Intermittent HypoxiaHypoChronoPerfNCT07072975
CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia
A study testing Normobaric hypoxia and normoxic condition in people with Intermittent Hypoxia and Exercise Recovery, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
Trial summary
Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- Intermittent Hypoxia, Exercise Recovery, Intermittent Exercise
- What is being tested?
- Normobaric hypoxia and normoxic condition
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 50 participants
- Where
- 1 siteFrance
- Study dates
- Oct 2025to Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- from 40 to 60 years
- follow-up in the pneumology unit of CHU Amiens - Picardie
- Chronic Obstructive Pulmonary Disease stade II
- Body mass index from 20 to 30 kg.m-2
- Tiffeneau index < 70% of predicted value
- FEV1 from 50 to 80% of predicted values
Show all 10Show fewer
- Smoking cessation since at least 1 week
- Sedentary or physical active
- Affiliate to social security
- Written consent
Who cannot join
- -
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site
CHRU Amiens
Amiens, 80480
Emeric Thiesset, MD, 33+3 22 08 80 51, Thiesset.emeric@chu-amiens.fr
About this study
Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses.
this randomized, controlled, study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.
Hypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.
- Conditions
- Intermittent Hypoxia, Exercise Recovery, Intermittent Exercise, Rating Exertion Perception, Sleep
- Being tested
- Normobaric hypoxia, normoxic condition
- Keywords
- intermittent hypoxia, exercise recovery, intermittent exercise, rating exertion perception, sleep
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Normobaric hypoxiaOther
Normobaric hypoxia (inspired oxygen fraction of 12.9%) applied between-sets recovery periods
normoxic conditionOther
Between-sets recovery periods under normoxic condition
| Study group | Role | What they receive |
|---|---|---|
| comparator | Experimental | On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed. Receives: Other: Normobaric hypoxia |
| sham | Sham comparator | Not described Receives: Other: normoxic condition |
What is being measured
The primary outcome is the main question the study is designed to answer.
Perception Exertion score with CR10
The modified Borg CR10 RPE scale measures exertion on a scale of 0 (no exertion or resting) to 10 (pushing yourself to the max).
Measured: day 1
Secondary outcomes (1)
Cardiorespiratory responses to exercise
Cardiorespiratory responses to exercise is measured with gaseous exchange volumes
Measured: day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jul 2025
- Study startOct 2025 (estimated)
- Primary completionJul 2027 (estimated)
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Intermittent HypoxiaStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire, AmiensThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire, Amiens
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07072975
- Sponsor's protocol ID
- PI2025_843_0029
- Acronym
- HypoChronoPerf
- Status last verified
- Sep 2025
- First submitted
- 9 Jul 2025
- Last updated
- 1 Oct 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia
- ClinicalTrials.gov ID
- NCT07072975
- Acronym / sponsor ID
- HypoChronoPerf / PI2025_843_0029
- Conditions
- Intermittent Hypoxia, Exercise Recovery, Intermittent Exercise, Rating Exertion Perception, Sleep
- Keywords
- intermittent hypoxia, exercise recovery, intermittent exercise, rating exertion perception, sleep
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Centre Hospitalier Universitaire, AmiensUniversity, hospital or other
- Study start
- Oct 2025 (estimated)
- Primary completion
- Jul 2027 (estimated)
- Study completion
- Aug 2027 (estimated)
- First posted
- 18 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses.
this randomized, controlled, study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.
Hypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| comparator | Experimental | Other: Normobaric hypoxiaOn separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed. |
| sham | Sham comparator | Other: normoxic condition |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (10 listed)
- from 40 to 60 years
- follow-up in the pneumology unit of CHU Amiens - Picardie
- Chronic Obstructive Pulmonary Disease stade II
- Body mass index from 20 to 30 kg.m-2
- Tiffeneau index < 70% of predicted value
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Normobaric hypoxiaNormobaric hypoxia (inspired oxygen fraction of 12.9%) applied between-sets recovery periods | Other | comparator |
| normoxic conditionBetween-sets recovery periods under normoxic condition | Other | sham |
Primary outcome
Perception Exertion score with CR10
Time frame: day 1
The modified Borg CR10 RPE scale measures exertion on a scale of 0 (no exertion or resting) to 10 (pushing yourself to the max).
1 secondary outcome
Cardiorespiratory responses to exercise
Time frame: day 1
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Oct 2025.
- Individual participant dataSharing planned: No
Related trials for Intermittent Hypoxia
Not yet recruiting
Acute Intermittent Hypoxia Therapy for Depression
Major Depressive Disorder (MDD)
Recruiting
Influence of Intermittent Hypoxia on Loop Gain in Healthy Subjects
Intermittent Hypoxia, Healthy Volunteers
Not yet recruiting
Safety and Efficacy of Carotid Artery Stenting Combined With Intermittent Hypoxia Intervention in Patients With Severe Internal Carotid Artery Stenosis
Internal Carotid Artery Stenosis
Recruiting
Brain Connectivity and Corticospinal Excitability in Response to Moderate Hypoxia
Normoxia, Intermittent Moderate Hypoxia
Recruiting
BioFLO for Respiratory Recovery in SCI
Spinal Cord Injuries
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Normobaric hypoxia and normoxic condition in people with Intermittent Hypoxia and Exercise Recovery, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 1 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Emeric Thiesset, MD (33+322088051, thiesset.emeric@chu-amiens.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Perception Exertion score with CR10 (time frame: day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Oct 2025.