Acute Coronary Syndrome Without ST Elevation on ElectrocardiogramSurvSCANCT07112547
Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
An observational study of Acute Coronary Syndrome Without ST Elevation on Electrocardiogram and Acute Coronary Syndromes (ACS), run by University Hospital, Strasbourg, France at 10 sites in France.
Trial summary
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- How many people
- 500 participants
- Where
- 10 sitesFrance
- Study dates
- 1 Sep 2025to 1 Oct 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients admitted to the emergency department and diagnosed with non-ST segment elevation ACS
Who may be able to join
- Adult (≥ 18 years old) patient admitted to the emergency department
- Able to understand the information provided
- Diagnosis of non-ST segment elevation ACS established according to the lastest guidelines from the European Society of Cardiology and the 4th Universal Definition of myocardial infarction
- No objection to participation in the study after receiving appropriate information
Who cannot join
- Patients subject to legal protection
- Patient with cognitive impairment
- Myocardial injury and/or symptoms attributable to Takotsubo syndrome, myocarditis, pericarditis, or acute heart failure
- Clinical evidence suggestive of type 2 myocardial infarction, including acute anemia with hemoglobin < 10 g/dL, sepsis, acute hypoxemic respiratory failure
Trial locations and contacts
10 sites in 1 country. Contact the study team or a site near you to ask about taking part.
10 sites in 1 country
France10 sites
Hôpital Louis Pasteur
Colmar, Haut-rhin, 68024
Kasarra BEN HAMMOUDA, Dr, kasarra.benhammouda@ch-colmar.fr
Kasarra BEN HAMMOUDA, Dr
Centre Hospitalier de Haguenau
Haguenau, Bas-Rhin, 67091
Florent BAICRY, Dr, +33606784563, florent.baicry@ch-haguenau.fr
Florent BAICRY, Dr
Hôpital Emilie Muller
Mulhouse, Haut-rhin, 68100
Marc NOIZET, Dr, +33638931388, marc.noizet@ghrmsa.fr
Marc NOIZET, Dr
CHRU de Nancy
Nancy, Meurthe-et-Moselle, 54000
Tahar CHOUIHED, Dr, +33383851496, t.chouihed@chru-nancy.fr
Tahar CHOUIHED, Dr
CHU de Poitiers, la Milétrie
Poitiers, Vienne, 86000
Nicolas MARJANOVIC, Dr, +33549444444, nicolas.marjanovic@chu-poitiers.fr
Nicolas MARJANOVIC, Dr
Centre Hospitalier de Pont-à-Mousson
Pont-à-Mousson, Meurthe-et-Moselle, 54701
Tahar CHOUIHED, Dr, +33383851496, t.chouihed@chru-nancy.fr
Tahar CHOUIHED, Dr
Hôpital Maison Blanche
Reims, Marne, 51092
Stéphane GENNAI, Dr, +33603590614, sgennai@chu-reims.fr
Stéphane GENNAI, Dr
Centre Hospitalier de Sélestat
Séléstat, Bas-Rhin, 67606
Mathieu OBERLIN, Dr, mathieu.oberlin@outlook.fr
Mathieu OBERLIN, Dr
Hôpitaux Universitaires de Strasbourg (NHC)
Strasbourg, Bas-Rhin, 67091
Sabrina GARNIER-KEPKA, Dr
Valérie WILME, Dr
Centre Hospitalier de Toul Saint-Charles
Toul, Meurthe-et-Moselle, 54200
Tahar CHOUIHED, Dr, +33383851496, t.chouihed@chru-nancy.fr
Tahar CHOUIHED, Dr
About this study
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death. There are two main types of ACS: ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation ACS (NSTE-ACS). While the occurrence of serious heart rhythm and conduction disturbances is well established in STEMI, these complications are believed to be much less frequent in NSTE-ACS. However, their actual frequency in this population remains unclear due to limited studies, especially in emergency settings.
The main purpose of this study is to estimate the frequency of serious rhythm and conduction disorders in patients presenting with NSTE-ACS in emergency departments. The hypothesis is that these events are rare in this population and may not justify routine continuous cardiac monitoring for all such patients, as currently recommended.
Secondary objectives include identifying risk factors for these complications, estimating their frequency during hospitalization, assessing the frequency of minor rhythm and conduction disorders, evaluating care times and patient flow in emergency departments, and assessing patient outcomes up to 30 days-including hospitalizations, length of stay, discharge disposition, all-cause mortality, and the occurrence of five major adverse cardiovascular events (5-point MACE).
- Conditions
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- Keywords
- Non-ST Segment Elevation Acute Coronary Syndrome, Cardiac Arrhythmias, Heart Conduction System Disease, Hospital Emergency Service, Electrocardiographic monitoring, Cardiovascular diseases
- Medical subject headings
- Acute Coronary Syndrome, Myocardial Infarction, Angina, Unstable, Death, Sudden, Cardiac, Stroke, Peripheral Arterial Disease, Arrhythmias, Cardiac, Emergencies
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Non-ST segment elevation ACS | 500 adult patients admitted to the emergency department and diagnosed with non-ST segment elevation ACS |
What is being measured
The primary outcome is the main question the study is designed to answer.
Occurrence of Serious Rhythm or Conduction Disturbances in the Emergency Department
Occurrence of at least one serious rhythm or conduction disturbance during emergency department management, including: sustained ventricular tachycardia (VT), ventricular fibrillation (VF), torsades de pointes, high-degree conduction disorders (Mobitz type II AV block, third-degree AV block, trifascicular block), pulseless electrical activity (PEA), and asystole.
Measured: During emergency department stay, assessed up to 24 hours
Secondary outcomes (24)
Incidence of Non-Life-Threatening Arrhythmias or Conduction Disorders in the Emergency Department
Occurrence of arrhythmias not immediately life-threatening: atrial fibrillation or flutter, Mobitz type I AV block, first-degree AV block, sinus node dysfunction, or non-sustained VT
Measured: During emergency department stay, assessed up to 24 hours
Number of patients presenting complications prior to a confirmed diagnosis of NSTE-ACS
Occurrence of complications such as syncope, presyncope, cardiogenic shock, respiratory distress, or rhythm/conduction disturbances before final diagnosis of NSTE-ACS.
Measured: Prior to establishing a confirmed diagnosis of NSTE-ACS in the ED, assessed up to 12 hours
Duration of Stay in the Emergency Department
Time spent in the emergency department and in the short-stay unit (UHCD) before transfer or discharge.
Measured: From ED admission to hospital admission, discharge, or UHCD discharge; up to 72 hours
Number of patients by disposition at emergency department discharge (home vs. hospital admission and type of admitting service
Disposition of patients: home discharge or hospital admission. For admitted patients, type of service recorded (ICU, coronary care unit, cardiology, internal medicine, short-stay unit, or other).
Measured: At the time of emergency department discharge or transfer, assessed up to 72 hours from ED admission
Duration of Hospitalization
Overall length of stay for hospitalized patients
Measured: From hospital admission to hospital discharge, assessed up to 14 days.
Number of patients with all-cause mortality or 5-point major adverse cardiovascular events (5P-MACE) at 30 days
This composite outcome includes the number of participants who experience either all-cause death or at least one of the following 5-point major adverse cardiovascular events (5P-MACE) within 30 days:
- Cardiovascular death
- Myocardial infarction
- Stroke or transient ischemic attack (TIA)
- Hospitalization for heart failure
- Coronary or peripheral revascularization Outcome events will be assessed through medical records and/or follow-up phone call if needed.
Measured: Day 30 post-ED management
Clinical features : weight
Weight (kg)
Measured: From admission to discharge from hospital, assessed up to 7 days
Clinical features : height
Height (cm)
Measured: From admission to discharge from hospital, assessed up to 7 days
Clinical features : heart rate
Heart rate (bpm)
Measured: From admission to discharge from hospital, assessed up to 7 days
Clinical data : blood and arterial pressure
systolic/diastolic blood pressure (mmHg) and mean arterial pressure (mmHg)
Measured: From admission to discharge from hospital, assessed up to 7 days
Clinical data : oxygen saturation
peripheral capillary oxygen saturation (%)
Measured: From admission to discharge from hospital, assessed up to 7 days
Clinical data : temperature
Temperature (°C)
Measured: From admission to discharge from hospital, assessed up to 7 days
clinical data : capillary blood glucose
Capillary blood glucose g/L
Measured: From admission to discharge from hospital, assessed up to 7 days
Cardiovascular history and risk factors
Cardiovascular history and risk factors : questionnaire on medical history and prior related treatments (anticoagulant, antiplatelet agent, analgesic, oxygen therapy, statin, beta blocker, ACE inhibitor, angiotensin II receptor blocker).
Measured: From admission to discharge from hospital, assessed up to 7 days
Biological workup : troponin
Troponin (1st, 2nd ; 3rd measurement) (ng/mL)
Measured: From admission to discharge from hospital, assessed up to 7 days
Biological work-up : NT-proBNP
NT-proBNP (ng/mL)
Measured: From admission to discharge from hospital, assessed up to 7 days
Biological workup : hemoglobin
hemoglobin (g/dL)
Measured: From admission to discharge from hospital, assessed up to 7 days
Biological workup : BNP
BNP (ng/mL)
Measured: From admission to discharge from hospital, assessed up to 7 days
Biological workup : platelets count
platelets (10^9/L or Giga/L)
Measured: From admission to discharge from hospital, assessed up to 7 days
Biological workup : mean corpuscular volume
mean corpuscular volume (fL or µm3)
Measured: From admission to discharge from hospital, assessed up to 7 days
Biological workup : potassium
potassium (mmol/L)
Measured: From admission to discharge from hospital, assessed up to 7 days
Biological workup : creatinine
creatinine (µmol/L)
Measured: From admission to discharge from hospital, assessed up to 7 days
Biological workup : creatinine clearance
creatinine clearance (mL/min/1,73m2)
Measured: From admission to discharge from hospital, assessed up to 7 days
Electrocardiogram (ECG)
Electrocardiogram (ECG) : presence or absence of ST elevation, T wave inversion, pathological
Measured: From admission to discharge from hospital, assessed up to 7 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Aug 2025
- Study start1 Sep 2025 (estimated)
- Primary completion1 Oct 2028 (estimated)
- Study completion1 Oct 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Acute Coronary Syndrome Without ST Elevation on ElectrocardiogramStudies of the same condition, open and under way.
- More trials run by University Hospital, Strasbourg, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Strasbourg, France
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Sabrina GARNIER-KEPKA, Dr, Principal investigator, Hôpitaux Universitaires de Strasbourg
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07112547
- Sponsor's protocol ID
- 9460
- Acronym
- SurvSCA
- Status last verified
- Aug 2025
- First submitted
- 27 May 2025
- Last updated
- 8 Aug 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Bouisset F, Ruidavets JB, Dallongeville J, Moitry M, Montaye M, Biasch K, Ferrieres J. Comparison of Short- and Long-Term Prognosis between ST-Elevation and Non-ST-Elevation Myocardial Infarction. J Clin Med. 2021 Jan 7;10(2):180. doi: 10.3390/jcm10020180.
PubMed 33430516Pines JM, Pollack CV Jr, Diercks DB, Chang AM, Shofer FS, Hollander JE. The association between emergency department crowding and adverse cardiovascular outcomes in patients with chest pain. Acad Emerg Med. 2009 Jul;16(7):617-25. doi: 10.1111/j.1553-2712.2009.00456.x. Epub 2009 Jun 22.
PubMed 19549010Timmis A, Vardas P, Townsend N, Torbica A, Katus H, De Smedt D, Gale CP, Maggioni AP, Petersen SE, Huculeci R, Kazakiewicz D, de Benito Rubio V, Ignatiuk B, Raisi-Estabragh Z, Pawlak A, Karagiannidis E, Treskes R, Gaita D, Beltrame JF, McConnachie A, Bardinet I, Graham I, Flather M, Elliott P, Mossialos EA, Weidinger F, Achenbach S; Atlas Writing Group, European Society of Cardiology. European Society of Cardiology: cardiovascular disease statistics 2021. Eur Heart J. 2022 Feb 22;43(8):716-799. doi: 10.1093/eurheartj/ehab892.
PubMed 35016208Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth Universal Definition of Myocardial Infarction (2018). Glob Heart. 2018 Dec;13(4):305-338. doi: 10.1016/j.gheart.2018.08.004. Epub 2018 Aug 25. No abstract available.
PubMed 30154043Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, Claeys MJ, Dan GA, Dweck MR, Galbraith M, Gilard M, Hinterbuchner L, Jankowska EA, Juni P, Kimura T, Kunadian V, Leosdottir M, Lorusso R, Pedretti RFE, Rigopoulos AG, Rubini Gimenez M, Thiele H, Vranckx P, Wassmann S, Wenger NK, Ibanez B; ESC Scientific Document Group. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023 Oct 12;44(38):3720-3826. doi: 10.1093/eurheartj/ehad191. No abstract available.
PubMed 37622654Collet JP, Thiele H, Barbato E, Barthelemy O, Bauersachs J, Bhatt DL, Dendale P, Dorobantu M, Edvardsen T, Folliguet T, Gale CP, Gilard M, Jobs A, Juni P, Lambrinou E, Lewis BS, Mehilli J, Meliga E, Merkely B, Mueller C, Roffi M, Rutten FH, Sibbing D, Siontis GCM; ESC Scientific Document Group. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Rev Esp Cardiol (Engl Ed). 2021 Jun;74(6):544. doi: 10.1016/j.rec.2021.05.002. No abstract available. English, Spanish.
PubMed 34020768
Study at a glance
From the registry record, last updated by the sponsor on 8 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
- ClinicalTrials.gov ID
- NCT07112547
- Acronym / sponsor ID
- SurvSCA / 9460
- Conditions
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- Keywords
- Non-ST Segment Elevation Acute Coronary Syndrome, Cardiac Arrhythmias, Heart Conduction System Disease, Hospital Emergency Service, Electrocardiographic monitoring, Cardiovascular diseases
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 500 participants (estimated)
- Lead sponsor
- University Hospital, Strasbourg, FranceUniversity, hospital or other
- Study start
- 1 Sep 2025 (estimated)
- Primary completion
- 1 Oct 2028 (estimated)
- Study completion
- 1 Oct 2028 (estimated)
- First posted
- 8 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death. There are two main types of ACS: ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation ACS (NSTE-ACS). While the occurrence of serious heart rhythm and conduction disturbances is well established in STEMI, these complications are believed to be much less frequent in NSTE-ACS. However, their actual frequency in this population remains unclear due to limited studies, especially in emergency settings.
The main purpose of this study is to estimate the frequency of serious rhythm and conduction disorders in patients presenting with NSTE-ACS in emergency departments. The hypothesis is that these events are rare in this population and may not justify routine continuous cardiac monitoring for all such patients, as currently recommended.
Secondary objectives include identifying risk factors for these complications, estimating their frequency during hospitalization, assessing the frequency of minor rhythm and conduction disorders, evaluating care times and patient flow in emergency departments, and assessing patient outcomes up to 30 days-including hospitalizations, length of stay, discharge disposition, all-cause mortality, and the occurrence of five major adverse cardiovascular events (5-point MACE).
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Non-ST segment elevation ACS | – | –500 adult patients admitted to the emergency department and diagnosed with non-ST segment elevation ACS |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients admitted to the emergency department and diagnosed with non-ST segment elevation ACS
Key inclusion criteria (4 listed)
- Adult (≥ 18 years old) patient admitted to the emergency department
- Able to understand the information provided
- Diagnosis of non-ST segment elevation ACS established according to the lastest guidelines from the European Society of Cardiology and the 4th Universal Definition of myocardial infarction
- No objection to participation in the study after receiving appropriate information
Key exclusion criteria (4 listed)
- Patients subject to legal protection
- Patient with cognitive impairment
- Myocardial injury and/or symptoms attributable to Takotsubo syndrome, myocarditis, pericarditis, or acute heart failure
- Clinical evidence suggestive of type 2 myocardial infarction, including acute anemia with hemoglobin < 10 g/dL, sepsis, acute hypoxemic respiratory failure
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Occurrence of Serious Rhythm or Conduction Disturbances in the Emergency Department
Time frame: During emergency department stay, assessed up to 24 hours
Occurrence of at least one serious rhythm or conduction disturbance during emergency department management, including: sustained ventricular tachycardia (VT), ventricular fibrillation (VF), torsades de pointes, high-degree conduction disorders (Mobitz type II AV block, third-degree AV block, trifascicular block), pulseless electrical activity (PEA), and asystole.
24 secondary outcomes
Incidence of Non-Life-Threatening Arrhythmias or Conduction Disorders in the Emergency Department
Time frame: During emergency department stay, assessed up to 24 hours
Number of patients presenting complications prior to a confirmed diagnosis of NSTE-ACS
Time frame: Prior to establishing a confirmed diagnosis of NSTE-ACS in the ED, assessed up to 12 hours
Duration of Stay in the Emergency Department
Time frame: From ED admission to hospital admission, discharge, or UHCD discharge; up to 72 hours
Number of patients by disposition at emergency department discharge (home vs. hospital admission and type of admitting service
Time frame: At the time of emergency department discharge or transfer, assessed up to 72 hours from ED admission
Duration of Hospitalization
Time frame: From hospital admission to hospital discharge, assessed up to 14 days.
Number of patients with all-cause mortality or 5-point major adverse cardiovascular events (5P-MACE) at 30 days
Time frame: Day 30 post-ED management
Clinical features : weight
Time frame: From admission to discharge from hospital, assessed up to 7 days
Clinical features : height
Time frame: From admission to discharge from hospital, assessed up to 7 days
Clinical features : heart rate
Time frame: From admission to discharge from hospital, assessed up to 7 days
Clinical data : blood and arterial pressure
Time frame: From admission to discharge from hospital, assessed up to 7 days
Clinical data : oxygen saturation
Time frame: From admission to discharge from hospital, assessed up to 7 days
Clinical data : temperature
Time frame: From admission to discharge from hospital, assessed up to 7 days
clinical data : capillary blood glucose
Time frame: From admission to discharge from hospital, assessed up to 7 days
Cardiovascular history and risk factors
Time frame: From admission to discharge from hospital, assessed up to 7 days
Biological workup : troponin
Time frame: From admission to discharge from hospital, assessed up to 7 days
Biological work-up : NT-proBNP
Time frame: From admission to discharge from hospital, assessed up to 7 days
Biological workup : hemoglobin
Time frame: From admission to discharge from hospital, assessed up to 7 days
Biological workup : BNP
Time frame: From admission to discharge from hospital, assessed up to 7 days
Biological workup : platelets count
Time frame: From admission to discharge from hospital, assessed up to 7 days
Biological workup : mean corpuscular volume
Time frame: From admission to discharge from hospital, assessed up to 7 days
Biological workup : potassium
Time frame: From admission to discharge from hospital, assessed up to 7 days
Biological workup : creatinine
Time frame: From admission to discharge from hospital, assessed up to 7 days
Biological workup : creatinine clearance
Time frame: From admission to discharge from hospital, assessed up to 7 days
Electrocardiogram (ECG)
Time frame: From admission to discharge from hospital, assessed up to 7 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Aug 2025.
- Background: PubMed 33430516Bouisset F, Ruidavets JB, Dallongeville J, Moitry M, Montaye M, Biasch K, Ferrieres J. Comparison of Short- and Long-Term Prognosis between ST-Elevation and Non-ST-Elevation Myocardial Infarction. J Clin Med. 2021 Jan 7;10(2):180. doi: 10.3390/jcm10020180.
- Background: PubMed 19549010Pines JM, Pollack CV Jr, Diercks DB, Chang AM, Shofer FS, Hollander JE. The association between emergency department crowding and adverse cardiovascular outcomes in patients with chest pain. Acad Emerg Med. 2009 Jul;16(7):617-25. doi: 10.1111/j.1553-2712.2009.00456.x. Epub 2009 Jun 22.
- Background: PubMed 35016208Timmis A, Vardas P, Townsend N, Torbica A, Katus H, De Smedt D, Gale CP, Maggioni AP, Petersen SE, Huculeci R, Kazakiewicz D, de Benito Rubio V, Ignatiuk B, Raisi-Estabragh Z, Pawlak A, Karagiannidis E, Treskes R, Gaita D, Beltrame JF, McConnachie A, Bardinet I, Graham I, Flather M, Elliott P, Mossialos EA, Weidinger F, Achenbach S; Atlas Writing Group, European Society of Cardiology. European Society of Cardiology: cardiovascular disease statistics 2021. Eur Heart J. 2022 Feb 22;43(8):716-799. doi: 10.1093/eurheartj/ehab892.
- Background: PubMed 30154043Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth Universal Definition of Myocardial Infarction (2018). Glob Heart. 2018 Dec;13(4):305-338. doi: 10.1016/j.gheart.2018.08.004. Epub 2018 Aug 25. No abstract available.
- Background: PubMed 37622654Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, Claeys MJ, Dan GA, Dweck MR, Galbraith M, Gilard M, Hinterbuchner L, Jankowska EA, Juni P, Kimura T, Kunadian V, Leosdottir M, Lorusso R, Pedretti RFE, Rigopoulos AG, Rubini Gimenez M, Thiele H, Vranckx P, Wassmann S, Wenger NK, Ibanez B; ESC Scientific Document Group. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023 Oct 12;44(38):3720-3826. doi: 10.1093/eurheartj/ehad191. No abstract available.
- Background: PubMed 34020768Collet JP, Thiele H, Barbato E, Barthelemy O, Bauersachs J, Bhatt DL, Dendale P, Dorobantu M, Edvardsen T, Folliguet T, Gale CP, Gilard M, Jobs A, Juni P, Lambrinou E, Lewis BS, Mehilli J, Meliga E, Merkely B, Mueller C, Roffi M, Rutten FH, Sibbing D, Siontis GCM; ESC Scientific Document Group. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Rev Esp Cardiol (Engl Ed). 2021 Jun;74(6):544. doi: 10.1016/j.rec.2021.05.002. No abstract available. English, Spanish.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Sabrina GARNIER-KEPKA, Dr principal investigator
Hôpitaux Universitaires de Strasbourg
10 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Coronary Syndrome Without ST Elevation on Electrocardiogram and Acute Coronary Syndromes (ACS), run by University Hospital, Strasbourg, France at 10 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 10 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sabrina GARNIER-KEPKA, Dr (+33369551335, Sabrina.GARNIER-KEPKA@chru-strasbourg.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Occurrence of Serious Rhythm or Conduction Disturbances in the Emergency Department (time frame: During emergency department stay, assessed up to 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07112547, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Aug 2025.