Root Canal TherapyNCT07005492
Factors Affecting Success and Survival Rates in Root Canal Retreatment
A study testing radiological and clinical examination in people with Root Canal Therapy and Root Canal Retreatment, run by Trakya University at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to evaluate the effects of pre-treatment and procedural factors on survival and success rates in teeth that underwent non-surgical root canal retreatment at Trakya University, Faculty of Dentistry between 2015-2017. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Root Canal Therapy, Root Canal Retreatment
- What is being tested?
- radiological and clinical examination
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 408 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jun 2023to 1 Mar 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- At least 18 years old at the time of treatment
- Systemically healthy (ASA 1-2)
- Acceptable obturation quality after treatment
Who cannot join
- Precense of seperated instrument before or after treatment
- Precense of perforation before or after treatment
- Apical surgery before of before or after treatment
- Immature root development
- Two adjacent teeth which required root canal treatment or treatment
- Pregnant women
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Trakya University, Faculty of Dentistry
Edirne, Merkez, 22061
About this study
The aim of this study is to evaluate the effects of pre-treatment and procedural factors on survival and success rates in teeth that underwent non-surgical root canal retreatment at Trakya University, Faculty of Dentistry between 2015-2017.
Pre-treatment factors examined:
- Age
- Gender
- Presence and size of periapical lesion
- Quality of root canal obturation
Factors examined during treatment:
- Type of restoration
- Status of restoration at recall
The null hypothesis was that these factors have no effect on survival and success rate.
Read the detailed description
Patients with teeth that had undergone non-surgical recurrent root canal treatment at Trakya University, Faculty of Dentistry between 2015-2017 were invited for examination. Clinical and radiological examinations were performed on patients who agreed to participate in the study. No additional interventional procedures were performed. As a result of radiological and clinical examinations, whether the tooth was in the mouth, its clinical and radiological health, current clinical symptoms, etc. were determined.
- Conditions
- Root Canal Therapy, Root Canal Retreatment
- Being tested
- radiological and clinical examination
- Keywords
- root canal retreatment, non-surgical root canal treatment, survival, success
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
radiological and clinical examinationDiagnostic test
Standard radiological (periapical radiography) and clinical (inspection, percussion, palpation tests etc.) examinations were performed.
| Study group | Role | What they receive |
|---|---|---|
| Radiological and clinical examination | Other | The patients were examined radiologically and clinically. Receives: Diagnostic Test: radiological and clinical examination |
What is being measured
The primary outcome is the main question the study is designed to answer.
Survival rate
Survival Rate:
Survival was assessed whether the tooth was in the mouth or not. Survival was scored positive if the tooth was in the mouth, regardless of the health status of the tooth in the clinical and radiological examination at the follow-up appointment.
Measured: 78.47 ± 10.48 months after treatment
Success rate
Success Rate:
Scored as successful or unsuccessful according to the following effects according to the clinical and radiological examinations; restoration status, health of the periapical tissues, presence of swelling and/or the sinus tract.
Success: The tooth had no clinical signs or symptoms, and the radiographs revealed complete resolution of periapical lesion Failure: The size of the periapical lesion was unchanged or increased or not completely healed, with or without clinical signs or symptoms
Measured: 78.47 +10.48 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Jun 2025
- Study start1 Jun 2023
- Primary completion1 Jun 2023
- Study completion1 Mar 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Root Canal TherapyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 408 participants (actual)
Sponsor and investigators
- Lead sponsor
- Trakya University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Burhan Can Çanakçi, Trakya University
- Investigators
- Burhan Can Çanakçş, Associate professor, Study director, Trakya University, Faculty of Dentistry, Department of Endodontics
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07005492
- Sponsor's protocol ID
- TUTF-2023\228
- Status last verified
- Jan 2025
- First submitted
- 13 Jan 2025
- Last updated
- 5 Jun 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Turan Gokduman C, Canakci BC, Arili Ozturk E, Er O. Factors affecting long-term success and survival in non-surgical root canal retreatment; a retrospective cohort study. Clin Oral Investig. 2025 Oct 9;29(11):491. doi: 10.1007/s00784-025-06592-y.
PubMed 41062676
Study at a glance
From the registry record, last updated by the sponsor on 5 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Factors Affecting Success and Survival Rates in Root Canal Retreatment
- ClinicalTrials.gov ID
- NCT07005492
- Acronym / sponsor ID
- TUTF-2023\228
- Conditions
- Root Canal Therapy, Root Canal Retreatment
- Keywords
- root canal retreatment, non-surgical root canal treatment, survival, success
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 408 participants (actual)
- Lead sponsor
- Trakya UniversityUniversity, hospital or other
- Study start
- 1 Jun 2023 (actual)
- Primary completion
- 1 Jun 2023 (actual)
- Study completion
- 1 Mar 2024 (actual)
- First posted
- 5 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to evaluate the effects of pre-treatment and procedural factors on survival and success rates in teeth that underwent non-surgical root canal retreatment at Trakya University, Faculty of Dentistry between 2015-2017.
Pre-treatment factors examined:
- Age
- Gender
- Presence and size of periapical lesion
- Quality of root canal obturation
Factors examined during treatment:
- Type of restoration
- Status of restoration at recall
The null hypothesis was that these factors have no effect on survival and success rate.
Detailed description
Patients with teeth that had undergone non-surgical recurrent root canal treatment at Trakya University, Faculty of Dentistry between 2015-2017 were invited for examination. Clinical and radiological examinations were performed on patients who agreed to participate in the study. No additional interventional procedures were performed. As a result of radiological and clinical examinations, whether the tooth was in the mouth, its clinical and radiological health, current clinical symptoms, etc. were determined.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Radiological and clinical examination | Other | Diagnostic Test: radiological and clinical examinationThe patients were examined radiologically and clinically. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- At least 18 years old at the time of treatment
- Systemically healthy (ASA 1-2)
- Acceptable obturation quality after treatment
Key exclusion criteria (6 listed)
- Precense of seperated instrument before or after treatment
- Precense of perforation before or after treatment
- Apical surgery before of before or after treatment
- Immature root development
- Two adjacent teeth which required root canal treatment or treatment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| radiological and clinical examinationStandard radiological (periapical radiography) and clinical (inspection, percussion, palpation tests etc.) examinations were performed. | Diagnostic test | Radiological and clinical examination |
Primary outcome
Survival rate
Time frame: 78.47 ± 10.48 months after treatment
Survival Rate: Survival was assessed whether the tooth was in the mouth or not. Survival was scored positive if the tooth was in the mouth, regardless of the health status of the tooth in the clinical and radiological examination at the follow-up appointment.
Success rate
Time frame: 78.47 +10.48 months
Success Rate: Scored as successful or unsuccessful according to the following effects according to the clinical and radiological examinations; restoration status, health of the periapical tissues, presence of swelling and/or the sinus tract. Success: The tooth had no clinical signs or symptoms, and the radiographs revealed complete resolution of periapical lesion Failure: The size of the periapical lesion was unchanged or increased or not completely healed, with or without clinical signs or symptoms
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Jun 2025.
- Derived from this study: PubMed 41062676Turan Gokduman C, Canakci BC, Arili Ozturk E, Er O. Factors affecting long-term success and survival in non-surgical root canal retreatment; a retrospective cohort study. Clin Oral Investig. 2025 Oct 9;29(11):491. doi: 10.1007/s00784-025-06592-y.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Burhan Can Çanakçş, Associate professor study director
Trakya University, Faculty of Dentistry, Department of Endodontics
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing radiological and clinical examination in people with Root Canal Therapy and Root Canal Retreatment, run by Trakya University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Survival rate (time frame: 78.47 ± 10.48 months after treatment). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07005492, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Jun 2025.