Glucose ResponseNCT06949683
Effects of Meal and Exercise Sequence on Glucose and Blood Pressure Responses
A study testing Meal-Exercise and Exercise-Meal in people with Glucose Response and Blood Pressure, run by National Taiwan Normal University at 1 site in Taiwan.
Trial summary
The purpose of this study is to investigate whether the sequence meal and exercise (exercise before meal or exercise after meal) affects the postprandial metabolism. Read more about this study
- Who is it for?
- Ages 20 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Glucose Response, Blood Pressure
- What is being tested?
- Meal-Exercise and Exercise-Meal
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteTaiwan
- Study dates
- 24 Nov 2023to 9 Jan 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between 20 and 45 years
- Body Mass Index (BMI) ranging from 18.5 to 27 kg/m2
- No habits of heavy drinking or smoking, or have quit smoking for at least 6 months
- Absence of diabetes, cardiovascular, or metabolic-related disorders
- Not currently taking medications, or other supplements that may affect blood sugar, blood pressure, or metabolic changes
- No current sports injuries or medical advice against exercise
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- No significant weight fluctuations in the past three months (within ±3% of usual body weight)
- Not experiencing shift work or travel across time zones within the past 6 months
- No current plans to change lifestyle habits and willing to adhere to the requirements of the study
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
About this study
The purpose of this study is to investigate whether the sequence meal and exercise (exercise before meal or exercise after meal) affects the postprandial metabolism.
Read the detailed description
Trial days In the 24 h prior to each main trial, participants were asked to refrain from performing any strenuous physical activity and from consuming alcohol/caffeine. Dinner intake was recorded before the first main trial and participants were asked to replicate this diet prior to their second main trial.
On main trial days, participants arrived at the laboratory between 8-9 am following a 10-hour fast. After measuring height, blood pressure, pulse, and obtaining finger-prick blood samples, participants underwent EM or ME intervention.
The entire experiment lasted a total of 150 minutes. During the initial 50 minutes, participants were randomly assigned to either exercise before or after breakfast. Participants were asked to finish their breakfast within approximately 5 minutes. The exercise regimen consisted of brisk walking for 22 minutes at a speed of 6 km/hr on the indoor track. After a 25-minute break, the second meal was provided. Participants then underwent a 75-minute observation period during the postprandial phase. Blood pressure and pulse were assessed with the individual seated in a relaxed, upright position on a chair, with the arm properly positioned. Two measurements of blood pressure and pulse were taken, and these values were averaged to ensure that the two readings were within 5 mmHg of each other. If the two readings differed by more than 5 mmHg, additional readings were taken until the outlying measurement was excluded. The test meal consists of red bean dorayaki (CHUAN LIAN Enterprise Co., Ltd.) and soy milk (I-MEI Foods Co., Ltd.). The breakfast provided contained 348 kcal, with a macronutrient distribution of 60% carbohydrates, 12% protein, and 28% fat. The second meal contained 207 kcal, with a macronutrient distribution of 66% carbohydrates, 6% protein, and 28% fat.
Finger-prick blood samples, blood pressure, and pulse were measured every 25 minutes during the experiment using the Freestyle Optium Neo (Abbott Diabetes Care, Ltd., UK) and the OMRON HEM-7320 blood pressure monitor (OMRON Co., Ltd., Japan). Two measurements of blood pressure and pulse were taken, and these values were averaged to ensure that the two readings were within 5 mmHg of each other. If the two readings differed by more than 5 mmHg, additional readings were taken until the outlying measurement was excluded. Blood pressure and pulse were assessed with the individual seated in a relaxed, upright position on a chair, with the arm properly positioned.
- Conditions
- Glucose Response, Blood Pressure
- Being tested
- Meal-Exercise, Exercise-Meal
- Keywords
- Fasted-exercise, Post-Exercise Hypotension, Postprandial glucose responses, Blood pressure
- Medical subject headings
- Post-Exercise Hypotension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Meal-ExerciseBehavioural
Breakfast intake before 22 minutes of brisk walking, followed by a lunch intake for another 75 minutes of observation period. The entire experiment lasted a total of 150 minutes.
Exercise-MealBehavioural
22 minutes of brisk walking before breakfast intake, followed by 75 minutes of observational period. The entire experiment lasted a total of 150 minutes
| Study group | Role | What they receive |
|---|---|---|
| Meal-Exercise | Experimental | Breakfast intake before 22 minutes of brisk walking Receives: Behavioral: Meal-Exercise |
| Exercise-Meal | Experimental | 22 minutes of brisk walking before breakfast intake Receives: Behavioral: Exercise-Meal |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postprandial glucose concentrations
Changes in glucose responses during trials
Measured: 150 minutes
Blood pressure
Changes in blood pressure (e.g., diastolic and systolic blood pressure) during trials
Measured: 150 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Apr 2025
- Study start24 Nov 2023
- Primary completion9 Jan 2024
- Study completion9 Jan 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Glucose ResponseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 18 participants (actual)
Sponsor and investigators
- Lead sponsor
- National Taiwan Normal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yung-Chih Chen, National Taiwan Normal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06949683
- Sponsor's protocol ID
- 202310HM014-1
- Status last verified
- Apr 2025
- First submitted
- 22 Apr 2025
- Last updated
- 2 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Meal and Exercise Sequence on Glucose and Blood Pressure Responses
- ClinicalTrials.gov ID
- NCT06949683
- Acronym / sponsor ID
- 202310HM014-1
- Conditions
- Glucose Response, Blood Pressure
- Keywords
- Fasted-exercise, Post-Exercise Hypotension, Postprandial glucose responses, Blood pressure
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 18 participants (actual)
- Lead sponsor
- National Taiwan Normal UniversityUniversity, hospital or other
- Study start
- 24 Nov 2023 (actual)
- Primary completion
- 9 Jan 2024 (actual)
- Study completion
- 9 Jan 2024 (actual)
- First posted
- 29 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to investigate whether the sequence meal and exercise (exercise before meal or exercise after meal) affects the postprandial metabolism.
Detailed description
Trial days In the 24 h prior to each main trial, participants were asked to refrain from performing any strenuous physical activity and from consuming alcohol/caffeine. Dinner intake was recorded before the first main trial and participants were asked to replicate this diet prior to their second main trial.
On main trial days, participants arrived at the laboratory between 8-9 am following a 10-hour fast. After measuring height, blood pressure, pulse, and obtaining finger-prick blood samples, participants underwent EM or ME intervention.
The entire experiment lasted a total of 150 minutes. During the initial 50 minutes, participants were randomly assigned to either exercise before or after breakfast. Participants were asked to finish their breakfast within approximately 5 minutes. The exercise regimen consisted of brisk walking for 22 minutes at a speed of 6 km/hr on the indoor track. After a 25-minute break, the second meal was provided. Participants then underwent a 75-minute observation period during the postprandial phase. Blood pressure and pulse were assessed with the individual seated in a relaxed, upright position on a chair, with the arm properly positioned. Two measurements of blood pressure and pulse were taken, and these values were averaged to ensure that the two readings were within 5 mmHg of each other. If the two readings differed by more than 5 mmHg, additional readings were taken until the outlying measurement was excluded. The test meal consists of red bean dorayaki (CHUAN LIAN Enterprise Co., Ltd.) and soy milk (I-MEI Foods Co., Ltd.). The breakfast provided contained 348 kcal, with a macronutrient distribution of 60% carbohydrates, 12% protein, and 28% fat. The second meal contained 207 kcal, with a macronutrient distribution of 66% carbohydrates, 6% protein, and 28% fat.
Finger-prick blood samples, blood pressure, and pulse were measured every 25 minutes during the experiment using the Freestyle Optium Neo (Abbott Diabetes Care, Ltd., UK) and the OMRON HEM-7320 blood pressure monitor (OMRON Co., Ltd., Japan). Two measurements of blood pressure and pulse were taken, and these values were averaged to ensure that the two readings were within 5 mmHg of each other. If the two readings differed by more than 5 mmHg, additional readings were taken until the outlying measurement was excluded. Blood pressure and pulse were assessed with the individual seated in a relaxed, upright position on a chair, with the arm properly positioned.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Meal-Exercise | Experimental | Behavioral: Meal-ExerciseBreakfast intake before 22 minutes of brisk walking |
| Exercise-Meal | Experimental | Behavioral: Exercise-Meal22 minutes of brisk walking before breakfast intake |
Who may qualify
- Ages
- 20 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (9 listed)
- Age between 20 and 45 years
- Body Mass Index (BMI) ranging from 18.5 to 27 kg/m2
- No habits of heavy drinking or smoking, or have quit smoking for at least 6 months
- Absence of diabetes, cardiovascular, or metabolic-related disorders
- Not currently taking medications, or other supplements that may affect blood sugar, blood pressure, or metabolic changes
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Meal-ExerciseBreakfast intake before 22 minutes of brisk walking, followed by a lunch intake for another 75 minutes of observation period. The entire experiment lasted a total of 150 minutes. | Behavioural | Meal-Exercise |
| Exercise-Meal22 minutes of brisk walking before breakfast intake, followed by 75 minutes of observational period. The entire experiment lasted a total of 150 minutes | Behavioural | Exercise-Meal |
Primary outcome
Postprandial glucose concentrations
Time frame: 150 minutes
Changes in glucose responses during trials
Blood pressure
Time frame: 150 minutes
Changes in blood pressure (e.g., diastolic and systolic blood pressure) during trials
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 May 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Meal-Exercise and Exercise-Meal in people with Glucose Response and Blood Pressure, run by National Taiwan Normal University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postprandial glucose concentrations (time frame: 150 minutes). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 May 2025.