Ischemic StrokeASSISTANTNCT07102693
Left Atrial Strain Assessment in Ischemic Stroke Patients
An observational study of Ischemic Stroke and Left Atrial Strain, run by Connolly Hospital Blanchardstown at 1 site in Ireland.
Trial summary
This study is investigating a potential link between a novel measurement made on cardiac ultrasound and the risk of ischemic stroke in patients with a normal heart rhythm. The novel measurement is called left atrial strain. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Ischemic Stroke, Left Atrial Strain, Sinus Rhythm
- How many people
- 468 participants
- Where
- 1 siteIreland
- Study dates
- 15 Jul 2024to 1 Jun 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients presenting to the emergency department with FAST positive symptoms suspicious for an acute stroke.
Who may be able to join
- Emergency department presentation with FAST positive symptoms
- Neuroimaging performed as part of stroke workup
- Echocardiogram performed during index admission
Who cannot join
- Any history of atrial fibrillation prior or during admission
- Age below 18 years of age
- No echocardiogram or echocardiogram images not of sufficient quality to perform left atrial strain analysis
- At least moderate mitral regurgitation
- ASD or PFO
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Left Atrial Strain Assessment in Ischemic Stroke Patients: a Retrospective Case-control Study - the ASSISTANT Study
This study is investigating a potential link between a novel measurement made on cardiac ultrasound and the risk of ischemic stroke in patients with a normal heart rhythm. The novel measurement is called left atrial strain. It uses speckle tracking echocardiography to measure the muscle function of the left atrium, one of the cardiac chambers. Investigators investigated whether patients with lower function of this chamber are at a higher risk of developing stroke from blood clots traveling to the brain. It is already known that patients with an irregular heart rhythm known as atrial fibrillation are at higher risk of these types of strokes. Investigators wanted to determine if there is a similar association in patients with normal heart rhythm but low left atrial strain.
- Conditions
- Ischemic Stroke, Left Atrial Strain, Sinus Rhythm
- Keywords
- left atrial strain
- Medical subject headings
- Ischemic Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Patients with Acute Ischemic Stroke | Patients presenting to the emergency department with FAST positive symptoms who are proven to have acute ischaemic stroke on neuroimaging. | |
| Patients without Acute Ischaemic Stroke | Patients presenting to the emergency department with FAST positive symptoms who do not have evidence of acute ischaemic stroke on neuroimaging and an alternative cause of their FAST symptoms is found |
What is being measured
The primary outcome is the main question the study is designed to answer.
Correlation between left atrial strain and acute ischaemic stroke
This correlation will be adjusted for common stroke risk factors such as age, gender, hypertension, smoking, dyslipidaemia, and diabetes.
Measured: 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Aug 2025
- Study start15 Jul 2024
- Primary completion1 Jun 2025
- Study completion1 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Ischemic StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Retrospective
- Enrolment
- 468 participants (actual)
Sponsor and investigators
- Lead sponsor
- Connolly Hospital Blanchardstown
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Michael J Daly, MA MD PhD, Connolly Hospital Blanchardstown
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07102693
- Sponsor's protocol ID
- CBH 024/23
- Acronym
- ASSISTANT
- Status last verified
- Aug 2025
- First submitted
- 30 Jul 2025
- Last updated
- 12 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Echo measurements: Left atrial strain measurements, left ventricular ejection fraction, interventricular septal thickness, E/e' Demographics: Age, gender, hypertension status, smoking status, diabetes status, dyslipidaemia status,
Publications
Trueick R, Shpigelman J, Dabash O, McCallig J, Ashfaque MA, Quidwai M, Donaghy L, Guilfoyle P, Saiva L, O'Neill J, Daly MJ. Impaired left atrial strain is associated with acute ischemic stroke in patients without atrial fibrillation. Front Stroke. 2026 Jul 14;5:1838151. doi: 10.3389/fstro.2026.1838151. eCollection 2026.
PubMed 42523707
Study at a glance
From the registry record, last updated by the sponsor on 12 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Left Atrial Strain Assessment in Ischemic Stroke Patients: a Retrospective Case-control Study - the ASSISTANT Study
- ClinicalTrials.gov ID
- NCT07102693
- Acronym / sponsor ID
- ASSISTANT / CBH 024/23
- Conditions
- Ischemic Stroke, Left Atrial Strain, Sinus Rhythm
- Keywords
- left atrial strain
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 468 participants (actual)
- Lead sponsor
- Connolly Hospital BlanchardstownUniversity, hospital or other
- Study start
- 15 Jul 2024 (actual)
- Primary completion
- 1 Jun 2025 (actual)
- Study completion
- 1 Jun 2025 (actual)
- First posted
- 5 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is investigating a potential link between a novel measurement made on cardiac ultrasound and the risk of ischemic stroke in patients with a normal heart rhythm. The novel measurement is called left atrial strain. It uses speckle tracking echocardiography to measure the muscle function of the left atrium, one of the cardiac chambers. Investigators investigated whether patients with lower function of this chamber are at a higher risk of developing stroke from blood clots traveling to the brain. It is already known that patients with an irregular heart rhythm known as atrial fibrillation are at higher risk of these types of strokes. Investigators wanted to determine if there is a similar association in patients with normal heart rhythm but low left atrial strain.
Study design
- Observational model
- Case-control
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Patients with Acute Ischemic Stroke | – | –Patients presenting to the emergency department with FAST positive symptoms who are proven to have acute ischaemic stroke on neuroimaging. |
| Patients without Acute Ischaemic Stroke | – | –Patients presenting to the emergency department with FAST positive symptoms who do not have evidence of acute ischaemic stroke on neuroimaging and an alternative cause of their FAST symptoms is found |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients presenting to the emergency department with FAST positive symptoms suspicious for an acute stroke.
Key inclusion criteria (3 listed)
- Emergency department presentation with FAST positive symptoms
- Neuroimaging performed as part of stroke workup
- Echocardiogram performed during index admission
Key exclusion criteria (5 listed)
- Any history of atrial fibrillation prior or during admission
- Age below 18 years of age
- No echocardiogram or echocardiogram images not of sufficient quality to perform left atrial strain analysis
- At least moderate mitral regurgitation
- ASD or PFO
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Correlation between left atrial strain and acute ischaemic stroke
Time frame: 2 weeks
This correlation will be adjusted for common stroke risk factors such as age, gender, hypertension, smoking, dyslipidaemia, and diabetes.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Aug 2025.
- Derived from this study: PubMed 42523707Trueick R, Shpigelman J, Dabash O, McCallig J, Ashfaque MA, Quidwai M, Donaghy L, Guilfoyle P, Saiva L, O'Neill J, Daly MJ. Impaired left atrial strain is associated with acute ischemic stroke in patients without atrial fibrillation. Front Stroke. 2026 Jul 14;5:1838151. doi: 10.3389/fstro.2026.1838151. eCollection 2026.
- Individual participant dataSharing planned: Yes. Echo measurements: Left atrial strain measurements, left ventricular ejection fraction, interventricular septal thickness, E/e' Demographics: Age, gender, hypertension status, smoking status, diabetes status, dyslipidaemia status,
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ischemic Stroke and Left Atrial Strain, run by Connolly Hospital Blanchardstown at 1 site in Ireland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Ireland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Correlation between left atrial strain and acute ischaemic stroke (time frame: 2 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07102693, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Aug 2025.