AgeingNCT07090603
The Effects of Age on Muscle Endurance During Resistance Exercise With and Without Blood Flow Restriction
A study testing Knee extension exercise in people with Ageing and Muscle Fatigue Caused by Repetitive Muscle Exercise, run by University of British Columbia at 1 site in Canada.
Trial summary
The purpose of this study is to learn how aging affects muscle endurance during resistance exercise, and how oxygen delivery to the muscles plays a role in these changes. To answer this question, we are comparing how many repetitions of a leg exercise (knee extensions) younger and older adults can do at different… Read more about this study
- Who is it for?
- Ages 19 years and olderHealthy volunteers can take part
- Conditions the study is for
- Ageing, Muscle Fatigue Caused by Repetitive Muscle Exercise
- What is being tested?
- Knee extension exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteCanada
- Study dates
- Sep 2025to Apr 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Able to understand and communicate in English
- 19-35 years of age
- 65 years of age or older
- All "No" answers on the CSEP Get Active questionnaire or doctors' approval to participate
Who cannot join
- BMI lower than 18 or greater than 32
- Current use of cigarettes or other nicotine devices
- Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
- Any medical condition impacting the ability to participate in maximal exercise
- Type one or type two diabetes
- Diagnosis of cancer or undergoing cancer treatment in the past 12 months
Show all 11Show fewer
- Taking blood-thinning medication or the presence of a bleeding disorder
- Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines)
- Lowest calculated exercise testing load is less than the lightest weight able to be provided by the lab gymnasium equipment
- In the past six months, completing more than 300 minutes of moderate physical activity or 150 minutes of vigorous physical activity per week
- In the past six months, completing less than 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Age-Related Differences in Skeletal Muscle Endurance Responses to Various Relative Loads of Dynamic Resistance Exercise With and Without Peripheral Blood Flow Occlusion
The purpose of this study is to learn how aging affects muscle endurance during resistance exercise, and how oxygen delivery to the muscles plays a role in these changes. To answer this question, we are comparing how many repetitions of a leg exercise (knee extensions) younger and older adults can do at different exercise intensities. We will also look at how the muscles use oxygen during these exercises.
Participants will take part in 12 different exercise sessions. In each session, they will perform as many knee extensions as possible using different amounts of weight-consisting of 20%, 30%, 40%, 50%, 60% and 70% of the maximum weight they can lift one time. Each weight will be tested both with and without a cuff on the leg that temporarily reduces blood flow to the muscle.
- Being tested
- Knee extension exercise
- Keywords
- muscle endurance, muscle contraction, critical occluding tension, muscle oxygenation, NIRS, ageing, muscle fatigue, contraction induced occlusion
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Knee extension exerciseOther
Maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of participants one rep max with and without blood flow occlusion
| Study group | Role | What they receive |
|---|---|---|
| Young cohort | Experimental | Young, healthy participants aged 19-35 will perform maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of their one rep max with and without blood flow occlusion. Receives: Other: Knee extension exercise |
| Older cohort | Experimental | Older, healthy participants aged 65 years and up will perform maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of their one rep max with and without blood flow occlusion. Receives: Other: Knee extension exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maximum repetitions performed during knee extension exercise
The primary outcome of the study will be the maximum number of knee extension repetitions that participants are able to perform at varying resistive exercise loads.
Measured: From enrollment to the end of the final study visit (~4 weeks)
Secondary outcomes (1)
Local muscle tissue oxygenation during knee extension exercise
Muscle tissue oxygenation status will be assessed during each knee extension exercise intervention using oxygen sensors placed on the outside of the thigh.
Measured: From enrollment to the end of the final study visit (~ 4 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jul 2025
- Study startSep 2025 (estimated)
- Primary completionApr 2026 (estimated)
- Study completionApr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AgeingStudies of the same condition, open and under way.
- More trials run by University of British ColumbiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of British Columbia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Cameron Mitchell, University of British Columbia
- Investigators
- Cameron J Mitchell, PhD (Kinesiology), Principal investigator, University of British Columbia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07090603
- Sponsor's protocol ID
- H25-01532
- Status last verified
- Jul 2025
- First submitted
- 21 Jul 2025
- Last updated
- 29 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Age-Related Differences in Skeletal Muscle Endurance Responses to Various Relative Loads of Dynamic Resistance Exercise With and Without Peripheral Blood Flow Occlusion
- ClinicalTrials.gov ID
- NCT07090603
- Acronym / sponsor ID
- H25-01532
- Keywords
- muscle endurance, muscle contraction, critical occluding tension, muscle oxygenation, NIRS, ageing, muscle fatigue, contraction induced occlusion
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- University of British ColumbiaUniversity, hospital or other
- Study start
- Sep 2025 (estimated)
- Primary completion
- Apr 2026 (estimated)
- Study completion
- Apr 2026 (estimated)
- First posted
- 29 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to learn how aging affects muscle endurance during resistance exercise, and how oxygen delivery to the muscles plays a role in these changes. To answer this question, we are comparing how many repetitions of a leg exercise (knee extensions) younger and older adults can do at different exercise intensities. We will also look at how the muscles use oxygen during these exercises.
Participants will take part in 12 different exercise sessions. In each session, they will perform as many knee extensions as possible using different amounts of weight-consisting of 20%, 30%, 40%, 50%, 60% and 70% of the maximum weight they can lift one time. Each weight will be tested both with and without a cuff on the leg that temporarily reduces blood flow to the muscle.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Young cohort | Experimental | Other: Knee extension exerciseYoung, healthy participants aged 19-35 will perform maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of their one rep max with and without blood flow occlusion. |
| Older cohort | Experimental | Other: Knee extension exerciseOlder, healthy participants aged 65 years and up will perform maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of their one rep max with and without blood flow occlusion. |
Who may qualify
- Ages
- 19 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Able to understand and communicate in English
- 19-35 years of age
- 65 years of age or older
- All "No" answers on the CSEP Get Active questionnaire or doctors' approval to participate
Key exclusion criteria (11 listed)
- BMI lower than 18 or greater than 32
- Current use of cigarettes or other nicotine devices
- Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
- Any medical condition impacting the ability to participate in maximal exercise
- Type one or type two diabetes
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Knee extension exerciseMaximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of participants one rep max with and without blood flow occlusion | Other | Older cohort, Young cohort |
Primary outcome
Maximum repetitions performed during knee extension exercise
Time frame: From enrollment to the end of the final study visit (~4 weeks)
The primary outcome of the study will be the maximum number of knee extension repetitions that participants are able to perform at varying resistive exercise loads.
1 secondary outcome
Local muscle tissue oxygenation during knee extension exercise
Time frame: From enrollment to the end of the final study visit (~ 4 weeks)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Jul 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Cameron J Mitchell, PhD (Kinesiology) principal investigator
University of British Columbia
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Knee extension exercise in people with Ageing and Muscle Fatigue Caused by Repetitive Muscle Exercise, run by University of British Columbia at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 29 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Abaigeal L Kelso (6138626994, akelso@student.ubc.ca), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maximum repetitions performed during knee extension exercise (time frame: From enrollment to the end of the final study visit (~4 weeks)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Jul 2025.