EpilepsyCORESOM-EPINCT06967935
Sleep and Rehearsal-Driven Memory in Epilepsy
An observational study of Epilepsy and Memory Consolidation, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Epilepsy, Memory Consolidation
- What is being tested?
- Cognitive memory task on a computer, Eye tracking and Questionnaires on task-related fatigue
- How many people
- 20 participants
- Where
- 1 siteFrance
- Study dates
- 30 Jun 2025to Jul 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients with epilepsy admitted to the Functional Neurology and Epileptology Department of the Hospices Civils de Lyon (University Hospital) for video-EEG monitoring will be invited by the investigating physician to participate in the study. If patients wish to take part, they will be asked to perform a cognitive task.
Who may be able to join
- Patient with epilepsy (any type of epilepsy)
- Hospitalized for video-EEG recording lasting at least 4 days
- Aged 18-65 years
Who cannot join
- Major cognitive impairment other than memory deficit
- Refusal to participate
- Pregnant women, women in labor or nursing mothers
- Persons deprived of their liberty by judicial or administrative decision
- Persons under psychiatric care
- Persons admitted to a health or social institution for purposes other than research
- Adults under legal protection (guardianship, curatorship)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Service de neurologie fonctionnelle et d'épileptologie, Hôpital neurologique Pierre Wertheimer
Bron, 69500
Laure PETER-DEREX, Professor, +334 72 07 17 69, laure.peter-derex@chu-lyon.fr
About this study
Official title: Rehearsal-Induced Memory Consolidation and Its Modulation by Sleep in People With Epilepsy
Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. However, the respective mechanisms of sleep- and rehearsal-induced consolidation-and their potential interactions-remain poorly understood, especially in patients with temporal lobe epilepsy, where rehearsal might help compensate for memory deficits linked to hippocampal dysfunction, and where sleep may exacerbate epileptic activity. The CORESOM-EPI study aims to compare the effects of rehearsal and sleep on memory consolidation in patients undergoing video-EEG monitoring. Participants will learn "object-place" associations under two conditions (single versus repeated encoding), with memory tested immediately and again after a 12-hour delay. This delay will either include a full day awake or a night of sleep, allowing direct comparison of sleep- and rehearsal-related consolidation effects. Each participant will perform the task twice, with "wake" and "sleep" condition, in a balanced order. As a preliminary phase of the CRIMES study (ANR-DFG 2024), CORESOM-EPI will help assess how sleep and rehearsal influence memory consolidation in epilepsy. It will also serve to adapt the behavioral task for clinical use, paving the way for a future intracranial EEG investigations that will explore the neural networks involved and their modulation by epileptic activity.
- Conditions
- Epilepsy, Memory Consolidation
- Being tested
- Cognitive memory task on a computer, Eye tracking, Questionnaires on task-related fatigue, Questionnaire on task difficulty, Karolinska scale
- Keywords
- Epilepsy, Memory consolidation, Sleep, Reharsal, Reactivation
- Medical subject headings
- Epilepsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cognitive memory task on a computerOther
Encoding: (1) Participants will learn 60 associations between pairs of items (cue and target) that are presented sequentially at unique locations on a screen, in a given context. 30 pairs are presented once, and 30 pairs are presented repeatedly (4 times).
(2) After learning, the first recall phase begins after a short delay of 30 minutes: 50% of the pairs are tested in a similar way, this time with an assessment of contextual memory.
(3) The remaining 50% of pairs are tested after a 12-hour delay, involving either a day awake (condition 1) or a night asleep (condition 2).
Eye trackingOther
Eye-tracking will be carried out during the task to ensure that participants are focused on the task (quantification of the number and duration of eye fixations in the area of interest corresponding to the target presentation)
Questionnaires on task-related fatigueOther
Questionnaire on task-related fatigue (Likert-scale) will be completed by participants between blocks of items during the task
Questionnaire on task difficultyOther
Questionnaires on task difficulty (Likert-scale) will be completed by participants at the end of the task
Karolinska scaleOther
Participants' state of sleepiness will be assessed at the beginning of each stage (encoding, immediate recall, delayed recall) using the Karolinska sleepiness scale
| Study group | Role | What they receive |
|---|---|---|
| WAKE - SLEEP | This group will start with the condition 1 " wake " (encoding+immediate recall in the morning (8 :00am) and delayed recall in the evening (8 :00pm)) and will end with the condition 2 " sleep " : (encoding+immediate recall in the evening (8 :00pm) and delayed recall in the morning (8 :00am)) Receives: Other: Cognitive memory task on a computer; Other: Eye tracking; Other: Questionnaires on task-related fatigue; Other: Questionnaire on task difficulty; Other: Karolinska scale | |
| SLEEP-WAKE | This group will start with the condition 2 " sleep "and will end with the condition 1 " wake " Receives: Other: Cognitive memory task on a computer; Other: Eye tracking; Other: Questionnaires on task-related fatigue; Other: Questionnaire on task difficulty; Other: Karolinska scale |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed.
For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Measured: Day 2
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed.
For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Measured: Day 2 + 12 hours
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed.
For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Measured: Day 2 + 36 hours
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed.
For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Measured: Day 2 + 48 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 May 2025
- Study start30 Jun 2025
- Primary completionJul 2027 (estimated)
- Study completionJul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for EpilepsyStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06967935
- Sponsor's protocol ID
- 69HCL25_0188
- Other IDs
- 2025-A00510-49
- Acronym
- CORESOM-EPI
- Status last verified
- Jun 2026
- First submitted
- 5 May 2025
- Last updated
- 23 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Rehearsal-Induced Memory Consolidation and Its Modulation by Sleep in People With Epilepsy
- ClinicalTrials.gov ID
- NCT06967935
- Acronym / sponsor ID
- CORESOM-EPI / 69HCL25_0188
- Conditions
- Epilepsy, Memory Consolidation
- Keywords
- Epilepsy, Memory consolidation, Sleep, Reharsal, Reactivation
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 30 Jun 2025 (actual)
- Primary completion
- Jul 2027 (estimated)
- Study completion
- Jul 2027 (estimated)
- First posted
- 13 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. However, the respective mechanisms of sleep- and rehearsal-induced consolidation-and their potential interactions-remain poorly understood, especially in patients with temporal lobe epilepsy, where rehearsal might help compensate for memory deficits linked to hippocampal dysfunction, and where sleep may exacerbate epileptic activity. The CORESOM-EPI study aims to compare the effects of rehearsal and sleep on memory consolidation in patients undergoing video-EEG monitoring. Participants will learn "object-place" associations under two conditions (single versus repeated encoding), with memory tested immediately and again after a 12-hour delay. This delay will either include a full day awake or a night of sleep, allowing direct comparison of sleep- and rehearsal-related consolidation effects. Each participant will perform the task twice, with "wake" and "sleep" condition, in a balanced order. As a preliminary phase of the CRIMES study (ANR-DFG 2024), CORESOM-EPI will help assess how sleep and rehearsal influence memory consolidation in epilepsy. It will also serve to adapt the behavioral task for clinical use, paving the way for a future intracranial EEG investigations that will explore the neural networks involved and their modulation by epileptic activity.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| WAKE - SLEEP | – | Other: Cognitive memory task on a computer, Other: Eye tracking, Other: Questionnaires on task-related fatigue, Other: Questionnaire on task difficulty, Other: Karolinska scaleThis group will start with the condition 1 " wake " (encoding+immediate recall in the morning (8 :00am) and delayed recall in the evening (8 :00pm)) and will end with the condition 2 " sleep " : (encoding+immediate recall in the evening (8 :00pm) and delayed recall in the morning (8 :00am)) |
| SLEEP-WAKE | – | Other: Cognitive memory task on a computer, Other: Eye tracking, Other: Questionnaires on task-related fatigue, Other: Questionnaire on task difficulty, Other: Karolinska scaleThis group will start with the condition 2 " sleep "and will end with the condition 1 " wake " |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients with epilepsy admitted to the Functional Neurology and Epileptology Department of the Hospices Civils de Lyon (University Hospital) for video-EEG monitoring will be invited by the investigating physician to participate in the study. If patients wish to take part, they will be asked to perform a cognitive task.
Key inclusion criteria (3 listed)
- Patient with epilepsy (any type of epilepsy)
- Hospitalized for video-EEG recording lasting at least 4 days
- Aged 18-65 years
Key exclusion criteria (7 listed)
- Major cognitive impairment other than memory deficit
- Refusal to participate
- Pregnant women, women in labor or nursing mothers
- Persons deprived of their liberty by judicial or administrative decision
- Persons under psychiatric care
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cognitive memory task on a computerEncoding: (1) Participants will learn 60 associations between pairs of items (cue and target) that are presented sequentially at unique locations on a screen, in a given context. 30 pairs are presented once, and 30 pairs are presented repeatedly (4 times). (2) After learning, the first recall phase begins after a short delay of 30 minutes: 50% of the pairs are tested in a similar way, this time with an assessment of contextual memory. (3) The remaining 50% of pairs are tested after a 12-hour delay, involving either a day awake (condition 1) or a night asleep (condition 2). | Other | SLEEP-WAKE, WAKE - SLEEP |
| Eye trackingEye-tracking will be carried out during the task to ensure that participants are focused on the task (quantification of the number and duration of eye fixations in the area of interest corresponding to the target presentation) | Other | SLEEP-WAKE, WAKE - SLEEP |
| Questionnaires on task-related fatigueQuestionnaire on task-related fatigue (Likert-scale) will be completed by participants between blocks of items during the task | Other | SLEEP-WAKE, WAKE - SLEEP |
| Questionnaire on task difficultyQuestionnaires on task difficulty (Likert-scale) will be completed by participants at the end of the task | Other | SLEEP-WAKE, WAKE - SLEEP |
| Karolinska scaleParticipants' state of sleepiness will be assessed at the beginning of each stage (encoding, immediate recall, delayed recall) using the Karolinska sleepiness scale | Other | SLEEP-WAKE, WAKE - SLEEP |
Primary outcome
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
Time frame: Day 2
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
Time frame: Day 2 + 12 hours
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
Time frame: Day 2 + 36 hours
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
Time frame: Day 2 + 48 hours
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Epilepsy and Memory Consolidation, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 23 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Laure PETER-DEREX, Professor (+334 72 07 17 69, laure.peter-derex@chu-lyon.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items. (time frame: Day 2). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jun 2026.