VapingEPIC/ADVANCENCT06919276
Nicotine and Cannabis Vape Labeling Experiment - Spring 2025
A study testing Vaping Device Labeling in people with Vaping and Adolescent, run by University of Southern California at 1 site in United States.
Trial summary
This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm. Read more about this study
- Who is it for?
- Ages 11 to 19 yearsHealthy volunteers can take part
- Conditions the study is for
- Vaping, Adolescent, Electronic Cigarette Use
- What is being tested?
- Vaping Device Labeling
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 3,048 participants
- Where
- 1 siteUnited States
- Study dates
- 3 Mar 2025to 1 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 11 to 19 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Participants must be enrolled in a partnering high school.
Who cannot join
- Participants who cannot independently understand study consent and the study surveys are ineligible.
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Southern California
Los Angeles, California, 90032
About this study
Official title: Longitudinal Patterns of Non-Combustible Tobacco Product Use in Adolescents (EPIC) / Assessing Development Patterns of Vaping, Alcohol, Nicotine, and Cannabis Use and Emotional Well-being (ADVANCE)
This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.
Read the detailed description
The primary objectives of the study: (1) Determine whether different device labels with the contained substance (nicotine or cannabis) affect adolescent use susceptibility, anticipated effects or impairment, and perceived health harms; (2) Determine whether device color/product flavor differentially impact the study outcomes.
- Conditions
- Vaping, Adolescent, Electronic Cigarette Use, Nicotine, Cannabis
- Being tested
- Vaping Device Labeling
- Keywords
- vaping device, product labeling, use susceptibility, perceived harm, nicotine, cannabis
- Medical subject headings
- Vaping, Marijuana Abuse
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vaping Device LabelingOther
Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.
The label conditions are:
- plain (i.e., no labeling on device)
- "contains THC"
- "contains 80% THC"
- "contains 80% THC - HIGH POTENCY"
- "contains nicotine"
- "contains 5% nicotine"
- "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
| Study group | Role | What they receive |
|---|---|---|
| Mint - Labeling Condition 1 | Experimental | Participants will view an image of a mint-colored and flavored vape with label condition 1. Receives: Other: Vaping Device Labeling |
| Mint - Labeling Condition 2 | Experimental | Participants will view an image of a mint-colored and flavored vape with label condition 2. Receives: Other: Vaping Device Labeling |
| Mint - Labeling Condition 3 | Experimental | Participants will view an image of a mint-colored and flavored vape with label condition 3. Receives: Other: Vaping Device Labeling |
| Mint - Labeling Condition 4 | Experimental | Participants will view an image of a mint-colored and flavored vape with label condition 4. Receives: Other: Vaping Device Labeling |
| Mint - Labeling Condition 5 | Experimental | Participants will view an image of a mint-colored and flavored vape with label condition 5. Receives: Other: Vaping Device Labeling |
| Mint - Labeling Condition 6 | Experimental | Participants will view an image of a mint-colored and flavored vape with label condition 6. Receives: Other: Vaping Device Labeling |
| Mint - Labeling Condition 7 | Experimental | Participants will view an image of a mint-colored and flavored vape with label condition 7. Receives: Other: Vaping Device Labeling |
| Original - Labeling Condition 1 | Experimental | Participants will view an image of a white colored and original vape with label condition 1. Receives: Other: Vaping Device Labeling |
| Original - Labeling Condition 2 | Experimental | Participants will view an image of a white colored and original vape with label condition 2. Receives: Other: Vaping Device Labeling |
| Original - Labeling Condition 3 | Experimental | Participants will view an image of a white colored and original vape with label condition 3. Receives: Other: Vaping Device Labeling |
| Original - Labeling Condition 4 | Experimental | Participants will view an image of a white colored and original vape with label condition 4. Receives: Other: Vaping Device Labeling |
| Original - Labeling Condition 5 | Experimental | Participants will view an image of a white colored and original vape with label condition 5. Receives: Other: Vaping Device Labeling |
| Original - Labeling Condition 6 | Experimental | Participants will view an image of a white colored and original vape with label condition 6. Receives: Other: Vaping Device Labeling |
| Original - Labeling Condition 7 | Experimental | Participants will view an image of a white colored and original vape with label condition 7. Receives: Other: Vaping Device Labeling |
| Blueberry - Labeling Condition 1 | Experimental | Participants will view an image of a blue-colored and blueberry flavored vape with label condition 1. Receives: Other: Vaping Device Labeling |
| Blueberry - Labeling Condition 2 | Experimental | Participants will view an image of a blue-colored and blueberry flavored vape with label condition 2. Receives: Other: Vaping Device Labeling |
| Blueberry - Labeling Condition 3 | Experimental | Participants will view an image of a blue-colored and blueberry flavored vape with label condition 3. Receives: Other: Vaping Device Labeling |
| Blueberry - Labeling Condition 4 | Experimental | Participants will view an image of a blue-colored and blueberry flavored vape with label condition 4. Receives: Other: Vaping Device Labeling |
| Blueberry - Labeling Condition 5 | Experimental | Participants will view an image of a blue-colored and blueberry flavored vape with label condition 5. Receives: Other: Vaping Device Labeling |
| Blueberry - Labeling Condition 6 | Experimental | Participants will view an image of a blue-colored and blueberry flavored vape with label condition 6. Receives: Other: Vaping Device Labeling |
| Blueberry - Labeling Condition 7 | Experimental | Participants will view an image of a blue-colored and blueberry flavored vape with label condition 1. Receives: Other: Vaping Device Labeling |
What is being measured
The primary outcome is the main question the study is designed to answer.
Use Intention Susceptibility
This 3-item self-report measure assesses participant interest in trying the vaping device in the future. A 4-level Likert scale is used: definitely not, probably not, probably yes, definitely yes.
Measured: 5 minutes
Perceived Health Harms
This 2-item self-report measure assesses participant perception of health harms and risks associated with using the vaping product. A 4-level Likert scale is used: definitely not, probably not, probably yes, definitely yes.
Measured: 5 minutes
Anticipated Subjective Effects
This 9-item self-report measure assesses anticipated subjective effects from using the vaping device. Participants will select all that apply.
Measured: 5 minutes
Anticipated Impairment/Enhancement
This 4-item self-report measure assesses participant anticipated enhancement or impairment effects on completing different activities due to using the vaping product. A 5-level Likert scale is used: definitely make it harder, probably make it harder, no effect, probably make it easier, definitely make it easier.
Measured: 5 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Apr 2025
- Study start3 Mar 2025
- Primary completion1 May 2025
- Study completion1 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for VapingStudies of the same condition, open and under way.
- More trials run by University of Southern CaliforniaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomized to one of seven labeling conditions and one of three device colors/flavors.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 3,048 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Southern California
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Drug Abuse (NIDA), National Cancer Institute (NCI)
- Responsible party
- Principal investigator, Adam Leventhal, University of Southern California
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06919276
- Sponsor's protocol ID
- UP-23-00483/HS-19-00682
- Other IDs
- 5K24DA048160, 5U54CA180905-12, 5R01CA229617-06
- Acronym
- EPIC/ADVANCE
- Status last verified
- May 2026
- First submitted
- 28 Feb 2025
- Last updated
- 22 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Longitudinal Patterns of Non-Combustible Tobacco Product Use in Adolescents (EPIC) / Assessing Development Patterns of Vaping, Alcohol, Nicotine, and Cannabis Use and Emotional Well-being (ADVANCE)
- ClinicalTrials.gov ID
- NCT06919276
- Acronym / sponsor ID
- EPIC/ADVANCE / UP-23-00483/HS-19-00682
- Conditions
- Vaping, Adolescent, Electronic Cigarette Use, Nicotine, Cannabis
- Keywords
- vaping device, product labeling, use susceptibility, perceived harm, nicotine, cannabis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 3,048 participants (actual)
- Lead sponsor
- University of Southern CaliforniaUniversity, hospital or other
- Collaborators
- National Institute on Drug Abuse (NIDA), National Cancer Institute (NCI)
- Study start
- 3 Mar 2025 (actual)
- Primary completion
- 1 May 2025 (actual)
- Study completion
- 1 Jun 2025 (actual)
- First posted
- 9 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.
Detailed description
The primary objectives of the study: (1) Determine whether different device labels with the contained substance (nicotine or cannabis) affect adolescent use susceptibility, anticipated effects or impairment, and perceived health harms; (2) Determine whether device color/product flavor differentially impact the study outcomes.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 21
- Model description
- Participants will be randomized to one of seven labeling conditions and one of three device colors/flavors.
| Arm | Type | Receives |
|---|---|---|
| Mint - Labeling Condition 1 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a mint-colored and flavored vape with label condition 1. |
| Mint - Labeling Condition 2 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a mint-colored and flavored vape with label condition 2. |
| Mint - Labeling Condition 3 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a mint-colored and flavored vape with label condition 3. |
| Mint - Labeling Condition 4 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a mint-colored and flavored vape with label condition 4. |
| Mint - Labeling Condition 5 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a mint-colored and flavored vape with label condition 5. |
| Mint - Labeling Condition 6 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a mint-colored and flavored vape with label condition 6. |
| Mint - Labeling Condition 7 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a mint-colored and flavored vape with label condition 7. |
| Original - Labeling Condition 1 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a white colored and original vape with label condition 1. |
| Original - Labeling Condition 2 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a white colored and original vape with label condition 2. |
| Original - Labeling Condition 3 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a white colored and original vape with label condition 3. |
| Original - Labeling Condition 4 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a white colored and original vape with label condition 4. |
| Original - Labeling Condition 5 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a white colored and original vape with label condition 5. |
| Original - Labeling Condition 6 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a white colored and original vape with label condition 6. |
| Original - Labeling Condition 7 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a white colored and original vape with label condition 7. |
| Blueberry - Labeling Condition 1 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a blue-colored and blueberry flavored vape with label condition 1. |
| Blueberry - Labeling Condition 2 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a blue-colored and blueberry flavored vape with label condition 2. |
| Blueberry - Labeling Condition 3 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a blue-colored and blueberry flavored vape with label condition 3. |
| Blueberry - Labeling Condition 4 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a blue-colored and blueberry flavored vape with label condition 4. |
| Blueberry - Labeling Condition 5 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a blue-colored and blueberry flavored vape with label condition 5. |
| Blueberry - Labeling Condition 6 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a blue-colored and blueberry flavored vape with label condition 6. |
| Blueberry - Labeling Condition 7 | Experimental | Other: Vaping Device LabelingParticipants will view an image of a blue-colored and blueberry flavored vape with label condition 1. |
Who may qualify
- Ages
- 11 to 19 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (1 listed)
- Participants must be enrolled in a partnering high school.
Key exclusion criteria (1 listed)
- Participants who cannot independently understand study consent and the study surveys are ineligible.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vaping Device LabelingParticipants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented. The label conditions are: 1. plain (i.e., no labeling on device) 2. "contains THC" 3. "contains 80% THC" 4. "contains 80% THC - HIGH POTENCY" 5. "contains nicotine" 6. "contains 5% nicotine" 7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry. | Other | Blueberry - Labeling Condition 1, Blueberry - Labeling Condition 2, Blueberry - Labeling Condition 3, Blueberry - Labeling Condition 4, Blueberry - Labeling Condition 5, Blueberry - Labeling Condition 6, Blueberry - Labeling Condition 7, Mint - Labeling Condition 1, Mint - Labeling Condition 2, Mint - Labeling Condition 3, Mint - Labeling Condition 4, Mint - Labeling Condition 5, Mint - Labeling Condition 6, Mint - Labeling Condition 7, Original - Labeling Condition 1, Original - Labeling Condition 2, Original - Labeling Condition 3, Original - Labeling Condition 4, Original - Labeling Condition 5, Original - Labeling Condition 6, Original - Labeling Condition 7 |
Primary outcome
Use Intention Susceptibility
Time frame: 5 minutes
This 3-item self-report measure assesses participant interest in trying the vaping device in the future. A 4-level Likert scale is used: definitely not, probably not, probably yes, definitely yes.
Perceived Health Harms
Time frame: 5 minutes
This 2-item self-report measure assesses participant perception of health harms and risks associated with using the vaping product. A 4-level Likert scale is used: definitely not, probably not, probably yes, definitely yes.
Anticipated Subjective Effects
Time frame: 5 minutes
This 9-item self-report measure assesses anticipated subjective effects from using the vaping device. Participants will select all that apply.
Anticipated Impairment/Enhancement
Time frame: 5 minutes
This 4-item self-report measure assesses participant anticipated enhancement or impairment effects on completing different activities due to using the vaping product. A 5-level Likert scale is used: definitely make it harder, probably make it harder, no effect, probably make it easier, definitely make it easier.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vaping Device Labeling in people with Vaping and Adolescent, run by University of Southern California at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Use Intention Susceptibility (time frame: 5 minutes). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 May 2026.