Laparotomy Closure After Abdominal SurgeryNCT07142395
Comparing Delayed vs Primary Wound Closure After Emergency Laparotomy: Impact on Infection, Healing, and Hospital Stay
A study testing Immediate skin closure and Delayed primary closure in people with Laparotomy Closure After Abdominal Surgery, run by Bkahtawar Amin Medical and Dental College Multan at 1 site in Pakistan.
Trial summary
The purpose of this study is to find out which type of wound closure after emergency abdominal surgery leads to fewer wound infections and better recovery: closing the wound immediately after surgery (called primary closure) or waiting a few days before closing the skin (called delayed primary closure). Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Laparotomy Closure After Abdominal Surgery
- What is being tested?
- Immediate skin closure and Delayed primary closure
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 82 participants
- Where
- 1 sitePakistan
- Study dates
- 16 May 2025to 15 Aug 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients 18 - 60 years of age
- Either male or female gender and
- Planned to undergo emergency laparotomy
Who cannot join
- Patients undergoing second laparotomy
- Re- laparotomy
- On steroid therapy and
- Patients who die within 28-days of surgery
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Bakhtawar Amin Medical and Dental College
Multan, Punjab Province, 60000
About this study
Official title: Comparison of Primary Skin Closure Versus Delayed Primary Skin Closure in Patients Undergoing Emergency Laparotomies
The purpose of this study is to find out which type of wound closure after emergency abdominal surgery leads to fewer wound infections and better recovery: closing the wound immediately after surgery (called primary closure) or waiting a few days before closing the skin (called delayed primary closure).
Wound infection is a common problem after emergency abdominal surgery (also called laparotomy). Some surgeons close the skin right away, while others wait a few days to reduce the risk of infection.
Read more
This study will help find out which method is better.
The main questions the study aims to answer are:
- . Does delayed primary closure lower the rate of wound infection compared to primary closure?
- . Does the wound open up (wound dehiscence) less often with delayed closure?
- . Does delayed closure affect the length of hospital stay?
In this clinical trial:
- Adult patients needing emergency abdominal surgery will be included.
- Half the patients will have their wounds closed immediately (primary closure), and half will have delayed closure after 3-5 days of daily dressing.
- All surgeries will be done by experienced surgeons using the same technique.
- Patients will be followed for 4 weeks after surgery to monitor wound infection, wound opening, and length of hospital stay.
The results will help doctors choose the safest and most effective way to close surgical wounds after emergency abdominal surgery.
- Being tested
- Immediate skin closure, Delayed primary closure
- Keywords
- wound infection, primary wound closure, delayed wound closure, Wound dehiscence
- Medical subject headings
- Wound Infection
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Immediate skin closureProcedure or surgery
After laparotomy wounds will be closed primarily using no. 1 vicryl suture
Delayed primary closureProcedure or surgery
Deeper layers of wound will be closed after surgery and loose mattress sutures will be applied to skin with prolene. After three to five days of daily dressing with bactericidal solution, the skin will be closed
| Study group | Role | What they receive |
|---|---|---|
| Primary Closure | Active comparator | Skin closed immediately after laparotomy Receives: Procedure: Immediate skin closure |
| Delayed Primary Closure | Experimental | Skin closed 3 - 5 days after laparotomy Receives: Procedure: Delayed primary closure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Wound Infection
Surgical Site infection - Presence any features of erythema, pain, pus discharge on examination of surgical wound and new onset fever (> 98.6 F)
Measured: From date of surgery to Four weeks postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2025
- Study start16 May 2025
- Primary completion15 Aug 2025
- Study completion15 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Laparotomy Closure After Abdominal SurgeryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 82 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bkahtawar Amin Medical and Dental College Multan
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Amjad A Professor, FRCS, Study chair, Bakhtawar Amin Medical and Dental College
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07142395
- Sponsor's protocol ID
- U1111-1326-2839
- Status last verified
- Sep 2025
- First submitted
- 6 Aug 2025
- Last updated
- 5 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Primary Skin Closure Versus Delayed Primary Skin Closure in Patients Undergoing Emergency Laparotomies
- ClinicalTrials.gov ID
- NCT07142395
- Acronym / sponsor ID
- U1111-1326-2839
- Keywords
- wound infection, primary wound closure, delayed wound closure, Wound dehiscence
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 82 participants (actual)
- Lead sponsor
- Bkahtawar Amin Medical and Dental College MultanUniversity, hospital or other
- Study start
- 16 May 2025 (actual)
- Primary completion
- 15 Aug 2025 (actual)
- Study completion
- 15 Aug 2025 (actual)
- First posted
- 26 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to find out which type of wound closure after emergency abdominal surgery leads to fewer wound infections and better recovery: closing the wound immediately after surgery (called primary closure) or waiting a few days before closing the skin (called delayed primary closure).
Wound infection is a common problem after emergency abdominal surgery (also called laparotomy). Some surgeons close the skin right away, while others wait a few days to reduce the risk of infection.
This study will help find out which method is better.
The main questions the study aims to answer are:
- . Does delayed primary closure lower the rate of wound infection compared to primary closure?
- . Does the wound open up (wound dehiscence) less often with delayed closure?
- . Does delayed closure affect the length of hospital stay?
In this clinical trial:
- Adult patients needing emergency abdominal surgery will be included.
- Half the patients will have their wounds closed immediately (primary closure), and half will have delayed closure after 3-5 days of daily dressing.
- All surgeries will be done by experienced surgeons using the same technique.
- Patients will be followed for 4 weeks after surgery to monitor wound infection, wound opening, and length of hospital stay.
The results will help doctors choose the safest and most effective way to close surgical wounds after emergency abdominal surgery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Primary Closure | Active comparator | Procedure: Immediate skin closureSkin closed immediately after laparotomy |
| Delayed Primary Closure | Experimental | Procedure: Delayed primary closureSkin closed 3 - 5 days after laparotomy |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Patients 18 - 60 years of age
- Either male or female gender and
- Planned to undergo emergency laparotomy
Key exclusion criteria (4 listed)
- Patients undergoing second laparotomy
- Re- laparotomy
- On steroid therapy and
- Patients who die within 28-days of surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Immediate skin closureAfter laparotomy wounds will be closed primarily using no. 1 vicryl suture | Procedure or surgery | Primary Closure |
| Delayed primary closureDeeper layers of wound will be closed after surgery and loose mattress sutures will be applied to skin with prolene. After three to five days of daily dressing with bactericidal solution, the skin will be closed | Procedure or surgery | Delayed Primary Closure |
Primary outcome
Wound Infection
Time frame: From date of surgery to Four weeks postoperatively
Surgical Site infection - Presence any features of erythema, pain, pus discharge on examination of surgical wound and new onset fever (> 98.6 F)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Sep 2025.
- Individual participant dataSharing planned: No
Related trials for Laparotomy Closure After Abdominal Surgery
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Prophylactic Mesh Reinforcement Versus Primary Closure After Emergency Midline Laparotomy (PREEMPT)
Incisional Hernia After Midline Laparotomy, Emergency Abdominal Surgery
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Duramesh™ vs Polydioxanone Suture for Laparotomy Closure
Laparotomy Closure After Abdominal Surgery
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NoPro - Norwegian Hernia Prophylaxis Study
Incisional Hernia After Midline Laparotomy, Quality of Life (QOL)
Not yet recruiting
Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT
Laparotomy, Dehiscence Wound
Recruiting
Abdominal Wall Closure After Laparotomy in Oncologic Surgery
Laparotomy
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Amjad A Professor, FRCS study chair
Bakhtawar Amin Medical and Dental College
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immediate skin closure and Delayed primary closure in people with Laparotomy Closure After Abdominal Surgery, run by Bkahtawar Amin Medical and Dental College Multan at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Wound Infection (time frame: From date of surgery to Four weeks postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Sep 2025.