Glucose LevelsNCT06949709
Effects of Fasted- Versus Fed-exercise on Metabolic Health in Physically Active Adults
A study testing Fasted-exercise and Fed-exercise in people with Glucose Levels and Lipid Profile, run by National Taiwan Normal University at 1 site in Taiwan.
Trial summary
The purpose of this study is to investigate whether the sequence meal and exercise (exercise before meal or exercise after meal) affects the postprandial metabolism. Read more about this study
- Who is it for?
- Ages 20 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Glucose Levels, Lipid Profile, Substrate Oxidation
- What is being tested?
- Fasted-exercise and Fed-exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 siteTaiwan
- Study dates
- 4 Apr 2024to 27 Nov 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between 20 and 45 years
- Regular walking habit of at least 7500 steps per day
- Engage in continuous walking for at least 20 minutes on 2 or more days per week
- Body Mass Index (BMI) ranging from 18.5 to 27 kg/m2
- No habits of heavy drinking or smoking, or have quit smoking for at least 6 months
- Absence of diabetes, cardiovascular, or metabolic-related disorders
Show all 11Show fewer
- Not currently taking prescription drugs, over-the-counter medications, or other supplements that may affect blood sugar, blood pressure, or metabolic changes
- No current sports injuries or medical advice against exercise
- No significant weight fluctuations in the past three months (within ±3% of usual body weight)
- Not experiencing shift work or travel across time zones within the past six months
- No current plans to change lifestyle habits and willing to adhere to the requirements of the study
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Fasted- Versus Fed-exercise on Glucose, Lipid and Blood Pressure Responses in Physically Active Adults
The purpose of this study is to investigate whether the sequence meal and exercise (exercise before meal or exercise after meal) affects the postprandial metabolism.
Read the detailed description
In the 48 h prior to each main trial, participants were asked to refrain from performing any strenuous physical activity and from consuming alcohol/caffeine for 24 h prior to the main trials. A dietary record was completed 24 h before the first main trial and participants were asked to replicate this diet prior to their second main trial.
On main trial days, participants arrived at the laboratory between 8-9 am following a 12-hour fast. The entire experiment lasted a total of 375 minutes. After anthropometric measurements, participants rested on a bed for 20 minutes, during which expired gas samples were collected. During the initial 60 minutes, participants then either consumed a meal before exercise (ME) or after exercise (EM). Participants were asked to finish their breakfast within 10 minutes. In both the ME and EM treatments, participants walked on the treadmill at 6 km/h (for females) and 6.4 km/h (for males) for 30 minutes. Expired gas samples were collected during this time, heart rate (HR) was monitored every 5 minutes and ratings of perceived exertion (RPE) were recorded every 10 minutes. After a 2-hour rest, lunch was provided and consumed within 15 minutes. Participants then underwent a 3-hour observation period during the postprandial phase.
Measurement:
Blood pressure was measured every 30 minutes during the experiment using the OMRON HEM-7320 blood pressure monitor (OMRON Co., Ltd., Japan). Three measurements of blood pressure and pulse were taken, and these values were averaged to ensure that the two readings were within 5 mmHg of each other. If the two readings differed by more than 5 mmHg, additional readings were taken until the outlying measurement was excluded. Blood pressure and pulse were assessed with the individual in a semi-sitting position on the bed, ensuring the arm was properly positioned.
Blood samples were taken at 0, 30, 60, 75, 90, 105, 120, 150, 180, 195, 210, 225, 240, 255, 285, 315, 345, and 375 minutes. The samples were appropriately processed, frozen, and stored in the Exercise Physiology Laboratory refrigerator at the Gongguan Campus of National Taiwan Normal University.
Gas sampling was conducted five times during the experiment. Samples were collected upon arrival at the laboratory, during exercise, one hour after breakfast or exercise, one hour after lunch, and two hours after lunch to determine resting metabolic rate (RMR) and energy expenditure using substrate oxidation.
Subjective self-assessments of appetite and mood were taken at 0, 30, 60, 120, 180, 195, 255, 315, and 375 minutes using a Visual Analog Scale (VAS) ranging from 0 to 100.
- Being tested
- Fasted-exercise, Fed-exercise
- Keywords
- Fasted-exercise, Glucose control, Lipid oxidation
- Medical subject headings
- Insulin Resistance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Fasted-exerciseBehavioural
Breakfast intake before 30 min brisk walking on a treadmill
Fed-exerciseBehavioural
30 min brisk walking on a treadmill before breakfast intake
| Study group | Role | What they receive |
|---|---|---|
| Fasted-exercise | Experimental | Breakfast intake before 30 min walking Receives: Behavioral: Fasted-exercise |
| Fed-exercise | Experimental | 30 min walking before breakfast intake Receives: Behavioral: Fed-exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Glucose responses
Changes in glucose concentrations between trials
Measured: 375 minutes
Insulin responses
Changes in insulin concentrations between trials
Measured: 375 minutes
Secondary outcomes (5)
Triacylglycerol responses
Changes in Triacylglycerol concentrations between trials
Measured: 375 minutes
Blood pressure
Changes in blood pressure (e.g., diastolic and systolic blood pressure) between trials
Measured: 375 minutes
Heart rate variability (HRV)
Changes in heart rate variability between trials
Measured: 375 minutes
Cognitive function
Changes in cognitive function (e.g., Accuracy and reaction time) between trials
Measured: 375 minutes
Visual Analog Scales (VAS)
Changes in VAS (e.g, appetite and mood) between trials
Measured: 375 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Apr 2025
- Study start4 Apr 2024
- Primary completion27 Nov 2024
- Study completion27 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Glucose LevelsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- National Taiwan Normal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yung-Chih Chen, National Taiwan Normal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06949709
- Sponsor's protocol ID
- 202310HM014-2
- Status last verified
- Apr 2025
- First submitted
- 22 Apr 2025
- Last updated
- 2 May 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Fasted- Versus Fed-exercise on Glucose, Lipid and Blood Pressure Responses in Physically Active Adults
- ClinicalTrials.gov ID
- NCT06949709
- Acronym / sponsor ID
- 202310HM014-2
- Keywords
- Fasted-exercise, Glucose control, Lipid oxidation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 16 participants (actual)
- Lead sponsor
- National Taiwan Normal UniversityUniversity, hospital or other
- Study start
- 4 Apr 2024 (actual)
- Primary completion
- 27 Nov 2024 (actual)
- Study completion
- 27 Nov 2024 (actual)
- First posted
- 29 Apr 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to investigate whether the sequence meal and exercise (exercise before meal or exercise after meal) affects the postprandial metabolism.
Detailed description
In the 48 h prior to each main trial, participants were asked to refrain from performing any strenuous physical activity and from consuming alcohol/caffeine for 24 h prior to the main trials. A dietary record was completed 24 h before the first main trial and participants were asked to replicate this diet prior to their second main trial.
On main trial days, participants arrived at the laboratory between 8-9 am following a 12-hour fast. The entire experiment lasted a total of 375 minutes. After anthropometric measurements, participants rested on a bed for 20 minutes, during which expired gas samples were collected. During the initial 60 minutes, participants then either consumed a meal before exercise (ME) or after exercise (EM). Participants were asked to finish their breakfast within 10 minutes. In both the ME and EM treatments, participants walked on the treadmill at 6 km/h (for females) and 6.4 km/h (for males) for 30 minutes. Expired gas samples were collected during this time, heart rate (HR) was monitored every 5 minutes and ratings of perceived exertion (RPE) were recorded every 10 minutes. After a 2-hour rest, lunch was provided and consumed within 15 minutes. Participants then underwent a 3-hour observation period during the postprandial phase.
Measurement:
Blood pressure was measured every 30 minutes during the experiment using the OMRON HEM-7320 blood pressure monitor (OMRON Co., Ltd., Japan). Three measurements of blood pressure and pulse were taken, and these values were averaged to ensure that the two readings were within 5 mmHg of each other. If the two readings differed by more than 5 mmHg, additional readings were taken until the outlying measurement was excluded. Blood pressure and pulse were assessed with the individual in a semi-sitting position on the bed, ensuring the arm was properly positioned.
Blood samples were taken at 0, 30, 60, 75, 90, 105, 120, 150, 180, 195, 210, 225, 240, 255, 285, 315, 345, and 375 minutes. The samples were appropriately processed, frozen, and stored in the Exercise Physiology Laboratory refrigerator at the Gongguan Campus of National Taiwan Normal University.
Gas sampling was conducted five times during the experiment. Samples were collected upon arrival at the laboratory, during exercise, one hour after breakfast or exercise, one hour after lunch, and two hours after lunch to determine resting metabolic rate (RMR) and energy expenditure using substrate oxidation.
Subjective self-assessments of appetite and mood were taken at 0, 30, 60, 120, 180, 195, 255, 315, and 375 minutes using a Visual Analog Scale (VAS) ranging from 0 to 100.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Fasted-exercise | Experimental | Behavioral: Fasted-exerciseBreakfast intake before 30 min walking |
| Fed-exercise | Experimental | Behavioral: Fed-exercise30 min walking before breakfast intake |
Who may qualify
- Ages
- 20 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (11 listed)
- Age between 20 and 45 years
- Regular walking habit of at least 7500 steps per day
- Engage in continuous walking for at least 20 minutes on 2 or more days per week
- Body Mass Index (BMI) ranging from 18.5 to 27 kg/m2
- No habits of heavy drinking or smoking, or have quit smoking for at least 6 months
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Fasted-exerciseBreakfast intake before 30 min brisk walking on a treadmill | Behavioural | Fasted-exercise |
| Fed-exercise30 min brisk walking on a treadmill before breakfast intake | Behavioural | Fed-exercise |
Primary outcome
Glucose responses
Time frame: 375 minutes
Changes in glucose concentrations between trials
Insulin responses
Time frame: 375 minutes
Changes in insulin concentrations between trials
5 secondary outcomes
Triacylglycerol responses
Time frame: 375 minutes
Blood pressure
Time frame: 375 minutes
Heart rate variability (HRV)
Time frame: 375 minutes
Cognitive function
Time frame: 375 minutes
Visual Analog Scales (VAS)
Time frame: 375 minutes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 May 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Fasted-exercise and Fed-exercise in people with Glucose Levels and Lipid Profile, run by National Taiwan Normal University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 11 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Glucose responses (time frame: 375 minutes). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 May 2025.