Carpal Tunnel SurgeryNCT07899203
Effect of Progressive Gamified Motor Rehabilitation After Carpal Tunnel Release
A study testing gamified motor rehabilitation and conventional physical therapy treatment for patient with carpal tunnel syndrome in people with Carpal Tunnel Surgery, run by Al-Zaytoonah University of Jordan.
Trial summary
Carpal tunnel syndrome is the most common peripheral entrapment neuropathy and may result in sensory and motor impairment, particularly in patients with severe disease and thenar muscle atrophy. Read more about this study
- Who is it for?
- Ages 40 to 65 years
- Conditions the study is for
- Carpal Tunnel Surgery
- What is being tested?
- gamified motor rehabilitation and conventional physical therapy treatment for patient with carpal tunnel syndrome
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- No sites listed yet
- Study dates
- 25 Oct 2026to 10 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients with unilateral severe carpal tunnel syndrome confirmed by clinical and electrophysiological assessment.
- Presence of thenar muscle atrophy on clinical examination.
- Patients who have undergone carpal tunnel release surgery for the affected hand.
- Medically cleared by the treating surgeon to participate in postoperative hand rehabilitation.
- Adequate wound healing allowing initiation of the prescribed rehabilitation program.
- Ability to understand and follow verbal and written instructions.
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- Ability to perform the required hand and thumb movements safely.
- Willingness to participate in the complete rehabilitation program and outcome assessments.
- Provision of written informed consent.
Who cannot join
- Previous surgery or major trauma involving the affected wrist or hand.
- Other peripheral neuropathies affecting the upper limb or hand.
- Cervical radiculopathy, cervical myelopathy, or other neurological disorders that may affect hand function.
- Coexisting neurological disorders affecting upper-limb motor function.
- Musculoskeletal conditions of the shoulder, elbow, wrist, or hand that significantly limit hand function or interfere with the intervention.
- Bilateral carpal tunnel syndrome requiring simultaneous rehabilitation of both hands.
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- Previous carpal tunnel release surgery on the same hand.
- Postoperative complications that prevent or substantially limit participation in rehabilitation.
- Severe cognitive, visual, or communication impairment that prevents understanding or performing the intervention.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effect of Progressive Gamified Motor Rehabilitation on Hand Function and Electrophysiological Outcomes After Carpal Tunnel Release: A Randomized Controlled Trial
Carpal tunnel syndrome is the most common peripheral entrapment neuropathy and may result in sensory and motor impairment, particularly in patients with severe disease and thenar muscle atrophy. Progressive gamified motor rehabilitation using sensor-based interactive technology may provide an engaging approach to facilitate repetitive, task-oriented hand and thumb movements while allowing progression according to the individual's performance and tolerance. However, the effectiveness of incorporating such an approach into conventional postoperative rehabilitation in patients with severe carpal tunnel syndrome and thenar atrophy remains unclear.
- Conditions
- Carpal Tunnel Surgery
- Being tested
- gamified motor rehabilitation, conventional physical therapy treatment for patient with carpal tunnel syndrome
- Keywords
- carpal tunnel release, game therapy, electrophysiological study
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
gamified motor rehabilitationOther
uses interactive smartphone apps connected with small ball via Bluetooth to turn standard hand and thumb exercises into engaging, game-like tasks.
conventional physical therapy treatment for patient with carpal tunnel syndromeOther
- Nerve Gliding (Neurodynamic) Exercises: Gentle movements of the wrist, fingers, and head help the median nerve slide smoothly through the carpal tunnel and prevent it from sticking to surrounding tissues.
- Tendon Gliding Exercises: Specific finger and hand sequences (such as moving from a straight hand to a hook, full fist, and tabletop position) encourage smooth tendon movement and decrease swelling.
- Stretching \& Strengthening: Gentle flexor and extensor stretches improve flexibility, while progressive strengthening exercises for the hand, wrist, and forearm are introduced once acute symptoms subside.
| Study group | Role | What they receive |
|---|---|---|
| Gamified motor group | Experimental | received gamified motor rehabilitation and conventional treatment Receives: Other: gamified motor rehabilitation |
| Standard therapy group | Active comparator | received conventional treatment (hand grip strengthening exercise functional care training) Receives: Other: conventional physical therapy treatment for patient with carpal tunnel syndrome |
What is being measured
The primary outcome is the main question the study is designed to answer.
Median Nerve Motor Distal Latency and Motor Conduction Velocity
Median nerve motor distal latency (DL), measured in milliseconds (ms), and motor conduction velocity (MCV), measured in meters per second (m/s), will be assessed using a nerve conduction study before and after the intervention to evaluate motor nerve conduction following carpal tunnel release.
Measured: 6 weeks
Secondary outcomes (2)
Arabic Version of the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) Questionnaire
Upper-limb disability and symptoms will be assessed using the Arabic version of the QuickDASH questionnaire, an 11-item patient-reported outcome measure. The total score ranges from 0 to 100, with higher scores indicating greater disability. The questionnaire will be administered at baseline and immediately after the intervention to assess changes in upper-limb functional status.
Measured: 6 weeks
Arabic Version of the Boston Carpal Tunnel Questionnaire (BCTQ) Score
Carpal tunnel syndrome symptoms and functional limitations will be assessed using the Arabic version of the Boston Carpal Tunnel Questionnaire (BCTQ), a patient-reported outcome measure consisting of two subscales: the Symptom Severity Scale (SSS; 11 items) and the Functional Status Scale (FSS; 8 items). Each item is scored on a 1-5 scale, with higher scores indicating greater symptom severity and functional limitation. The questionnaire will be administered at baseline and immediately after the intervention.
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Oct 2026
- Study start25 Oct 2026 (estimated)
- Primary completion31 Dec 2026 (estimated)
- Study completion10 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Carpal Tunnel SurgeryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Al-Zaytoonah University of Jordan
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hanan Hosny M Battesha, Al-Zaytoonah University of Jordan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07899203
- Sponsor's protocol ID
- Carpal Tunnel Release
- Status last verified
- Oct 2026
- First submitted
- 18 Oct 2026
- Last updated
- 27 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Progressive Gamified Motor Rehabilitation on Hand Function and Electrophysiological Outcomes After Carpal Tunnel Release: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07899203
- Acronym / sponsor ID
- Carpal Tunnel Release
- Conditions
- Carpal Tunnel Surgery
- Keywords
- carpal tunnel release, game therapy, electrophysiological study
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Al-Zaytoonah University of JordanUniversity, hospital or other
- Study start
- 25 Oct 2026 (estimated)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 10 Jan 2027 (estimated)
- First posted
- 27 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Carpal tunnel syndrome is the most common peripheral entrapment neuropathy and may result in sensory and motor impairment, particularly in patients with severe disease and thenar muscle atrophy. Progressive gamified motor rehabilitation using sensor-based interactive technology may provide an engaging approach to facilitate repetitive, task-oriented hand and thumb movements while allowing progression according to the individual's performance and tolerance. However, the effectiveness of incorporating such an approach into conventional postoperative rehabilitation in patients with severe carpal tunnel syndrome and thenar atrophy remains unclear.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Gamified motor group | Experimental | Other: gamified motor rehabilitationreceived gamified motor rehabilitation and conventional treatment |
| Standard therapy group | Active comparator | Other: conventional physical therapy treatment for patient with carpal tunnel syndromereceived conventional treatment (hand grip strengthening exercise functional care training) |
Who may qualify
- Ages
- 40 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- Patients with unilateral severe carpal tunnel syndrome confirmed by clinical and electrophysiological assessment.
- Presence of thenar muscle atrophy on clinical examination.
- Patients who have undergone carpal tunnel release surgery for the affected hand.
- Medically cleared by the treating surgeon to participate in postoperative hand rehabilitation.
- Adequate wound healing allowing initiation of the prescribed rehabilitation program.
Key exclusion criteria (9 listed)
- Previous surgery or major trauma involving the affected wrist or hand.
- Other peripheral neuropathies affecting the upper limb or hand.
- Cervical radiculopathy, cervical myelopathy, or other neurological disorders that may affect hand function.
- Coexisting neurological disorders affecting upper-limb motor function.
- Musculoskeletal conditions of the shoulder, elbow, wrist, or hand that significantly limit hand function or interfere with the intervention.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| gamified motor rehabilitationuses interactive smartphone apps connected with small ball via Bluetooth to turn standard hand and thumb exercises into engaging, game-like tasks. | Other | Gamified motor group |
| conventional physical therapy treatment for patient with carpal tunnel syndrome* Nerve Gliding (Neurodynamic) Exercises: Gentle movements of the wrist, fingers, and head help the median nerve slide smoothly through the carpal tunnel and prevent it from sticking to surrounding tissues. * Tendon Gliding Exercises: Specific finger and hand sequences (such as moving from a straight hand to a hook, full fist, and tabletop position) encourage smooth tendon movement and decrease swelling. * Stretching \& Strengthening: Gentle flexor and extensor stretches improve flexibility, while progressive strengthening exercises for the hand, wrist, and forearm are introduced once acute symptoms subside. | Other | Standard therapy group |
Primary outcome
Median Nerve Motor Distal Latency and Motor Conduction Velocity
Time frame: 6 weeks
Median nerve motor distal latency (DL), measured in milliseconds (ms), and motor conduction velocity (MCV), measured in meters per second (m/s), will be assessed using a nerve conduction study before and after the intervention to evaluate motor nerve conduction following carpal tunnel release.
2 secondary outcomes
Arabic Version of the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) Questionnaire
Time frame: 6 weeks
Arabic Version of the Boston Carpal Tunnel Questionnaire (BCTQ) Score
Time frame: 6 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing gamified motor rehabilitation and conventional physical therapy treatment for patient with carpal tunnel syndrome in people with Carpal Tunnel Surgery, run by Al-Zaytoonah University of Jordan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact hanan mohamed, associate professor (+962775661825, h.hosny@zuj.edu.jo), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Median Nerve Motor Distal Latency and Motor Conduction Velocity (time frame: 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.