Clinical trials: Root Canal Therapy
Root Canal Therapy, Periapical Periodontitis
Comparision of Non Surgical Retreatment and Endodontic Surgery of Failed Root Canal Treated Teeth
To the best of our knowledge, only two studies are available which have provided a direct comparison between outcome of nonsurgical retreatment and endodontic surgery. The results of the two studies are contradictory in nature.
- Trial name
- NCT03918733
- Testing
- surgical treatment, Non surgical retreatment
- Where
- India
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Symptomatic Irreversible Pulpitis (SIP)
Comparison Of Acetaminophen, NSAIDs, And Trypsin-Chymotrypsin Plus Acetaminophen For Post-Endodontic Pain After Single-Visit Root Canal Treatment
This randomized control trial will be planned according to PRIRATE 2020 guideline for reporting randomized trials in Endodontics.
- Trial name
- NCT07759349
- Testing
- Acetaminophen, NSAID, trypsin-chymotrypsin
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Pain Postoperative
Foraminal Enlargement and Postoperative Pain.
The purpose of this study is to determine whether enlarging the apical foramen causes postoperative pain in teeth with necrotic pulp and apical periodontitis.
- Trial name
- NCT02770053
- Testing
- Foraminal enlargement
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Isparta Military Hospital
Root Canal
A Study Evaluating the Sonendo GentleWave™ System
A post market, observational study evaluating the treatment of 1st and 2nd molars indicated for root canal therapy and treated with the Sonendo GentleWave System and obturated with CPoint and BC Sealer in at least one canal.
- Trial name
- To The Point (NCT02478723)
- Testing
- Sonendo GentleWave™ System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sonendo, Inc.
Symptomatic Irreversible Pulpitis
Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic
This study evaluates postoperative pain and treatment outcomes following vital pulp therapy and root canal treatment in patients with symptomatic teeth.
- Trial name
- NCT07549620
- Testing
- Vital Pulp Therapy, Root Canal Treatment
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Ain Shams University
Endodontic-Periodontal Lesions, Apical Periodontitis
The MTA Effect on Healing and Biomarkers in Endo-Perio Lesions
This project is a randomized controlled clinical study investigating the effect of Mineral Trioxide Aggregate (MTA) used as an apical plug in root canal obturation on periodontal healing and inflammatory biomarkers in teeth with…
- Conditions
- Endodontic-Periodontal Lesions, Apical Periodontitis, Periapical Disease
- Trial name
- NCT07653997
- Testing
- Root Canal Treatment with MTA Apical Plug, Root Canal Treatment with Resin-Based Sealer (AH Plus), Periodontal Therapy (Scaling and Root Planing)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Apical Periodontitis
Effect of Coronal Extent of Obturation on Endo-perio Lesions
Increased incidence of apical periodontitis was reported where root filling was found coronal to the marginal bone due to communication between pulp and periodontal space.
- Trial name
- NCT03171376
- Testing
- Root canal treatment and coronal restoration
- Volunteers
- 60 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Endodontic Disease, Endodontically Treated Teeth
Outcome of Endodontic Treatment and Retreatment With a Bioceramic Sealer
This study is a prospective randomized controlled study of patients who come to the University. The aim is to evaluate the success rate of treatment and retreatment of canals using BioRoot ™ RCS cement compared with AH Plus up to…
- Trial name
- NCT04528979
- Testing
- BioRoot RCS® root canal sealer, AH Plus® root canal sealer
- Where
- Spain
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Juan Gonzalo Olivieri
Pain
Comparative Evaluation of Post Obturation Pain After Root Canal Treatment Using Tricalcium Silicate vs Resin-Based Sealers
This is a randomized controlled trial comparing the mean and standard deviation of postobturation pain using two different sealers: a tricalcium silicate-based sealer (CeraSeal) and a resin-based sealer (Endoplus) in patients…
- Trial name
- NCT07388368
- Testing
- Tricalcium silicate sealar, Resin based sealer
- Where
- Pakistan
- Volunteers
- 118 people
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Dental Pulp Necrosis
Investigation of the Effect of Low Torque and Speed on Post-Operative Pain After Root Canal Treatment
Root canal preparation is one of the most important stages in root canal treatment. Nowadays, the use of Nickel-Titanium(Ni-Ti) rotary instrument systems for root canal expansion is becoming very popular.
- Trial name
- NCT06309095
- Testing
- use of VDW Silver Endodontic motor
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of Anal Canal
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of Anal Canal, Colorectal Cancer, Squamous Cell Carcinoma of the Lung
- Trial name
- NCT04429542
- Testing
- BCA101, Pembrolizumab
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 473 people
- Sponsor
- Bicara Therapeutics
Necrotic Pulp
Postoperative Pain Following Treatment of Asymptomatic Necrotic Mandibular Molars in Single Visit Using Wave-one Reciprocating Instruments Versus One-Shape Rotary Instruments
The aim of this study is to evaluate the post treatment pain after instrumentation of root canals with a single file reciprocating (Wave-One Ni Ti file, DENTSPLY Maillefer) or rotary(One Shape, Micro Mega, France) file system in…
- Trial name
- NCT03301259
- Testing
- One-shape rotationary system
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periapical Diseases, Periapical Periodontitis
Postoperative Pain After Conservative Root Canal Preparation
The goal of this clinical trial is to compare the pain experienced by healthy participants after root canal treatment with small versus large root canal sizes. The main questions it aims to answer are: 1.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Postoperative Pain, Pulp Necroses
- Trial name
- NCT06545773
- Testing
- Root Canal Treatment with ProTaper Next Nickel-Titanium File (PTN), Root Canal Treatment withTruNatomy Nickel-Titanium File (TN)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Endodontic Disease
Effect of Music on Young Practitioner's Stress During Endodontic Treatment
According to several studies, patients consider endodontic treatment as one of the most stress-inducing dental procedures. Two studies demonstrated that music enables the patient to be less stressed during RCT.
- Trial name
- MUSIQUENDO (NCT04471558)
- Testing
- Music
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Pain, Postoperative
Ibuprofen Versus Ibuprofen/Acetaminophen Postoperatively in Patients Needing Root Canal Therapy
Aim: The purpose of this study was to compare ibuprofen versus an ibuprofen/acetaminophen combination for postoperative pain control in patients requiring root canal treatment with a tooth that is painful to cold and biting.
- Trial name
- NCT03631433
- Testing
- Ibuprofen 600 mg, ibuprofen 600 mg and acetaminophen 650 mg
- Volunteers
- 102 people
- Sponsor
- Ohio State University
Asymptomatic Apical Periodontitis
Evaluation of Postoperative Pain After Using Resin-Based and Bioceramic Sealers in Mandibular Molars With Asymptomatic Apical Periodontitis
This study aims to evaluate the effect of two different root canal sealers-BioRoot RCS (a bioceramic-based sealer) and AH Plus (a resin-based sealer)-on postoperative pain following single-visit root canal treatment in mandibular…
- Trial name
- NCT07289633
- Testing
- BioRoot RCS, AH Plus
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- AZİZ ŞAHİN ERDOĞAN
Endodontic Treatment
Disinfection Effect of Gaseous Ozone
The current study aimed to investigate the effect of gaseous ozone in disinfection the root canals of primary teeth. Thirty-six primary molars of 36 completely healthy patients (aged 5-10) were included in the study.The included…
- Trial name
- NCT06470126
- Testing
- 2.5% NaOCl group: The interventions performed in the study are root- canal therapies and disinfection procedure of these therapies., 0.9% sterile saline solution combined with 80 seconds: The OzonyTronX® interventions performed in the study are root- canal therapies and disinfection procedure of these therapies., 2.5% NaOCl with 80 seconds OzonyTronX®:The interventions performed in the study are root- canal therapies and disinfection procedure of these therapies.
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ankara University
Cancer That is Associated With a Chronic Viral Infection, p16 Positive SCCHN
Avelumab With Valproic Acid in Virus-associated Cancer
Up to 20% of all cancers may be associated with a bacterial or viral infection. In some instances, the infection may be one of the reasons why the cancer developed in the first place.
- Conditions
- Cancer That is Associated With a Chronic Viral Infection, p16 Positive SCCHN, Squamous Cell Carcinoma of the Cervix, p16 Positive Squamous Cell Carcinoma of the Vagina or Vulva
- Trial name
- LATENT (NCT03357757)
- Testing
- Valproic Acid, Avelumab
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- AHS Cancer Control Alberta
Endodontic Disease, Post Operative Pain
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
- Conditions
- Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- Trial name
- NCT05338671
- Testing
- Local anesthetic
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
Squamous Cell Carcinoma of External Auditory Canal, Locally Advanced Tumor
Induction Chemotherapy Combined With Tislelizumab for Locally Advanced Squamous Cell Carcinoma of the External Auditory Canal
To evaluate the efficacy and safety of induction chemotherapy combined with tislelizumab as neoadjuvant therapy in patients with locally advanced squamous cell carcinoma of the external auditory canal; to explore the improvement…
- Trial name
- NCT07370337
- Testing
- Tislelizumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Eye & ENT Hospital of Fudan University