Malocclusion, Angle Class IMOPsNCT07155018

Micro-Osteoperforations to Accelerate Maxillary Canine Retraction in Class I Malocclusion

A study testing Micro-osteoperforations (MOPs) and Conventional Canine Retraction in people with Malocclusion, Angle Class I, run by Can Tho University of Medicine and Pharmacy at 1 site in Vietnam.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

This single-blinded, split-mouth randomized controlled trial investigates whether micro-osteoperforations (MOPs) can accelerate maxillary canine retraction in orthodontic patients requiring bilateral premolar extraction. Read more about this study

Who is it for?: Ages 16 to 25 yearsHealthy volunteers can take part
Conditions the study is for: Malocclusion, Angle Class I
What is being tested?: Micro-osteoperforations (MOPs) and Conventional Canine Retraction
Type of treatment: Surgery or procedure
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 40 participants
Where: 1 siteVietnam
Study dates: 1 Jan 2025to 30 Jun 2025
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 16 to 25 years
All sexes
Healthy volunteers accepted
Child, Adult

Who may be able to join

Age 16-25 years
Patients requiring bilateral extraction of maxillary first premolars as part of orthodontic treatment
Angle Class I molar relationship
No previous orthodontic treatment

Who cannot join

History of craniofacial trauma or congenital anomalies
Systemic or bone-related diseases
Current smoking
Use of medications affecting bone metabolism

Trial locations and contacts

1 site in 1 country.

Vietnam1 site

Can Tho University Hospital
Can Tho

Other trials in Vietnam

About this study

Official title: Effectiveness of Micro-Osteoperforations (MOPs) in Accelerating Maxillary Canine Retraction in Angle Class I Malocclusion: A Randomized Controlled Trial.

Read the detailed description

MOPs are a flapless, minimally invasive surgical technique that stimulates bone remodeling and may reduce orthodontic treatment time. In this trial, one side of each patient receives MOPs while the contralateral side serves as control. Canine retraction is performed using miniscrews, power arms, and NiTi coil springs. Outcomes include the rate of canine movement over 16 weeks and pain assessment using VAS.

Conditions: Malocclusion, Angle Class I
Being tested: Micro-osteoperforations (MOPs), Conventional Canine Retraction
Medical subject headings: Malocclusion, Angle Class I

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Micro-osteoperforations (MOPs)Procedure or surgery
Maxillary canine retraction with miniscrew anchorage and NiTi closed-coil springs, without micro-osteoperforations.
Conventional Canine RetractionProcedure or surgery
Maxillary canine retraction with miniscrew anchorage and NiTi closed-coil springs, without micro-osteoperforations

Study groups in NCT07155018
Study group	Role	What they receive
Experimental: Micro-osteoperforations	Experimental	On the experimental side, micro-osteoperforations (MOPs) were performed distal to the maxillary canine under local anesthesia using the Excellerator RT device. Three perforations, each 1.5 mm in diameter and 5 mm deep, were created in the attached gingiva. Canine retraction was then carried out using miniscrew anchorage and NiTi closed-coil springs. Receives: Procedure: Micro-osteoperforations (MOPs)
Control: Conventional Retraction	Active comparator	On the control side, maxillary canine retraction was performed using miniscrew anchorage and NiTi closed-coil springs without any micro-osteoperforations. The mechanics were identical to the experimental side to ensure comparability. Receives: Procedure: Conventional Canine Retraction

What is being measured

The primary outcome is the main question the study is designed to answer.

Rate of Maxillary Canine Retraction
Distance of maxillary canine retraction measured on 3D digital dental models using intraoral scanning.
Measured: Baseline, 4, 8, 12, and 16 weeks

Secondary outcomes (1)

Pain Level (VAS Score)
atient-reported pain intensity measured using a 10-cm Visual Analog Scale (VAS), with scores ranging from 0 (no pain) to 10 (worst pain imaginable).
Measured: Day 1, Day 3, Day 7 after intervention

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Jan 202530 Jun 2025

First posted4 Sep 2025
Study start1 Jan 2025
Primary completion30 Apr 2025
Study completion30 Jun 2025

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (1)Papers the sponsor has linked to this study.
Other trials for Malocclusion, Angle Class IStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Crossover
Model description: This is a single-blinded, split-mouth randomized controlled trial. Each participant received both interventions: on one side of the maxillary arch, micro-osteoperforations (MOPs) were performed distal to the canine, while the contralateral side served as the control with conventional retraction. Outcomes were measured within the same patient, reducing inter-individual variability.
Masking: Single blind
Who is masked: Outcomes assessor
Enrolment: 40 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07155018
Sponsor's protocol ID: DuongThaoTrangCtump
Other IDs: IRB-164-
Acronym: MOPs
Status last verified: Aug 2025
First submitted: 27 Aug 2025
Last updated: 4 Sep 2025
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No: Individual participant data (IPD) will not be shared because the study has a small sample size and the data may compromise patient confidentiality.

Publications

Duong TT, Le LN, Truong NBT. "Effectiveness of micro-osteoperforations in accelerating maxillary canine retraction in Angle Class I malocclusion: A randomized controlled trial". J Orthod Sci. 2026 Sep 16;15:28. doi: 10.4103/jos.jos_165_25. eCollection 2026.
PubMed 42852432

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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Effect of Early Versus Late Premolar Extraction on Orthodontic Tooth Movement
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Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System
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All Malocclusion, Angle Class I trials

Study at a glance

From the registry record, last updated by the sponsor on 4 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Effectiveness of Micro-Osteoperforations (MOPs) in Accelerating Maxillary Canine Retraction in Angle Class I Malocclusion: A Randomized Controlled Trial.
ClinicalTrials.gov ID: NCT07155018
Acronym / sponsor ID: MOPs / DuongThaoTrangCtump
Conditions: Malocclusion, Angle Class I
Study type: Interventional
Recruitment status: Completed
Enrolment: 40 participants (actual)
Lead sponsor: Can Tho University of Medicine and PharmacyUniversity, hospital or other
Study start: 1 Jan 2025 (actual)
Primary completion: 30 Apr 2025 (actual)
Study completion: 30 Jun 2025 (actual)
First posted: 4 Sep 2025 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Crossover
Masking: Single blind (outcomes assessor)
Number of arms: 2
Model description: This is a single-blinded, split-mouth randomized controlled trial. Each participant received both interventions: on one side of the maxillary arch, micro-osteoperforations (MOPs) were performed distal to the canine, while the contralateral side served as the control with conventional retraction. Outcomes were measured within the same patient, reducing inter-individual variability.

Arm	Type	Receives
Experimental: Micro-osteoperforations	Experimental	Procedure: Micro-osteoperforations (MOPs)On the experimental side, micro-osteoperforations (MOPs) were performed distal to the maxillary canine under local anesthesia using the Excellerator RT device. Three perforations, each 1.5 mm in diameter and 5 mm deep, were created in the attached gingiva. Canine retraction was then carried out using miniscrew anchorage and NiTi closed-coil springs.
Control: Conventional Retraction	Active comparator	Procedure: Conventional Canine RetractionOn the control side, maxillary canine retraction was performed using miniscrew anchorage and NiTi closed-coil springs without any micro-osteoperforations. The mechanics were identical to the experimental side to ensure comparability.

Who may qualify

Ages: 16 to 25 years
Sex: All
Healthy volunteers: Accepted
Age groups: Child, Adult

Key inclusion criteria (4 listed)

Age 16-25 years
Patients requiring bilateral extraction of maxillary first premolars as part of orthodontic treatment
Angle Class I molar relationship
No previous orthodontic treatment

Key exclusion criteria (4 listed)

History of craniofacial trauma or congenital anomalies
Systemic or bone-related diseases
Current smoking
Use of medications affecting bone metabolism

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Micro-osteoperforations (MOPs)Maxillary canine retraction with miniscrew anchorage and NiTi closed-coil springs, without micro-osteoperforations.	Procedure or surgery	Experimental: Micro-osteoperforations
Conventional Canine RetractionMaxillary canine retraction with miniscrew anchorage and NiTi closed-coil springs, without micro-osteoperforations	Procedure or surgery	Control: Conventional Retraction

Primary outcome

Rate of Maxillary Canine Retraction
Time frame: Baseline, 4, 8, 12, and 16 weeks
Distance of maxillary canine retraction measured on 3D digital dental models using intraoral scanning.

1 secondary outcome

Pain Level (VAS Score)
Time frame: Day 1, Day 3, Day 7 after intervention

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 4 Sep 2025.
Derived from this study: PubMed 42852432Duong TT, Le LN, Truong NBT. "Effectiveness of micro-osteoperforations in accelerating maxillary canine retraction in Angle Class I malocclusion: A randomized controlled trial". J Orthod Sci. 2026 Sep 16;15:28. doi: 10.4103/jos.jos_165_25. eCollection 2026.
Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared because the study has a small sample size and the data may compromise patient confidentiality.

Related trials for Malocclusion, Angle Class I

Recruiting
Comparing 3D-Printed and Milled Titanium Plates in Jaw Surgery (Le Fort I): Accuracy and Operative Time
Malocclusion, Angle Class II, Malocclusion, Angle Class III
Recruiting
Effect of Early Versus Late Premolar Extraction on Orthodontic Tooth Movement
Malocclusion Class II, Malocclusion, Angle Class I
Not yet recruiting
3D Printed Occlusal Splints for Intraoperative Use
Malocclusion, Angle Class I, Malocclusion, Angle Class II
Not yet recruiting
Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System
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Recruiting
Clinical Performance of Direct-Printed Versus Thermoformed Aligners
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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Lam Nguyen Le, Ph.D.DDS study chair

Department of Pediatrics Dentistry and Orthodontics, Faculty of Odonto- Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Micro-osteoperforations (MOPs) and Conventional Canine Retraction in people with Malocclusion, Angle Class I, run by Can Tho University of Medicine and Pharmacy at 1 site in Vietnam.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 4 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Vietnam. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Rate of Maxillary Canine Retraction (time frame: Baseline, 4, 8, 12, and 16 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07155018, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Sep 2025.