TenosynovitisNCT06918158
Mobilization With Movement Versus Joint-Specific Manipulation in De Quervain's Tenosynovitis
A study testing Mobilization with Movement and Joint Specific Manipulation in people with Tenosynovitis, run by Riphah International University at 1 site in Pakistan.
Trial summary
A comparative study on the effectiveness of mobilization with movement (MWM) versus joint-specific manipulation (JSM) in patients with De Quervain's tenosynovitis typically aims to assess how each technique impacts pain relief and functional improvement. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Tenosynovitis
- What is being tested?
- Mobilization with Movement and Joint Specific Manipulation
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 32 participants
- Where
- 1 sitePakistan
- Study dates
- 17 Feb 2025to 17 Feb 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Inclusion Criteria:o Patients clinically diagnosed with De Quervain's tenosynovitis
- Age between 25-45 years.
- Positive Finkelstein test.
- Pain over the first dorsal compartment.
- Limited wrist and thumb function.
- Willingness to take part and adhere to the study's guidelines.
Exclusion Criteria:Participants fall in this category would be excluded of the study.
- Previous surgery of wrist or thumb.
- Presence of neurological symptoms like numbness, weakeness.
- Rheumatological conditions like rheumatoid arthritis.
- Pregnancy.
- Presence of wrist fracture or osteoporosis.
- Carpel tunnel syndrome.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Riphah international University Malakand Campus
Malakand, KPK, 23060
About this study
Official title: Comparative Study on the Effectiveness of Mobilization With Movement Versus Joint Specific Manipulation on Pain and Function in Patient With Dequervains Tenosynovitis
A comparative study on the effectiveness of mobilization with movement (MWM) versus joint-specific manipulation (JSM) in patients with De Quervain's tenosynovitis typically aims to assess how each technique impacts pain relief and functional improvement. De Quervain's tenosynovitis is an inflammation of the tendons around the thumb and wrist, often causing pain, swelling, and difficulty in performing everyday tasks. The study would likely compare the two interventions by measuring pain levels, range of motion, and overall functional outcomes before and after treatment. MWM involves applying specific, controlled movements while the patient is actively engaging in their joint motion, targeting the tissue's mobility and reducing pain. JSM, on the other hand, focuses on manipulating the joint directly to restore normal function, specifically targeting the wrist and thumb regions affected by the condition.
Read the detailed description
A comparative study on the effectiveness of Mobilization with Movement (MWM) versus Joint-Specific Manipulation (JSM) in patients with De Quervain's Tenosynovitis would delve deeper into the physiological mechanisms and clinical outcomes associated with each technique, providing valuable evidence for therapeutic decision-making. De Quervain's Tenosynovitis is a condition characterized by the inflammation of the tendons at the base of the thumb, particularly affecting the abductor pollicis longus and extensor pollicis brevis tendons. This condition is commonly caused by repetitive strain, overuse, or trauma, leading to pain, swelling, and restricted movement, which significantly impacts the patient's daily activities.
- Conditions
- Tenosynovitis
- Being tested
- Mobilization with Movement, Joint Specific Manipulation
- Keywords
- Tenosynovitis
- Medical subject headings
- Tenosynovitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mobilization with MovementOther
Mobilization with Movement
- The proximal row of carpals glides passively radially.
- Active thumb and wrist movements superimposed on the glide.
Therapeutic excercises:
- Ball Toss
- Static web gripping
- Gentle ROM activities to maintain mobility
- Isometric exercises in all direction
Joint Specific ManipulationOther
Joint Specific Manipulation
- High-velocity, low-amplitude thrust to the first carpometacarpal joint
- Radiocarpal wrist mobilization .Grade III-IV applied at end range. 2. Therapeutic excercises:
- Ball Toss
- Static web gripping
- Gentle ROM activities to maintain mobility
- Isometric exercises in all direction Ergonomics modifications
| Study group | Role | What they receive |
|---|---|---|
| Joint-specific Manipulation | Experimental | Group A Receives: Other: Joint Specific Manipulation |
| Mobilization with Movement | Placebo comparator | Group B Receives: Other: Mobilization with Movement |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Reduction - Measured using the Numeric Pain Rating Scale (NPRS) (0-10 scale).
Pain intensity will be assessed using the Numeric Pain Rating Scale (NPRS), a validated tool where participants rate their pain on a scale from 0 no pain to 10 worst possible pain.
Measured: 6 Months
Secondary outcomes (1)
Wrist Function - Assessed with the Patient-Rated Wrist Evaluation (PRWE) (0-100 scale).
Functional wrist use will be assessed using the Patient-Rated Wrist Evaluation (PRWE), which evaluates pain and disability on a 100-point scale, with higher scores indicating greater impairment. Clinical signs will be assessed using Finkelstein's Test, a standard diagnostic test for De Quervain's tenosynovitis, recorded as positive or negative. Data will be analyzed using pre- and post-intervention comparisons within and between groups to determine the effectiveness of each intervention.
Measured: 6months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Apr 2025
- Study start17 Feb 2025
- Primary completion17 Feb 2025
- Study completion17 Feb 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for TenosynovitisStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Single group
- Model description
- RCT
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Dr.Nadeem Ahmad, MS, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06918158
- Sponsor's protocol ID
- REC-01001 Khaista Bacha
- Status last verified
- Apr 2025
- First submitted
- 20 Feb 2025
- Last updated
- 25 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Study on the Effectiveness of Mobilization With Movement Versus Joint Specific Manipulation on Pain and Function in Patient With Dequervains Tenosynovitis
- ClinicalTrials.gov ID
- NCT06918158
- Acronym / sponsor ID
- REC-01001 Khaista Bacha
- Conditions
- Tenosynovitis
- Keywords
- Tenosynovitis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 17 Feb 2025 (actual)
- Primary completion
- 17 Feb 2025 (actual)
- Study completion
- 17 Feb 2025 (actual)
- First posted
- 9 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A comparative study on the effectiveness of mobilization with movement (MWM) versus joint-specific manipulation (JSM) in patients with De Quervain's tenosynovitis typically aims to assess how each technique impacts pain relief and functional improvement. De Quervain's tenosynovitis is an inflammation of the tendons around the thumb and wrist, often causing pain, swelling, and difficulty in performing everyday tasks. The study would likely compare the two interventions by measuring pain levels, range of motion, and overall functional outcomes before and after treatment. MWM involves applying specific, controlled movements while the patient is actively engaging in their joint motion, targeting the tissue's mobility and reducing pain. JSM, on the other hand, focuses on manipulating the joint directly to restore normal function, specifically targeting the wrist and thumb regions affected by the condition.
Detailed description
A comparative study on the effectiveness of Mobilization with Movement (MWM) versus Joint-Specific Manipulation (JSM) in patients with De Quervain's Tenosynovitis would delve deeper into the physiological mechanisms and clinical outcomes associated with each technique, providing valuable evidence for therapeutic decision-making. De Quervain's Tenosynovitis is a condition characterized by the inflammation of the tendons at the base of the thumb, particularly affecting the abductor pollicis longus and extensor pollicis brevis tendons. This condition is commonly caused by repetitive strain, overuse, or trauma, leading to pain, swelling, and restricted movement, which significantly impacts the patient's daily activities.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- RCT
| Arm | Type | Receives |
|---|---|---|
| Joint-specific Manipulation | Experimental | Other: Joint Specific ManipulationGroup A |
| Mobilization with Movement | Placebo comparator | Other: Mobilization with MovementGroup B |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mobilization with MovementMobilization with Movement * The proximal row of carpals glides passively radially. * Active thumb and wrist movements superimposed on the glide. Therapeutic excercises: * Ball Toss * Static web gripping * Gentle ROM activities to maintain mobility * Isometric exercises in all direction | Other | Mobilization with Movement |
| Joint Specific ManipulationJoint Specific Manipulation * High-velocity, low-amplitude thrust to the first carpometacarpal joint * Radiocarpal wrist mobilization .Grade III-IV applied at end range. 2. Therapeutic excercises: * Ball Toss * Static web gripping * Gentle ROM activities to maintain mobility * Isometric exercises in all direction Ergonomics modifications | Other | Joint-specific Manipulation |
Primary outcome
Pain Reduction - Measured using the Numeric Pain Rating Scale (NPRS) (0-10 scale).
Time frame: 6 Months
Pain intensity will be assessed using the Numeric Pain Rating Scale (NPRS), a validated tool where participants rate their pain on a scale from 0 no pain to 10 worst possible pain.
1 secondary outcome
Wrist Function - Assessed with the Patient-Rated Wrist Evaluation (PRWE) (0-100 scale).
Time frame: 6months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Apr 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Dr.Nadeem Ahmad, MS principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mobilization with Movement and Joint Specific Manipulation in people with Tenosynovitis, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Reduction - Measured using the Numeric Pain Rating Scale (NPRS) (0-10 scale). (time frame: 6 Months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Apr 2025.