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EpilepsyNCT06954922

The Effect of Memory-Based Exercise and Planned Training Applied to Epilepsy Patients on Quality of Life

A study testing memory-based exercise and training intervention and educational initiative about epilepsy in people with Epilepsy and Memory Consolidation, run by Ataturk University.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Official record
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Trial summary

Epilepsy; It is a chronic, neurological disease that can occur regardless of social class, race and age. Every year, approximately 5 million people worldwide are diagnosed with epilepsy and 50 million people are affected by this disease, constituting a significant part of the disease burden in the world. Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
memory-based exercise and training intervention and educational initiative about epilepsy
Could I receive a placebo?
No, everyone receives an active treatment
How many people
50 participants
Where
No sites listed yet
Study dates
May 2025to Jan 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Being literate,
  • Being over the age of 18,
  • Having sufficient communication skills to answer oral and written questions and follow instructions,
  • Being at a cognitive level to be able to use a mobile phone and perform the memory exercise.
  • Not having severe vision problems,
  • Having been diagnosed with epilepsy for at least 6 months

Who cannot join

  • Being under 18 years of age
  • Residing outside Bilecik Province
  • Having psychiatric diagnoses such as Bipolar Disorder and Schizophrenia

About this study

Epilepsy; It is a chronic, neurological disease that can occur regardless of social class, race and age. Every year, approximately 5 million people worldwide are diagnosed with epilepsy and 50 million people are affected by this disease, constituting a significant part of the disease burden in the world. When we look at the rate of patients in the population who actively experience symptoms of the disease and need treatment, this rate is approximately 4 to 10 people per 1000 people. According to estimates, 700,000 people in Turkey are actively diagnosed with epilepsy. It is accepted that this disease occurs as a result of sudden, abnormal discharge of neurons in some parts of the central nervous system, and the disease generally progresses with recurrent changes in consciousness. The symptoms accompanying epilepsy are perceived negatively by patients and significantly affect their lives. Epilepsy treatment; It consists of several options such as medical drugs, ketogenic diet and surgical intervention. The ultimate goal of treatment is to achieve seizure control, reduce the frequency of seizures, minimize drug side effects that may occur due to long-term treatment, and improve the patient's quality of life. Along with pharmacological treatment, non-pharmacological treatment is also a valuable approach in the treatment of epilepsy. One of the non-pharmacological approaches is rehabilitation interventions with mind and memory exercises. Epilepsy is a disease that requires a complex psychological adaptation for the patient and affects the whole family. In this disease, it is very important for the patient to comply with the treatment requirements, to have self-control over his/her behavior, as well as to cope with the difficulties of living with epilepsy. Increasing the quality of life and preventing possible behavioral problems is possible by keeping mental functions at an optimal level on the one hand, and providing psychological counseling to the patient and his family on the other. Nowadays, epileptic seizures are often more easily controlled with developing pharmacological treatment options. Therefore, the fight against epilepsy should be expanded to include other educational, mental, psychotherapeutic and behavioral interventions besides drug therapy. In a study conducted by the National Center for Health and Care Research (NIHR), electrical activity scans in the brain of 25 epilepsy patients were examined. Some images in different categories were presented to epilepsy patients for a certain period of time. Later, when asked to remember the images shown in the previous step, it was noted that slow waves occurred in the brain during sleep. As a result of the research, it was revealed that the effect of epileptic spikes on brain activity decreased with the emergence of slow waves. This study has demonstrated for the first time a potential protective mechanism used by the brain to counteract epileptic activity. Patients diagnosed with epilepsy who are admitted to the neurology outpatient clinic or admitted to the neurology clinic will be introduced and informed about the study. Patients who want to participate in the study and meet the inclusion criteria will be determined. After patient consent is obtained, groups will be determined according to the randomization list.

The patient introduction form and the Quality of Life in Epilepsy Scale will be administered to the patients in both groups by the researcher using the face-to-face interview technique (pre-test). Patients in the experimental group will be informed about memory-based exercise and planned training.

Read more

Patients in the control group will only be informed about the planned training to be given.

The experimental group will be given memory-based exercises that will last approximately 15-20 minutes every day for 2 months. Four sessions of epilepsy training will be given, one session per week.

The control group will receive 4 sessions of epilepsy training, one session per week.

At the end of two months, the Quality of Life in Epilepsy Scale (posttest) will be applied to both groups.

Being tested
memory-based exercise and training intervention, educational initiative about epilepsy
Keywords
quality of life, epilepsy, education of patiens, memory
Medical subject headings
Epilepsy

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • memory-based exercise and training interventionBehavioural

    The experimental group will be given memory-based exercises that will last approximately 15-20 minutes every day for 2 months. Four sessions of epilepsy training will be given, one session per week.

  • educational initiative about epilepsyBehavioural

    This group will be given 4 sessions of epilepsy training, one session per week.

Study groups in NCT06954922
Study groupRoleWhat they receive
memory-based exercise and training groupExperimentalNot described
Receives: Behavioral: memory-based exercise and training intervention
training groupExperimentalNot described
Receives: Behavioral: educational initiative about epilepsy

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Patient Introduction Form

    It was prepared by the researcher by examining the literature. It consists of 26 questions, including questions such as age, gender, marital status, educational status, family type, social security, income status, epilepsy diagnosis period, frequency of seizures, presence of another disease, constantly used medication.

    Measured: 2 month

  2. Quality of Life Scale in Epilepsy

    QOLIE-31 was developed by Vickrey et al. in 1993. Mollaoğlu and his colleagues were the researchers who conducted the validity and reliability studies of this scale in Turkey in 2015. QOLIE-31; It consists of a total of 31 questions and 7 subcomponents: 5 on the seizure-related concerns sub-dimension, 3 on the effects of medications sub-dimension, 4 on the energy/fatigue sub-dimension, 5 on the emotional well-being sub-dimension, 6 on the cognitive function sub-dimension, 5 on the social function sub-dimension, 2 on the total quality of life sub-dimension and an additional question assessing the total health status. Scale scoring ranges from 0-100 points. A high score indicates a high quality of life. The total Cronbach's Alpha value in the original scale was determined to be 0.91. In this study, the total Cronbach Alpha value of the scale was found to be 0.90.

    Measured: 2 month

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 May 2025
  2. Study startMay 2025 (estimated)
  3. Primary completionJan 2026 (estimated)
  4. Study completionJan 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Health services research
Allocation
Randomised
Intervention model
Sequential
Masking
None (open label)
Enrolment
50 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06954922
Sponsor's protocol ID
ATAÜNİ-SBE-AS-02
Status last verified
Apr 2025
First submitted
10 Apr 2025
Last updated
2 May 2025
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A study testing memory-based exercise and training intervention and educational initiative about epilepsy in people with Epilepsy and Memory Consolidation, run by Ataturk University.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: opening soon, as of the sponsor's last update on 2 May 2025. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Patient Introduction Form (time frame: 2 month). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 May 2025; AzTrials last refreshed its copy on 27 Oct 2026.

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