Achilles TendinopathyNCT06905756
Comparative Effect of Accelerated Rehabilitation and Eccentric Strengthening Exercises on Patients With AT
A study testing Accelerated rehabilitation and Eccentric strengthening exercises in people with Achilles Tendinopathy, run by Superior University at 1 site in Pakistan.
Trial summary
A common overuse injury to the Achilles tendon, Achilles tendinopathy frequently causes pain, restricted range of motion, and functional impairment. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Achilles Tendinopathy
- What is being tested?
- Accelerated rehabilitation and Eccentric strengthening exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 sitePakistan
- Study dates
- 20 Mar 2025to 20 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Male and female patients, age greater than 18 years, clinically diagnosed with Achilles tendinopathy.
- Participants that are clinically diagnosed with Achilles tendinopathy.
- Duration of symptoms or pain for more than 1 month.
- Positive clinical tests, such as Thompson test, confirming Achilles tendinopathy.
- Tenderness to palpation along the Achilles tendon or localized pain during activity.
- Patients with a history of overuse injuries related to repetitive activities, such as running or jumping.
Who cannot join
- Following participants will be excluded from this study:
- Presence of systemic conditions such as rheumatoid arthritis, diabetes, or other inflammatory or neuromuscular disorders.
- History of complete Achilles tendon rupture or previous surgical intervention on the affected tendon.
- Patients with other lower limb injuries or conditions (e.g., fractures, ligament tears) that could interfere with Achilles tendinopathy treatment.
- Severe tendon degeneration or calcification confirmed by imaging, unsuitable for rehabilitation.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Punjab Social Security Health Management Hospital Manga Raiwind
Lahore, Punjab Province
About this study
Official title: Compartive Effect of Accelerated Rehabilitation and Eccentric Strengthing Exercises on Patient With Achilles Tendinopathy
A common overuse injury to the Achilles tendon, Achilles tendinopathy frequently causes pain, restricted range of motion, and functional impairment.
Read the detailed description
The purpose of this randomized clinical research is to evaluate the benefits of eccentric strengthening exercises and rapid rehabilitation on Achilles tendinopathy patients. Using techniques including TENS, isometric exercises, balance training, and endurance exercises, the 12-week accelerated rehabilitation program emphasizes pain management, mobility restoration, and functional recovery through incremental phases. However, in order to improve tendon strength and resilience, eccentric strengthening entails progressively raising resistance and functional loading. Both approaches are backed by earlier research but lack direct comparison in terms of effectiveness. This study will open the door for more research and improve rehabilitation techniques worldwide by adding to the expanding corpus of material on Achilles tendinopathy care.
- Conditions
- Achilles Tendinopathy
- Being tested
- Accelerated rehabilitation, Eccentric strengthening exercises
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Accelerated rehabilitationDiagnostic test
15 subjects in group A will be receiving Accelerated Rehabilitation protocol alongwith baseline treatment. Accelerated rehabilitation consisting of three phases, following 12 week exercise regime. Pain reduction, mobility, strengthening, and functional recovery are part of the accelerated rehabilitation protocol for Achilles tendinopathy. Ice, TENS, range-of-motion exercises, isometric calf contractions, and a progressive transition to full weight-bearing based are the mainstays of Phase 1 (Weeks 1-4). Phase 2 (Weeks 5-8) focuses on balance training, resistance band exercises, and seated and standing calf raises as well as light functional workouts like cycling or walking. Phase 3 (Weeks 9-12) progresses to sport-specific and endurance exercises like swimming or running after including plyometric drills, eccentric heel drops, and advanced strengthening. Each exercise will be performed under supervision of skilled physiotherapist for 2 times daily, 2 sets of 5 repetitions.
Eccentric strengthening exercisesCombination product
Group B will be receiving eccentric strengthening exercises alongwith baseline treatment. Techniques of Curwin, Stanish et al will be used for eccentric training. For every exercise, participants do three sets of 15 repetitions, with a 30-second break in between. Weight is added gradually to enhance resistance (5-10 lbs or more, depending on tolerance). The eccentric strengthening regimen for Achilles tendinopathy advances every week. Participants use both feet without dorsiflexion to perform eccentric contractions in Week 1. By Week 3, the focus of the workouts is on the injured foot in maximum dorsiflexion. In Week 4, 10% body weight resistance is introduced, and in Week 5, an extra 5-10 pounds. From Week 6 to Week 8, resistance rises every two weeks. From Weeks 9 to 12, functional motions like hopping, single-leg heel drops, and sport-specific drills are incorporated, all of which are customized to meet individual goals.
| Study group | Role | What they receive |
|---|---|---|
| Accelerated rehabilitation | Experimental | Not described Receives: Diagnostic Test: Accelerated rehabilitation |
| Eccentric strengthening exercises | Experimental | Not described Receives: Combination Product: Eccentric strengthening exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numerical pain rating scale
The Pain Scale has a numerical rating system (NRS) with 11 points, with 0 denoting no pain and 10 denoting the most excruciating pain. The following categories apply to scores:
0= denotes no pain 1-3= mild pain 4-6=moderate pain 7-10= severe pain.(12)
Measured: 12 Months
WHOQOL (world health organization and quality of life)
The WHOQOL uses 26 questions to calculate quality of life across the four domains. Each item is scored on a 5-point Likert scale (1 to 5), where higher scores indicate a better quality of life, lower score indicate, poor quality of life. Average total score for healthy populations is about 90.
0-20 = Poor Quality of Life 21-40 = Moderate Quality of Life 41-60 = Good Quality of Life 61-80 or greater than 80 = Very Good Quality of life.
Measured: 12 Months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Apr 2025
- Study start20 Mar 2025
- Primary completion20 Jun 2025 (estimated)
- Study completion20 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Achilles TendinopathyStudies of the same condition, open and under way.
- More trials run by Superior UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Superior University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Muhammad Naveed Babur, Superior University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06905756
- Sponsor's protocol ID
- MSRSW/Batch-Fall23/788
- Status last verified
- Mar 2025
- First submitted
- 25 Mar 2025
- Last updated
- 1 Apr 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Compartive Effect of Accelerated Rehabilitation and Eccentric Strengthing Exercises on Patient With Achilles Tendinopathy
- ClinicalTrials.gov ID
- NCT06905756
- Acronym / sponsor ID
- MSRSW/Batch-Fall23/788
- Conditions
- Achilles Tendinopathy
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Superior UniversityUniversity, hospital or other
- Study start
- 20 Mar 2025 (actual)
- Primary completion
- 20 Jun 2025 (estimated)
- Study completion
- 20 Feb 2026 (estimated)
- First posted
- 1 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A common overuse injury to the Achilles tendon, Achilles tendinopathy frequently causes pain, restricted range of motion, and functional impairment.
Detailed description
The purpose of this randomized clinical research is to evaluate the benefits of eccentric strengthening exercises and rapid rehabilitation on Achilles tendinopathy patients. Using techniques including TENS, isometric exercises, balance training, and endurance exercises, the 12-week accelerated rehabilitation program emphasizes pain management, mobility restoration, and functional recovery through incremental phases. However, in order to improve tendon strength and resilience, eccentric strengthening entails progressively raising resistance and functional loading. Both approaches are backed by earlier research but lack direct comparison in terms of effectiveness. This study will open the door for more research and improve rehabilitation techniques worldwide by adding to the expanding corpus of material on Achilles tendinopathy care.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Accelerated rehabilitation | Experimental | Diagnostic Test: Accelerated rehabilitation |
| Eccentric strengthening exercises | Experimental | Combination Product: Eccentric strengthening exercises |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Male and female patients, age greater than 18 years, clinically diagnosed with Achilles tendinopathy.
- Participants that are clinically diagnosed with Achilles tendinopathy.
- Duration of symptoms or pain for more than 1 month.
- Positive clinical tests, such as Thompson test, confirming Achilles tendinopathy.
- Tenderness to palpation along the Achilles tendon or localized pain during activity.
Key exclusion criteria (5 listed)
- Following participants will be excluded from this study:
- Presence of systemic conditions such as rheumatoid arthritis, diabetes, or other inflammatory or neuromuscular disorders.
- History of complete Achilles tendon rupture or previous surgical intervention on the affected tendon.
- Patients with other lower limb injuries or conditions (e.g., fractures, ligament tears) that could interfere with Achilles tendinopathy treatment.
- Severe tendon degeneration or calcification confirmed by imaging, unsuitable for rehabilitation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Accelerated rehabilitation15 subjects in group A will be receiving Accelerated Rehabilitation protocol alongwith baseline treatment. Accelerated rehabilitation consisting of three phases, following 12 week exercise regime. Pain reduction, mobility, strengthening, and functional recovery are part of the accelerated rehabilitation protocol for Achilles tendinopathy. Ice, TENS, range-of-motion exercises, isometric calf contractions, and a progressive transition to full weight-bearing based are the mainstays of Phase 1 (Weeks 1-4). Phase 2 (Weeks 5-8) focuses on balance training, resistance band exercises, and seated and standing calf raises as well as light functional workouts like cycling or walking. Phase 3 (Weeks 9-12) progresses to sport-specific and endurance exercises like swimming or running after including plyometric drills, eccentric heel drops, and advanced strengthening. Each exercise will be performed under supervision of skilled physiotherapist for 2 times daily, 2 sets of 5 repetitions. | Diagnostic test | Accelerated rehabilitation |
| Eccentric strengthening exercisesGroup B will be receiving eccentric strengthening exercises alongwith baseline treatment. Techniques of Curwin, Stanish et al will be used for eccentric training. For every exercise, participants do three sets of 15 repetitions, with a 30-second break in between. Weight is added gradually to enhance resistance (5-10 lbs or more, depending on tolerance). The eccentric strengthening regimen for Achilles tendinopathy advances every week. Participants use both feet without dorsiflexion to perform eccentric contractions in Week 1. By Week 3, the focus of the workouts is on the injured foot in maximum dorsiflexion. In Week 4, 10% body weight resistance is introduced, and in Week 5, an extra 5-10 pounds. From Week 6 to Week 8, resistance rises every two weeks. From Weeks 9 to 12, functional motions like hopping, single-leg heel drops, and sport-specific drills are incorporated, all of which are customized to meet individual goals. | Combination product | Eccentric strengthening exercises |
Primary outcome
Numerical pain rating scale
Time frame: 12 Months
The Pain Scale has a numerical rating system (NRS) with 11 points, with 0 denoting no pain and 10 denoting the most excruciating pain. The following categories apply to scores: 0= denotes no pain 1-3= mild pain 4-6=moderate pain 7-10= severe pain.(12)
WHOQOL (world health organization and quality of life)
Time frame: 12 Months
The WHOQOL uses 26 questions to calculate quality of life across the four domains. Each item is scored on a 5-point Likert scale (1 to 5), where higher scores indicate a better quality of life, lower score indicate, poor quality of life. Average total score for healthy populations is about 90. 0-20 = Poor Quality of Life 21-40 = Moderate Quality of Life 41-60 = Good Quality of Life 61-80 or greater than 80 = Very Good Quality of life.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Apr 2025.
- Individual participant dataSharing planned: No
Related trials for Achilles Tendinopathy
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Recruiting
Single-Row Versus Double-Row Repair for Achilles Insertional Tendinopathy
Achilles Insertional Tendinopathy, Achilles Tendinopathy
Enrolling by invitationObservational study
Achilles Non-SNIS REGENETEN
Complete Mid-portion Achilles Rupture
Not yet recruitingObservational study
Human Tendon Tissue Collection
Tendinopathy, Musculoskeletal Diseases or Conditions
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Achilles Injuries Tendon, Achilles Tendinopathy (AT)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Accelerated rehabilitation and Eccentric strengthening exercises in people with Achilles Tendinopathy, run by Superior University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 1 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numerical pain rating scale (time frame: 12 Months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Apr 2025.