AzTrials
AzTrials

Non-small Cell CarcinomaPhase 3NCT07144280

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

A Phase 3 study testing PF-08046054 and Docetaxel monotherapy in people with Non-small Cell Carcinoma and Non-Small Cell Lung Cancer Metastatic, run by Pfizer at 447 sites in 29 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

The purpose of this study is to understand if PF-08046054 alone works well compared to standard-of-care docetaxel alone in participants with non-small cell lung cancer (NSCLC) with PD-L1 expression greater than or equal to 1% and had cancer progression during or after treatment with PD-L1 or PD-1 inhibitors… Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
PF-08046054 and Docetaxel monotherapy
Type of treatment
Injection or infusion
Could I receive a placebo?
No, everyone receives an active treatment
How many people
680 participants
Where
447 sitesin 29 countries
Study dates
29 Sep 2025to 10 Mar 2032
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Histologically or cytologically confirmed diagnosis of NSCLC with locally advanced, unresectable Stage IIIB or IIIC not eligible for definitive chemoradiotherapy or metastatic (Stage IV: M1a, M1b, or M1c) disease per the American Joint Committee on Cancer (AJCC) Staging Manual, Version 8.0, and the Union for International Cancer Control (UICC) Staging System. Note: Participants with a neuroendocrine component or histology are not eligible.
  • PD-L1 expression on ≥1% of tumor cells based on local immunohistochemistry (IHC) testing with an assay utilizing the anti-PD-L1 monoclonal antibody clones 22C3 or SP263.
  • Participants who have NSCLC with known AGAs are permitted.
  • Able to provide any of the following tumor tissues for biomarker analysis:
  • Archival specimen (preferably collected within 12 months after the last anticancer therapy) (see laboratory manual for details); or
  • De novo biopsy from a tumor lesion, if medically feasible.
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  • Participants must have received the following therapies and progressed during or relapsed after receiving their most recent prior therapy, or have been intolerant to their most recent therapy:
  • Participants with no known AGAs must fulfill 1 of the following conditions:
  • Received a platinum-based combination therapy for the treatment of metastatic or recurrent disease, and unless contraindicated, a PD-(L)1 monoclonal antibody (concurrently or sequentially with platinum-based chemotherapy).
  • Experienced disease progression within 6 months of the last dose of platinum-based chemotherapy in the adjuvant, neoadjuvant, or chemoradiotherapy setting and received a PD-(L)1 monoclonal antibody at any time during the course of treatment.
  • Participants with known AGAs (eg, EGFR mutations, ALK translocations, or other relevant actionable mutations) must fulfill the following conditions:
  • Must have received at least 1 relevant AGA-targeted therapy if locally available and, in the opinion of the investigator, additional AGA-targeted therapy is not in the best interest of the participant
  • Received a platinum-based combination therapy for the treatment of metastatic or recurrent disease, or experienced disease progression within 6 months of the last dose of platinum-based chemotherapy in the adjuvant, neoadjuvant, or chemoradiotherapy setting.
  • May have received PD-(L)1 monoclonal antibody (concurrently or sequentially with platinum-based chemotherapy).

Who cannot join

  • History of another malignancy within 3 years before the first dose of PF-08046054, or any evidence of residual disease from a previously diagnosed malignancy. Exceptions are malignancies with a negligible risk of metastasis or death (eg, 5-year overall survival [OS] ≥90%), such as adequately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, localized prostate cancer, ductal carcinoma in situ, or Stage I uterine cancer.
  • Any central nervous system (CNS) lesions, unless definitively treated with CNS-directed local therapy (surgery and/or radiotherapy). Participants with definitively treated brain metastases are eligible if they meet the following criteria:
  • The participant is on a stable dose of ≤10 mg/day of prednisone or equivalent for at least >14 days prior to randomization (if requiring steroid treatment).
  • No clinical or radiographic progression in the CNS following CNS-directed definitive radiotherapy and/or surgery.
  • Time since CNS-directed treatment is ≥28 days prior to randomization.
  • Participants with a history of leptomeningeal metastasis are excluded.
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  • Prior treatment with an anti-PD-L1 agent (where indicated per protocol) within 5 half-lives.
  • Previous receipt of an MMAE-containing agent or prior docetaxel.
  • There are additional inclusion and exclusion criteria. The study center will determine if criteria for participations are met.

Trial locations and contacts

447 sites in 29 countries. Contact the study team or a site near you to ask about taking part.

Pfizer CT.gov Call Center contact

1-800-718-1021

ClinicalTrials.gov_Inquiries@pfizer.com

447 sites in 29 countries

United States241 sites, 241 recruiting

  • Texas Oncology - West Texas

    Abilene, Texas, 79606

    Recruiting

  • Alabama Oncology, Shelby

    Alabaster, Alabama, 35007

    Recruiting

  • Texas Oncology-Northeast Texas

    Allen, Texas, 75013

    Recruiting

  • Texas Oncology-West Texas

    Amarillo, Texas, 79124

    Recruiting

  • Alaska Oncology and Hematology

    Anchorage, Alaska, 99508

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Annapolis, Maryland, 21401

    Recruiting

  • Texas Oncology - DFW

    Arlington, Texas, 76012

    Recruiting

  • The Center for Cancer and Blood Disorders

    Arlington, Texas, 76014

    Recruiting

  • Texas Oncology - DFW

    Arlington, Texas, 76104

    Recruiting

  • Illinois Cancer Specialists

    Arlington Heights, Illinois, 60005

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Aurora, Colorado, 80012

    Recruiting

  • Texas Oncology- Central South.

    Austin, Texas, 78705

    Recruiting

  • Texas Oncology Central South

    Austin, Texas, 78731

    Recruiting

  • Texas Oncology- Central South.

    Austin, Texas, 78745

    Recruiting

  • Texas Oncology - Central South (Renfert Way)

    Austin, Texas, 78758

    Recruiting

  • University Hospitals Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio, 44011

    Recruiting

  • Baptist Cancer Center

    Bartlett, Tennessee, 38133

    Recruiting

  • Mary Bird Perkins Cancer Center

    Baton Rouge, Louisiana, 70809

    Recruiting

  • Texas Oncology - Gulf Coast

    Beaumont, Texas, 77702

    Recruiting

  • OHSU Knight Cancer Institute, Beaverton

    Beaverton, Oregon, 97006

    Recruiting

  • Texas Oncology - DFW

    Bedford, Texas, 76022

    Recruiting

  • Essex Oncology of North Jersey

    Belleville, New Jersey, 07109

    Recruiting

  • Nebraska Medicine-Bellevue Medical Center

    Bellevue, Nebraska, 68123

    Recruiting

  • Alliance Cancer Specialists, PC

    Bensalem, Pennsylvania, 19020

    Recruiting

  • Alta Bates Summit Medical Center Comprehensive Cancer Center

    Berkeley, California, 94704

    Recruiting

  • Alabama Oncology, Bessemer

    Bessemer, Alabama, 35022

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Bethesda, Maryland, 20817

    Recruiting

  • Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana

    Billings, Montana, 59102

    Recruiting

  • Alabama Oncology, St Vincent's Birmingham

    Birmingham, Alabama, 35205

    Recruiting

  • Alabama Oncology, Brookwood

    Birmingham, Alabama, 35209

    Recruiting

  • Alabama Oncology, Princeton

    Birmingham, Alabama, 35211

    Recruiting

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233

    Recruiting

  • Alabama Oncology, St Vincent's East

    Birmingham, Alabama, 35235

    Recruiting

  • Alabama Oncology, Grandview Cancer Center

    Birmingham, Alabama, 35243

    Recruiting

  • University of Alabama at Birmingham, IDS Pharmacy

    Birmingham, Alabama, 35249

    Recruiting

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35249

    Recruiting

  • Oncology & Hematology Associates of Southwest Virginia,Inc.DBA Blue Ridge Cancer Care

    Blacksburg, Virginia, 24060

    Recruiting

  • Illinois CancerCare- Bloomington

    Bloomington, Illinois, 61704

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Boulder, Colorado, 80303

    Recruiting

  • Bozeman Health Deaconess Hospital - Bozeman Health Cancer Center

    Bozeman, Montana, 59715

    Recruiting

  • Bozeman Health Deaconess Hospital - Bozeman Health Clinical Research

    Bozeman, Montana, 59715

    Recruiting

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana, 59715

    Recruiting

  • Maryland Oncology Hematology, PA

    Brandywine, Maryland, 20613

    Recruiting

  • Consultants in Medical Oncology and Hematology, P.C.

    Broomall, Pennsylvania, 19008

    Recruiting

  • The Center for Cancer and Blood Disorders

    Burleson, Texas, 76028

    Recruiting

  • Minnesota Oncology Hematology, PA

    Burnsville, Minnesota, 55337

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Centennial, Colorado, 80112

    Recruiting

  • Tennessee Oncology, PLLC - Chattanooga Downtown

    Chattanooga, Tennessee, 37403

    Recruiting

  • Tennessee Oncology, PLLC - Chattanooga Med Park II

    Chattanooga, Tennessee, 37404

    Recruiting

  • Tennessee Oncology, PLLC - Chattanooga Memorial

    Chattanooga, Tennessee, 37404

    Recruiting

  • Tennessee Oncology, PLLC - Investigational Drug Services/Supply Storage

    Chattanooga, Tennessee, 37404

    Recruiting

  • Illinois Cancer Specialists

    Chicago, Illinois, 60631

    Recruiting

  • Oncology_Hematology Care Clinical Trials,LLC

    Cincinnati, Ohio, 45211

    Recruiting

  • Oncology_Hematology Care Clinical Trials,LLC

    Cincinnati, Ohio, 45242

    Recruiting

  • Oncology_Hematology Care Clinical Trials,LLC

    Cincinnati, Ohio, 45245

    Recruiting

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106

    Recruiting

  • Tennessee Oncology, PLLC - Cleveland

    Cleveland, Tennessee, 37311

    Recruiting

  • Baptist Cancer Center

    Collierville, Tennessee, 38017

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Colorado Springs, Colorado, 80907

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Colorado Springs, Colorado, 80923

    Recruiting

  • Maryland Oncology Hematology

    Columbia, Maryland, 21044

    Recruiting

  • Missouri Cancer Associates

    Columbia, Missouri, 65201

    Recruiting

  • John Muir Health Clinical Research Center

    Concord, California, 94520

    Recruiting

  • The University of Texas, MD Anderson Cancer Center - Woodlands

    Conroe, Texas, 77384

    Recruiting

  • Allina Health Cancer Institute - Mercy Hospital

    Coon Rapids, Minnesota, 55433

    Recruiting

  • Minnesota Oncology Hematology, PA

    Coon Rapids, Minnesota, 55433

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75203

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75230

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75231

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75237

    Recruiting

  • Texas Oncology - DFW

    Dallas, Texas, 75246

    Recruiting

  • Tennessee Oncology, PLLC - Dalton

    Dalton, Georgia, 30720

    Recruiting

  • Southern Cancer Center

    Daphne, Alabama, 36526

    Recruiting

  • Texas Oncology-Northeast Texas

    Denison, Texas, 75020

    Recruiting

  • Texas Oncology-Northeast Texas

    Denton, Texas, 76201

    Recruiting

  • Rocky Mountain Cancer Centers,LLP

    Denver, Colorado, 80218

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Denver, Colorado, 80220

    Recruiting

  • Alliance Cancer Specialists, PC

    Doylestown, Pennsylvania, 18901

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Edina, Minnesota, 55435

    Recruiting

  • Texas Oncology-West Texas

    El Paso, Texas, 79902

    Recruiting

  • Texas Oncology-West Texas

    El Paso, Texas, 79915

    Recruiting

  • Texas Oncology-West Texas

    El Paso, Texas, 79938

    Recruiting

  • UC San Diego Medical Center - Encinitas

    Encinitas, California, 92024

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Englewood, Colorado, 80113

    Recruiting

  • Oncology Associates of Oregon, P.C.

    Eugene, Oregon, 97401

    Recruiting

  • Oncology_Hematology Care Clinical Trials,LLC

    Fairfield, Ohio, 45014

    Recruiting

  • Highlands Oncology Group, PA

    Fayetteville, Arkansas, 72703

    Recruiting

  • Texas Oncology-Northeast Texas

    Flower Mound, Texas, 75028

    Recruiting

  • Southern Cancer Center, PC

    Foley, Alabama, 36535

    Recruiting

  • Texas Oncology - DFW

    Fort Worth, Texas, 76104

    Recruiting

  • The Center for Cancer and Blood Disorders

    Fort Worth, Texas, 76104

    Recruiting

  • Providence Medical Foundation

    Fullerton, California, 92835

    Recruiting

  • Providence St. Jude Medical Center

    Fullerton, California, 92835

    Recruiting

  • Illinois CancerCare Galesburg

    Galesburg, Illinois, 61401

    Recruiting

  • Maryland Oncology Hematology P.A.

    Germantown, Maryland, 20876

    Recruiting

  • The West Clinic PC dba West Cancer Center

    Germantown, Tennessee, 38138

    Recruiting

  • Texas Oncology - DFW

    Grapevine, Texas, 76051

    Recruiting

  • OHSU Knight Cancer Institute, Gresham

    Gresham, Oregon, 97030

    Recruiting

  • Texas Oncology- Central South

    Harlingen, Texas, 78550

    Recruiting

  • Alliance Cancer Specialists, PC

    Horsham, Pennsylvania, 19044

    Recruiting

  • Texas Oncology - Gulf Coast

    Houston, Texas, 77024

    Recruiting

  • The University of Texas MD Anderson Cancer Center Diagnostic Imaging

    Houston, Texas, 77030

    Recruiting

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030

    Recruiting

  • The University of Texas, MD Anderson Cancer Center- Interventional Radiology

    Houston, Texas, 77030

    Recruiting

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030

    Recruiting

  • The University of Texas MD Anderson Cancer Center Clinical Research Imaging

    Houston, Texas, 77054

    Recruiting

  • The University of Texas, MD Anderson Cancer Center - West Houston

    Houston, Texas, 77079

    Recruiting

  • Texas Oncology - Gulf Coast

    Humble, Texas, 77338

    Recruiting

  • US Oncology Investigational Product Center (IPC)

    Irving, Texas, 75063

    Recruiting

  • US Oncology Investigational Products Center (IPC)

    Irving, Texas, 75063

    Recruiting

  • US Oncology Investigational Products Center(IPC)

    Irving, Texas, 75063

    Recruiting

  • Tennessee Cancer Specialists

    Knoxville, Tennessee, 37909

    Recruiting

  • Tennessee Cancer Specialists - Parkwest Location

    Knoxville, Tennessee, 37932

    Recruiting

  • UC San Diego Medical Center-La Jolla (Jacobs Medical Center/Thornton Pavilion

    La Jolla, California, 92037

    Recruiting

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92037

    Recruiting

  • UCSD Koman Family Outpatient Pavilion

    La Jolla, California, 92037

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Lakewood, Colorado, 80228

    Recruiting

  • Alliance Cancer Specialists, P.C.

    Langhorne, Pennsylvania, 19047

    Recruiting

  • Maryland Oncology Hematology, P.A

    Largo, Maryland, 20774

    Recruiting

  • The University of Texas, MD Anderson Cancer Center - League City

    League City, Texas, 77573

    Recruiting

  • Tennessee Oncology, PLLC - Lebanon

    Lebanon, Tennessee, 37090

    Recruiting

  • Texas Oncology-Northeast Texas

    Lewisville, Texas, 75056

    Recruiting

  • Accellacare of Duly

    Lisle, Illinois, 60532

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Littleton, Colorado, 80120

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Lone Tree, Colorado, 80124

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Longmont, Colorado, 80504

    Recruiting

  • Texas Oncology-Northeast Texas

    Longview, Texas, 75601

    Recruiting

  • Norton Cancer Institute Downtown

    Louisville, Kentucky, 40202

    Recruiting

  • Norton Cancer Institute, Downtown

    Louisville, Kentucky, 40202

    Recruiting

  • Norton Hospital

    Louisville, Kentucky, 40202

    Recruiting

  • Norton Audubon Hospital

    Louisville, Kentucky, 40217

    Recruiting

  • Norton Cancer Institute, Audubon Hospital Campus

    Louisville, Kentucky, 40217

    Recruiting

  • Norton Brownsboro Hospital

    Louisville, Kentucky, 40241

    Recruiting

  • Norton Cancer Institute, Brownsboro Hospital Campus

    Louisville, Kentucky, 40241

    Recruiting

  • Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer care| Emmett Medical & Surgical Center

    Low Moor, Virginia, 24457

    Recruiting

  • Covenant Children's Hospital- Joe Arrington Cancer Research and Treatment Center

    Lubbock, Texas, 79410

    Recruiting

  • Minnesota Oncology Hematology PA

    Maple Grove, Minnesota, 55369

    Recruiting

  • Minnesota Oncology Hematology, P.A.

    Maplewood, Minnesota, 55109

    Recruiting

  • Texas Oncology -Central South

    McAllen, Texas, 78503

    Recruiting

  • Texas Oncology-Northeast Texas

    McKinney, Texas, 75071

    Recruiting

  • Alliance Cancer Specialists, PC

    Media, Pennsylvania, 19063

    Recruiting

  • Baptist Cancer Center

    Memphis, Tennessee, 38120

    Recruiting

  • Baptist Clinical Research Institute

    Memphis, Tennessee, 38120

    Recruiting

  • University Hospitals Seidman Cancer Center at UH Mentor Health Center

    Mentor, Ohio, 44060

    Recruiting

  • Texas Oncology-West Texas

    Midland, Texas, 79701

    Recruiting

  • Minnesota Oncology Hematology, P.A...

    Minneapolis, Minnesota, 55404

    Recruiting

  • Allina Health Cancer Institute - Abbott Northwestern Hospital

    Minneapolis, Minnesota, 55407

    Recruiting

  • Tennessee Oncology, PLLC - Mount Juliet

    Mount Juliet, Tennessee, 37122

    Recruiting

  • Tennessee Oncology, PLLC - Murfreesboro

    Murfreesboro, Tennessee, 37129

    Recruiting

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203

    Recruiting

  • Tennessee Oncology, PLLC - Investigational Drug Services

    Nashville, Tennessee, 37203

    Recruiting

  • Tennessee Oncology, PLLC - Nashville Elliston Place Plaza Medical Oncology & Hematology Clinic

    Nashville, Tennessee, 37203

    Recruiting

  • Tennessee Oncology, PLLC - Nashville Saint Thomas West

    Nashville, Tennessee, 37205

    Recruiting

  • Medical Oncology Hematology Consultants, PA

    Newark, Delaware, 19713

    Recruiting

  • Texas Oncology-West Texas

    Odessa, Texas, 79761

    Recruiting

  • American Oncology Network Vista Oncology Division-West office

    Olympia, Washington, 98502

    Recruiting

  • American Oncology Network Vista Oncology Division-East office

    Olympia, Washington, 98506

    Recruiting

  • Nebraska Medicine

    Omaha, Nebraska, 68105

    Recruiting

  • Nebraska Medicine - Village Pointe

    Omaha, Nebraska, 68118

    Recruiting

  • University Of Nebraska Medical Center

    Omaha, Nebraska, 68198

    Recruiting

  • UH Minoff Health Center at Chagrin Highlands

    Orange, Ohio, 44122

    Recruiting

  • Illinois CancerCare-Ottawa-Fox River Cancer Center

    Ottawa, Illinois, 61350

    Recruiting

  • Texas Oncology-Northeast Texas

    Palestine, Texas, 75801

    Recruiting

  • Cancer Care Centers of Brevard, Inc.

    Palm Bay, Florida, 32901

    Recruiting

  • Florida Cancer Affiliates - Panama City

    Panama City, Florida, 32405

    Recruiting

  • Texas Oncology-Northeast Texas

    Paris, Texas, 75460

    Recruiting

  • Texas Oncology - Gulf Coast

    Pearland, Texas, 77584

    Recruiting

  • Illinois CancerCare- Pekin

    Pekin, Illinois, 61554

    Recruiting

  • Illinois Cancer Care

    Peoria, Illinois, 61615

    Recruiting

  • Illinois CancerCare-Peru - Valley Regional Cancer Center

    Peru, Illinois, 61354

    Recruiting

  • Texas Oncology - DFW

    Plano, Texas, 75075

    Recruiting

  • Texas Oncology - DFW

    Plano, Texas, 75093

    Recruiting

  • OHSU Knight Cancer Institute, Northwest

    Portland, Oregon, 97210

    Recruiting

  • Providence Cancer Institute Franz Clinic

    Portland, Oregon, 97213

    Recruiting

  • OHSU Knight Cancer Institute, East Portland

    Portland, Oregon, 97216

    Recruiting

  • Providence Investigational Drug Service - Westside

    Portland, Oregon, 97225

    Recruiting

  • Providence Oncology and Hematology Care -Westside

    Portland, Oregon, 97225

    Recruiting

  • OHSU Research Pharmacy Services, CHH2

    Portland, Oregon, 97239

    Recruiting

  • Oregon Health and Science University, CHH1

    Portland, Oregon, 97239

    Recruiting

  • Oregon Health and Science University, CHH2

    Portland, Oregon, 97239

    Recruiting

  • Oregon Health and Science University

    Portland, Oregon, 97239

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Pueblo, Colorado, 81003

    Recruiting

  • VCU Emergency Center at New Kent

    Quinton, Virginia, 23141

    Recruiting

  • Renown Health Medical Oncology

    Reno, Nevada, 89502

    Recruiting

  • Renown Office of Clinical Research

    Reno, Nevada, 89502

    Recruiting

  • Renown Regional Medical Center

    Reno, Nevada, 89502

    Recruiting

  • VCU Medical Center Gateway Building

    Richmond, Virginia, 23219

    Recruiting

  • Virginia Commonwealth University

    Richmond, Virginia, 23219

    Recruiting

  • VCU Health Short Pump Pavilion

    Richmond, Virginia, 23233

    Recruiting

  • VCU Health Stony Point

    Richmond, Virginia, 23235

    Recruiting

  • Massey Cancer Center Clinical & Translational Research Lab

    Richmond, Virginia, 23298

    Recruiting

  • Virginia Commonwealth University

    Richmond, Virginia, 23298

    Recruiting

  • Tennessee Oncology, PLLC - Ringgold

    Ringgold, Georgia, 30736

    Recruiting

  • Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care

    Roanoke, Virginia, 24014

    Recruiting

  • Maryland Oncology Hematology PA

    Rockville, Maryland, 20850

    Recruiting

  • Highlands Oncology Group, PA

    Rogers, Arkansas, 72758

    Recruiting

  • Roseville Medical Plaza Care Center

    Roseville, California, 95661

    Recruiting

  • Sutter Medical Center, Sacramento Infusion Center at Roseville

    Roseville, California, 95661

    Recruiting

  • Baylor Scott & White Health - Round Rock

    Round Rock, Texas, 78665

    Recruiting

  • Buhler Specialty Pavilion

    Sacramento, California, 95816

    Recruiting

  • Sutter Medical Center, Sacramento Infusion Center

    Sacramento, California, 95816

    Recruiting

  • Allina Health Cancer Institute - United Hospital

    Saint Paul, Minnesota, 55102

    Recruiting

  • Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care

    Salem, Virginia, 24153

    Recruiting

  • UC San Diego McGrath Outpatient Pavilion - Hillcrest

    San Diego, California, 92103

    Recruiting

  • UC San Diego Medical Center - Hillcrest

    San Diego, California, 92103

    Recruiting

  • UCSD Medical Center - Rancho Bernardo

    San Diego, California, 92127

    Recruiting

  • CHRISTUS St. Vincent Regional Cancer Center

    Santa Fe, New Mexico, 87505

    Recruiting

  • Christus St. Vincent Regional Medical Center

    Santa Fe, New Mexico, 87505

    Recruiting

  • Alliance Cancer Specialists, PC

    Sellersville, Pennsylvania, 18960

    Recruiting

  • Tennessee Oncology, PLLC - Shelbyville

    Shelbyville, Tennessee, 37160

    Recruiting

  • Maryland Oncology Hematology, P.A.

    Silver Spring, Maryland, 20904

    Recruiting

  • Tennessee Oncology, PLLC - Smyrna

    Smyrna, Tennessee, 37167

    Recruiting

  • VCU Health Community Memorial Hospital

    South Hill, Virginia, 23970

    Recruiting

  • Baptist Cancer Center

    Southaven, Mississippi, 38671

    Recruiting

  • Highlands Oncology Group, PA

    Springdale, Arkansas, 72762

    Recruiting

  • Highlands Oncology Group

    Springdale, Arkansas, 72762

    Recruiting

  • The University of Texas, MD Anderson Cancer Center - Sugar Land

    Sugar Land, Texas, 77478

    Recruiting

  • Texas Oncology - Gulf Coast

    Sugar Land, Texas, 77479

    Recruiting

  • VCU Health Tappahannock Hospital

    Tappahannock, Virginia, 22560

    Recruiting

  • Montefiore Medical Center - Montefiore Medical Park

    The Bronx, New York, 10461

    Recruiting

  • Texas Oncology - Gulf Coast

    The Woodlands, Texas, 77380

    Recruiting

  • Rocky Mountain Cancer Centers LLP

    Thornton, Colorado, 80260

    Recruiting

  • OHSU Knight Cancer Institute, Tualatin

    Tualatin, Oregon, 97062

    Recruiting

  • Texas Oncology-Northeast Texas

    Tyler, Texas, 75702

    Recruiting

  • UC San Diego Medical Center - Vista

    Vista, California, 92081

    Recruiting

  • Texas Oncology- Central South

    Waco, Texas, 76712

    Recruiting

  • Texas Oncology-Central South

    Waco, Texas, 76712

    Recruiting

  • John Muir Health Cancer Center

    Walnut Creek, California, 94598

    Recruiting

  • John Muir Health Clinical Research Center

    Walnut Creek, California, 94598

    Recruiting

  • John Muir Medical Center - Walnut Creek Campus

    Walnut Creek, California, 94598

    Recruiting

  • Illinois CancerCare - Washington

    Washington, Illinois, 61571

    Recruiting

  • The Center for Cancer and Blood Disorders

    Weatherford, Texas, 76086

    Recruiting

  • Texas Oncology - Gulf Coast

    Webster, Texas, 77598

    Recruiting

  • Texas Oncology - Central South

    Weslaco, Texas, 78596

    Recruiting

  • White Plains Hospital

    White Plains, New York, 10601

    Recruiting

  • Texas Oncology-West Texas

    Wichita Falls, Texas, 76310

    Recruiting

  • Shenandoah Oncology, P.C.

    Winchester, Virginia, 22601

    Recruiting

  • Minnesota Oncology Hematology, PA

    Woodbury, Minnesota, 55125

    Recruiting

  • University of Massachusetts Worcester

    Worcester, Massachusetts, 01655

    Recruiting

  • Alliance Cancer Specialists, PC

    Wynnewood, Pennsylvania, 19096

    Recruiting

  • Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care

    Wytheville, Virginia, 24382

    Recruiting

Other trials in United States

China24 sites, 24 recruiting

  • Beijing Friendship Hospital Affiliate of Capital University

    Beijing, Beijing Municipality, 100050

    Not yet recruiting

  • Beijing Cancer hospital

    Beijing, Beijing Municipality, 100142

    Recruiting

  • Hunan Cancer Hospital

    Changsha, Hunan, 410013

    Recruiting

  • The First People's Hospital of Changzhou

    Changzhou, Jiangsu, 213003

    Recruiting

  • West China Hospital, Sichuan University

    Chengdu, Sichuan, 610041

    Recruiting

  • Chongqing University Cancer Hospital

    Chongqing, Chongqing Municipality, 400030

    Recruiting

  • Fujian Cancer Hospital

    Fuzhou, Fujian, 350014

    Recruiting

  • Southern Medical University Nanfang Hospital

    Guangzhou, Guangdong, 510515

    Recruiting

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310022

    Recruiting

  • Harbin Medical University Cancer Hospital

    Harbin, Heilongjiang, 150081

    Recruiting

  • Anhui Provincial Hospital

    Hefei, Anhui, 230001

    Recruiting

  • The First Affiliated Hospital of Anhui Medical University

    Hefei, Anhui, 230022

    Recruiting

  • Jinan Central Hospital

    Jinan, Shandong, 250013

    Recruiting

  • Yunnan Province Cancer Hospital

    Kunming, Yunnan, 650118

    Recruiting

  • The First Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330209

    Recruiting

  • Jiangsu Province Hospital

    Nanjing, Jiangsu, 210029

    Recruiting

  • Guangxi Medical University Affiliated Tumor Hospital

    Nanning, Guangxi, 530021

    Recruiting

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai Municipality, 200032

    Recruiting

  • Shanghai East Hospital

    Shanghai, Shanghai Municipality, 200123

    Recruiting

  • Taizhou Hospital of Zhejiang Province

    Taizhou, Zhejiang, 317000

    Recruiting

  • Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, Hubei, 430030

    Recruiting

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, Shaanxi, 710061

    Recruiting

  • The Affiliated Hospital of Xuzhou Medical College

    Xuzhou, Jiangsu, 221006

    Recruiting

  • Henan Cancer Hospital

    Zhengzhou, 450008

    Recruiting

Other trials in China

Japan19 sites, 19 recruiting

  • Hyogo Cancer Center

    Akashi, Hyōgo, 673-8558

    Not yet recruiting

  • National Hospital Organization Beppu Medical Center

    Beppu-shi, Oita Prefecture, 874-0011

    Recruiting

  • Nippon Medical School Hospital

    Bunkyo-ku, Tokyo, 113-8603

    Recruiting

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395

    Recruiting

  • National Hospital Organization Tokyo National Hospital

    Kiyose, Tokyo, 204-8585

    Not yet recruiting

  • National Hospital Organization Kochi National Hospital

    Kochi, Kochi, 780-8077

    Recruiting

  • National Hospital Organization Kure Medical Center and Chugoku Cancer Center

    Kure, Hiroshima, 737-0023

    Recruiting

  • Kurume University Hospital

    Kurume, Fukuoka, 830-0011

    Recruiting

  • National Hospital Organization Kyoto Medical Center

    Kyoto, 612-8555

    Recruiting

  • Shizuoka Cancer Center

    Nagaizumi-cho, Shizuoka, 411-8777

    Recruiting

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1192

    Recruiting

  • National Hospital Organization Nagasaki Medical Center

    Ōmura, Nagasaki, 856-8562

    Recruiting

  • Osaka International Cancer Institute

    Osaka, 541-8567

    Recruiting

  • Kindai University Hospital

    Sakai, Osaka, 590-0197

    Recruiting

  • NHO Kinki Chuo Chest Medical Center

    Sakai, Osaka, 591-8555

    Not yet recruiting

  • Sendai Kousei Hospital

    Sendai, Miyagi, 9810914

    Recruiting

  • Osaka University Hospital

    Suita, Osaka, 565-0871

    Recruiting

  • The University of Osaka Hospital

    Suita, Osaka, 565-0871

    Recruiting

  • Mie Chuo Medical Center

    Tsu, Mie-ken, 514-1101

    Recruiting

Other trials in Japan

Germany15 sites, 15 recruiting

  • Zentralklinik Bad Berka GmbH

    Bad Berka, 99437

    Recruiting

  • Vivantes Auguste-Viktoria-Klinikum

    Berlin, 12157

    Recruiting

  • Universitätsklinikum Bonn

    Bonn, North Rhine-Westphalia, 53127

    Recruiting

  • Universitaetsklinikum Essen West German Cancer Center

    Essen, 45147

    Recruiting

  • Krankenhaus Nordwest GmbH

    Frankfurt am Main, Hesse, D-60488

    Recruiting

  • UKGM Gießen/Marburg

    Giessen, Hesse, 35392

    Recruiting

  • LungenClinic Grosshansdorf

    Großhansdorf, Schleswig-Holstein, 22927

    Recruiting

  • Thoraxklinik-Heidelberg gGmbH

    Heidelberg, Baden-Wurttemberg, 69126

    Recruiting

  • MVZ am Klinikum Aschaffenburg

    Hösbach, Bavaria, 63768

    Recruiting

  • Lungenfachklinik Immenhausen

    Immenhausen, Hesse, 34376

    Recruiting

  • Universitaetsklinikum Jena

    Jena, 07747

    Recruiting

  • Klinikum Kassel GmbH

    Kassel, Hesse, 34125

    Recruiting

  • InVO Institut für Versorgungsforschung in der Onkologie

    Koblenz, Rhineland-Palatinate, 56068

    Recruiting

  • Central Apotheke

    Steinbach, 61449

    Recruiting

  • Robert-Bosch-Krankenhaus

    Stuttgart, Baden-Wurttemberg, 70376

    Recruiting

Other trials in Germany

Spain14 sites, 14 recruiting

  • CHUAC-Complejo Hospitalario Universitario A Coruña

    A Coruña, A Coruña [LA Coruña], 15006

    Recruiting

  • Hospital Universitario de Badajoz

    Badajoz, 06006

    Recruiting

  • Institut Català d'Oncologia (ICO) - Badalona

    Badalona, Barcelona [barcelona], 08916

    Recruiting

  • Hospital Universitari Vall d'Hebron

    Barcelona, Barcelona [barcelona], 08035

    Recruiting

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Catalunya [cataluña], 08041

    Recruiting

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08025

    Recruiting

  • Hospital Universitario San Cecilio

    Granada, 18016

    Recruiting

  • Hospital General Universitario Gregorio Marañon

    Madrid, Madrid, Comunidad de, 28009

    Recruiting

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, Comunidad de, 28041

    Recruiting

  • Hospital Universitari Son Espases

    Palma, 07120

    Recruiting

  • Hospital Universitario Virgen de Valme

    Seville, 41014

    Recruiting

  • Hospital General Universitario de Valencia

    Valencia, 46014

    Recruiting

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026

    Recruiting

  • Hospital Clínico Universitario Lozano Blesa

    Zaragoza, 50009

    Recruiting

Other trials in Spain

France11 sites, 11 recruiting

  • Institut Bergonié

    Bordeaux, 33076

    Recruiting

  • Centre Hospitalier Universitaire Cavale Blanche

    Brest, Brittany Region, 29200

    Recruiting

  • CHU Lille - Institut Coeur Poumon

    Lille, NORD, 59037

    Recruiting

  • Assistance Publique Hôpitaux de Marseille - Hôpital Nord

    Marseille, 13915

    Recruiting

  • Hopital Cochin

    Paris, 75014

    Recruiting

  • Institut Curie

    Paris, 75248

    Recruiting

  • Hôpital Tenon

    Paris, 75970

    Recruiting

  • Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou

    Rennes, Ille-et-vilaine, 35033

    Recruiting

  • Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes

    Saint-Herblain, Loire-atlantique, 44800

    Recruiting

  • CHU de Toulouse - Hopital Larrey

    Toulouse, Haute-garonne, 31059

    Recruiting

  • Gustave Roussy

    Villejuif, Val-de-marne, 94805

    Recruiting

Other trials in France

Italy11 sites, 11 recruiting

  • Cro-Irccs

    Aviano, Pordenone, 33081

    Recruiting

  • Cliniche Gavazzeni S.p.A. - Humanitas Gavazzeni

    Bergamo, 24125

    Recruiting

  • AORN Sant'Anna e San Sebastiano

    Caserta, 81100

    Recruiting

  • Azienda Ospedaliera Universitaria Careggi

    Florence, Tuscany, 50134

    Recruiting

  • IRCCS Azienda Ospedaliera Metropolitana (AOM)

    Genova, 16132

    Recruiting

  • Ospedale San Raffaele

    Milan, 20132

    Recruiting

  • Istituto Europeo di Oncologia IRCCS

    Milan, 20141

    Recruiting

  • Ausl Della Romagna- Ospedale Santa Maria Delle Croci Ravenna

    Ravenna, 48121

    Recruiting

  • Ospedale Isola Tiberina Gemelli Isola

    Roma, ROME, 00186

    Recruiting

  • Istituto Nazionale Tumori Regina Elena

    Rome, ROMA, 00144

    Recruiting

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento

    Verona, Veneto, 37126

    Recruiting

Other trials in Italy

South Korea11 sites, 11 recruiting

  • Chungbuk National University Hospital

    Cheongju-si, Chungcheongbuk-do [chungbuk], 28644

    Recruiting

  • Boramae Medical Center

    Dongjak-gu, Seoul-teukbyeolsi [seoul], 07061

    Recruiting

  • National Cancer Center

    Goyang-si, Kyǒnggi-do, 10408

    Recruiting

  • Inje University Haeundae Paik Hospital

    Haeundae-gu, Pusan-kwangyǒkshi, 48108

    Recruiting

  • Seoul National University Bundang Hospital

    Seongnam, Kyǒnggi-do, 13620

    Recruiting

  • CHA Bundang Medical Center, CHA University

    Seongnam-si, Kyǒnggi-do, 13496

    Recruiting

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul-teukbyeolsi [seoul], 03722

    Recruiting

  • Asan Medical Center

    Seoul, Seoul-teukbyeolsi [seoul], 05505

    Recruiting

  • Samsung Medical Center

    Seoul, Seoul-teukbyeolsi [seoul], 06351

    Recruiting

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital

    Seoul, Seoul-teukbyeolsi [seoul], 06591

    Recruiting

  • The Catholic University Of Korea St. Vincent's Hospital

    Suwon, Kyǒnggi-do, 16247

    Recruiting

Other trials in South Korea

Canada10 sites, 10 recruiting

  • Arthur J.E. Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2

    Recruiting

  • Sante Quebec Monteregie-Centre

    Greenfield Park, Quebec, J4V2H1

    Recruiting

  • Sante Quebec Laval, Hopital de la Cite-de-la-Sante

    Laval, Quebec, H7M 3L9

    Recruiting

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1

    Recruiting

  • Lakeridge Health

    Oshawa, Ontario, L1G 2B9

    Recruiting

  • Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus

    Québec, G1J 1Z4

    Recruiting

  • IUCPQ-Universite Laval

    Québec, G1V 4G5

    Recruiting

  • Centre de Services Ambulatoire de St-Jerome

    Saint-Jérôme, Quebec, J7Y 0L1

    Recruiting

  • Unité de Recherche Clinique du CISSS des Laurentides

    Saint-Jérôme, Quebec, J7Z 2V4

    Recruiting

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9

    Recruiting

Other trials in Canada

Greece8 sites, 8 recruiting

  • Thoracic General Hospital of Athens "I Sotiria"

    Athens, Attikí, 115 27

    Recruiting

  • ?enry Dunant Hospital Center Fourth Department of Oncology and Clinical Trials Unit

    Athens, 115 26

    Recruiting

  • University General Hospital of Heraklion

    Heraklion, Irakleío, 715 00

    Recruiting

  • University General Hospital of Heraklion

    Irakleio, Irakleío, 71110

    Recruiting

  • University General Hospital of Larissa

    Larissa, Thessalía, 41110

    Recruiting

  • Metropolitan Hospital

    Piraeus, Attikí, 185 47

    Recruiting

  • Agios Loukas Clinic

    Thessaloniki, Thessaloníki, 552 36

    Recruiting

  • European Interbalkan Medical Center

    Thessaloniki, Thessaloníki, 570 01

    Recruiting

Other trials in Greece

Argentina7 sites, 7 recruiting

  • Instituto Argentino de Diagnóstico y Tratamiento (IADT)

    Buenos Aires, C1122AAL

    Recruiting

  • Fundación Respirar

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ABP

    Recruiting

  • Hospital Privado Universitario de Córdoba

    Córdoba, 5016

    Recruiting

  • Centro de Investigaciones Oncológicas Colon

    Mar del Plata, 7600

    Recruiting

  • Sanatorio Parque

    Rosario, Santa Fe Province, 2000

    Recruiting

  • Sanatorio Británico

    Rosario, Santa Fe Province, S2000CVB

    Recruiting

  • COE (Centro Oncológico de Excelencia)

    San Juan, 5400

    Recruiting

Other trials in Argentina

Czechia6 sites, 6 recruiting

  • Fakultní nemocnice Brno Bohunice Klinika nemocí plicních a tuberkulózy

    Brno, 625 00

    Recruiting

  • Nemocnice AGEL Novy Jicin a.s.

    Nový Jičín, 741 01

    Recruiting

  • Fakultni nemocnice Olomouc

    Olomouc, 779 00

    Recruiting

  • Nemocnice AGEL Ostrava - Vítkovice a.s. Plicní ambulance - pneumoonkologická ambulance

    Ostrava, Ostrava Město, 703 00

    Recruiting

  • Vseobecna fakultni nemocnice v Praze (Onkologicka klinika)

    Prague, 128 08

    Recruiting

  • Fakultni nemocnice Motol a Homolka

    Prague, 15006.

    Recruiting

Other trials in Czechia

India6 sites, 6 recruiting

  • Fortis Hospital

    Delhi, 110088

    Recruiting

  • Caritas Hospital

    Kerala, 686630

    Recruiting

  • Apollo Multispeciality Hospitals limited

    Kolkata, West Bengal, 700054

    Recruiting

  • Tata Memorial Hospital

    Mumbai, Maharashtra, 400012

    Recruiting

  • Rajiv Gandhi Cancer Institute And Research Centre

    New Delhi, National Capital Territory of Delhi, 110085

    Recruiting

  • Sahyadri Super Speciality Hospital

    Pune, Maharashtra, 411004

    Recruiting

Other trials in India

Israel6 sites, 6 recruiting

  • Shaare Zedek Medical Center

    Jerusalem, Jerusalem, 9013102

    Recruiting

  • Hadassah Medical Center

    Jerusalem, Jerusalem, 9112001

    Recruiting

  • Rabin Medical Center

    Petah Tikva, Central District, 4941492

    Recruiting

  • Sheba Medical Center

    Ramat Gan, Central District, 5265601

    Not yet recruiting

  • Sourasky Medical Center

    Tel Aviv, TELL ABĪB, 6423906

    Recruiting

  • Yitzhak Shamir Medical Center

    Ẕerifin, Central District, 70300

    Recruiting

Other trials in Israel

Taiwan6 sites, 6 recruiting

  • Changhua Christian Hospital

    Changhua County, Changhua, 50006

    Recruiting

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807

    Recruiting

  • Taichung Veterans General Hospital

    Taichung, 407219

    Recruiting

  • National Cheng Kung University Hospital

    Tainan, 704

    Recruiting

  • National Taiwan University Hospital

    Taipei, 10002

    Recruiting

  • Taipei Veterans General Hospital

    Taipei, 11217

    Recruiting

Other trials in Taiwan

Belgium5 sites, 5 recruiting

  • Algemeen Ziekenhuis klina

    Brasschaat, 2930

    Recruiting

  • Grand Hôpital de Charleroi -

    Charleroi, Hainaut, 6060

    Recruiting

  • Jessa Ziekenhuis

    Hasselt, Limburg, 3500

    Recruiting

  • Jessa Ziekenhuis

    Hasselt, 3500

    Recruiting

  • AZ Sint-Maarten

    Mechelen, Antwerpen, 2800

    Recruiting

Other trials in Belgium

Brazil5 sites, 5 recruiting

  • Hospital Santo Antonio

    Blumenau, Santa Catarina, 89015-200

    Recruiting

  • Hospital de Clínicas de Passo Fundo

    Passo Fundo, Rio Grande do Sul, 99010-260

    Recruiting

  • IBCC - Instituto Brasileiro de Controle do Câncer

    São Paulo, 03102-002

    Recruiting

  • IBCC - Núcleo de Pesquisa e Ensino

    São Paulo, 04014-002

    Recruiting

  • Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein

    São Paulo, 05652-900

    Recruiting

Other trials in Brazil

Denmark5 sites, 5 recruiting

  • Aarhus University Hospital

    Aarhus N, 8200

    Recruiting

  • Rigshospitalet Department of Oncology

    Copenhagen, Capital Region, 2100

    Recruiting

  • Herlev and Gentofte Hospital

    Copenhagen, Capital Region, 2730

    Recruiting

  • Odense Universitetshospital

    Odense, Region Syddanmark, 5000

    Recruiting

  • Roskilde Sygehus

    Roskilde, Region Sjælland, 4000

    Recruiting

Other trials in Denmark

Australia4 sites, 4 recruiting

  • Grampians Health

    Ballarat, Victoria, 3350

    Recruiting

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000

    Recruiting

  • Calvary Mater Newcastle

    Waratah, New South Wales, 2298

    Recruiting

  • Westmead Hospital

    Westmead, New South Wales, 2145

    Recruiting

Other trials in Australia

Bulgaria4 sites, 4 recruiting

  • Specialized Hospital for Active Treatment of Oncology - Haskovo

    Haskovo, 6300

    Not yet recruiting

  • MBAL Uni Hospital

    Panagyurishte, Pazardzhik, 4500

    Not yet recruiting

  • MHAT for Women's Health Nadezhda

    Sofia, 1330

    Recruiting

  • Trakia Hospital

    Stara Zagora, 6000

    Not yet recruiting

Other trials in Bulgaria

Finland4 sites, 4 recruiting

  • Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)

    Helsinki, Uusimaa, 00029

    Recruiting

  • Kuopion Yliopistollinen Sairaala

    Kuopio, Northern Savonia, 70210

    Recruiting

  • Turku University Hospital

    Turku, Southwest Finland, 20521

    Recruiting

  • Vaasan Keskussairaala

    Vaasa, Pohjanmaa, 65130

    Not yet recruiting

Other trials in Finland

Netherlands4 sites, 4 recruiting

  • Amsterdam UMC, locatie VUmc

    Amsterdam, North Holland, 1081 HV

    Recruiting

  • Maastricht UMC+

    Maastricht, Limburg, 6229 HX

    Recruiting

  • Erasmus Medisch Centrum

    Rotterdam, South Holland, 3015 GD

    Recruiting

  • St. Antonius Ziekenhuis, locatie Utrecht

    Utrecht, 3543 AZ

    Recruiting

Other trials in Netherlands

Poland4 sites, 4 recruiting

  • Instytut MSF Sp zoo

    Lodz, Łódź Voivodeship, 90-302

    Recruiting

  • Instytut Genetyki i Immunologii GENIM

    Lublin, Lublin Voivodeship, 20-609

    Recruiting

  • Uniwersytecki Szpital Kliniczny w Poznaniu

    Poznan, 60-569

    Not yet recruiting

  • Provita Centrum Medyczne Spółka Z Ograniczoną Odpowiedzialnością, Provita Prolife

    Tomaszów Mazowiecki, 97-200

    Not yet recruiting

Other trials in Poland

Slovakia4 sites, 4 recruiting

  • Univerzitna nemocnica Bratislava, Nemocnica Ruzinov

    Bratislava, 826 06

    Recruiting

  • Narodny onkologicky ustav

    Bratislava, 833 10

    Recruiting

  • Nemocnica s poliklinikou Stefana Kukuru Michalovce, a.s.

    Michalovce, 07101

    Recruiting

  • Fakultna nemocnica s poliklinikou Nove Zamky

    Nové Zámky, 940 34

    Recruiting

Other trials in Slovakia

United Kingdom4 sites, 4 recruiting

  • St Bartholomew's Hospital

    London, London, CITY of, EC1A 7BE

    Recruiting

  • Sarah Cannon Research Institute UK

    London, London, CITY of, w1g 6ad

    Recruiting

  • Barts Health NHS Trust , The Royal London Hospital

    London, E1 1FR

    Recruiting

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX

    Recruiting

Other trials in United Kingdom

Mexico3 sites, 3 recruiting

  • Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde"

    Guadalajara, Jalisco, 44280

    Recruiting

  • Centro de Investigacion Clinica de Oaxaca

    Oaxaca City, Oaxaca, 68020

    Recruiting

  • Clinica Integral Internacional de Oncolgia S. de R.L. de C.V ú Oncocenter

    Puebla City, 72530

    Recruiting

Other trials in Mexico

Sweden3 sites, 3 recruiting

  • Mälarsjukhuset

    Eskilstuna, Södermanlands LÄN [se-04], 631 88

    Recruiting

  • Sjukhuset I Gävle

    Gävle, Gävleborgs LÄN [se-21], 80187

    Recruiting

  • Sahlgrenska Universitetssjukhuset

    Gothenburg, Västra Götalands LÄN [se-14], 413 45

    Recruiting

Other trials in Sweden

South Africa2 sites, 2 recruiting

  • The Oncology Centre

    Durban, KwaZulu-Natal, 4091

    Recruiting

  • The Medical Oncology Centre of Rosebank

    Johannesburg, Gauteng, 2196

    Recruiting

Other trials in South Africa

Puerto Rico1 site, 1 recruiting

  • Ad-Vance Medical Research

    Ponce, 00717

    Recruiting

Other trials in Puerto Rico

About this study

Official title: PADL1NK-005: A Randomized, Phase 3, Open-Label Study to Evaluate PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

The purpose of this study is to understand if PF-08046054 alone works well compared to standard-of-care docetaxel alone in participants with non-small cell lung cancer (NSCLC) with PD-L1 expression greater than or equal to 1% and had cancer progression during or after treatment with PD-L1 or PD-1 inhibitors, platinum-based chemotherapy, and targeted treatment regimen(s) for participants with known actionable genomic alterations (AGAs). Participants in this study must have cancer that has spread through their body or can't be removed with surgery or treated with definitive radiation.

Participants will randomly (like a flip of the coin) be assigned to either the PF-08046054 treatment group or the docetaxel treatment group. Participants in the PF-08046054 treatment group will receive an IV infusion (injected directly into the veins) twice during each 21-day cycle. Participants in the docetaxel treatment group will receive an IV infusion once during each 21-day cycle. Study participation may be up to 5 years if the participant's NSCLC is responding to treatment. The study team will see how each participant is doing with the study treatment during regular visits at the clinic.

Being tested
PF-08046054, Docetaxel monotherapy
Keywords
Non-small cell lung cancer NSCLC, NSCLC
Medical subject headings
Carcinoma, Non-Small-Cell Lung

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • PF-08046054Drug

    Also called SGN-PDL1V

    Antibody Drug Conjugate

    Participants will receive PF-08046054, administered as an IV infusion.

  • Docetaxel monotherapyDrug

    Participants will receive Docetaxel, administered as an IV infusion.

Study groups in NCT07144280
Study groupRoleWhat they receive
PF-08046054 monotherapyExperimentalPF-08046054 monotherapy
Receives: Drug: PF-08046054
Docetaxel monotherapyActive comparatorDocetaxel monotherapy
Receives: Drug: Docetaxel monotherapy

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Overall Survival

    Overall survival defined as the time from the date of randomization to the date of death due to any cause.

    Measured: Approximately 5 years

Secondary outcomes (15)

  1. Progression Free Survival (PFS) assessed by blinded independent central review (BICR)

    Progression-free survival is defined as the time from the date of randomization to the date of the first documentation of objective PD assessed by BICR per RECIST v1.1, or death due to any cause, whichever occurs first.

    Measured: Approximately 5 years

  2. Objective Response Rate as assessed by BICR

    The proportion of participants who have a confirmed CR or PR, as best overall response assessed by BICR as per RECIST 1.1.

    Measured: Approximately 5 years

  3. Progression Free Survival as assessed by Investigator

    Progression Free Survival (PFS) is defined as the time from the date of randomization to the date of the first documentation of objective PD assessed by investigator per RECIST v1.1, or death due to any cause, whichever occurs first.

    Measured: Approximately 5 years

  4. Objective Response Rate (ORR) as assessed by Investigator

    The proportion of participants who have a confirmed CR or PR, as best overall response assessed by investigator as per RECIST 1.1.

    Measured: Approximately 5 years

  5. Duration of Response as assessed by BICR

    The time from the first documentation of objective response (CR or PR that is subsequently confirmed) to the date of the first documentation of PD as determined by BICR assessment per RECIST v1.1, or death due to any cause, whichever occurs first.

    Measured: Approximately 5 years

  6. Duration of Response as assessed by Investigator

    The time from the first documentation of objective response (CR or PR that is subsequently confirmed) to the date of the first documentation of PD as determined by investigator assessment per RECIST v1.1, or death due to any cause, whichever occurs first.

    Measured: Approximately 5 years

  7. Incidence of Treatment Emergent Adverse Events (TEAEs) estimated during the Adverse Events (AE) evaluation

    An AE is any untoward medical occurrence in a patient or clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.

    Measured: Through 90 days after the last study intervention; Approximately 5 years

  8. Mean scores and Change from baseline in the global health status/quality of life (QoL) score on the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)

    The EORTC QLQ-C30 is a questionnaire for quantitative measure of health-related quality of life pertinent to participants with a broad range of cancers who are participating in international clinical trials.

    Measured: Approximately 5 years

  9. Mean scores and Change from baseline in physical functioning and role functioning scores on the EORTC QLQ-C30

    The EORTC QLQ-C30 is a questionnaire for quantitative measure of health-related quality of life pertinent to participants with a broad range of cancers who are participating in international clinical trials.

    Measured: Approximately 5 years

  10. Mean scores and Change from Baseline in dyspnea, cough, and chest pain scores on the EORTC Quality of Life Cancer Questionnaire - Lung Cancer 13 QLQ-LC13

    The EORTC QLQ-LC13 is a lung cancer specific module and consists of 13 item questionnaire assessing lung cancer-associated symptoms and treatment-related effects.

    Measured: Approximately 5 years

  11. Time to definitive deterioration (TTdD) in in the global health status/QoL score on the EORTC QLQ-C30

    TTdD is defined as the time from date of randomization to first onset of Patient Reported Outcome (PRO) deterioration without subsequent recovery.

    Measured: Approximately 5 years

  12. TTdD in physical functioning and role functioning scores on the EORTC QLQ-C30

    TTdD is defined as the time from date of randomization to first onset of Patient Reported Outcome (PRO) deterioration without subsequent recovery.

    Measured: Approximately 5 years

  13. TTdD in the dyspnea, cough, and chest pain scores on the EORTC QLQ-LC13

    TTdD is defined as the time from date of randomization to first onset of Patient Reported Outcome (PRO) deterioration without subsequent recovery.

    Measured: Approximately 5 years

  14. Pharmacokinetics (PK): Plasma concentration of PF-08046054 and and its components

    To characterize the pharmacokinetics (PK) of PF-08046054

    Measured: Approximately 48 weeks

  15. Incidence of Anti-Drug Antibody (ADA)

    To characterize the immunogenicity of PF-08046054

    Measured: Approximately 48 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Aug 2025
  2. Study start29 Sep 2025
  3. Primary completion10 Mar 2028 (estimated)
  4. Study completion10 Mar 2032 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
680 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07144280
Sponsor's protocol ID
C5851005
Other IDs
2025-521281-97-00, 2025
Status last verified
Oct 2026
First submitted
20 Aug 2025
Last updated
13 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing PF-08046054 and Docetaxel monotherapy in people with Non-small Cell Carcinoma and Non-Small Cell Lung Cancer Metastatic, run by Pfizer at 447 sites in 29 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 14 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 13 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 447 sites in United States, China, Japan, Germany, Spain and 24 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Pfizer CT.gov Call Center (1-800-718-1021, ClinicalTrials.gov_Inquiries@pfizer.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Overall Survival (time frame: Approximately 5 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07144280.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Oct 2026; AzTrials last refreshed its copy on 27 Oct 2026.

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