Perceptual DisordersNOTENNCT07145970
Standardization of Spatial Neglect Assessment Tests
A study testing Neuropsychological assessment tests for spatial neglect in people with Perceptual Disorders and Healthy Volunteers, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
Trial summary
Spatial neglect is a common cognitive disorder in stroke patients, characterized by a lateralized deficit in attention and intention. This research focuses on defining norms for tests to assess spatial neglect. Read more about this study
- Who is it for?
- Ages 20 to 89 yearsHealthy volunteers can take part
- Conditions the study is for
- Perceptual Disorders, Healthy Volunteers, Reference Values
- What is being tested?
- Neuropsychological assessment tests for spatial neglect
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 210 participants
- Where
- 1 siteFrance
- Study dates
- 7 Jan 2026to 7 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 89 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy volunteer attending the neurovascular department of Raymond-Poincaré Hospital
- Aged between 20 and 89 years
- Affiliated with a health insurance scheme
- French-speaking
- Has freely and knowingly expressed their non-opposition
Who cannot join
- Known history of central neurological disease: stroke (ischemic or hemorrhagic), transient ischemic attack, encephalitis, multiple sclerosis, or epilepsy.
- Medical interview suggesting past central nervous system involvement: history of episodes such as sensorimotor deficits, dysarthria, aphasia, blurred or double vision, or positive symptoms such as visual or sensory hallucinations (e.g., paresthesias).
- Significant visual impairment - as judged by the examiner - in near vision despite correction, or monocular blindness. Specifically, inability to distinguish the targets with gaps in the example (pre-test) of the Apples Cancellation Test.
- Abnormal neurological examination:
- National Institutes of Health Stroke Scale (NIHSS) score > 0
- Pyramidal reflex syndrome (hyperactive deep tendon reflexes with extended reflexogenic zones and spread).
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- Use of substances (alcohol or drugs) within 24 hours prior to the assessment.
- Presence of cognitive or psychiatric disorders, assessed during the inclusion interview and neurological examination, at the examiner's discretion.
- Language barrier or aphasia, assessed during the inclusion interview and neurological examination, at the examiner's discretion.
- Participant under legal protection (guardianship, curatorship, or legal safeguard).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Jean-Baptiste BRUNET de COURSSOU, Dr contact
France1 site, 1 recruiting
- Recruiting
CHU Raymond Poincarré
Garche, 92380
Jean Baptiste BRUNET DE COURSSOU, PhD, 147 10 44 68 ext. +33, jean-baptiste.brunet-de-courssou@aphp.fr
About this study
Official title: Standardization of Spatial Neglect Assessment Tests in a Francophone Population
Spatial neglect is a common cognitive disorder in stroke patients, characterized by a lateralized deficit in attention and intention.
This research focuses on defining norms for tests to assess spatial neglect. The norms correspond to the results obtained in a population free of any disorder that could have an impact on test performance. These results can vary in a normal, non-pathological way, with certain parameters such as age, sex, laterality or level of education. Defining these norms in healthy volunteers is therefore essential for interpreting results in patients suspected of spatial neglect, and in particular for defining pathological thresholds above which the diagnosis of spatial neglect can be retained.
To answer the research question, we plan to include 210 people with no central neurological disease (stroke, epilepsy and multiple sclerosis in particular), in a single-center study in the neurovascular department of the Raymond-Poincaré hospital (Garches). The 210 subjects will be divided into 10-year age groups, from 20 to 89 years, with the recruitment of 30 participants per age group (15 men and 15 women): 20-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years, 70-79 years, 80-89 years.
Read the detailed description
Spatial neglect is a loss of attention to stimuli in the absence of sensory damage. It is most often a left egocentric hemineglect, due to involvement of the right perisylvian cortex, in which the patient neglects stimuli to his left. More recently, allocentric neglect has been described, where the patient neglects the right or left part of each stimulus. Egocentric neglect is common in stroke patients and correlates with poorer functional recovery and degraded quality of life. The prevalence and impact of allocentric neglect on patients is less well known, not least because of a lack of assessment tools. Tests have recently been developed in English to screen simultaneously for allocentric and egocentric visual neglect. These tests are based on target cancellation, such as whole or open apples in the Apples cancellation test of the Birmingham Cognitive Screen. There is currently no validated French-language version of these tests.
In the case of personal, motor and tactile neglect, these three components are difficult to separate. A patient's ability to indicate blindly, by tactile exploration, the middle of a ruler, or to explore by touch different targets placed in front of him/her, should, after standardization, enable exploration of these last two types of neglect. A simplified version of the Comb and Razor Test should enable assessment of personal and motor neglect.
The aim of this study is to establish mean scores for healthy French-speaking volunteers without central neurological disease on different spatial neglect assessment tests according to their age, sex and level of professional qualification, using French-translated instructions for taking and scoring the tests.
Healthy volunteers with no known history of stroke or cognitive impairment will be included prospectively in the neurovascular department of the Raymond-Poincaré hospital in Garches. We aim to recruit 30 subjects (15 men and 15 women) in 10-year age groups (20 to 29, 30 to 39, 40 to 49, 50 to 59, 60 to 69, 70 to 79 and 80 to 89), i.e. 210 subjects.
The significance threshold will be defined at 0.05. Statistical analyses will be performed using Rstudio software.
Qualitative variables will be described by their numbers and percentages, and quantitative variables by their means, standard deviations, minimums, maximums, as well as their medians and interquartile ranges (25th percentile - 75th percentile).
To identify the association between the variables (age, gender, level of qualification and laterality) and the metrics relating to the results of the following tests (Apples cancellation test, Comb and razor test, Peg test and Ruler blind bisection test) and their completion times, a linear regression will be conducted. The variables to be explained will be the metrics relating to the results of the following tests (Apple test, Comb and razor test, Plot test and Ruler bisection test) and their completion times. Explanatory variables will be age, gender, level of qualification, hand used and laterality.
If no significant association is found between the explanatory variables and the metrics relating to test results and completion times, a mean score with its 95% confidence interval will be estimated.
If there is a significant association between the explanatory variables and the metrics relating to the test results and their completion times, taking into account the characteristics of the healthy volunteers, a mean score for the metrics associated with its 95% confidence interval will be estimated.
- Conditions
- Perceptual Disorders, Healthy Volunteers, Reference Values
- Being tested
- Neuropsychological assessment tests for spatial neglect
- Keywords
- Spatial neglect, Tactile neglect, Visual neglect, Directional motor neglect
- Medical subject headings
- Perceptual Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neuropsychological assessment tests for spatial neglectOther
Standardized administration of four paper-and-pencil tests designed to assess different forms of spatial neglect:
- Apples Cancellation Test (Birmingham Cognitive Screen) for egocentric and allocentric neglect,
- Simplified Comb and Razor Test for personal and motor neglect,
- Line Bisection Test (30 cm ruler, blind version) for tactile neglect,
- Dot Test for visual exploration.
The purpose is to establish normative reference scores in healthy French-speaking adults according to age, sex, and professional qualification. No therapeutic intervention or patient population is involved.
| Study group | Role | What they receive |
|---|---|---|
| group | Experimental | Not described Receives: Other: Neuropsychological assessment tests for spatial neglect |
What is being measured
The primary outcome is the main question the study is designed to answer.
To establish average scores for healthy French-speaking volunteers without central neurological disorders on the Apples Cancellation Test (from the BCoS), using French-translated administration and scoring instructions
The average scores for healthy French-speaking volunteers without central neurological disorders on the Apples Cancellation Test (from the BCoS), using French-translated administration instructions.
The number of the box in which the first crossed-out apple is located, the total performance, the spatial asymmetry score (egocentric neglect), the object asymmetry score (allocentric neglect) and the passing time, in seconds.
Measured: 12 months
Secondary outcomes (3)
To establish average scores for healthy French-speaking volunteers without central neurological disorders on the simplified Comb and Razor Test, using French-language administration instructions
The average scores for healthy French-speaking volunteers without central neurological disorders on the simplified Comb and Razor Test, with French-language administration instructions.
Measured: inclusion
To establish average scores for healthy French-speaking volunteers without central neurological disorders on the Peg Test, according to their age, sex, and level of occupational qualification.
The average scores for healthy French-speaking volunteers without central neurological disorders on the Peg Test, according to their age, sex, and level of occupational qualification.
Measured: inclusion
To establish average scores for healthy French-speaking volunteers without central neurological disorders on the 30 cm blind line bisection test using an architect's ruler, according to their age, sex, and level of occupational qualification.
The average scores for healthy French-speaking volunteers without central neurological disorders on the 30 cm blind line bisection test using an architect's ruler, according to their age, sex, and level of occupational qualification.
Measured: inclusion
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Aug 2025
- Study start7 Jan 2026
- Primary completion7 Jan 2027 (estimated)
- Study completion7 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Perceptual DisordersStudies of the same condition, open and under way.
- More trials run by Assistance Publique - Hôpitaux de ParisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 210 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07145970
- Sponsor's protocol ID
- APHP250520
- Acronym
- NOTEN
- Status last verified
- Jul 2025
- First submitted
- 20 Aug 2025
- Last updated
- 10 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Standardization of Spatial Neglect Assessment Tests in a Francophone Population
- ClinicalTrials.gov ID
- NCT07145970
- Acronym / sponsor ID
- NOTEN / APHP250520
- Conditions
- Perceptual Disorders, Healthy Volunteers, Reference Values
- Keywords
- Spatial neglect, Tactile neglect, Visual neglect, Directional motor neglect
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 210 participants (estimated)
- Lead sponsor
- Assistance Publique - Hôpitaux de ParisUniversity, hospital or other
- Study start
- 7 Jan 2026 (actual)
- Primary completion
- 7 Jan 2027 (estimated)
- Study completion
- 7 Jan 2027 (estimated)
- First posted
- 28 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Spatial neglect is a common cognitive disorder in stroke patients, characterized by a lateralized deficit in attention and intention.
This research focuses on defining norms for tests to assess spatial neglect. The norms correspond to the results obtained in a population free of any disorder that could have an impact on test performance. These results can vary in a normal, non-pathological way, with certain parameters such as age, sex, laterality or level of education. Defining these norms in healthy volunteers is therefore essential for interpreting results in patients suspected of spatial neglect, and in particular for defining pathological thresholds above which the diagnosis of spatial neglect can be retained.
To answer the research question, we plan to include 210 people with no central neurological disease (stroke, epilepsy and multiple sclerosis in particular), in a single-center study in the neurovascular department of the Raymond-Poincaré hospital (Garches). The 210 subjects will be divided into 10-year age groups, from 20 to 89 years, with the recruitment of 30 participants per age group (15 men and 15 women): 20-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years, 70-79 years, 80-89 years.
Detailed description
Spatial neglect is a loss of attention to stimuli in the absence of sensory damage. It is most often a left egocentric hemineglect, due to involvement of the right perisylvian cortex, in which the patient neglects stimuli to his left. More recently, allocentric neglect has been described, where the patient neglects the right or left part of each stimulus. Egocentric neglect is common in stroke patients and correlates with poorer functional recovery and degraded quality of life. The prevalence and impact of allocentric neglect on patients is less well known, not least because of a lack of assessment tools. Tests have recently been developed in English to screen simultaneously for allocentric and egocentric visual neglect. These tests are based on target cancellation, such as whole or open apples in the Apples cancellation test of the Birmingham Cognitive Screen. There is currently no validated French-language version of these tests.
In the case of personal, motor and tactile neglect, these three components are difficult to separate. A patient's ability to indicate blindly, by tactile exploration, the middle of a ruler, or to explore by touch different targets placed in front of him/her, should, after standardization, enable exploration of these last two types of neglect. A simplified version of the Comb and Razor Test should enable assessment of personal and motor neglect.
The aim of this study is to establish mean scores for healthy French-speaking volunteers without central neurological disease on different spatial neglect assessment tests according to their age, sex and level of professional qualification, using French-translated instructions for taking and scoring the tests.
Healthy volunteers with no known history of stroke or cognitive impairment will be included prospectively in the neurovascular department of the Raymond-Poincaré hospital in Garches. We aim to recruit 30 subjects (15 men and 15 women) in 10-year age groups (20 to 29, 30 to 39, 40 to 49, 50 to 59, 60 to 69, 70 to 79 and 80 to 89), i.e. 210 subjects.
The significance threshold will be defined at 0.05. Statistical analyses will be performed using Rstudio software.
Qualitative variables will be described by their numbers and percentages, and quantitative variables by their means, standard deviations, minimums, maximums, as well as their medians and interquartile ranges (25th percentile - 75th percentile).
To identify the association between the variables (age, gender, level of qualification and laterality) and the metrics relating to the results of the following tests (Apples cancellation test, Comb and razor test, Peg test and Ruler blind bisection test) and their completion times, a linear regression will be conducted. The variables to be explained will be the metrics relating to the results of the following tests (Apple test, Comb and razor test, Plot test and Ruler bisection test) and their completion times. Explanatory variables will be age, gender, level of qualification, hand used and laterality.
If no significant association is found between the explanatory variables and the metrics relating to test results and completion times, a mean score with its 95% confidence interval will be estimated.
If there is a significant association between the explanatory variables and the metrics relating to the test results and their completion times, taking into account the characteristics of the healthy volunteers, a mean score for the metrics associated with its 95% confidence interval will be estimated.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| group | Experimental | Other: Neuropsychological assessment tests for spatial neglect |
Who may qualify
- Ages
- 20 to 89 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Healthy volunteer attending the neurovascular department of Raymond-Poincaré Hospital
- Aged between 20 and 89 years
- Affiliated with a health insurance scheme
- French-speaking
- Has freely and knowingly expressed their non-opposition
Key exclusion criteria (10 listed)
- Known history of central neurological disease: stroke (ischemic or hemorrhagic), transient ischemic attack, encephalitis, multiple sclerosis, or epilepsy.
- Medical interview suggesting past central nervous system involvement: history of episodes such as sensorimotor deficits, dysarthria, aphasia, blurred or double vision, or positive symptoms such as visual or sensory hallucinations (e.g., paresthesias).
- Significant visual impairment - as judged by the examiner - in near vision despite correction, or monocular blindness. Specifically, inability to distinguish the targets with gaps in the example (pre-test) of the Apples Cancellation Test.
- Abnormal neurological examination:
- Use of substances (alcohol or drugs) within 24 hours prior to the assessment.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neuropsychological assessment tests for spatial neglectStandardized administration of four paper-and-pencil tests designed to assess different forms of spatial neglect: * Apples Cancellation Test (Birmingham Cognitive Screen) for egocentric and allocentric neglect, * Simplified Comb and Razor Test for personal and motor neglect, * Line Bisection Test (30 cm ruler, blind version) for tactile neglect, * Dot Test for visual exploration. The purpose is to establish normative reference scores in healthy French-speaking adults according to age, sex, and professional qualification. No therapeutic intervention or patient population is involved. | Other | group |
Primary outcome
To establish average scores for healthy French-speaking volunteers without central neurological disorders on the Apples Cancellation Test (from the BCoS), using French-translated administration and scoring instructions
Time frame: 12 months
The average scores for healthy French-speaking volunteers without central neurological disorders on the Apples Cancellation Test (from the BCoS), using French-translated administration instructions. The number of the box in which the first crossed-out apple is located, the total performance, the spatial asymmetry score (egocentric neglect), the object asymmetry score (allocentric neglect) and the passing time, in seconds.
3 secondary outcomes
To establish average scores for healthy French-speaking volunteers without central neurological disorders on the simplified Comb and Razor Test, using French-language administration instructions
Time frame: inclusion
To establish average scores for healthy French-speaking volunteers without central neurological disorders on the Peg Test, according to their age, sex, and level of occupational qualification.
Time frame: inclusion
To establish average scores for healthy French-speaking volunteers without central neurological disorders on the 30 cm blind line bisection test using an architect's ruler, according to their age, sex, and level of occupational qualification.
Time frame: inclusion
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jean-Baptiste BRUNET de COURSSOU, Dr contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neuropsychological assessment tests for spatial neglect in people with Perceptual Disorders and Healthy Volunteers, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 10 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jean-Baptiste BRUNET de COURSSOU, Dr (+33 1 47 10 72 55, jean-baptiste.brunet-de-courssou@aphp.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To establish average scores for healthy French-speaking volunteers without central neurological disorders on the Apples Cancellation Test (from the BCoS), using French-translated administration and scoring instructions (time frame: 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Feb 2026; AzTrials last refreshed its copy on 29 Oct 2026.