coronary Syndrome
Acute Coronary Syndromes (ACS)
RecruitingObservational study
Cardiovascular Acoustics for Early Disease Detection
Valvular Heart Disease, Coronary Artery Disease
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Coronary Artery Disease, run by China National Center for Cardiovascular Diseases at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Sensitivity of the algorithm (time frame: at the end of enrollment (6 months)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Dec 2025.