Carpal Tunnel Syndrome (CTS)NCT06926777
Comparative Analysis of Median Nerve Parameters for Carpal Tunnel Syndrome (CTS) Diagnosis: Ultrasound Versus Nerve Conduction Studies (NCS)
A study testing Nerve Conduction Study in people with Carpal Tunnel Syndrome (CTS) and Nerve Conduction, run by Combined Military Hospital Kohat Pakistan at 1 site in Pakistan.
Trial summary
Comparative Analysis of Median Nerve Parameters for Carpal Tunnel Syndrome (CTS) Diagnosis: Ultrasound vs. Nerve Conduction Study (NCS) This clinical study aims to determine whether ultrasound can be as practical as NCS in diagnosing CTS. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Carpal Tunnel Syndrome (CTS), Nerve Conduction, Ultrasound
- What is being tested?
- Nerve Conduction Study
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 sitePakistan
- Study dates
- 1 May 2025to 1 Jul 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older.
- Patients with clinical symptoms of CTS, including numbness, tingling, pain, or weakness in the hand.
- Positive findings on clinical examination, such as Tinel's sign, Phalen's test, or Durkan's test.
- Willingness to undergo both ultrasound and NCS for diagnostic evaluation.
Who cannot join
- Previous surgery for CTS in the affected hand.
- History of peripheral neuropathy such as diabetic neuropathy
- Other neuromuscular disorders affecting the upper limb such as cervical radiculopathy.
- Pregnant women.
- Severe comorbid conditions that may interfere with study participation.
- Inability to provide informed consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
Combined Military Hospital
Kohat, KPK, 26000
Syed Tameem Ul Hassan, MBBS, FCPS, 00923368885877, drtameem2@gmail.com
About this study
Comparative Analysis of Median Nerve Parameters for Carpal Tunnel Syndrome (CTS) Diagnosis: Ultrasound vs. Nerve Conduction Study (NCS) This clinical study aims to determine whether ultrasound can be as practical as NCS in diagnosing CTS. It will also evaluate the accuracy of different median nerve measurements in both tests.
The main questions it aims to answer are:
Read more
Can ultrasound accurately detect CTS compared to NCS? Which median nerve measurements (such as size, speed, or function) are most useful for diagnosis? Researchers will compare ultrasound and NCS results in patients with CTS symptoms to determine which test is more reliable and patient-friendly.
Participants will:
- Undergo both an ultrasound and a NCS for comparison.
- Visit the clinic for testing and evaluation as part of the study.
- Provide information about their symptoms and medical history related to CTS. This study aims to improve diagnosis accuracy and explore whether ultrasound could be a more comfortable and quicker alternative to NCS for detecting CTS.
Read the detailed description
This study aims to compare ultrasound and NCS for diagnosing CTS by analyzing key median nerve parameters in both tests. CTS is a common condition caused by compression of the median nerve at the wrist, leading to symptoms such as numbness, tingling, and weakness in the hand. Accurate diagnosis is essential to ensure appropriate treatment.
Currently, NCS is considered the standard test for CTS diagnosis, measuring nerve function by assessing conduction velocity and latency. However, ultrasound has emerged as a potential alternative by providing structural imaging of the median nerve, including parameters like cross-sectional area (CSA), echogenicity, and flattening ratio.
The primary objective of this study is to determine whether ultrasound can be a reliable, non-invasive, and patient-friendly alternative to NCS for CTS diagnosis. By comparing nerve measurements obtained from both methods, researchers aim to evaluate their diagnostic accuracy, sensitivity, and specificity.
Participants with suspected CTS will undergo both ultrasound and NCS for comparison. Data will be analyzed to determine which test provides the most precise and clinically useful information. The findings of this study may help refine diagnostic protocols, potentially reducing the need for NCS in certain cases and offering a faster, more comfortable option for patients.
- Conditions
- Carpal Tunnel Syndrome (CTS), Nerve Conduction, Ultrasound
- Being tested
- Nerve Conduction Study
- Keywords
- Carpal Tunnel Syndrome, Numbness, Tingling, Ultrasound, Nerve Conduction Study, Hand Weakness
- Medical subject headings
- Carpal Tunnel Syndrome, Hypesthesia, Paresthesia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Nerve Conduction StudyDiagnostic test
This study involves two diagnostic interventions for evaluating CTS:
Ultrasound Examination (Diagnostic Intervention)
- A high-frequency ultrasound probe will be used to assess the median nerve at the wrist.
- Parameters measured include cross-sectional area, flattening ratio, and echogenicity.
The goal is to determine if ultrasound can accurately diagnose CTS compared to NCS.
NCS (Diagnostic Intervention)
- Surface electrodes will be placed on the skin to stimulate and record median nerve conduction.
- Parameters such as latency, conduction velocity, and amplitude will be recorded.
- NCS serves as the gold standard for diagnosing CTS and will be used for comparison with ultrasound results.
Each participant will undergo both ultrasound and NCS, allowing researchers to compare their effectiveness in diagnosing CTS.
| Study group | Role | What they receive |
|---|---|---|
| Ultrasound Diagnostic Arm | Other | Participants in this arm will undergo ultrasound imaging of the median nerve at the wrist. Measurements such as CSA and flattening ratio will be recorded. The goal is to evaluate ultrasound's effectiveness in diagnosing CTS compared to NCS. Receives: Diagnostic Test: Nerve Conduction Study |
| Nerve Conduction Study (NCS) Group (Diagnostic Arm) | Other | Participants in this arm will undergo an NCS to assess median nerve function. Parameters such as nerve conduction velocity, latency, and amplitude will be recorded. NCS findings will serve as the gold standard for comparison with ultrasound results. Receives: Diagnostic Test: Nerve Conduction Study |
What is being measured
The primary outcome is the main question the study is designed to answer.
Diagnostic Accuracy of Ultrasound Compared to Nerve Conduction Study for Carpal Tunnel Syndrome
Measuring the sensitivity, specificity, and overall accuracy of ultrasound in diagnosing CTS compared to NCS Parameters, including Median Nerve Latency, Amplitude, and Nerve Conduction Velocity
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Apr 2025
- Study start1 May 2025 (estimated)
- Primary completion1 Jul 2025 (estimated)
- Study completion1 Jul 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Carpal Tunnel Syndrome (CTS)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Combined Military Hospital Kohat Pakistan
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Syed Tameem Ul Hassan, Combined Military Hospital Kohat Pakistan
- Investigators
- Syed Tameem Ul Hassan, MBBS, FCPS, Principal investigator, Combined Military Hospital Kohat
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06926777
- Sponsor's protocol ID
- E-2005/A/114
- Status last verified
- Apr 2025
- First submitted
- 15 Mar 2025
- Last updated
- 15 Apr 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Following IPD will be shared 1. De-identified demographic data that is age, gender, relevant medical history. 2. Ultrasound measurements of the median nerve such as CSA and flattening ratio. 3. NCS results such as latency, conduction velocity and amplitude. 4. Clinical assessment findings such as Tinel's sign, Phalen's test results.
Study at a glance
From the registry record, last updated by the sponsor on 15 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Analysis of Median Nerve Parameters for Carpal Tunnel Syndrome (CTS) Diagnosis: Ultrasound Versus Nerve Conduction Studies (NCS)
- ClinicalTrials.gov ID
- NCT06926777
- Acronym / sponsor ID
- E-2005/A/114
- Conditions
- Carpal Tunnel Syndrome (CTS), Nerve Conduction, Ultrasound
- Keywords
- Carpal Tunnel Syndrome, Numbness, Tingling, Ultrasound, Nerve Conduction Study, Hand Weakness
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Combined Military Hospital Kohat PakistanOther government
- Study start
- 1 May 2025 (estimated)
- Primary completion
- 1 Jul 2025 (estimated)
- Study completion
- 1 Jul 2025 (estimated)
- First posted
- 15 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Comparative Analysis of Median Nerve Parameters for Carpal Tunnel Syndrome (CTS) Diagnosis: Ultrasound vs. Nerve Conduction Study (NCS) This clinical study aims to determine whether ultrasound can be as practical as NCS in diagnosing CTS. It will also evaluate the accuracy of different median nerve measurements in both tests.
The main questions it aims to answer are:
Can ultrasound accurately detect CTS compared to NCS? Which median nerve measurements (such as size, speed, or function) are most useful for diagnosis? Researchers will compare ultrasound and NCS results in patients with CTS symptoms to determine which test is more reliable and patient-friendly.
Participants will:
- Undergo both an ultrasound and a NCS for comparison.
- Visit the clinic for testing and evaluation as part of the study.
- Provide information about their symptoms and medical history related to CTS. This study aims to improve diagnosis accuracy and explore whether ultrasound could be a more comfortable and quicker alternative to NCS for detecting CTS.
Detailed description
This study aims to compare ultrasound and NCS for diagnosing CTS by analyzing key median nerve parameters in both tests. CTS is a common condition caused by compression of the median nerve at the wrist, leading to symptoms such as numbness, tingling, and weakness in the hand. Accurate diagnosis is essential to ensure appropriate treatment.
Currently, NCS is considered the standard test for CTS diagnosis, measuring nerve function by assessing conduction velocity and latency. However, ultrasound has emerged as a potential alternative by providing structural imaging of the median nerve, including parameters like cross-sectional area (CSA), echogenicity, and flattening ratio.
The primary objective of this study is to determine whether ultrasound can be a reliable, non-invasive, and patient-friendly alternative to NCS for CTS diagnosis. By comparing nerve measurements obtained from both methods, researchers aim to evaluate their diagnostic accuracy, sensitivity, and specificity.
Participants with suspected CTS will undergo both ultrasound and NCS for comparison. Data will be analyzed to determine which test provides the most precise and clinically useful information. The findings of this study may help refine diagnostic protocols, potentially reducing the need for NCS in certain cases and offering a faster, more comfortable option for patients.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Ultrasound Diagnostic Arm | Other | Diagnostic Test: Nerve Conduction StudyParticipants in this arm will undergo ultrasound imaging of the median nerve at the wrist. Measurements such as CSA and flattening ratio will be recorded. The goal is to evaluate ultrasound's effectiveness in diagnosing CTS compared to NCS. |
| Nerve Conduction Study (NCS) Group (Diagnostic Arm) | Other | Diagnostic Test: Nerve Conduction StudyParticipants in this arm will undergo an NCS to assess median nerve function. Parameters such as nerve conduction velocity, latency, and amplitude will be recorded. NCS findings will serve as the gold standard for comparison with ultrasound results. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adults aged 18 years or older.
- Patients with clinical symptoms of CTS, including numbness, tingling, pain, or weakness in the hand.
- Positive findings on clinical examination, such as Tinel's sign, Phalen's test, or Durkan's test.
- Willingness to undergo both ultrasound and NCS for diagnostic evaluation.
Key exclusion criteria (6 listed)
- Previous surgery for CTS in the affected hand.
- History of peripheral neuropathy such as diabetic neuropathy
- Other neuromuscular disorders affecting the upper limb such as cervical radiculopathy.
- Pregnant women.
- Severe comorbid conditions that may interfere with study participation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Nerve Conduction StudyThis study involves two diagnostic interventions for evaluating CTS: Ultrasound Examination (Diagnostic Intervention) 1. A high-frequency ultrasound probe will be used to assess the median nerve at the wrist. 2. Parameters measured include cross-sectional area, flattening ratio, and echogenicity. The goal is to determine if ultrasound can accurately diagnose CTS compared to NCS. NCS (Diagnostic Intervention) 1. Surface electrodes will be placed on the skin to stimulate and record median nerve conduction. 2. Parameters such as latency, conduction velocity, and amplitude will be recorded. 3. NCS serves as the gold standard for diagnosing CTS and will be used for comparison with ultrasound results. Each participant will undergo both ultrasound and NCS, allowing researchers to compare their effectiveness in diagnosing CTS. | Diagnostic test | Nerve Conduction Study (NCS) Group (Diagnostic Arm), Ultrasound Diagnostic Arm |
Primary outcome
Diagnostic Accuracy of Ultrasound Compared to Nerve Conduction Study for Carpal Tunnel Syndrome
Time frame: Baseline
Measuring the sensitivity, specificity, and overall accuracy of ultrasound in diagnosing CTS compared to NCS Parameters, including Median Nerve Latency, Amplitude, and Nerve Conduction Velocity
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Apr 2025.
- Individual participant dataSharing planned: Yes. Following IPD will be shared 1. De-identified demographic data that is age, gender, relevant medical history. 2. Ultrasound measurements of the median nerve such as CSA and flattening ratio. 3. NCS results such as latency, conduction velocity and amplitude. 4. Clinical assessment findings such as Tinel's sign, Phalen's test results.
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Hand Function Outcome After the Application of Transfer Energy Capacitive and Resistive on Post-burn Patients Presented With Carpal Tunnel Syndrome
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Syed Tameem Ul Hassan, MBBS, FCPS principal investigator
Combined Military Hospital Kohat
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Nerve Conduction Study in people with Carpal Tunnel Syndrome (CTS) and Nerve Conduction, run by Combined Military Hospital Kohat Pakistan at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 15 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Syed Tameem Ul Hassan, MBBS, FCPS (00923368885877, drtameem2@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Diagnostic Accuracy of Ultrasound Compared to Nerve Conduction Study for Carpal Tunnel Syndrome (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Apr 2025.