Post-cardiac Arrest Brain InjuryNCT07912411
Continuous Noninvasive Multimodal Neuromonitoring at the ICU After Cardiac Arrest
An observational study of Post-cardiac Arrest Brain Injury, run by Maastricht University Medical Center at 1 site in Netherlands.
Trial summary
The goal of this observational study is to investigate the relationship between non-invasive brain monitoring measurements and neurological recovery six months after cardiac arrest in patients admitted to the intensive care unit (ICU). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Post-cardiac Arrest Brain Injury
- How many people
- 100 participants
- Where
- 1 siteNetherlands
- Study dates
- 19 Feb 2024to 1 Jun 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult post-resuscitation patients admitted to the ICU, who are enrolled in the institutional post-resuscitation and neuroprognostication protocol and therefore comatose and mechanically ventilated.
Who may be able to join
- Comatose (RASS -5), mechanically ventilated adults (≥ 18 years)
- Resuscitated patients admitted to the ICU, for whom the institutional post-resuscitation and neuroprognostication protocol is initiated
Who cannot join
- Early moribund prognosis
- Forehead wounds or traumatic abnormalities precluding sensor placement
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Netherlands1 site
Maastricht University Medical Center
Maastricht, Limburg, 6202 AZ
About this study
Official title: Continuous Noninvasive Multimodal Neuromonitoring After Cardiac Arrest
The goal of this observational study is to investigate the relationship between non-invasive brain monitoring measurements and neurological recovery six months after cardiac arrest in patients admitted to the intensive care unit (ICU).
After admission to the ICU, patients who have had a cardiac arrest will undergo non-invasive brain monitoring. Six months later, their neurological outcome will be assessed using a telephone interview with the patient or their caregiver.
Based on this assessment, patients will be classified as having either a good or poor neurological outcome. The study will then investigate whether the brain monitoring measurements can help distinguish between these two groups.
- Conditions
- Post-cardiac Arrest Brain Injury
What is being measured
The primary outcome is the main question the study is designed to answer.
Neurological outcome
Determined by the the Cerebral Performance Category (CPC) score.
Measured: 6 months after ICU admission
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Nov 2026
- Study start19 Feb 2024
- Primary completion1 Jun 2027 (estimated)
- Study completion1 Jun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post-cardiac Arrest Brain InjuryStudies of the same condition, open and under way.
- More trials run by Maastricht University Medical CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Maastricht University Medical Center
- Sponsor type
- University, hospital or other
- Collaborators
- Maastricht University
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07912411
- Sponsor's protocol ID
- 2019-0743_PR24-26
- Status last verified
- Oct 2026
- First submitted
- 27 Oct 2026
- Last updated
- 3 Nov 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 3 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Continuous Noninvasive Multimodal Neuromonitoring After Cardiac Arrest
- ClinicalTrials.gov ID
- NCT07912411
- Acronym / sponsor ID
- 2019-0743_PR24-26
- Conditions
- Post-cardiac Arrest Brain Injury
- Study type
- Observational
- Recruitment status
- Enrolling by invitation
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Maastricht University Medical CenterUniversity, hospital or other
- Collaborators
- Maastricht University
- Study start
- 19 Feb 2024 (actual)
- Primary completion
- 1 Jun 2027 (estimated)
- Study completion
- 1 Jun 2027 (estimated)
- First posted
- 3 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to investigate the relationship between non-invasive brain monitoring measurements and neurological recovery six months after cardiac arrest in patients admitted to the intensive care unit (ICU).
After admission to the ICU, patients who have had a cardiac arrest will undergo non-invasive brain monitoring. Six months later, their neurological outcome will be assessed using a telephone interview with the patient or their caregiver.
Based on this assessment, patients will be classified as having either a good or poor neurological outcome. The study will then investigate whether the brain monitoring measurements can help distinguish between these two groups.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult post-resuscitation patients admitted to the ICU, who are enrolled in the institutional post-resuscitation and neuroprognostication protocol and therefore comatose and mechanically ventilated.
Key inclusion criteria (2 listed)
- Comatose (RASS -5), mechanically ventilated adults (≥ 18 years)
- Resuscitated patients admitted to the ICU, for whom the institutional post-resuscitation and neuroprognostication protocol is initiated
Key exclusion criteria (2 listed)
- Early moribund prognosis
- Forehead wounds or traumatic abnormalities precluding sensor placement
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Neurological outcome
Time frame: 6 months after ICU admission
Determined by the the Cerebral Performance Category (CPC) score.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Nov 2026.
- Individual participant dataSharing planned: Undecided
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Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
RecruitingObservational study
Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Cardiac Arrest
Cardiac Arrest
Recruiting
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
Active, not recruitingObservational study
Psychoactive Drug Use and Acute Care Use After Trauma and Out-of-Hospital Cardiac Arrest
Wounds and Injuries, Out-of-Hospital Cardiac Arrest
Recruiting
Cerebral Oximetry in Management of Post Cardiac Arrest
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Post-cardiac Arrest Brain Injury, run by Maastricht University Medical Center at 1 site in Netherlands.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 3 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Netherlands. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Neurological outcome (time frame: 6 months after ICU admission). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2026.