SciaticaNCT06947785
Effectiveness of Combined Neural Mobilization With Manual Myofascial Release for Sciatic Pain Relief
A study testing Combined Neural Mobilization with Manual myofascial Release, Neural Mobilization and Manual Myofascial Release in people with Sciatica, run by Riphah International University at 1 site in Pakistan.
Trial summary
This study will address to evaluate and compare both Neural mobilization and Manual Myofascial Release of piriformis and Lumbar muscles in sciatic pain with the aim of evaluating and identifying the most effective intervention for managing this specific condition, and provide valuable insights into the effectiveness… Read more about this study
- Who is it for?
- Ages 20 to 40 years
- Conditions the study is for
- Sciatica
- What is being tested?
- Combined Neural Mobilization with Manual myofascial Release, Neural Mobilization and Manual Myofascial Release
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Apr 2025to 31 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Clinically diagnosed unilateral sciatic pain for >3 months.
- Positive Straight Leg Raise (SLR).
Who cannot join
- Participants fall in this category would be excluded of the study.
- Recent spinal surgery or trauma.
- Neurological deficits or systemic conditions affecting the nervous system.
- Any other red flags
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Riphah International University, Malakand
Chakdara, KPK, 18800
About this study
This study will address to evaluate and compare both Neural mobilization and Manual Myofascial Release of piriformis and Lumbar muscles in sciatic pain with the aim of evaluating and identifying the most effective intervention for managing this specific condition, and provide valuable insights into the effectiveness, mechanisms, and practical considerations associated with these interventions, ultimately contributing to evidence based and patient centered care.
Read the detailed description
MFR is a hands-on technique targeting fascial restrictions that may contribute to pain and reduced mobility. Barnes proposed that releasing fascial adhesions can improve circulation, reduce nerve compression, and enhance tissue flexibility. In a study by Ajimsha et al. , MFR was found to significantly reduce pain and improve physical function in patients with nonspecific low back pain. There is a lack of comparative research assessing the relative efficacy of neural mobilization andMFR in sciatic pain management. While both techniques are rooted in distinct mechanisms neural desensitization versus fascial release they may have overlapping benefits in improving mobility and reducing pain. This study addresses this research gap by directly comparing the two approaches in individuals with sciatic pain.
- Conditions
- Sciatica
- Being tested
- Combined Neural Mobilization with Manual myofascial Release, Neural Mobilization, Manual Myofascial Release
- Keywords
- Neural Mobilization, Myofascial Release, Sciatic Pain
- Medical subject headings
- Sciatica
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Combined Neural Mobilization with Manual myofascial ReleaseOther
Also called Neural Mobilization, Manual Myofascial Release
Combined neural mobilization with manual myofascial release will be provided to each subject.
Neural MobilizationOther
Also called Combined Neural Mobilization with Manual myofascial Release, Manual Myofascial Release
neural mobilization will be provided to each subject.
Manual Myofascial ReleaseOther
Also called Combined Neural Mobilization with Manual myofascial Release, Neural Mobilization
Manual myofascial release will be provided to each subject.
| Study group | Role | What they receive |
|---|---|---|
| Combined Neural Mobilization with Manual myofascial Release | Experimental | Combined neural mobilization of Sciatic nerve and manual myofascial release of piriformis and back muscles will be given to this group. Receives: Other: Combined Neural Mobilization with Manual myofascial Release |
| Neural Mobilization | Active comparator | Only neural mobilization of Sciatic nerve will be given to this group. Receives: Other: Neural Mobilization |
| Manual Myofascial Release | Active comparator | Only manual myofascial release of piriformis and back muscles will be given to this group. Receives: Other: Manual Myofascial Release |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numerical pain rating scale
A subjective pain assessment tool where patients rate their pain intensity on a scale from 0 (no pain) to 10 (worst imaginable pain).
Measured: Four Weeks
Universal Goniometer
Joint range of motion will be measured using a Universal Goniometer in degrees (°). Each joint movement will be assessed individually. The goniometer will be used following standardized procedures as per the American Academy of Orthopaedic Surgeons (AAOS) guidelines. Unit of Measure is degrees.
Measured: Four Weeks
Patient-Specific Functional Scale
The Patient-Specific Functional Scale is a validated patient-reported outcome measure used to assess functional limitations based on activities identified by the patient. Participants will rate their ability to perform 3-5 self-selected activities that are important to them, using an 11-point scale ranging from 0 to 10.
Minimum score: 0 (indicating the patient is unable to perform the activity)
Maximum score: 10 (indicating the patient can perform the activity at their prior level with no difficulty)
Interpretation: Higher scores indicate better functional status.
The average score across all selected activities will be used for analysis.
Measured: Four Weeks
SLR (Straight Leg Raise)
A clinical test used to assess sciatic nerve irritation or lumbar radiculopathy by raising the extended leg while the patient lies supine.
Measured: Four Weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Apr 2025
- Study start15 Apr 2025
- Primary completion3 Oct 2025
- Study completion31 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for SciaticaStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 48 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Amnah Anum, MSPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06947785
- Sponsor's protocol ID
- REC-01004 Anwar Ullah
- Status last verified
- Apr 2026
- First submitted
- 7 Apr 2025
- Last updated
- 8 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Combined Neural Mobilization With Manual Myofascial Release for Sciatic Pain Relief
- ClinicalTrials.gov ID
- NCT06947785
- Acronym / sponsor ID
- REC-01004 Anwar Ullah
- Conditions
- Sciatica
- Keywords
- Neural Mobilization, Myofascial Release, Sciatic Pain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 48 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 15 Apr 2025 (actual)
- Primary completion
- 3 Oct 2025 (actual)
- Study completion
- 31 Dec 2025 (actual)
- First posted
- 27 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will address to evaluate and compare both Neural mobilization and Manual Myofascial Release of piriformis and Lumbar muscles in sciatic pain with the aim of evaluating and identifying the most effective intervention for managing this specific condition, and provide valuable insights into the effectiveness, mechanisms, and practical considerations associated with these interventions, ultimately contributing to evidence based and patient centered care.
Detailed description
MFR is a hands-on technique targeting fascial restrictions that may contribute to pain and reduced mobility. Barnes proposed that releasing fascial adhesions can improve circulation, reduce nerve compression, and enhance tissue flexibility. In a study by Ajimsha et al. , MFR was found to significantly reduce pain and improve physical function in patients with nonspecific low back pain. There is a lack of comparative research assessing the relative efficacy of neural mobilization andMFR in sciatic pain management. While both techniques are rooted in distinct mechanisms neural desensitization versus fascial release they may have overlapping benefits in improving mobility and reducing pain. This study addresses this research gap by directly comparing the two approaches in individuals with sciatic pain.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Combined Neural Mobilization with Manual myofascial Release | Experimental | Other: Combined Neural Mobilization with Manual myofascial ReleaseCombined neural mobilization of Sciatic nerve and manual myofascial release of piriformis and back muscles will be given to this group. |
| Neural Mobilization | Active comparator | Other: Neural MobilizationOnly neural mobilization of Sciatic nerve will be given to this group. |
| Manual Myofascial Release | Active comparator | Other: Manual Myofascial ReleaseOnly manual myofascial release of piriformis and back muscles will be given to this group. |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Clinically diagnosed unilateral sciatic pain for >3 months.
- Positive Straight Leg Raise (SLR).
Key exclusion criteria (4 listed)
- Participants fall in this category would be excluded of the study.
- Recent spinal surgery or trauma.
- Neurological deficits or systemic conditions affecting the nervous system.
- Any other red flags
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Combined Neural Mobilization with Manual myofascial ReleaseAlso: Neural Mobilization, Manual Myofascial ReleaseCombined neural mobilization with manual myofascial release will be provided to each subject. | Other | Combined Neural Mobilization with Manual myofascial Release |
| Neural MobilizationAlso: Combined Neural Mobilization with Manual myofascial Release, Manual Myofascial Releaseneural mobilization will be provided to each subject. | Other | Neural Mobilization |
| Manual Myofascial ReleaseAlso: Combined Neural Mobilization with Manual myofascial Release, Neural MobilizationManual myofascial release will be provided to each subject. | Other | Manual Myofascial Release |
Primary outcome
Numerical pain rating scale
Time frame: Four Weeks
A subjective pain assessment tool where patients rate their pain intensity on a scale from 0 (no pain) to 10 (worst imaginable pain).
Universal Goniometer
Time frame: Four Weeks
Joint range of motion will be measured using a Universal Goniometer in degrees (°). Each joint movement will be assessed individually. The goniometer will be used following standardized procedures as per the American Academy of Orthopaedic Surgeons (AAOS) guidelines. Unit of Measure is degrees.
Patient-Specific Functional Scale
Time frame: Four Weeks
The Patient-Specific Functional Scale is a validated patient-reported outcome measure used to assess functional limitations based on activities identified by the patient. Participants will rate their ability to perform 3-5 self-selected activities that are important to them, using an 11-point scale ranging from 0 to 10. Minimum score: 0 (indicating the patient is unable to perform the activity) Maximum score: 10 (indicating the patient can perform the activity at their prior level with no difficulty) Interpretation: Higher scores indicate better functional status. The average score across all selected activities will be used for analysis.
SLR (Straight Leg Raise)
Time frame: Four Weeks
A clinical test used to assess sciatic nerve irritation or lumbar radiculopathy by raising the extended leg while the patient lies supine.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Amnah Anum, MSPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Combined Neural Mobilization with Manual myofascial Release, Neural Mobilization and Manual Myofascial Release in people with Sciatica, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numerical pain rating scale (time frame: Four Weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2026.