Panvascular DiseasesPRO-PVDNCT07151183
Diagnosis, Prognosis, and Mechanisms in Panvascular Disease
An observational study of Panvascular Diseases and Cardiovascular Diseases, run by Jinwei Tian at 1 site in China.
Trial summary
This study aims to establish a standardized cohort for panvascular diseases, encompassing biological materials such as DNA samples, along with extensive patient medical records and follow-up information. The design of this database will enable it to serve as a comprehensive resource for future medical research. Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Panvascular Diseases, Cardiovascular Diseases
- How many people
- 1,000 participants
- Where
- 1 siteChina
- Study dates
- 1 Dec 2024to 31 Dec 2030
- How long will I take part?
- 1 Year
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Patients with panvascular diseases
Who may be able to join
- Male or female aged 18 to 80 years old;
- Diagnosed or suspected panvascular disease, defined as the presence of atherosclerotic lesions in at least two or more vascular regions, such as intracranial arteries, carotid arteries, coronary arteries, aorta, and peripheral arteries;
- Voluntary participation in this study and provision of signed informed consent.
Who cannot join
- Severe hemodynamic instability;
- Severe cardiac dysfunction (EF < 30%);
- Severe arrhythmias;
- Severe valvular heart disease;
- Cardiomyopathy caused by non-coronary artery diseases;
- Non-atherosclerotic coronary artery disease (e.g., coronary artery dissection, embolism, etc.);
Show all 9Show fewer
- Severe non-cardiovascular diseases;
- Women who are pregnant or breastfeeding;
- Individuals who refuse to provide signed informed consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Harbin Medical University
Harbin, Heilongjiang, 150086
Wang Y Yan Wang, MD, PhD, +86-13936462066, wangyandr2022@hrbmu.edu.cn
About this study
Official title: A Prospective Research on Diagnosis, Prognosis, and Mechanisms of Panvascular Disease
This study aims to establish a standardized cohort for panvascular diseases, encompassing biological materials such as DNA samples, along with extensive patient medical records and follow-up information. The design of this database will enable it to serve as a comprehensive resource for future medical research.
Upon data collection, researchers will conduct various statistical analyses to enhance our understanding of the factors and mechanisms contributing to various panvascular diseases, including coronary heart disease, myocardial infarction, stroke, and peripheral vascular disease. These statistical analyses will also aid in identifying more effective treatment strategies for these conditions.
By amassing a large volume of data from a significant number of patients with panvascular diseases, researchers will be able to perform highly precise analyses of the factors influencing the onset, progression, and treatment of these diseases. The results of these precise analyses can then be utilized to optimize clinical practices for the prevention and treatment of panvascular diseases.
Read the detailed description
Panvascular diseases are a group of complex disorders affecting the entire vascular system, with their development influenced by multiple risk factors, including genetic susceptibility, metabolic abnormalities (such as hypertension, hyperlipidemia, and diabetes), inflammatory responses, oxidative stress, and unhealthy lifestyle habits (such as smoking and physical inactivity). In-depth research into the mechanisms of these factors can help uncover the core drivers of the disease, providing a theoretical foundation for early prevention and intervention. Additionally, elucidating specific molecular pathways (such as inflammatory signaling, lipid metabolism, and endothelial dysfunction-related pathways) and molecular regulatory mechanisms (such as non-coding RNAs and epigenetic modifications) can offer new targets for precise diagnosis and treatment. By integrating multi-omics data and high-throughput technologies, the molecular networks of panvascular diseases can be systematically clarified, advancing the development of personalized medicine. This will significantly improve patient outcomes, reduce disease burden, and hold substantial scientific value and clinical application prospects.
This study aims to establish a standardized cohort for panvascular diseases, encompassing various biological materials such as DNA samples, as well as comprehensive patient medical records and long-term follow-up information. The database will systematically collect multidimensional data, including patient questionnaire data (e.g., lifestyle, family history, dietary habits), imaging examination results (e.g., ultrasound, CT, MRI), DNA and other biochemical indicators extracted from blood samples, as well as non-invasive physiological parameters such as blood pressure and heart rate, and examinations related to arterial health assessment (e.g., pulse wave velocity, ankle-brachial index). By integrating these multi-source data, researchers will be able to conduct in-depth analyses of the genetic, metabolic, and clinical characteristics of panvascular diseases, identify disease-related biomarkers and predictive factors, and thereby provide a valuable resource for investigating the mechanisms of panvascular diseases.
Based on this database, researchers can systematically explore the risk factors of panvascular diseases and their dynamic evolution patterns, uncovering the key driving mechanisms behind disease development. Furthermore, through high-throughput sequencing, multi-omics analysis, and machine learning technologies, researchers can identify potential molecular targets and therapeutic strategies, advancing the field of precision medicine. These research outcomes will not only contribute to the development of novel diagnostic methods and personalized treatment plans but also provide a scientific basis for the early prevention and intervention of panvascular diseases, ultimately improving patient prognosis and reducing disease burden. The establishment of this resource platform will provide critical support for research and clinical practice in panvascular diseases, holding profound scientific significance and practical value.
- Conditions
- Panvascular Diseases, Cardiovascular Diseases
- Being tested
- No intervention
- Keywords
- Panvascular disease, Cardiovascular Diseases
- Medical subject headings
- Cardiovascular Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No interventionOther
No intervention
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of participants with Cardiovascular mortality, Nonfatal myocardial Infarction, Ischemic stroke, Arteriosclerosis Obliterans
Cardiovascular mortality, Nonfatal myocardial Infarction, Ischemic stroke, Arteriosclerosis Obliterans
Measured: Up to 5 years from baseline
Secondary outcomes (3)
All-cause death
Measured: Up to 5 years from baseline
Rate of receiving vascular revascularization
Measured: Up to 5 years from baseline
Readmission rate for vascular reasons
Measured: Up to 5 years from baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Sep 2025
- Study start1 Dec 2024
- Primary completion31 Dec 2030 (estimated)
- Study completion31 Dec 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Panvascular DiseasesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 1,000 participants (estimated)
- Target duration
- 1 Year
Sponsor and investigators
- Lead sponsor
- Jinwei Tian
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Jinwei Tian, Harbin Medical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07151183
- Sponsor's protocol ID
- KY2024-233
- Acronym
- PRO-PVD
- Status last verified
- Sep 2025
- First submitted
- 14 Aug 2025
- Last updated
- 3 Sep 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Azad RK, Shulaev V. Metabolomics technology and bioinformatics for precision medicine. Brief Bioinform. 2019 Nov 27;20(6):1957-1971. doi: 10.1093/bib/bbx170.
PubMed 29304189Johnson CH, Ivanisevic J, Siuzdak G. Metabolomics: beyond biomarkers and towards mechanisms. Nat Rev Mol Cell Biol. 2016 Jul;17(7):451-9. doi: 10.1038/nrm.2016.25. Epub 2016 Mar 16.
PubMed 26979502Aitekenov S, Sultangaziyev A, Abdirova P, Yussupova L, Gaipov A, Utegulov Z, Bukasov R. Raman, Infrared and Brillouin Spectroscopies of Biofluids for Medical Diagnostics and for Detection of Biomarkers. Crit Rev Anal Chem. 2023;53(7):1561-1590. doi: 10.1080/10408347.2022.2036941. Epub 2022 Feb 14.
PubMed 35157535Matsuura Y, Kanter JE, Bornfeldt KE. Highlighting Residual Atherosclerotic Cardiovascular Disease Risk. Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):e1-e9. doi: 10.1161/ATVBAHA.118.311999. No abstract available.
PubMed 30586334Ozcan C, Deleskog A, Schjerning Olsen AM, Nordahl Christensen H, Lock Hansen M, Hilmar Gislason G. Coronary artery disease severity and long-term cardiovascular risk in patients with myocardial infarction: a Danish nationwide register-based cohort study. Eur Heart J Cardiovasc Pharmacother. 2018 Jan 1;4(1):25-35. doi: 10.1093/ehjcvp/pvx009.
PubMed 28444162Steg PG, Bhatt DL, Wilson PW, D'Agostino R Sr, Ohman EM, Rother J, Liau CS, Hirsch AT, Mas JL, Ikeda Y, Pencina MJ, Goto S; REACH Registry Investigators. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA. 2007 Mar 21;297(11):1197-206. doi: 10.1001/jama.297.11.1197.
PubMed 17374814
Study at a glance
From the registry record, last updated by the sponsor on 3 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Prospective Research on Diagnosis, Prognosis, and Mechanisms of Panvascular Disease
- ClinicalTrials.gov ID
- NCT07151183
- Acronym / sponsor ID
- PRO-PVD / KY2024-233
- Conditions
- Panvascular Diseases, Cardiovascular Diseases
- Keywords
- Panvascular disease, Cardiovascular Diseases
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 1,000 participants (estimated)
- Lead sponsor
- Jinwei TianUniversity, hospital or other
- Study start
- 1 Dec 2024 (actual)
- Primary completion
- 31 Dec 2030 (estimated)
- Study completion
- 31 Dec 2030 (estimated)
- First posted
- 3 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to establish a standardized cohort for panvascular diseases, encompassing biological materials such as DNA samples, along with extensive patient medical records and follow-up information. The design of this database will enable it to serve as a comprehensive resource for future medical research.
Upon data collection, researchers will conduct various statistical analyses to enhance our understanding of the factors and mechanisms contributing to various panvascular diseases, including coronary heart disease, myocardial infarction, stroke, and peripheral vascular disease. These statistical analyses will also aid in identifying more effective treatment strategies for these conditions.
By amassing a large volume of data from a significant number of patients with panvascular diseases, researchers will be able to perform highly precise analyses of the factors influencing the onset, progression, and treatment of these diseases. The results of these precise analyses can then be utilized to optimize clinical practices for the prevention and treatment of panvascular diseases.
Detailed description
Panvascular diseases are a group of complex disorders affecting the entire vascular system, with their development influenced by multiple risk factors, including genetic susceptibility, metabolic abnormalities (such as hypertension, hyperlipidemia, and diabetes), inflammatory responses, oxidative stress, and unhealthy lifestyle habits (such as smoking and physical inactivity). In-depth research into the mechanisms of these factors can help uncover the core drivers of the disease, providing a theoretical foundation for early prevention and intervention. Additionally, elucidating specific molecular pathways (such as inflammatory signaling, lipid metabolism, and endothelial dysfunction-related pathways) and molecular regulatory mechanisms (such as non-coding RNAs and epigenetic modifications) can offer new targets for precise diagnosis and treatment. By integrating multi-omics data and high-throughput technologies, the molecular networks of panvascular diseases can be systematically clarified, advancing the development of personalized medicine. This will significantly improve patient outcomes, reduce disease burden, and hold substantial scientific value and clinical application prospects.
This study aims to establish a standardized cohort for panvascular diseases, encompassing various biological materials such as DNA samples, as well as comprehensive patient medical records and long-term follow-up information. The database will systematically collect multidimensional data, including patient questionnaire data (e.g., lifestyle, family history, dietary habits), imaging examination results (e.g., ultrasound, CT, MRI), DNA and other biochemical indicators extracted from blood samples, as well as non-invasive physiological parameters such as blood pressure and heart rate, and examinations related to arterial health assessment (e.g., pulse wave velocity, ankle-brachial index). By integrating these multi-source data, researchers will be able to conduct in-depth analyses of the genetic, metabolic, and clinical characteristics of panvascular diseases, identify disease-related biomarkers and predictive factors, and thereby provide a valuable resource for investigating the mechanisms of panvascular diseases.
Based on this database, researchers can systematically explore the risk factors of panvascular diseases and their dynamic evolution patterns, uncovering the key driving mechanisms behind disease development. Furthermore, through high-throughput sequencing, multi-omics analysis, and machine learning technologies, researchers can identify potential molecular targets and therapeutic strategies, advancing the field of precision medicine. These research outcomes will not only contribute to the development of novel diagnostic methods and personalized treatment plans but also provide a scientific basis for the early prevention and intervention of panvascular diseases, ultimately improving patient prognosis and reducing disease burden. The establishment of this resource platform will provide critical support for research and clinical practice in panvascular diseases, holding profound scientific significance and practical value.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 1 Year
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Patients with panvascular diseases
Key inclusion criteria (3 listed)
- Male or female aged 18 to 80 years old;
- Diagnosed or suspected panvascular disease, defined as the presence of atherosclerotic lesions in at least two or more vascular regions, such as intracranial arteries, carotid arteries, coronary arteries, aorta, and peripheral arteries;
- Voluntary participation in this study and provision of signed informed consent.
Key exclusion criteria (9 listed)
- Severe hemodynamic instability;
- Severe cardiac dysfunction (EF < 30%);
- Severe arrhythmias;
- Severe valvular heart disease;
- Cardiomyopathy caused by non-coronary artery diseases;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No interventionNo intervention | Other | – |
Primary outcome
Number of participants with Cardiovascular mortality, Nonfatal myocardial Infarction, Ischemic stroke, Arteriosclerosis Obliterans
Time frame: Up to 5 years from baseline
Cardiovascular mortality, Nonfatal myocardial Infarction, Ischemic stroke, Arteriosclerosis Obliterans
3 secondary outcomes
All-cause death
Time frame: Up to 5 years from baseline
Rate of receiving vascular revascularization
Time frame: Up to 5 years from baseline
Readmission rate for vascular reasons
Time frame: Up to 5 years from baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Sep 2025.
- Background: PubMed 29304189Azad RK, Shulaev V. Metabolomics technology and bioinformatics for precision medicine. Brief Bioinform. 2019 Nov 27;20(6):1957-1971. doi: 10.1093/bib/bbx170.
- Background: PubMed 26979502Johnson CH, Ivanisevic J, Siuzdak G. Metabolomics: beyond biomarkers and towards mechanisms. Nat Rev Mol Cell Biol. 2016 Jul;17(7):451-9. doi: 10.1038/nrm.2016.25. Epub 2016 Mar 16.
- Results publication: PubMed 35157535Aitekenov S, Sultangaziyev A, Abdirova P, Yussupova L, Gaipov A, Utegulov Z, Bukasov R. Raman, Infrared and Brillouin Spectroscopies of Biofluids for Medical Diagnostics and for Detection of Biomarkers. Crit Rev Anal Chem. 2023;53(7):1561-1590. doi: 10.1080/10408347.2022.2036941. Epub 2022 Feb 14.
- Results publication: PubMed 30586334Matsuura Y, Kanter JE, Bornfeldt KE. Highlighting Residual Atherosclerotic Cardiovascular Disease Risk. Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):e1-e9. doi: 10.1161/ATVBAHA.118.311999. No abstract available.
- Results publication: PubMed 28444162Ozcan C, Deleskog A, Schjerning Olsen AM, Nordahl Christensen H, Lock Hansen M, Hilmar Gislason G. Coronary artery disease severity and long-term cardiovascular risk in patients with myocardial infarction: a Danish nationwide register-based cohort study. Eur Heart J Cardiovasc Pharmacother. 2018 Jan 1;4(1):25-35. doi: 10.1093/ehjcvp/pvx009.
- Results publication: PubMed 17374814Steg PG, Bhatt DL, Wilson PW, D'Agostino R Sr, Ohman EM, Rother J, Liau CS, Hirsch AT, Mas JL, Ikeda Y, Pencina MJ, Goto S; REACH Registry Investigators. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA. 2007 Mar 21;297(11):1197-206. doi: 10.1001/jama.297.11.1197.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Panvascular Diseases and Cardiovascular Diseases, run by Jinwei Tian at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Tian J Jinwei Tian, MD, PhD (+86-0451-86605180, tianjinweidr2009@163.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of participants with Cardiovascular mortality, Nonfatal myocardial Infarction, Ischemic stroke, Arteriosclerosis Obliterans (time frame: Up to 5 years from baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07151183, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Sep 2025.