Post Arrest PatientsNCT07107776
Central Venous Oxygen Saturation Prognostic Impact in Post Arrest Patients
An observational study of Post Arrest Patients, run by Assiut University at 1 site in Egypt.
Trial summary
The study aim will be to assess the prognostic impact and value of central venous oxygen saturation on post arrest patients. Read more about this study
- Who is it for?
- Ages 16 years and older
- Conditions the study is for
- Post Arrest Patients
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Aug 2025to 1 Aug 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: post arrest patients in assiut university hospital both genders above 16 years old
Who may be able to join
- adults above 16 years old, critically ill patients
- both genders
- post arrest patients
Who cannot join
- if patients does not experience cardiac arrest
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Assiut university
Asyut
Lydia M Sadek, bachelore, 01098293921, lydia.mamdouh97@gmail.com
Taghreed S Meshref, lecturer, 010036521135, taghreed.meshref@aun.edu.eg
About this study
Official title: Central Venous Oxygen Saturation Impact on Prognosis of Post Arrest Patients
The study aim will be to assess the prognostic impact and value of central venous oxygen saturation on post arrest patients.
Read the detailed description
Central venous oxygen saturation (ScvO₂) is a very important measurement which can be easily taken in a critical care environment by both medical and nursing staff. It provides an understanding of the patient's oxygen delivery, oxygen consumption and cardiac output. It has a key role within early goal-directed therapy and has been shown to decrease mortality when taken and analysed appropriately. (Central venous oxygen saturation: analysis, clinical use and effects on mortality,2013) Venous oxygen saturation (SvO2) measures the blood's oxygen content returning to the right side of the heart after perfusing the entire body. When the oxygen supply is insufficient to meet the metabolic demands of the tissues, an abnormal SvO2 ensues and reflects an inadequacy in systemic oxygenation. SvO2 is, therefore, dependent on oxygen delivery and oxygen extraction. Venous oximetry is used in specific clinical settings of hemodynamic instability, such as in critical illnesses, perioperative periods of major surgeries, heart failure, sepsis andd post arrest patients. The venous blood in the pulmonary artery represents oxygen extraction in the whole body and is called mixed venous oxygen saturation (SmvO2). It was measured using a pulmonary artery catheter (PAC). A second, less invasive method of measuring SvO2 is via a central venous catheter (CVC) positioned in the superior vena cava and is called the central venous oxygen saturation (ScvO2).
Central venous oxygen saturation (ScvO(2)) is suggested to reflect the adequacy of oxygen delivery, and the main objective of the present study was to determine whether ScvO(2) is associated with outcome in haemodynamically stabilized post arrest patients predicting mortality and outcome based on central venous oxygen saturation
- Conditions
- Post Arrest Patients
- Keywords
- post arrest patients, central venous oxygen saturation
What is being measured
The primary outcome is the main question the study is designed to answer.
central venous oxygen saturation impact on prognosis of post arrest patients
evaluating prognostic impact of oxygen saturation extracted from a central venous line blood sample on post arrest patients sample from (internal jagular vein) more or less than 50% oxygen saturation on prognosis of post arrest patients and recurrent arrests and overall improvement and time of expected and full recovery
Measured: time of follow up expected from time of successful ROSC until full improvement or recurrent arrest and death From date of cardiac arrest until date of first documented improvement or date of death due to any cause whichever came first assessed up in 2 mo
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Aug 2025
- Study start1 Aug 2025 (estimated)
- Primary completion1 Aug 2026 (estimated)
- Study completion1 Aug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Post Arrest PatientsStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Lydia Mamdouh Sadek Botros, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07107776
- Sponsor's protocol ID
- CVO2 prognosis in post arrest
- Status last verified
- Aug 2025
- First submitted
- 29 Jul 2025
- Last updated
- 7 Aug 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Gallet R, Lellouche N, Mitchell-Heggs L, Bouhemad B, Bensaid A, Dubois-Rande JL, Gueret P, Lim P. Prognosis value of central venous oxygen saturation in acute decompensated heart failure. Arch Cardiovasc Dis. 2012 Jan;105(1):5-12. doi: 10.1016/j.acvd.2011.10.005. Epub 2012 Jan 13.
PubMed 22369912Grand J, Hassager C, Schmidt H, Molstrom S, Nyholm B, Hoigaard HF, Dahl JS, Meyer M, Beske RP, Obling L, Kjaergaard J, Moller JE. Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest. Crit Care. 2023 Oct 27;27(1):410. doi: 10.1186/s13054-023-04704-2.
PubMed 37891623Rodriguez-Scarpetta MA, Sepulveda-Tobon AM, Daza-Arana JE, Lozada-Ramos H, Alzate-Sanchez RA. Central Oxygen Venous Saturation and Mortality in Patients Undergoing Coronary Artery Bypass Grafting. Ther Clin Risk Manag. 2023 Jun 3;19:447-454. doi: 10.2147/TCRM.S407454. eCollection 2023.
PubMed 37292584
Study at a glance
From the registry record, last updated by the sponsor on 7 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Central Venous Oxygen Saturation Impact on Prognosis of Post Arrest Patients
- ClinicalTrials.gov ID
- NCT07107776
- Acronym / sponsor ID
- CVO2 prognosis in post arrest
- Conditions
- Post Arrest Patients
- Keywords
- post arrest patients, central venous oxygen saturation
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Aug 2025 (estimated)
- Primary completion
- 1 Aug 2026 (estimated)
- Study completion
- 1 Aug 2027 (estimated)
- First posted
- 6 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study aim will be to assess the prognostic impact and value of central venous oxygen saturation on post arrest patients.
Detailed description
Central venous oxygen saturation (ScvO₂) is a very important measurement which can be easily taken in a critical care environment by both medical and nursing staff. It provides an understanding of the patient's oxygen delivery, oxygen consumption and cardiac output. It has a key role within early goal-directed therapy and has been shown to decrease mortality when taken and analysed appropriately. (Central venous oxygen saturation: analysis, clinical use and effects on mortality,2013) Venous oxygen saturation (SvO2) measures the blood's oxygen content returning to the right side of the heart after perfusing the entire body. When the oxygen supply is insufficient to meet the metabolic demands of the tissues, an abnormal SvO2 ensues and reflects an inadequacy in systemic oxygenation. SvO2 is, therefore, dependent on oxygen delivery and oxygen extraction. Venous oximetry is used in specific clinical settings of hemodynamic instability, such as in critical illnesses, perioperative periods of major surgeries, heart failure, sepsis andd post arrest patients. The venous blood in the pulmonary artery represents oxygen extraction in the whole body and is called mixed venous oxygen saturation (SmvO2). It was measured using a pulmonary artery catheter (PAC). A second, less invasive method of measuring SvO2 is via a central venous catheter (CVC) positioned in the superior vena cava and is called the central venous oxygen saturation (ScvO2).
Central venous oxygen saturation (ScvO(2)) is suggested to reflect the adequacy of oxygen delivery, and the main objective of the present study was to determine whether ScvO(2) is associated with outcome in haemodynamically stabilized post arrest patients predicting mortality and outcome based on central venous oxygen saturation
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- post arrest patients in assiut university hospital both genders above 16 years old
Key inclusion criteria (3 listed)
- adults above 16 years old, critically ill patients
- both genders
- post arrest patients
Key exclusion criteria (1 listed)
- if patients does not experience cardiac arrest
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
central venous oxygen saturation impact on prognosis of post arrest patients
Time frame: time of follow up expected from time of successful ROSC until full improvement or recurrent arrest and death From date of cardiac arrest until date of first documented improvement or date of death due to any cause whichever came first assessed up in 2 mo
evaluating prognostic impact of oxygen saturation extracted from a central venous line blood sample on post arrest patients sample from (internal jagular vein) more or less than 50% oxygen saturation on prognosis of post arrest patients and recurrent arrests and overall improvement and time of expected and full recovery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Aug 2025.
- Background: PubMed 22369912Gallet R, Lellouche N, Mitchell-Heggs L, Bouhemad B, Bensaid A, Dubois-Rande JL, Gueret P, Lim P. Prognosis value of central venous oxygen saturation in acute decompensated heart failure. Arch Cardiovasc Dis. 2012 Jan;105(1):5-12. doi: 10.1016/j.acvd.2011.10.005. Epub 2012 Jan 13.
- Background: PubMed 37891623Grand J, Hassager C, Schmidt H, Molstrom S, Nyholm B, Hoigaard HF, Dahl JS, Meyer M, Beske RP, Obling L, Kjaergaard J, Moller JE. Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest. Crit Care. 2023 Oct 27;27(1):410. doi: 10.1186/s13054-023-04704-2.
- Background: PubMed 37292584Rodriguez-Scarpetta MA, Sepulveda-Tobon AM, Daza-Arana JE, Lozada-Ramos H, Alzate-Sanchez RA. Central Oxygen Venous Saturation and Mortality in Patients Undergoing Coronary Artery Bypass Grafting. Ther Clin Risk Manag. 2023 Jun 3;19:447-454. doi: 10.2147/TCRM.S407454. eCollection 2023.
- Individual participant dataSharing planned: No
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Active, not recruitingPhase 3
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Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
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Cerebral Oximetry in Management of Post Cardiac Arrest
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Active, not recruitingObservational study
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Post Arrest Patients, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 7 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
central venous oxygen saturation impact on prognosis of post arrest patients (time frame: time of follow up expected from time of successful ROSC until full improvement or recurrent arrest and death From date of cardiac arrest until date of first documented improvement or date of death due to any cause whichever came first assessed up in 2 mo). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07107776, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Aug 2025; AzTrials last refreshed its copy on 6 Nov 2026.