Knee OsteoarthritisNCT07063953
Effects of Egoscue Exercises in Patients With Knee Osteoarthritis
A study testing Standard Physical Therapy and Egoscue Exercises in people with Knee Osteoarthritis, run by Riphah International University at 1 site in Pakistan.
Trial summary
Knee osteoarthritis (KOA) is a chronic, debilitating illness with multiple etiologies that affects the entire knee joint. It is a leading cause of disability among the elderly population and necessitates effective interventions beyond pharmacotherapy due to the associated risks. Read more about this study
- Who is it for?
- Ages 45 to 65 years
- Conditions the study is for
- Knee Osteoarthritis
- What is being tested?
- Standard Physical Therapy and Egoscue Exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 42 participants
- Where
- 1 sitePakistan
- Study dates
- Jul 2025to Oct 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age group between 45 and 65 years ,
- Both genders male and female ,
- BMI ˃ 25 , and Knee OA clinically or radiologically diagnosed by Kellgren-Lawrence Method, Grade II and III
Who cannot join
- Age less than 45 years or older than 65 years,
- BMI < 25, Knee OA in grade I and IV, and
- Patients on steroid therapy and intra articular injection
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site
Basharat Hospital, Sahiwal
Sahiwal, Punjab Province, 54000
Fouzia Basharat, MSPT, 923368701931, hananbasharat1@gmail.com
About this study
Official title: Effects of Egoscue Exercises on Pain, Range of Motion and Physical Function in Patients With Knee Osteoarthritis
Knee osteoarthritis (KOA) is a chronic, debilitating illness with multiple etiologies that affects the entire knee joint. It is a leading cause of disability among the elderly population and necessitates effective interventions beyond pharmacotherapy due to the associated risks.
This study will address the existing literature gap by focusing on a novel therapeutic approach known as 'Egoscue Exercises', for managing knee osteoarthritis in the affected population.
Read the detailed description
This Randomized Controlled Trial will be conducted at Riphah Rehab Training and Research Center, Lahore and District Health Quarter Hospital (DHQ), Sahiwal in a time span of 8 months. A sample of 42 participants aged 45-65 years, diagnosed with Grade 02 and 03 Knee Osteoarthritis, will undergo a comprehensive physiotherapy protocol, which includes standard physiotherapy knee OA treatment, either alone or in combination with Egoscue exercises. Participants will receive a minimum of 3 sessions per week, across four weeks.
Randomization, conducted by computer-generated stratified randomization, will ensure unbiased allocation to the two groups. Data collection will be carried out at baseline, 2 weeks, and 4 weeks, and includes outcomes in the form of pain measured by Numeric Pain Rating Scale (NPRS), range of motion measured by Goniometer, and physical function evaluated by Western Ontario and McMaster Universities Arthritis (WOMAC) index. The single-blind study will incorporate rigorous statistical analysis, using IBM SPSS software, version 25 for descriptive statistics, normality, and intergroup differences via t-tests and U tests.
- Conditions
- Knee Osteoarthritis
- Being tested
- Standard Physical Therapy, Egoscue Exercises
- Keywords
- Pain, Physical Function, Range of motion
- Medical subject headings
- Osteoarthritis, Knee, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standard Physical TherapyOther
Hot pack \& Transcutaneous Electric Nerve Stimulation (TENS) Myofascial Release Mulligan Mobilization with Movement Exercises
Egoscue ExercisesOther
Warm Up Exercises (5 min) which includes Stretching ,Walking (Forward, Backward, Sideways), Arm Circles, Side bends, March on the spot, Knee lifts, Standing Gluteal Contractions , Sitting heel raises, Isolated hip flexor lifts on a towel, Supine groin stretch on towels, Static back, Sitting Knee Pillow Squeezes, Sitting floor, Progressive supine groin, Supine calf-hamstring stretch with a strap,Foot circles and point flexes, Cool Down and Breathing Exercises
| Study group | Role | What they receive |
|---|---|---|
| Egoscue Exercises | Experimental | Warm Up Exercises (5 min) which includes Stretching ,Walking (Forward, Backward, Sideways), Arm Circles, Side bends, March on the spot, Knee lifts, Standing Gluteal Contractions , Sitting heel raises, Isolated hip flexor lifts on a towel, Supine groin stretch on towels, Static back, Sitting Knee Pillow Squeezes, Sitting floor, Progressive supine groin, Supine calf-hamstring stretch with a strap,Foot circles and point flexes, Cool Down and Breathing Exercises Receives: Other: Egoscue Exercises |
| Standard Physical Therapy | Active comparator | Hot pack \& Transcutaneous Electric Nerve Stimulation (TENS) Myofascial Release Mulligan Mobilization with Movement Exercises Receives: Other: Standard Physical Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Range of Motion
The range of motion will be measured by using Universal Goniometer, which is a highly reliable and valid tool. It will measure knee joint range of motion which includes knee flexion and extension.
Measured: upto 4 weeks
Western Ontario and McMaster Universities Arthritis (WOMAC) index
WOMAC Index is widely used in the evaluation of Knee Osteoarthritis. It is a 24 item questionnaire divided into 3 subscales:
- Pain (5 items): during walking, using stairs, in bed, sitting or lying, and standing upright
- Stiffness (2 items): after first waking and later in the day
- Physical Function (17 items): using stairs, rising from sitting, standing, bending, walking, getting in / out of a car, shopping, putting on / taking off socks, rising from bed, lying in bed, getting in / out of bath, sitting, getting on / off toilet, heavy domestic duties, light domestic duties.
Measured: upto 4 weeks
Numerical Pain Rating Scale (NPRS)
The Numeric Pain Rating Scale (NPRS) is perhaps the most frequently applied scale used to quantify pain intensity in the clinical setting. It is an 11-point numeric scale, ranging from 0 indicating no pain to 10 indicating worst pain imaginable
Measured: upto 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2025
- Study startJul 2025 (estimated)
- Primary completionSep 2025 (estimated)
- Study completionOct 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 42 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Samrood Akram, PhD*, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07063953
- Sponsor's protocol ID
- REC/RCR &AHS/24/0146 Momina
- Status last verified
- Jul 2025
- First submitted
- 3 Jul 2025
- Last updated
- 14 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Sharma L. Osteoarthritis of the Knee. N Engl J Med. 2021 Jan 7;384(1):51-59. doi: 10.1056/NEJMcp1903768. No abstract available.
PubMed 33406330Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine. 2020 Nov 26;29-30:100587. doi: 10.1016/j.eclinm.2020.100587. eCollection 2020 Dec.
PubMed 34505846Giorgino R, Albano D, Fusco S, Peretti GM, Mangiavini L, Messina C. Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update. Int J Mol Sci. 2023 Mar 29;24(7):6405. doi: 10.3390/ijms24076405.
PubMed 37047377Kondal S, Kulkarni V, Gaikwad A, Kharat A, Pant A. Automatic Grading of Knee Osteoarthritis on the Kellgren-Lawrence Scale from Radiographs Using Convolutional Neural Networks [Internet]. arXiv.org. 2020 [cited 2024 Jun 25].
Yunus MHM, Nordin A, Kamal H. Pathophysiological Perspective of Osteoarthritis. Medicina (Kaunas). 2020 Nov 16;56(11):614. doi: 10.3390/medicina56110614.
PubMed 33207632Siddiq MAB, Clegg D, Jansen TL, Rasker JJ. Emerging and New Treatment Options for Knee Osteoarthritis. Curr Rheumatol Rev. 2022;18(1):20-32. doi: 10.2174/1573397117666211116111738.
PubMed 34784876
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Egoscue Exercises on Pain, Range of Motion and Physical Function in Patients With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT07063953
- Acronym / sponsor ID
- REC/RCR &AHS/24/0146 Momina
- Conditions
- Knee Osteoarthritis
- Keywords
- Pain, Physical Function, Range of motion
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 42 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- Jul 2025 (estimated)
- Primary completion
- Sep 2025 (estimated)
- Study completion
- Oct 2025 (estimated)
- First posted
- 14 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Knee osteoarthritis (KOA) is a chronic, debilitating illness with multiple etiologies that affects the entire knee joint. It is a leading cause of disability among the elderly population and necessitates effective interventions beyond pharmacotherapy due to the associated risks.
This study will address the existing literature gap by focusing on a novel therapeutic approach known as 'Egoscue Exercises', for managing knee osteoarthritis in the affected population.
Detailed description
This Randomized Controlled Trial will be conducted at Riphah Rehab Training and Research Center, Lahore and District Health Quarter Hospital (DHQ), Sahiwal in a time span of 8 months. A sample of 42 participants aged 45-65 years, diagnosed with Grade 02 and 03 Knee Osteoarthritis, will undergo a comprehensive physiotherapy protocol, which includes standard physiotherapy knee OA treatment, either alone or in combination with Egoscue exercises. Participants will receive a minimum of 3 sessions per week, across four weeks.
Randomization, conducted by computer-generated stratified randomization, will ensure unbiased allocation to the two groups. Data collection will be carried out at baseline, 2 weeks, and 4 weeks, and includes outcomes in the form of pain measured by Numeric Pain Rating Scale (NPRS), range of motion measured by Goniometer, and physical function evaluated by Western Ontario and McMaster Universities Arthritis (WOMAC) index. The single-blind study will incorporate rigorous statistical analysis, using IBM SPSS software, version 25 for descriptive statistics, normality, and intergroup differences via t-tests and U tests.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Egoscue Exercises | Experimental | Other: Egoscue ExercisesWarm Up Exercises (5 min) which includes Stretching ,Walking (Forward, Backward, Sideways), Arm Circles, Side bends, March on the spot, Knee lifts, Standing Gluteal Contractions , Sitting heel raises, Isolated hip flexor lifts on a towel, Supine groin stretch on towels, Static back, Sitting Knee Pillow Squeezes, Sitting floor, Progressive supine groin, Supine calf-hamstring stretch with a strap,Foot circles and point flexes, Cool Down and Breathing Exercises |
| Standard Physical Therapy | Active comparator | Other: Standard Physical TherapyHot pack \& Transcutaneous Electric Nerve Stimulation (TENS) Myofascial Release Mulligan Mobilization with Movement Exercises |
Who may qualify
- Ages
- 45 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age group between 45 and 65 years ,
- Both genders male and female ,
- BMI ˃ 25 , and Knee OA clinically or radiologically diagnosed by Kellgren-Lawrence Method, Grade II and III
Key exclusion criteria (3 listed)
- Age less than 45 years or older than 65 years,
- BMI < 25, Knee OA in grade I and IV, and
- Patients on steroid therapy and intra articular injection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standard Physical TherapyHot pack \& Transcutaneous Electric Nerve Stimulation (TENS) Myofascial Release Mulligan Mobilization with Movement Exercises | Other | Standard Physical Therapy |
| Egoscue ExercisesWarm Up Exercises (5 min) which includes Stretching ,Walking (Forward, Backward, Sideways), Arm Circles, Side bends, March on the spot, Knee lifts, Standing Gluteal Contractions , Sitting heel raises, Isolated hip flexor lifts on a towel, Supine groin stretch on towels, Static back, Sitting Knee Pillow Squeezes, Sitting floor, Progressive supine groin, Supine calf-hamstring stretch with a strap,Foot circles and point flexes, Cool Down and Breathing Exercises | Other | Egoscue Exercises |
Primary outcome
Range of Motion
Time frame: upto 4 weeks
The range of motion will be measured by using Universal Goniometer, which is a highly reliable and valid tool. It will measure knee joint range of motion which includes knee flexion and extension.
Western Ontario and McMaster Universities Arthritis (WOMAC) index
Time frame: upto 4 weeks
WOMAC Index is widely used in the evaluation of Knee Osteoarthritis. It is a 24 item questionnaire divided into 3 subscales: 1. Pain (5 items): during walking, using stairs, in bed, sitting or lying, and standing upright 2. Stiffness (2 items): after first waking and later in the day 3. Physical Function (17 items): using stairs, rising from sitting, standing, bending, walking, getting in / out of a car, shopping, putting on / taking off socks, rising from bed, lying in bed, getting in / out of bath, sitting, getting on / off toilet, heavy domestic duties, light domestic duties.
Numerical Pain Rating Scale (NPRS)
Time frame: upto 4 weeks
The Numeric Pain Rating Scale (NPRS) is perhaps the most frequently applied scale used to quantify pain intensity in the clinical setting. It is an 11-point numeric scale, ranging from 0 indicating no pain to 10 indicating worst pain imaginable
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2025.
- Background: PubMed 33406330Sharma L. Osteoarthritis of the Knee. N Engl J Med. 2021 Jan 7;384(1):51-59. doi: 10.1056/NEJMcp1903768. No abstract available.
- Background: PubMed 34505846Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine. 2020 Nov 26;29-30:100587. doi: 10.1016/j.eclinm.2020.100587. eCollection 2020 Dec.
- Background: PubMed 37047377Giorgino R, Albano D, Fusco S, Peretti GM, Mangiavini L, Messina C. Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update. Int J Mol Sci. 2023 Mar 29;24(7):6405. doi: 10.3390/ijms24076405.
- BackgroundKondal S, Kulkarni V, Gaikwad A, Kharat A, Pant A. Automatic Grading of Knee Osteoarthritis on the Kellgren-Lawrence Scale from Radiographs Using Convolutional Neural Networks [Internet]. arXiv.org. 2020 [cited 2024 Jun 25].
- Background: PubMed 33207632Yunus MHM, Nordin A, Kamal H. Pathophysiological Perspective of Osteoarthritis. Medicina (Kaunas). 2020 Nov 16;56(11):614. doi: 10.3390/medicina56110614.
- Background: PubMed 34784876Siddiq MAB, Clegg D, Jansen TL, Rasker JJ. Emerging and New Treatment Options for Knee Osteoarthritis. Curr Rheumatol Rev. 2022;18(1):20-32. doi: 10.2174/1573397117666211116111738.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Samrood Akram, PhD* principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Standard Physical Therapy and Egoscue Exercises in people with Knee Osteoarthritis, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Samrood Akram, PhD Scholar (03324806143, samrood.akram@riphah.edu.pk.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Range of Motion (time frame: upto 4 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07063953, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2025.