Cervicogenic HeadacheNCT07006454
Comparison of Ventro-Cephalic to Dorso-Caudal Translatoric Glides in Management of Cervicogenic Headache
A study testing Ventro-Cephalic Translatoric Glide and Dorso-Caudal Translatoric Glide in people with Cervicogenic Headache, run by Foundation University Islamabad at 1 site in Pakistan.
Trial summary
This study is a randomised control trial and the purpose of this study is to compare ventro-cephalic to dorso-caudal translatoric glides in management of cervicogenic headache. Read more about this study
- Who is it for?
- Ages 18 to 44 years
- Conditions the study is for
- Cervicogenic Headache
- What is being tested?
- Ventro-Cephalic Translatoric Glide and Dorso-Caudal Translatoric Glide
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 sitePakistan
- Study dates
- 18 Jul 2024to 20 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 44 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- • Age 18 to 44 years old
- Both male and female A- Any headache fulling criterion C. B- Clinical and/or imaging evidence of lesion or disorder in cervical spine or soft tissues of neck that can cause headache.
- C- Evidence of cause of headache demonstrated by at least 2 of these:
- headache has developed in temporal relation to the onset of the cervical disorder or lesion.
- headache has significantly improved or resolved in parallel with improvement in cervical lesion or disorder.
- cervical range of motion is reduced, and headache is made significantly worse by provocative maneuvers.
- headache is abolished following diagnostic blocked of cervical structure. D- Not better accounted for by another ICHD-3 diagnosis
Who cannot join
- 1- Tension-type headaches and migraine 2- History of Vertigo or Dizziness 3- Already taking manual therapy treatment 4- Prior surgery to the head and neck 5- Trauma
Trial locations and contacts
1 site in 1 country.
Pakistan1 site, 1 recruiting
- Recruiting
Foundation University College of Physical Therapy
Islamabad, 44000
Hafiz Ali Bin Asim, MS-SPT, +923135088144, ali.asim@fui.edu.pk
About this study
This study is a randomised control trial and the purpose of this study is to compare ventro-cephalic to dorso-caudal translatoric glides in management of cervicogenic headache.
Read the detailed description
Participants will be recruited into their respective groups using a coin toss method.Cervicogenic headache will be assesed using International Classification of Headache Disorders, 3rd edition:
A- Any headache fulling criterion C. B- Clinical and/or imaging evidence of lesion or disorder in cervical spine or soft tissues of neck that can cause headache.
C- Evidence of cause of headache demonstrated by at least 2 of these:
- headache has developed in temporal relation to the onset of the cervical disorder or lesion.
- headache has significantly improved or resolved in parallel with improvement in cervical lesion or disorder.
- cervical range of motion is reduced, and headache is made significantly worse by provocative maneuvers.
- headache is abolished following anaesthetic blocked of cervical structure. D- Not better accounted for by another ICHD-3 diagnosis.
CEH subject selection is based on clinical criteria, however anaesthetic blockades is not used as a criterion.
- Conditions
- Cervicogenic Headache
- Being tested
- Ventro-Cephalic Translatoric Glide, Dorso-Caudal Translatoric Glide
- Medical subject headings
- Post-Traumatic Headache
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ventro-Cephalic Translatoric GlideProcedure or surgery
Participants of group A will receive ventro-cephalic translatoric glides, total of 3 sets with 15 repetitions per set.
PROCEDURE:
- Patient sits on low chair with back straight and therapist stand facing the patient's right side.
- Therapist's stable hand: with the thumb and index finger of left hand fixate caudal vertebra.
- Therapist's moving hand: therapist will place his/her right hand on left side of patient's head and cervical spine than place little finger around cranial vertebra of segment to be moved.
- Apply glide in ventro-cranial direction in the right angle of the treatment plane of the facet joint.
Dorso-Caudal Translatoric GlideProcedure or surgery
Participants of group B will receive Dorso-caudal translatoric glides, total of 3 sets with 15 repetitions per set.
PROCEDURE:
- Patient sits on low chair with back straight and therapist stand facing the patient's left side.
- Therapist's stable hand: with the thumb and index finger of right hand fixate caudal vertebra.
- Therapist's moving hand: therapist will place his/her left hand on right side of patient's head and cervical spine than place little finger around cranial vertebra of segment to be moved.
- Apply glide in dorso-caudal direction in the right angle of the treatment plane of the facet joint.
| Study group | Role | What they receive |
|---|---|---|
| Group A | Experimental | Participants of group A will receive ventro-cephalic translatoric glide, total of 3 sets with 15 repetitions per set.
Duration (5 treatment sessions per week for 2 weeks) Receives: Procedure: Ventro-Cephalic Translatoric Glide |
| Group B | Experimental | Participants of group B will receive Dorso-caudal translatoric glide, total of 3 sets with 15 repetitions per set.
Duration (5 treatment sessions per week for 2 weeks) Receives: Procedure: Dorso-Caudal Translatoric Glide |
What is being measured
The primary outcome is the main question the study is designed to answer.
Headache intensity
It will be measured on a numeric pain rating scale where participant select number ranging from 0 to 10 based on pain intensity, with 0 representing no pain and 10 denotes extreme pain.
Measured: Variable will be evaluated at baseline and then weekly for next 2 weeks.
Headache disability
It will be measured using headache disability index (HDI) which is a 25 item self-rated questionnaire in which participants rate their headache disability by selecting an option from 1 to 3 (yes= 4 points, sometimes= 2 points, and No = 0 point) then sum of responses is used to get final score.
Interpretation:
10 to 28= mild disability 30 to 48= moderate disability 50 to 68= severe disability 72 or more= complete disability
Measured: Variable will be evaluated at baseline and then weekly for next 2 weeks
Quality of Life of patient
It will be measured using headache impact test (HIT-6), this tool is used to measure impact of headache on ability to function, a 6 items self-rated questionnaire in which participant select an option from 1 to 5 (Never= 6 points, rarely= 8, sometimes= 10, very often= 11, always= 13) then sum of responses is used to get final score.
Interpretation:
60 or more= Very severe impact 56 to 59= Substantial impact 50 to 55= Some impact 49 or less= Little or no impact
Measured: Variable will be evaluated at baseline and then weekly for next 2 weeks
Headache Frequency
It will be measured using medical diary, which is a self-reported measure in which the patient will be asked to report the number of headache days per week through a medical logbook, which will be recorded every day and night.
Measured: Variable will be evaluated at baseline and then weekly for next 2 weeks
Cervical range of motion
It will be measured using CROM instrument a plastic frame device that is fastened to the head with help of Velcro-strap, it consist of 3 separate inclinometers that are fixed to frame (1 in sagittal plan which evaluates range of motion in flexion and extension, where 2nd in frontal plane which evaluates range of motion in side bending, and 3rd in horizontal plan which indicates range of motion in rotation)
Measured: Variable will be evaluated at baseline and then weekly for next 2 weeks
Cervical flexion rotation test
It is used to evaluate impairment of cervical function as the diagnostic criterion of internation headache society (IHS) consist of subjective feathers which includes impairments at atlanto-axial motion segments which is assessed by cervical flexion rotation test.
Measured: Variable will be evaluated at baseline and then weekly for next 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Jun 2025
- Study start18 Jul 2024
- Primary completion20 Jun 2025 (estimated)
- Study completion20 Jun 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cervicogenic HeadacheStudies of the same condition, open and under way.
- More trials run by Foundation University IslamabadThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized Control Trial
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Foundation University Islamabad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07006454
- Sponsor's protocol ID
- FUI/CTR/2024/79
- Status last verified
- Jul 2024
- First submitted
- 28 May 2025
- Last updated
- 16 Jun 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Ventro-Cephalic to Dorso-Caudal Translatoric Glides in Management of Cervicogenic Headache
- ClinicalTrials.gov ID
- NCT07006454
- Acronym / sponsor ID
- FUI/CTR/2024/79
- Conditions
- Cervicogenic Headache
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Foundation University IslamabadUniversity, hospital or other
- Study start
- 18 Jul 2024 (actual)
- Primary completion
- 20 Jun 2025 (estimated)
- Study completion
- 20 Jun 2025 (estimated)
- First posted
- 5 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is a randomised control trial and the purpose of this study is to compare ventro-cephalic to dorso-caudal translatoric glides in management of cervicogenic headache.
Detailed description
Participants will be recruited into their respective groups using a coin toss method.Cervicogenic headache will be assesed using International Classification of Headache Disorders, 3rd edition:
A- Any headache fulling criterion C. B- Clinical and/or imaging evidence of lesion or disorder in cervical spine or soft tissues of neck that can cause headache.
C- Evidence of cause of headache demonstrated by at least 2 of these:
- headache has developed in temporal relation to the onset of the cervical disorder or lesion.
- headache has significantly improved or resolved in parallel with improvement in cervical lesion or disorder.
- cervical range of motion is reduced, and headache is made significantly worse by provocative maneuvers.
- headache is abolished following anaesthetic blocked of cervical structure. D- Not better accounted for by another ICHD-3 diagnosis.
CEH subject selection is based on clinical criteria, however anaesthetic blockades is not used as a criterion.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Randomized Control Trial
| Arm | Type | Receives |
|---|---|---|
| Group A | Experimental | Procedure: Ventro-Cephalic Translatoric GlideParticipants of group A will receive ventro-cephalic translatoric glide, total of 3 sets with 15 repetitions per set. Duration (5 treatment sessions per week for 2 weeks) |
| Group B | Experimental | Procedure: Dorso-Caudal Translatoric GlideParticipants of group B will receive Dorso-caudal translatoric glide, total of 3 sets with 15 repetitions per set. Duration (5 treatment sessions per week for 2 weeks) |
Who may qualify
- Ages
- 18 to 44 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- • Age 18 to 44 years old
- headache has developed in temporal relation to the onset of the cervical disorder or lesion.
- headache has significantly improved or resolved in parallel with improvement in cervical lesion or disorder.
- cervical range of motion is reduced, and headache is made significantly worse by provocative maneuvers.
- headache is abolished following diagnostic blocked of cervical structure. D- Not better accounted for by another ICHD-3 diagnosis
Key exclusion criteria (1 listed)
- 1- Tension-type headaches and migraine 2- History of Vertigo or Dizziness 3- Already taking manual therapy treatment 4- Prior surgery to the head and neck 5- Trauma
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ventro-Cephalic Translatoric GlideParticipants of group A will receive ventro-cephalic translatoric glides, total of 3 sets with 15 repetitions per set. PROCEDURE: 1. Patient sits on low chair with back straight and therapist stand facing the patient's right side. 2. Therapist's stable hand: with the thumb and index finger of left hand fixate caudal vertebra. 3. Therapist's moving hand: therapist will place his/her right hand on left side of patient's head and cervical spine than place little finger around cranial vertebra of segment to be moved. 4. Apply glide in ventro-cranial direction in the right angle of the treatment plane of the facet joint. | Procedure or surgery | Group A |
| Dorso-Caudal Translatoric GlideParticipants of group B will receive Dorso-caudal translatoric glides, total of 3 sets with 15 repetitions per set. PROCEDURE: 1. Patient sits on low chair with back straight and therapist stand facing the patient's left side. 2. Therapist's stable hand: with the thumb and index finger of right hand fixate caudal vertebra. 3. Therapist's moving hand: therapist will place his/her left hand on right side of patient's head and cervical spine than place little finger around cranial vertebra of segment to be moved. 4. Apply glide in dorso-caudal direction in the right angle of the treatment plane of the facet joint. | Procedure or surgery | Group B |
Primary outcome
Headache intensity
Time frame: Variable will be evaluated at baseline and then weekly for next 2 weeks.
It will be measured on a numeric pain rating scale where participant select number ranging from 0 to 10 based on pain intensity, with 0 representing no pain and 10 denotes extreme pain.
Headache disability
Time frame: Variable will be evaluated at baseline and then weekly for next 2 weeks
It will be measured using headache disability index (HDI) which is a 25 item self-rated questionnaire in which participants rate their headache disability by selecting an option from 1 to 3 (yes= 4 points, sometimes= 2 points, and No = 0 point) then sum of responses is used to get final score. Interpretation: 10 to 28= mild disability 30 to 48= moderate disability 50 to 68= severe disability 72 or more= complete disability
Quality of Life of patient
Time frame: Variable will be evaluated at baseline and then weekly for next 2 weeks
It will be measured using headache impact test (HIT-6), this tool is used to measure impact of headache on ability to function, a 6 items self-rated questionnaire in which participant select an option from 1 to 5 (Never= 6 points, rarely= 8, sometimes= 10, very often= 11, always= 13) then sum of responses is used to get final score. Interpretation: 60 or more= Very severe impact 56 to 59= Substantial impact 50 to 55= Some impact 49 or less= Little or no impact
Headache Frequency
Time frame: Variable will be evaluated at baseline and then weekly for next 2 weeks
It will be measured using medical diary, which is a self-reported measure in which the patient will be asked to report the number of headache days per week through a medical logbook, which will be recorded every day and night.
Cervical range of motion
Time frame: Variable will be evaluated at baseline and then weekly for next 2 weeks
It will be measured using CROM instrument a plastic frame device that is fastened to the head with help of Velcro-strap, it consist of 3 separate inclinometers that are fixed to frame (1 in sagittal plan which evaluates range of motion in flexion and extension, where 2nd in frontal plane which evaluates range of motion in side bending, and 3rd in horizontal plan which indicates range of motion in rotation)
Cervical flexion rotation test
Time frame: Variable will be evaluated at baseline and then weekly for next 2 weeks
It is used to evaluate impairment of cervical function as the diagnostic criterion of internation headache society (IHS) consist of subjective feathers which includes impairments at atlanto-axial motion segments which is assessed by cervical flexion rotation test.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jun 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ventro-Cephalic Translatoric Glide and Dorso-Caudal Translatoric Glide in people with Cervicogenic Headache, run by Foundation University Islamabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 16 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Aeysha Bibi, DPT (+923058766593, ayeshaaltaf604@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Headache intensity (time frame: Variable will be evaluated at baseline and then weekly for next 2 weeks.). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jun 2025.