TrainingNCT07105410
Hypoalgesic Effects of Exercise and Training of Different Modalities
A study testing Aim #1: The effect of post-exercise circulatory occlusion on H-reflex and V-wave, Aim #2: The hypoalgesic effects of acute exercise of different modalities and Aim #3: The hypoalgesic effects of chronic training of different modalities in people with Training and Exercise, run by Faculdade de Motricidade Humana at 1 site in Portugal.
Trial summary
Further research is needed to explore the analgesic effects of post-acute and chronic exercise and if effects are partially dependent on lower H-reflex/V-wave inhibition by group III and IV muscle afferents desensitization. Read more about this study
- Who is it for?
- Ages 18 to 35 years, men onlyHealthy volunteers can take part
- What is being tested?
- Aim #1: The effect of post-exercise circulatory occlusion on H-reflex and V-wave, Aim #2: The hypoalgesic effects of acute exercise of different modalities and Aim #3: The hypoalgesic effects of chronic training of different modalities
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- 1 sitePortugal
- Study dates
- 1 Jan 2022to 30 May 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- 18 - 35 years males
- Healthy (health status determined from a health-screening questionnaire performed at study admission)
- Normal arterial blood pressure (ABP) (cut-off values for systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) of ≤ 120/80 mmHg)
Who cannot join
- Neurologic disease
- Metabolic disease
- Cardiovascular disease
- Respiratory disease
- Musculoskeletal issues in the 3 previous months limiting exercise performance
- Taking any chronic medications for the treatment of pain or had any pain related condition
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Influence of Nociception on Exercise Induced Fatigue: the Analgesic Role of Acute Exercise and Long-term Training of Different Exercise Modalities
Further research is needed to explore the analgesic effects of post-acute and chronic exercise and if effects are partially dependent on lower H-reflex/V-wave inhibition by group III and IV muscle afferents desensitization. In addition, it is important to note that the available research examining the interaction between exercise (acute and chronic) and pain did not compare the effect of different exercise modalities. Moreover, since discharge rate of III and IV afferents is highly dependent on specific task-metabolic requirements, it is relevant to determine if exercise modality differentially modulates the possible analgesic response via metaboreflex desensitization.
Therefore, with this project, the investigators aim at exploring the influence of experimentally induced metaboreflex activation (group III and IV afferents) (maintained submaximal isometric contraction followed by blood-flow occlusion - post-exercise circulatory occlusion (PECO)) Vs. a control condition (no isometric contraction nor blood flow occlusion), on H-reflex recruitment curve and V-wave excitability (aim #1). Since the activation of group III/IV afferents can inhibit the corticospinal pathway, the investigators hypothesize that the normalized maximal amplitude of H- and V-wave and the slope of the ascending limb of the H-recruitment curve will decrease with metaboreflex activation (during PECO). Additionally, the investigators intend to examine the acute impact of different lower-limb exercise regimens (aerobic, anaerobic and dynamic resistance) on pain sensitivity (by the application of a foot cold pain tolerance test, by determining pressure pain threshold of exercising and non-exercising muscles and through self-reported leg ischemic pain ratings (0-10 Cook scale) - during PECO) (aim #2). Participants are also asked to mark the intensity of cold pain sensation using a visual analogue scale (VAS) with a horizontal line of 100mm, every 30 s of testing.This will allow the investigators to investigate the analgesic role of different acute exercise paradigms through possible metaboreflex desensitization given by altered neuromuscular responses at post-exercise time point (attenuated inhibition of H-reflex and V-wave amplitude during PECO). Also, once past research has shown that muscle metaboreflex activation reduces the sensitivity of the baroreflex, the investigators will measure arterial pressure (AP) and heart rate variability (HRV) during cold test and AP during ischemic testing. Despite all exercise modalities could enhance reducing pain sensibility after exercise, the investigators hypothesize that resistance and anaerobic exercise stimuli will enhance pain threshold/tolerance and reduced pain ratings via metaboreflex desensitization compared to that seen with endurance exercise (attenuated increase of AP and sympathetic component of HRV during cold pressor test and attenuated increase of AP during ischemic pain test). Finally, the investigators intend to explore the impact of long-term aerobic, anaerobic and resistance training on pain sensibility, using the same tests of aim #2 (aim #3). The investigators hypothesize that chronic EIH will be of greater magnitude after anaerobic and resistance exercise training vs. endurance training. This will be related with attenuated inhibition of H-reflex and V-wave amplitude measured during PECO and attenuated increase of AP and sympathetic component of HRV during metaboreflex activation after those training modalities. Nevertheless, the investigators expect to see an increased motor performance in all training regimens via heightened H-reflex (aerobic and anaerobic groups) and V-wave (resistance group) excitability.
- Being tested
- Aim #1: The effect of post-exercise circulatory occlusion on H-reflex and V-wave, Aim #2: The hypoalgesic effects of acute exercise of different modalities, Aim #3: The hypoalgesic effects of chronic training of different modalities
- Keywords
- hypoalgesia, pain
- Medical subject headings
- Motor Activity, Fatigue, Bites and Stings, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Aim #1: The effect of post-exercise circulatory occlusion on H-reflex and V-waveOther
Aim #1 follows a randomized and crossover design in which 16 young and healthy males are evaluated during thigh circulatory occlusion performed after a submaximal isometric plantar flexion contraction (PECO day). In the other session, participants are evaluated during free-flow conditions and without previous fatiguing contraction (no-PECO day). In PECO day, participants complete a 3-min contraction at 40% of maximal force. Then, for testing, blood flow from lower-leg is blocked during 4 min, by an inflatable cuff around the ipsilateral thigh before task termination, during which H- reflex is tested. At the end of recordings, the cuff is deflated. Participants ware allowed to rest for 5-10 min. Then, they are requested to perform a new 3 min contraction with the cuff being inflated before task termination. The cuff remains inflated for ~ 2 min during which V-wave recordings are obtained. In both days, leg pain intensity is reported by participants and brachial AP is measured.
Aim #2: The hypoalgesic effects of acute exercise of different modalitiesOther
Aim #2 follows a randomized and crossover-controlled design, consisting on two experimental sessions. 24 healthy male (all diferent from Experiment 1) are randomly allocated to one of the following exercising regimens: aerobic, anaerobic or dynamic resistance (8 participants for each exercise group). In one of the experimental days, participants are evaluated for pain sensitivity and neuromuscular responses both before and after a lower-limb acute exercise protocol (exercise day) and in the other day before and after 15 min of quiet rest (non-exercise day). In both sessions, participants are evaluated for rectus femoris, upper trapezius and biceps brachiis muscles pressure pain threshold, followed by the application of a cold pain tolerance test on the foot. The intensity of pain is reported by a 0-100mm VAS and AP and HRV continously measured. Then, participants are tested for H-reflex and V-wave excitability during PECO, with leg pain intensity (0-10) and brachial AP recorded.
Aim #3: The hypoalgesic effects of chronic training of different modalitiesOther
Aim #3 follows a randomized-controlled design. 32 healthy male (all the 24 participants from Experimental 2 plus 8 new subjects) are randomly allocated to one of the following groups: aerobic, anaerobic, dynamic resistance training and no-training (control) (8 participants for each group). Each intervention group perform 6 weeks of exercise training (3x week). Participants allocated to each training group are evaluated before and after training (2 assessment days in each time-point). On one day participants are tested for pressure pain threshold and cold pain tolerance with concomitant measures of pain ratings (0-100mm VAS), AP and HRV. The influence of metaboreflex activation on H-reflex and V-wave is also measured (during PECO). In addition, during PECO ischemic pain rating and AP are obtained. On another day, participants are evaluated for motor performance (maximal oxygen uptake, maximal voluntary contraction and peak power) and neuromuscular adaptations (i.e. H-reflex and V-wave)
| Study group | Role | What they receive |
|---|---|---|
| PECO and No-PECO | Experimental | Not described Receives: Other: Aim #1: The effect of post-exercise circulatory occlusion on H-reflex and V-wave |
| Aerobic, Anaerobic and Dynamic Resistance Exercise | Experimental | Not described Receives: Other: Aim #2: The hypoalgesic effects of acute exercise of different modalities |
| Aerobic, Anaerobic, Dynamic Resistance Training and Control Group | Experimental | Not described Receives: Other: Aim #3: The hypoalgesic effects of chronic training of different modalities |
What is being measured
The primary outcome is the main question the study is designed to answer.
H-reflex
With soleus electromyographic recording electrode (Delsys) and electrical stimulation of the tibial nerve (Stimsola) the H-reflex recruitment curve parameters (spinal excitability) will be obtained in a 4-min protocol
Measured: During PECO and No-PECO conditions (aim #1); Pre-post acute exercise during PECO (aim #2); Pre-post 6 weeks of training during PECO (aim #3)
V-wave
With soleus electromyographic recording electrode (Delsys) and electrical stimulation of the tibial nerve (Stimsola) the V-wave parameters (spinal and supraspinal excitability) will be obtained
Measured: During PECO and No-PECO conditions (aim #1); Pre-post acute exercise during PECO (aim #2); Pre-post 6 weeks of training during PECO (aim #3)
Ischemic pain ratings
Participants will be asked to rate their leg pain intensity twice at the 4-min H-reflex protocol (at 2nd and 4th min of the procedure) using a Cook pain sale (0-10). In the scale, 0 represents no pain while 10 represents the worst possible pain
Measured: During PECO and No-PECO conditions (aim #1); Pre-post acute exercise during PECO (aim #2); Pre-post 6 weeks of training during PECO (aim #3)
Arterial blood pressure
Brachial arterial pressure will be measured twice at the 4-min H-reflex protocol (at 2nd and 4th min of the procedure) by an automated equiment (Tango SunTech Medical)
Measured: During PECO and No-PECO conditions (aim #1); Pre-post acute exercise during PECO (aim #2); Pre-post 6 weeks of training during PECO (aim #3)
Pressure pain threshold
It will be assessed with an analogue algometer (FDK 60, Wagner Instruments) (in rectus femoris, upper-trapezius and biceps brachiis muscles). It measures the kg of force at the time participants report they are feeling pain intead of pressure
Measured: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
Cold pain tolerance
It will be assessed with participants immersing their right foot into a container with cold water between 0 and 2ºC. It measures the time participants can endure the cold painful stimuli
Measured: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
Cold pain ratings
While participants immerse their right foot into a container with cold water between 0 and 2ºC, they will beasked to rate the intensity of pain they perceived each minute by writing in a visual analogue scale (0-100mm) that pain intensity. 0 is considered no-pain and 100 the worst possible pain
Measured: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
Heart rate variability during cold pain testing
It will be measured continuosly during the time participants have their foot in cold water using a heart rate monitor (Polar H10)
Measured: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
Arterial blood pressure during cold pain testing
It will be measured each minute during the time participants have their foot in cold water using an automatic equipment (Tango SunTech Medical)
Measured: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
Maximal oxygen uptake
For the aerobic group, it will be determined in a treadmill graded exercise testing using a gas analyses system (Metamax, Cortex)
Measured: Pre-post 6 weeks of training (aim #3)
Peak power
For the anaerobic group, it will be determined with a 30-s Wingate all-out test (Monark cycloergometer)
Measured: Pre-post 6 weeks of training (aim #3)
Maximal voluntary isometric contraction
For the dynamic resistance group, it will be determined for the knee extensors muscles using an isokinetic dynamometer (Biodex)
Measured: Pre-post 6 weeks of training (aim #3)
H-reflex after training
With soleus electromyographic recording electrode (Delsys) and electrical stimulation of the tibial nerve (Stimsola) the H-reflex recruitment curve parameters (spinal excitability) will be obtained
Measured: Pre-post 6 weeks of training (aim #3)
V-wave after training
With soleus electromyographic recording electrode (Delsys) and electrical stimulation of the tibial nerve (Stimsola) the V-wave parameters (spinal and supraspinal excitability) will be obtained
Measured: Pre-post 6 weeks of training (aim #3)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Aug 2025
- Study start1 Jan 2022
- Primary completion30 Dec 2022
- Study completion30 May 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 48 participants (actual)
Sponsor and investigators
- Lead sponsor
- Faculdade de Motricidade Humana
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, André Dias Gonçalves, Faculdade de Motricidade Humana
- Investigators
- Gonçalo V Mendonça, PhD, Principal investigator, Faculdade de Motricidade Humana
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07105410
- Sponsor's protocol ID
- CEIFMH Nº33/2021
- Status last verified
- Jul 2025
- First submitted
- 17 Jul 2025
- Last updated
- 5 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Influence of Nociception on Exercise Induced Fatigue: the Analgesic Role of Acute Exercise and Long-term Training of Different Exercise Modalities
- ClinicalTrials.gov ID
- NCT07105410
- Acronym / sponsor ID
- CEIFMH Nº33/2021
- Keywords
- hypoalgesia, pain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 48 participants (actual)
- Lead sponsor
- Faculdade de Motricidade HumanaUniversity, hospital or other
- Study start
- 1 Jan 2022 (actual)
- Primary completion
- 30 Dec 2022 (actual)
- Study completion
- 30 May 2025 (actual)
- First posted
- 5 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Further research is needed to explore the analgesic effects of post-acute and chronic exercise and if effects are partially dependent on lower H-reflex/V-wave inhibition by group III and IV muscle afferents desensitization. In addition, it is important to note that the available research examining the interaction between exercise (acute and chronic) and pain did not compare the effect of different exercise modalities. Moreover, since discharge rate of III and IV afferents is highly dependent on specific task-metabolic requirements, it is relevant to determine if exercise modality differentially modulates the possible analgesic response via metaboreflex desensitization.
Therefore, with this project, the investigators aim at exploring the influence of experimentally induced metaboreflex activation (group III and IV afferents) (maintained submaximal isometric contraction followed by blood-flow occlusion - post-exercise circulatory occlusion (PECO)) Vs. a control condition (no isometric contraction nor blood flow occlusion), on H-reflex recruitment curve and V-wave excitability (aim #1). Since the activation of group III/IV afferents can inhibit the corticospinal pathway, the investigators hypothesize that the normalized maximal amplitude of H- and V-wave and the slope of the ascending limb of the H-recruitment curve will decrease with metaboreflex activation (during PECO). Additionally, the investigators intend to examine the acute impact of different lower-limb exercise regimens (aerobic, anaerobic and dynamic resistance) on pain sensitivity (by the application of a foot cold pain tolerance test, by determining pressure pain threshold of exercising and non-exercising muscles and through self-reported leg ischemic pain ratings (0-10 Cook scale) - during PECO) (aim #2). Participants are also asked to mark the intensity of cold pain sensation using a visual analogue scale (VAS) with a horizontal line of 100mm, every 30 s of testing.This will allow the investigators to investigate the analgesic role of different acute exercise paradigms through possible metaboreflex desensitization given by altered neuromuscular responses at post-exercise time point (attenuated inhibition of H-reflex and V-wave amplitude during PECO). Also, once past research has shown that muscle metaboreflex activation reduces the sensitivity of the baroreflex, the investigators will measure arterial pressure (AP) and heart rate variability (HRV) during cold test and AP during ischemic testing. Despite all exercise modalities could enhance reducing pain sensibility after exercise, the investigators hypothesize that resistance and anaerobic exercise stimuli will enhance pain threshold/tolerance and reduced pain ratings via metaboreflex desensitization compared to that seen with endurance exercise (attenuated increase of AP and sympathetic component of HRV during cold pressor test and attenuated increase of AP during ischemic pain test). Finally, the investigators intend to explore the impact of long-term aerobic, anaerobic and resistance training on pain sensibility, using the same tests of aim #2 (aim #3). The investigators hypothesize that chronic EIH will be of greater magnitude after anaerobic and resistance exercise training vs. endurance training. This will be related with attenuated inhibition of H-reflex and V-wave amplitude measured during PECO and attenuated increase of AP and sympathetic component of HRV during metaboreflex activation after those training modalities. Nevertheless, the investigators expect to see an increased motor performance in all training regimens via heightened H-reflex (aerobic and anaerobic groups) and V-wave (resistance group) excitability.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| PECO and No-PECO | Experimental | Other: Aim #1: The effect of post-exercise circulatory occlusion on H-reflex and V-wave |
| Aerobic, Anaerobic and Dynamic Resistance Exercise | Experimental | Other: Aim #2: The hypoalgesic effects of acute exercise of different modalities |
| Aerobic, Anaerobic, Dynamic Resistance Training and Control Group | Experimental | Other: Aim #3: The hypoalgesic effects of chronic training of different modalities |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- 18 - 35 years males
- Healthy (health status determined from a health-screening questionnaire performed at study admission)
- Normal arterial blood pressure (ABP) (cut-off values for systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) of ≤ 120/80 mmHg)
Key exclusion criteria (6 listed)
- Neurologic disease
- Metabolic disease
- Cardiovascular disease
- Respiratory disease
- Musculoskeletal issues in the 3 previous months limiting exercise performance
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Aim #1: The effect of post-exercise circulatory occlusion on H-reflex and V-waveAim #1 follows a randomized and crossover design in which 16 young and healthy males are evaluated during thigh circulatory occlusion performed after a submaximal isometric plantar flexion contraction (PECO day). In the other session, participants are evaluated during free-flow conditions and without previous fatiguing contraction (no-PECO day). In PECO day, participants complete a 3-min contraction at 40% of maximal force. Then, for testing, blood flow from lower-leg is blocked during 4 min, by an inflatable cuff around the ipsilateral thigh before task termination, during which H- reflex is tested. At the end of recordings, the cuff is deflated. Participants ware allowed to rest for 5-10 min. Then, they are requested to perform a new 3 min contraction with the cuff being inflated before task termination. The cuff remains inflated for ~ 2 min during which V-wave recordings are obtained. In both days, leg pain intensity is reported by participants and brachial AP is measured. | Other | PECO and No-PECO |
| Aim #2: The hypoalgesic effects of acute exercise of different modalitiesAim #2 follows a randomized and crossover-controlled design, consisting on two experimental sessions. 24 healthy male (all diferent from Experiment 1) are randomly allocated to one of the following exercising regimens: aerobic, anaerobic or dynamic resistance (8 participants for each exercise group). In one of the experimental days, participants are evaluated for pain sensitivity and neuromuscular responses both before and after a lower-limb acute exercise protocol (exercise day) and in the other day before and after 15 min of quiet rest (non-exercise day). In both sessions, participants are evaluated for rectus femoris, upper trapezius and biceps brachiis muscles pressure pain threshold, followed by the application of a cold pain tolerance test on the foot. The intensity of pain is reported by a 0-100mm VAS and AP and HRV continously measured. Then, participants are tested for H-reflex and V-wave excitability during PECO, with leg pain intensity (0-10) and brachial AP recorded. | Other | Aerobic, Anaerobic and Dynamic Resistance Exercise |
| Aim #3: The hypoalgesic effects of chronic training of different modalitiesAim #3 follows a randomized-controlled design. 32 healthy male (all the 24 participants from Experimental 2 plus 8 new subjects) are randomly allocated to one of the following groups: aerobic, anaerobic, dynamic resistance training and no-training (control) (8 participants for each group). Each intervention group perform 6 weeks of exercise training (3x week). Participants allocated to each training group are evaluated before and after training (2 assessment days in each time-point). On one day participants are tested for pressure pain threshold and cold pain tolerance with concomitant measures of pain ratings (0-100mm VAS), AP and HRV. The influence of metaboreflex activation on H-reflex and V-wave is also measured (during PECO). In addition, during PECO ischemic pain rating and AP are obtained. On another day, participants are evaluated for motor performance (maximal oxygen uptake, maximal voluntary contraction and peak power) and neuromuscular adaptations (i.e. H-reflex and V-wave) | Other | Aerobic, Anaerobic, Dynamic Resistance Training and Control Group |
Primary outcome
H-reflex
Time frame: During PECO and No-PECO conditions (aim #1); Pre-post acute exercise during PECO (aim #2); Pre-post 6 weeks of training during PECO (aim #3)
With soleus electromyographic recording electrode (Delsys) and electrical stimulation of the tibial nerve (Stimsola) the H-reflex recruitment curve parameters (spinal excitability) will be obtained in a 4-min protocol
V-wave
Time frame: During PECO and No-PECO conditions (aim #1); Pre-post acute exercise during PECO (aim #2); Pre-post 6 weeks of training during PECO (aim #3)
With soleus electromyographic recording electrode (Delsys) and electrical stimulation of the tibial nerve (Stimsola) the V-wave parameters (spinal and supraspinal excitability) will be obtained
Ischemic pain ratings
Time frame: During PECO and No-PECO conditions (aim #1); Pre-post acute exercise during PECO (aim #2); Pre-post 6 weeks of training during PECO (aim #3)
Participants will be asked to rate their leg pain intensity twice at the 4-min H-reflex protocol (at 2nd and 4th min of the procedure) using a Cook pain sale (0-10). In the scale, 0 represents no pain while 10 represents the worst possible pain
Arterial blood pressure
Time frame: During PECO and No-PECO conditions (aim #1); Pre-post acute exercise during PECO (aim #2); Pre-post 6 weeks of training during PECO (aim #3)
Brachial arterial pressure will be measured twice at the 4-min H-reflex protocol (at 2nd and 4th min of the procedure) by an automated equiment (Tango SunTech Medical)
Pressure pain threshold
Time frame: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
It will be assessed with an analogue algometer (FDK 60, Wagner Instruments) (in rectus femoris, upper-trapezius and biceps brachiis muscles). It measures the kg of force at the time participants report they are feeling pain intead of pressure
Cold pain tolerance
Time frame: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
It will be assessed with participants immersing their right foot into a container with cold water between 0 and 2ºC. It measures the time participants can endure the cold painful stimuli
Cold pain ratings
Time frame: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
While participants immerse their right foot into a container with cold water between 0 and 2ºC, they will beasked to rate the intensity of pain they perceived each minute by writing in a visual analogue scale (0-100mm) that pain intensity. 0 is considered no-pain and 100 the worst possible pain
Heart rate variability during cold pain testing
Time frame: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
It will be measured continuosly during the time participants have their foot in cold water using a heart rate monitor (Polar H10)
Arterial blood pressure during cold pain testing
Time frame: Pre-post acute exercise (aim #2); Pre-post 6 weeks of training (aim #3)
It will be measured each minute during the time participants have their foot in cold water using an automatic equipment (Tango SunTech Medical)
Maximal oxygen uptake
Time frame: Pre-post 6 weeks of training (aim #3)
For the aerobic group, it will be determined in a treadmill graded exercise testing using a gas analyses system (Metamax, Cortex)
Peak power
Time frame: Pre-post 6 weeks of training (aim #3)
For the anaerobic group, it will be determined with a 30-s Wingate all-out test (Monark cycloergometer)
Maximal voluntary isometric contraction
Time frame: Pre-post 6 weeks of training (aim #3)
For the dynamic resistance group, it will be determined for the knee extensors muscles using an isokinetic dynamometer (Biodex)
H-reflex after training
Time frame: Pre-post 6 weeks of training (aim #3)
With soleus electromyographic recording electrode (Delsys) and electrical stimulation of the tibial nerve (Stimsola) the H-reflex recruitment curve parameters (spinal excitability) will be obtained
V-wave after training
Time frame: Pre-post 6 weeks of training (aim #3)
With soleus electromyographic recording electrode (Delsys) and electrical stimulation of the tibial nerve (Stimsola) the V-wave parameters (spinal and supraspinal excitability) will be obtained
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Aug 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gonçalo V Mendonça, PhD principal investigator
Faculdade de Motricidade Humana
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Aim #1: The effect of post-exercise circulatory occlusion on H-reflex and V-wave, Aim #2: The hypoalgesic effects of acute exercise of different modalities and Aim #3: The hypoalgesic effects of chronic training of different modalities in people with Training and Exercise, run by Faculdade de Motricidade Humana at 1 site in Portugal.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Portugal. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
H-reflex (time frame: During PECO and No-PECO conditions (aim #1); Pre-post acute exercise during PECO (aim #2); Pre-post 6 weeks of training during PECO (aim #3)). The study lists 14 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Aug 2025.