HealthTIMENCT07107386
Temporal Investigation of Multimodal Elements
An observational study of Health, run by Buck Institute for Research on Aging at 1 site in United States.
Trial summary
The TIME Study is a research project aiming to understand the body's natural rhythms. The goal is to see how daily and weekly changes in our bodies-from what's happening at a molecular level to data from wearable devices-are connected. Read more about this study
- Who is it for?
- Ages 55 years and olderHealthy volunteers can take part
- Conditions the study is for
- Health
- How many people
- 120 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Jun 2025to Jun 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 55 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The study population consists of healthy older adults aged 55 years or older.
Who may be able to join
- Healthy adults aged 55 years or older.
- Own a smartphone capable of running study-specific apps.
- Willing and able to attend in-person visits at the Buck Institute in Novato, CA.
- Reside in the Pacific or Mountain Time Zones.
- Able to speak, read, and write English.
- Willing to wear study devices continuously and allow researchers access to all data.
- Able to provide informed consent.
Who cannot join
- Hospitalization within the last 3 months.
- Needing assistance with daily living activities.
- Working night or irregular shifts.
- Certain musculoskeletal, pulmonary, or cardiovascular conditions.
- Uncontrolled high blood pressure (BP > 180/100 mmHg).
- Bleeding disorders, anemia requiring treatment, or recent blood donation.
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- Poor vein access.
- Unstable health conditions.
- Chronic antibiotic use.
- Certain psychiatric disorders.
- Use of excluded medications, supplements, or products, including certain antibiotics or frequent sleep aids.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Brianna Stubbs, Research Assistant Professor, PhD. contact
Alison Le, Project Manager contact
United States1 site, 1 recruiting
- Recruiting
Buck Institute
Novato, California, 94945
Brianna Stubbs, Research Assistant Profressor, PhD., 4152517451, time-study@buckinstitute.org
Alison Le, Project Manager, time-study@buckinstitute.org
About this study
Official title: An Observational, Longitudinal Study to Characterize the Dynamic Structure of Molecular and Digital Health Data in Healthy Older Adults
The TIME Study is a research project aiming to understand the body's natural rhythms. The goal is to see how daily and weekly changes in our bodies-from what's happening at a molecular level to data from wearable devices-are connected.
What is the study about? This study is trying to create a detailed map of how a person's body changes over time. By looking at information from blood, urine, and other samples, as well as data from smartwatches and other devices, researchers want to learn how our bodies' natural cycles work in healthy older adults. The long-term goal is to use this knowledge to help develop more personalized healthcare in the future.
Read more
Who can participate? The study is looking for healthy adults, age 55 or older, who have a smartphone and are able to travel to the Buck Institute in Novato, California, for study visits.
Participants will be asked to:
Attend weekly visits over 11 weeks to provide blood and other samples.
Wear health-tracking devices like a smart ring and watch.
Use a smartphone app to answer questions about their daily routines.
Complete two "challenge" tests, including drinking a glucose solution and exercising on a stationary bicycle.
Return for follow-up visits after 6 and 12 months.
Are there any risks or benefits? Benefits: There are no direct health benefits for participants. However, the information gained will help scientists create better diagnostic tools and treatments for future generations.
Risks: The main risks are minor discomfort from things like blood draws or skin irritation from the wearable devices. All personal information and data are kept private and secure.
- Conditions
- Health
What is being measured
The primary outcome is the main question the study is designed to answer.
Generation of a longitudinal multi-omic and digital health dataset characterizing biorhythms in older adults
Establish a publicly shareable reference dataset integrating blood-based proteomic, metabolomic, and lipidomic profiles with continuous digital health data and microbiome samples from healthy older adults over time, capturing daily, weekly, and perturbation-induced physiological dynamics.
Measured: 12 months
Secondary outcomes (1)
Characterization of associations between molecular biomarkers and digital health data across time
Identify and quantify temporal correlations between blood-derived molecular biomarkers and physiological signals collected via wearable devices, including responses to standardized challenges.
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Aug 2025
- Study start15 Jun 2025
- Primary completionJun 2027 (estimated)
- Study completionJun 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Buck Institute for Research on Aging
- Sponsor type
- University, hospital or other
- Collaborators
- Phenome Health
- Responsible party
- Sponsor
- Investigators
- James Yurkovich, PhD, Principal investigator, Phenome Health, The Buck Institute for Research on Aging
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07107386
- Sponsor's protocol ID
- BUCK 2502
- Other IDs
- 1AY2AX000072-01
- Acronym
- TIME
- Status last verified
- Aug 2025
- First submitted
- 30 Jul 2025
- Last updated
- 15 Aug 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 15 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- An Observational, Longitudinal Study to Characterize the Dynamic Structure of Molecular and Digital Health Data in Healthy Older Adults
- ClinicalTrials.gov ID
- NCT07107386
- Acronym / sponsor ID
- TIME / BUCK 2502
- Conditions
- Health
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- Buck Institute for Research on AgingUniversity, hospital or other
- Collaborators
- Phenome Health
- Study start
- 15 Jun 2025 (actual)
- Primary completion
- Jun 2027 (estimated)
- Study completion
- Jun 2028 (estimated)
- First posted
- 6 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The TIME Study is a research project aiming to understand the body's natural rhythms. The goal is to see how daily and weekly changes in our bodies-from what's happening at a molecular level to data from wearable devices-are connected.
What is the study about? This study is trying to create a detailed map of how a person's body changes over time. By looking at information from blood, urine, and other samples, as well as data from smartwatches and other devices, researchers want to learn how our bodies' natural cycles work in healthy older adults. The long-term goal is to use this knowledge to help develop more personalized healthcare in the future.
Who can participate? The study is looking for healthy adults, age 55 or older, who have a smartphone and are able to travel to the Buck Institute in Novato, California, for study visits.
Participants will be asked to:
Attend weekly visits over 11 weeks to provide blood and other samples.
Wear health-tracking devices like a smart ring and watch.
Use a smartphone app to answer questions about their daily routines.
Complete two "challenge" tests, including drinking a glucose solution and exercising on a stationary bicycle.
Return for follow-up visits after 6 and 12 months.
Are there any risks or benefits? Benefits: There are no direct health benefits for participants. However, the information gained will help scientists create better diagnostic tools and treatments for future generations.
Risks: The main risks are minor discomfort from things like blood draws or skin irritation from the wearable devices. All personal information and data are kept private and secure.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 55 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of healthy older adults aged 55 years or older.
Key inclusion criteria (7 listed)
- Healthy adults aged 55 years or older.
- Own a smartphone capable of running study-specific apps.
- Willing and able to attend in-person visits at the Buck Institute in Novato, CA.
- Reside in the Pacific or Mountain Time Zones.
- Able to speak, read, and write English.
Key exclusion criteria (11 listed)
- Hospitalization within the last 3 months.
- Needing assistance with daily living activities.
- Working night or irregular shifts.
- Certain musculoskeletal, pulmonary, or cardiovascular conditions.
- Uncontrolled high blood pressure (BP > 180/100 mmHg).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Generation of a longitudinal multi-omic and digital health dataset characterizing biorhythms in older adults
Time frame: 12 months
Establish a publicly shareable reference dataset integrating blood-based proteomic, metabolomic, and lipidomic profiles with continuous digital health data and microbiome samples from healthy older adults over time, capturing daily, weekly, and perturbation-induced physiological dynamics.
1 secondary outcome
Characterization of associations between molecular biomarkers and digital health data across time
Time frame: 12 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Aug 2025.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Brianna Stubbs, Research Assistant Professor, PhD. contact
Alison Le, Project Manager contact
James Yurkovich, PhD principal investigator
Phenome Health, The Buck Institute for Research on Aging
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Health, run by Buck Institute for Research on Aging at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Brianna Stubbs, Research Assistant Professor, PhD. ((415) 209-2072, TIME-Study@buckinstitute.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Generation of a longitudinal multi-omic and digital health dataset characterizing biorhythms in older adults (time frame: 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Aug 2025.