Clinical trials: Reference Values
Child Development
LIFE Child (LIFE Leipzig Research Centre for Civilization Diseases)
The Leipzig Research Centre for Civilization Diseases (LIFE) Child Study is a prospective longitudinal population-based study with a life course approach to health and disease.
- Trial name
- NCT02550236
- Where
- Germany
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Critical Illness Polyneuromyopathy
Reference Values for Compound Muscle Action Potential Amplitude Obtained by Direct Muscle Stimulation
Direct muscle stimulation (DMS) method is one of the electrodiagnostic methods used in the diagnosis of critical illness myopathy (CIM) and critical illness neuropathy (CIN).
- Trial name
- NCT04227548
- Testing
- needle electromyography
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Adana City Training and Research Hospital
Development, Child, Activity, Motor
Reference Values for the Muscle Power Sprint Test
The goal of this prospective, cross-sectional study is to develop updated reference values for the Muscle Power Sprint Test (MPST) in children aged 5-12 years.
- Trial name
- Ref MPST (NCT06448520)
- Testing
- Muscle Power Sprint Test
- Where
- Netherlands
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Gall Stone, Gallbladder Inflammation
Benchmarks in Elective Laparoscopic Cholecystectomy
The aim of this observational cohort study is to define peri- and postoperative reference values for elective laparoscopic cholecystectomy, using the achievable benchmarks of care methodology (ABC™).
- Conditions
- Gall Stone, Gallbladder Inflammation, Gall Bladder Pain, Gallstone
- Trial name
- NCT06692517
- Testing
- Laparoscopic cholecystectomy
- Volunteers
- 60,000 people
- Sponsor
- Region Östergötland
Arterial Hypertension, Healthy Control
Non-invasive Validation of Non-invasive Central Blood Pressure Measurements Using Oscillometric Pulse Wave Analysis
There is growing evidence that central blood pressure is a better predictor of hypertensive end-organ damage and cardiovascular outcome than routine brachial readings.
- Conditions
- Arterial Hypertension, Healthy Control, Coronary Heart Disease, Diabetes Mellitus
- Trial name
- MEASURE-cBP2 (NCT03049709)
- Where
- Germany
- Volunteers
- 119 people
- Sponsor
- Universitätsmedizin Mannheim
Mechanical Ventilation Complication, Pediatric ALL
Measuring Thickness of the Normal Diaphragm in Children Via Ultrasound.
Critically ill children treated with invasive mechanical ventilation (iMV) in a paediatric intensive care unit (PICU) may suffer from complications leading to prolonged duration of ventilation and PICU stay.
- Conditions
- Mechanical Ventilation Complication, Pediatric ALL, Intensive Care Unit Acquired Weakness
- Trial name
- NCT04589910
- Testing
- diaphragm thickness and thickening fraction
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Anorectal Disorder, Fecal Incontinence
Normal Values in Ano-rectal 3D High Resolution Manometry
Ano-rectal manometry is indicative in patients with either fecal incontinence or constipation. Recently anorectal 3D- high resolution manometry has been developed.
- Conditions
- Anorectal Disorder, Fecal Incontinence, Constipation
- Trial name
- NOMAD (NCT01710579)
- Testing
- Anorectal 3D-high resolution manometry, Anorectal radial endosonography (rotative 360° probe), Dynamic anorectal endosonography (sagittal and radial)
- Where
- France
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Salivary Immunity
Salivary Immunoglobulin A (sIgA) Normal Range Study
Salivary Immunoglobulin A (sIgA) is a marker of immune system activity. Typically, sIgA is determined by an ELISA test in which samples have to be sent to a specialized laboratory for testing.
- Trial name
- sIgA (NCT06248788)
- Testing
- PoC Device
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- 4Life Research, LLC
Arterial Hypertension, Coronary Heart Disease
Invasive Validation of Non-invasive Central Blood Pressure Measurements Using Oscillometric Pulse Wave Analysis
There is growing evidence that central blood pressure is a better predictor of hypertensive end-organ damage and cardiovascular outcome than routine brachial readings.
- Trial name
- MEASURE-cBP1 (NCT03046264)
- Volunteers
- 106 people
- Sponsor
- Universitätsmedizin Mannheim
Healthy
Normal Reference Range Study With the TEG6s Heparin Neutralization Cartridge in Healthy Volunteers
This trial holds minimal risk to the trial volunteers and consists of obtaining whole blood via venipuncture to perform coagulation parameter measurements to define a Normal Reference Range.
- Trial name
- NCT06261580
- Testing
- TEG 6s Citrated K, KH, RTH, and FFH Cartridge, Clauss Fibrinogen
- Where
- 3 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Haemonetics Corporation
Non-hepatobiliary Indications
EUS-Guided ATI and SWE in Individuals With Normal FibroScan
The goal of this observational study is to establish preliminary reference values for Endoscopic Ultrasound (EUS)-guided Attenuation Imaging (ATI) and Shear Wave Elastography (SWE) in adults undergoing diagnostic EUS for…
- Trial name
- EUS ATI&SWE (NCT07714941)
- Testing
- Endoscopic Ultrasound (EUS), EUS-guided Attenuation Imaging (ATI), EUS-Guided Shear Wave Elastography (SWE)
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Asian Institute of Gastroenterology, India
Fetal Growth Retardation, Fetal Neurodevelopmental Disorder
Fetal Magnetic Resonance Imaging: Z-score Reference Ranges for a Large Patient Population in Normal Neuroimaging Measurement
This study aims to establish the z score reference ranges of fetal head circumference and other measurement of fetal measurements including biparietal diameter, fronto-occipital diameter, length of the corpus callosum, lateral…
- Trial name
- FMZSCORE (NCT07004283)
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Mechanical Ventilation Complication
Determination of Normal Values of Regional Pulmonary Strain Using a New Ultrasonographic Tool in Healthy Volunteers
Mechanical ventilation is frequently used in the operating room and the intensive care settings. Although essential in many cases, mechanical ventilation can be responsible for ventilator-induced lung injury (VILI).
- Trial name
- Strain (NCT04194346)
- Testing
- Lung ultrasound
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
High Altitude
Establishing the Reference Interval for Pulse Oxygen Saturation in Neonates at High Altitude
The now widely used reference interval for pulse oxygen saturation of the neonate after 24 hours of birth has been developed relying on data from low altitude.It is not suitable for neonates at high altitude.
- Trial name
- NCT05115721
- Testing
- no intervention
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Growth Hormone Deficiency
Reference Values for Body Composition Parameters and IGF-I in the Adult NordiNet® International Outcome Study
The treatment of Growth Hormone deficiency (GHD) patients with GH, often induce fluid retention; this effect is dose dependent and temporary. The symptoms are swelling of soft tissue and joint stiffness.
- Trial name
- NCT01120977
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Oxidative Stress
Normal Values of Oxidative Stress, Taurine, and Related Markers
The role of oxidative stress in disease pathology is increasingly recognized. At present, the development of biomarkers of this state is in its infancy and the availability of clinically validated assays is lacking.
- Trial name
- NCT02649777
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Delivery Uterine
Noninvasive Continuous Measurement of SpHb After Spontaneous Vaginal Delivery
Aim of this study is to determine the physiological reference individual values (RI) of maternal continuous SpHb immediately after delivery in the post-partum period (continuous monitoring up to 2 hours after delivery) in order…
- Trial name
- NCT01505192
- Testing
- continuous Hb monitor
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Città di Roma Hospital
Sequence Optimization, Protocol Optimization
Optimization of Cardiac-MR Protocols
The aim of the present study is the optimization of various magnetic resonance (MR) investigation protocols of the heart and the lung without contrast agent application as well as the generation of normal values from cardiac MR…
- Conditions
- Sequence Optimization, Protocol Optimization, Normal Values, Feasibility
- Trial name
- NCT00557869
- Where
- Austria
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Ovarian Cancer
Elecsys HE4 Chinese Reference Value Study
Aim of this study is to provide specimens for establishing reference values of HE4 in an apparently healthy Chinese population using the Roche Elecsys HE4 assay tested on variety of Elecsys and cobas brand immunoassay analyzers.
- Trial name
- NCT01738269
- Where
- 9 sites in China
- Volunteers
- 2,351 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Thyroid, Reference Values
Gestational Age Specific Thyroid Function Reference Range
It has been well accepted that maternal thyroid dysfunction has adverse affects on both mothers and fetuses. However, the dramatical changes during pregnancy make the interpretation of thyroid function test (TFT, i.e.
- Conditions
- Thyroid, Reference Values, Pregnancy
- Trial name
- NCT03663517
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong